8 results on '"Perri J"'
Search Results
2. A Statewide Multi-institutional Study of Asymptomatic Pre-Treatment Testing of Radiation Therapy Patients for SARS-CoV-2 in a High-Incidence Region of the United States
- Author
-
Dragun, A.E., primary, Modi, C., additional, Henson, C.F., additional, Jain, S., additional, Ahlawat, S., additional, Eastwick, G., additional, Kubicek, G.J., additional, Mezera, M.A., additional, Mulvihill, D.J., additional, Perri, J., additional, Juneja, B., additional, Ennis, R.D., additional, and Haffty, B.G., additional more...
- Published
- 2020
- Full Text
- View/download PDF
Catalog
3. Function-structure connectivity in patients with severe brain injury as measured by MRI-DWI and FDG-PET
- Author
-
J. Annen, L. Heine, E. Ziegler, G. Frasso, M. Bahri, C. Di Perri, J. Stender, C. Martial, S. Wannez, K. D'ostilio, E. Amico, G. Antonopoulos, C. Bernard, F. Tshibanda, R. Hustinx, S. Laureys
- Published
- 2016
- Full Text
- View/download PDF
4. Effects of Prenatal Exposure to Alcohol and Smoking on Fetal Heart Rate and Movement Regulation
- Author
-
Maristella Lucchini, Lauren C. Shuffrey, J. David Nugent, Nicoló Pini, Ayesha Sania, Margaret Shair, Lucy Brink, Carlie du Plessis, Hein J. Odendaal, Morgan E. Nelson, Christa Friedrich, Jyoti Angal, Amy J. Elliott, Coen A. Groenewald, Larry T. Burd, Michael M. Myers, William P. Fifer, Gary DV Hankins, Kimberly A Dukes, Lisa M Sullivan, Tara Tripp, Fay Robinson, Cheri Raffo, Julie M Petersen, Rebecca A Young, Cindy Mai, Elena Grillo, Travis Baker, Gregory Toland, Michael Carmen, Hannah C Kinney, Robin L Haynes, Rebecca D Folkerth, Ingrid A Holm, Theonia Boyd, David S Paterson, Hanno Steen, Kyriacos Markianos, Drucilla Roberts, Kevin G Broadbelt, Richard G Goldstein, Laura L. Nelsen, Jacob Cotton, Perri Jacobs, Amy J Elliott, Larr Burd, Jessica Gromer, H Eugene Hoyme, Margaret Jackson, Luke Mack, Bradley B Randall, Mary Ann Sens, Deborah Tobacco, Peter Van Eerden, Hendrik Odendaal, Colleen Wright, Lut Geerts, Greetje de Jong, Pawel Schubert, Shabbir Wadee, Johan Dempers, Elsie Burger, Janetta Harbron, Coen Groenewald, William Fifer, Michael Myers, Joseph Isler, Yvonne Sininger, J David Nugent, Carmen Condon, Margaret C Shair, Tracy Thai, Marian Willinger, Dale Hereld, Howard J Hoffman, and Chuan-Ming Li more...
- Subjects
fetal heart rate ,fetal movement ,autonomic nervous system ,prenatal ,alcohol ,smoking ,Physiology ,QP1-981 - Abstract
Negative associations of prenatal tobacco and alcohol exposure (PTE and PAE) on birth outcomes and childhood development have been well documented, but less is known about underlying mechanisms. A possible pathway for the adverse fetal outcomes associated with PTE and PAE is the alteration of fetal autonomic nervous system development. This study assessed PTE and PAE effects on measures of fetal autonomic regulation, as quantified by heart rate (HR), heart rate variability (SD-HR), movement, and HR-movement coupling in a population of fetuses at ≥ 34 weeks gestational age. Participants are a subset of the Safe Passage Study, a prospective cohort study that enrolled pregnant women from clinical sites in Cape Town, South Africa, and the Northern Plains region, United States. PAE was defined by six levels: no alcohol, low quit early, high quit early, low continuous, moderate continuous, and high continuous; while PTE by 4 levels: no smoking, quit early, low continuous, and moderate/high continuous. Linear regression analyses of autonomic measures were employed controlling for fetal sex, gestational age at assessment, site, maternal education, household crowding, and depression. Analyses were also stratified by sleep state (1F and 2F) and site (South Africa, N = 4025, Northern Plains, N = 2466). The final sample included 6491 maternal-fetal-dyad assessed in the third trimester [35.21 ± 1.26 (mean ± SD) weeks gestation]. PTE was associated with a decrease in mean HR in state 2F, in a dose dependent fashion, only for fetuses of mothers who continued smoking after the first trimester. In state 1F, there was a significant increase in mean HR in fetuses whose mother quit during the first trimester. This effect was driven by the Norther Plains cohort. PTE was also associated with a significant reduction in fetal movement in the most highly exposed group. In South Africa a significant increase in mean HR both for the high quit early and the high continuous group was observed. In conclusion, this investigation addresses a critical knowledge gap regarding the relationship between PTE and PAE and fetal autonomic regulation. We believe these results can contribute to elucidating mechanisms underlying risk for adverse outcomes. more...
