10 results on '"Pennacchioni, M"'
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2. From Neandertals to modern humans: New data on the Uluzzian
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Villa, P, Pollarolo, L, Conforti, J, Marra, F, Biagioni, C, Degano, I, Lucejko, J, Tozzi, C, Pennacchioni, M, Zanchetta, G, Nicosia, C, Martini, M, Sibilia, E, Panzeri, L, Villa, Paola, Pollarolo, Luca, Conforti, Jacopo, Marra, Fabrizio, Biagioni, Cristian, Degano, Ilaria, Lucejko, Jeannette J., Tozzi, Carlo, Pennacchioni, Massimo, Zanchetta, Giovanni, Nicosia, Cristiano, Martini, Marco, Sibilia, Emanuela, Panzeri, Laura, Villa, P, Pollarolo, L, Conforti, J, Marra, F, Biagioni, C, Degano, I, Lucejko, J, Tozzi, C, Pennacchioni, M, Zanchetta, G, Nicosia, C, Martini, M, Sibilia, E, Panzeri, L, Villa, Paola, Pollarolo, Luca, Conforti, Jacopo, Marra, Fabrizio, Biagioni, Cristian, Degano, Ilaria, Lucejko, Jeannette J., Tozzi, Carlo, Pennacchioni, Massimo, Zanchetta, Giovanni, Nicosia, Cristiano, Martini, Marco, Sibilia, Emanuela, and Panzeri, Laura
- Abstract
Having thrived in Eurasia for 350,000 years Neandertals disappeared from the record around 40,000–37,000 years ago, after modern humans entered Europe. It was a complex process of population interactions that included cultural exchanges and admixture between Neandertals and dispersing groups of modern humans. In Europe Neandertals are always associated with the Mousterian while the Aurignacian is associated with modern humans only. The onset of the Aurignacian is preceded by “transitional” industries which show some similarities with the Mousterian but also contain modern tool forms. Information on these industries is often incomplete or disputed and this is true of the Uluzzian. We present the results of taphonomic, typological and technological analyses of two Uluzzian sites, Grotta La Fabbrica (Tuscany) and the newly discovered site of Colle Rotondo (Latium). Comparisons with Castelcivita and Grotta del Cavallo show that the Uluzzian is a coherent cultural unit lasting about five millennia, replaced by the Protoaurignacian before the eruption of the Campanian Ignimbrite. The lack of skeletal remains at our two sites and the controversy surrounding the stratigraphic position of modern human teeth at Cavallo makes it difficult to reach agreement about authorship of the Uluzzian, for which alternative hypotheses have been proposed. Pending the discovery of DNA or further human remains, these hypotheses can only be evaluated by archaeological arguments, i.e. evidence of continuities and discontinuities between the Uluzzian and the preceding and succeeding culture units in Italy. However, in the context of “transitional” industries with disputed dates for the arrival of modern humans in Europe, and considering the case of the Châtelperronian, an Upper Paleolithic industry made by Neandertals, typo-technology used as an indicator of hominin authorship has limited predictive value. We corroborate previous suggestions that the Middle-to-Upper Paleolithic transition occur
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- 2018
3. New insights into the onset and evolution of the central Apennine extensional intermontane basins based on the tectonically active L'Aquila Basin (central Italy)
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Cosentino, D., Asti, R., Nocentini, M., Gliozzi, E., Kotsakis, T., Mattei, M., Esu, D., Spadi, M., Tallini, M., Cifelli, F., Pennacchioni, M., Cavuoto, G., Di Fiore, V., Spadi, Marco, Dipartimento di Scienze [Roma], Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Geologiche [Roma TRE], Dipartimento di Scienze della Terra, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Dipartimento di Ingegneria Civile, Edile-Architettura, Ambientale (DICEAA), Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Istituto per l’Ambiente Marino Costiero, Consiglio Nazionale delle Ricerche [Napoli] (CNR), Cosentino, Domenico, Asti, Riccardo, Nocentini, Marco, Gliozzi, Elsa, Kotsakis, Anastassio, Mattei, Massimo, Esu, D., Spadi, Marco, Tallini, M., Cifelli, Francesca, Pennacchioni, Massimo, Cavuoto, G., Di Fiore, V, Università degli Studi Roma Tre, Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Università degli Studi dell'Aquila (UNIVAQ), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS)