- Published
- 2021
- Full Text
- View/download PDF
5. Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study
- Author
-
Arunnjah Vivekanandarajah, Morgan E. Nelson, Hannah C. Kinney, Amy J. Elliott, Rebecca D. Folkerth, Hoa Tran, Jacob Cotton, Perri Jacobs, Megan Minter, Kristin McMillan, Jhodie R. Duncan, Kevin G. Broadbelt, Kathryn Schissler, Hein J. Odendaal, Jyoti Angal, Lucy Brink, Elsie H. Burger, Jean A. Coldrey, Johan Dempers, Theonia K. Boyd, William P. Fifer, Elaine Geldenhuys, Coen Groenewald, Ingrid A. Holm, Michael M. Myers, Bradley Randall, Pawel Schubert, Mary Ann Sens, Colleen A. Wright, Drucilla J. Roberts, Laura Nelsen, Shabbir Wadee, Dan Zaharie, Robin L. Haynes, and PASS Network more...
- Subjects
acetylcholine ,serotonin ,cardiorespiratory ,arousal ,medulla oblongata ,mesopontine tegmentum ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Pre-natal exposures to nicotine and alcohol are known risk factors for sudden infant death syndrome (SIDS), the leading cause of post-neonatal infant mortality. Here, we present data on nicotinic receptor binding, as determined by 125I-epibatidine receptor autoradiography, in the brainstems of infants dying of SIDS and of other known causes of death collected from the Safe Passage Study, a prospective, multicenter study with clinical sites in Cape Town, South Africa and 5 United States sites, including 2 American Indian Reservations. We examined 15 pons and medulla regions related to cardiovascular control and arousal in infants dying of SIDS (n = 12) and infants dying from known causes (n = 20, 10 pre-discharge from time of birth, 10 post-discharge). Overall, there was a developmental decrease in 125I-epibatidine binding with increasing postconceptional age in 5 medullary sites [raphe obscurus, gigantocellularis, paragigantocellularis, centralis, and dorsal accessory olive (p = 0.0002–0.03)], three of which are nuclei containing serotonin cells. Comparing SIDS with post-discharge known cause of death (post-KCOD) controls, we found significant decreased binding in SIDS in the nucleus pontis oralis (p = 0.02), a critical component of the cholinergic ascending arousal system of the rostral pons (post-KCOD, 12.1 ± 0.9 fmol/mg and SIDS, 9.1 ± 0.78 fmol/mg). In addition, we found an effect of maternal smoking in SIDS (n = 11) combined with post-KCOD controls (n = 8) on the raphe obscurus (p = 0.01), gigantocellularis (p = 0.02), and the paragigantocellularis (p = 0.002), three medullary sites found in this study to have decreased binding with age and found in previous studies to have abnormal indices of serotonin neurotransmission in SIDS infants. At these sites, 125I-epibatidine binding increased with increasing cigarettes per week. We found no effect of maternal drinking on 125I-epibatidine binding at any site measured. Taken together, these data support changes in nicotinic receptor binding related to development, cause of death, and exposure to maternal cigarette smoking. These data present new evidence in a prospective study supporting the roles of developmental factors, as well as adverse exposure on nicotinic receptors, in serotonergic nuclei of the rostral medulla—a finding that highlights the interwoven and complex relationship between acetylcholine (via nicotinic receptors) and serotonergic neurotransmission in the medulla. more...
- Published
- 2021
- Full Text
- View/download PDF
6. Expression of fibroblast growth factor receptor 1 correlates inversely with the efficacy of single-agent fibroblast growth factor receptor-specific inhibitors in pancreatic cancer.
- Author
-
Lin Q, Serratore A, Perri J, Roy Chaudhuri T, Qu J, Ma WW, Kandel ES, and Straubinger RM
- Subjects
- Humans, Cell Line, Tumor, Gemcitabine, Receptor, Fibroblast Growth Factor, Type 1, Adenocarcinoma, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms genetics
- Abstract
Background and Purpose: Elevated fibroblast growth factor receptor (FGFR) activity correlates with pancreatic adenocarcinoma (PDAC) progression and poor prognosis. However, its potential as a therapeutic target remains largely unexplored., Experimental Approach: The mechanisms of action and therapeutic effects of selective pan-FGFR inhibitors (pan-FGFRi) were explored using in vitro and in vivo PDAC models ranging from gemcitabine-sensitive to highly gemcitabine-resistant (GemR). Gain-/loss-of-function investigations were employed to define the role of individual FGFRs in cell proliferation, migration, and treatment response and resistance., Results: The pan-FGFRi NVP-BGJ398 significantly inhibited cell proliferation, migration, and invasion, and downregulated key cell survival- and invasiveness markers in multiple PDAC cell lines. Gemcitabine is a standard-of-care for PDAC, but development of resistance to gemcitabine (GemR) compromises its efficacy. Acquired GemR was modelled experimentally by developing highly GemR cells using escalating gemcitabine exposure in vitro and in vivo. FGFRi treatment inhibited GemR cell proliferation, migration, GemR marker expression, and tumour progression. FGFR2 or FGFR3 loss-of-function by shRNA knockdown failed to decrease cell growth, whereas FGFR1 knockdown was lethal. FGFR1 overexpression promoted cell migration more than proliferation, and reduced FGFRi-mediated inhibition of proliferation and migration. Single-agent FGFRi suppressed the viability and growth of multiple patient-derived xenografts inversely with respect to FGFR1 expression, underscoring the influence of FGFR1-dependent tumour responses to FGFRi. Importantly, secondary data analysis showed that PDAC tumours expressed FGFR1 at lower levels than in normal pancreas tissue., Conclusions and Implications: Single-agent FGFR inhibitors mediate selective, molecularly-targeted suppression of PDAC proliferation, and their effects are greatest in PDAC tumours expressing low-to-moderate levels of FGFR1., (© 2023 British Pharmacological Society.) more...
- Published
- 2024
- Full Text
- View/download PDF
7. A Statewide Multi-Institutional Study of Asymptomatic Pretreatment Testing of Radiation Therapy Patients for SARS-CoV-2 in a High-Incidence Region of the United States.
- Author
-
Modi C, Dragun AE, Henson CF, Jain S, Ahlawat S, Eastwick G, Kubicek GJ, Mezera M, Mulvihill DJ, Perri J, Juneja B, Khullar K, Ennis RD, and Haffty BG
- Abstract
Purpose: Our purpose was to establish the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in asymptomatic patients scheduled to receive radiation therapy and its effect on management decisions., Methods and Materials: Between April 2020 and July 2020, patients without influenza-like illness symptoms at four radiation oncology departments (two academic university hospitals and two community hospitals) underwent polymerase chain reaction testing for SARS-CoV-2 before the initiation of treatment. Patients were tested either before radiation therapy simulation or after simulation but before treatment initiation. Patients tested for indications of influenza-like illness symptoms were excluded from this analysis. Management of SARS-CoV-2-positive patients was individualized based on disease site and acuity., Results: Over a 3-month period, a total of 385 tests were performed in 336 asymptomatic patients either before simulation (n = 75), post-simulation, before treatment (n = 230), or on-treatment (n = 49). A total of five patients tested positive for SARS-CoV-2, for a pretreatment prevalence of 1.3% (2.6% in north/central New Jersey and 0.4% in southern New Jersey/southeast Pennsylvania). The median age of positive patients was 58 years (range, 38-78 years). All positive patients were white and were relatively equally distributed with regard to sex (2 male, 3 female) and ethnicity (2 Hispanic and 3 non-Hispanic). The median Charlson comorbidity score among positive patients was five. All five patients were treated for different primary tumor sites, the large majority had advanced disease (80%), and all were treated for curative intent. The majority of positive patients were being treated with either sequential or concurrent immunosuppressive systemic therapy (80%). Initiation of treatment was delayed for 14 days with the addition of retesting for four patients, and one patient was treated without delay but with additional infectious-disease precautions., Conclusions: Broad-based pretreatment asymptomatic testing of radiation oncology patients for SARS-CoV-2 is of limited value, even in a high-incidence region. Future strategies may include focused risk-stratified asymptomatic testing., (© 2021 Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.) more...
- Published
- 2021
- Full Text
- View/download PDF
8. Zonda is a novel early component of the autophagy pathway in Drosophila .
- Author
-
Melani M, Valko A, Romero NM, Aguilera MO, Acevedo JM, Bhujabal Z, Perez-Perri J, de la Riva-Carrasco RV, Katz MJ, Sorianello E, D'Alessio C, Juhász G, Johansen T, Colombo MI, and Wappner P
- Subjects
- Animals, Autophagy-Related Proteins, Drosophila Proteins genetics, Drosophila Proteins metabolism, Drosophila melanogaster genetics, Drosophila melanogaster metabolism, Immunophilins genetics, Phagosomes metabolism, Phosphatidylinositol 3-Kinases metabolism, Phosphatidylinositol Phosphates metabolism, Signal Transduction, Autophagy physiology, Class III Phosphatidylinositol 3-Kinases metabolism, Immunophilins metabolism
- Abstract
Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically required for starvation-induced autophagy. We show that Zonda operates at early stages of the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. Zonda displays an even distribution under basal conditions and, soon after starvation, nucleates in endoplasmic reticulum-associated foci that colocalize with omegasome markers. Zonda nucleation depends on Atg1, Atg13, and Atg17 but does not require Vps34, Vps15, Atg6, or Atg14. Zonda interacts physically with Atg1 through its kinase domain, as well as with Atg6 and Vps34. We propose that Zonda is an early component of the autophagy cascade necessary for Vps34-dependent PI3P deposition and omegasome formation., (© 2017 Melani, Valko, Romero, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).) more...
- Published
- 2017
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.