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[SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics ,geography ,Extensional fault ,geography.geographical_feature_category ,Rift ,010504 meteorology & atmospheric sciences ,BACK-ARC EXTENSION ,EARLY PLEISTOCENE ,NORTHERN APENNINES ,NORMAL-FAULT ,QUATERNARY ,SEDIMENTARY ,SUBDUCTION ,REGION ,NEOGENE ,HISTORY ,Geology ,Late Miocene ,Structural basin ,Sedimentary basin ,Fault (geology) ,010502 geochemistry & geophysics ,Extensional intermontane basins, Pliocene-Pleistocene continental deposits, Tectonically active sedimentary basins, L'Aquila Basin, central Apennines ,01 natural sciences ,Paleontology ,13. Climate action ,Sedimentary rock ,14. Life underwater ,Foreland basin ,Seismology ,0105 earth and related environmental sciences - Abstract
International audience; Study of the tectonically active L'Aquila Basin offers new insights into both the creation of the extensional intermontane basins of the central Apennines of Italy and their tectono-sedimentary evolution through time. The combination of large mammal remains, ostracods, molluscs, Mousterian tools, and 14 C dating allows better definition of the onset and stratigraphic evolution of the L'Aquila Basin. Interpretation of a seismic reflection profile and well-log data allow evaluation of the subsurface setting of this sedimentary basin and its tectono-sedimentary evolution. The occurrence of a wedge-shaped seismic unit at the base of the basin sedimentary succession defines the first phase of basin fill during a late Piacenzian–Gelasian synrift stage. Activity along the main fault of the extensional fault system responsible for the onset and subsequent development of the western sector of the L'Aquila Basin (L'Aquila– Scoppito subbasin) migrated from southwest to northeast, reaching the presently active Mount Pettino normal fault only in the late Pleistocene–Holocene. The onset of sedimentation in the L'Aquila Basin was synchronous with the onset in the Tiberino Basin, and so the idea that these extensional GSA Bulletin; Month/Month 2017; v. 129; no. intermontane basins become progressively younger from the Tyrrhenian toward the Adriatic side of the central Apennines is rejected. In the northern and central Apen-nines, only two major syndepositional ex-tensional domains can be recognized: a late Miocene rifting area, which includes all the late Miocene extensional basins in Tuscany, and a late Pliocene to earliest Pleistocene rifting area, which possibly includes all the intermontane basins from the Tiberino Basin to the Sulmona Basin. The different time gaps between compressional and exten-sional deformation at any given locality in the central Apennines could indicate a partial decoupling of processes responsible for the migration of shortening and extension toward the foreland. Diachroneity between the eastward migration of shortening in the foreland and extension in the inner part of the orogen supports the notion that the central Apennines were created as a result of a partially decoupled collision zone. Study of the onset of the central Apennine extensional intermontane basins, together with their seismic activity, indicates that the central Apennine postorogenic extensional domain represents an archive of ~3 m.y. of continued crustal extension. These findings help to refine models of the long-term extensional rate of the central Apennines, and they provide a basis for more reliable seismotectonic models for one of the most seismically active sectors of the central Mediterranean area.
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- 2017
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4. The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
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Cohen, At, Gitt, Ak, Bauersachs, R, Fronk, Em, Laeis, P, Mismetti, P, Monreal, M, Willich, Sn, Bramlage, P, Agnelli, G, Brodmann, M, Rief, P, Eischer, L, Stoshikj, S, Hirschl, M, Weinmann, S, Peter Marschang, P, Abbadie, F, Achkar, A, Addala, A, Reynaldo, P, Adnet, F, Alexandra, Jf, Aquilanti, S, Belhassane, A, Benaroya, B, Berremili, T, Grenot, Mc, Birr, V, Holtea, D, Bonnin, C, Bosler, F, Bresin Durand MG, Brisot, D, Brousse, C, De La Fuente, T, Cayman, C, Cazaubon, M, Champion, O, Chanut, M, Chevalet, P, Connault, J, Durant, C, Constans, J, Cordeanu, M, Couturaud, F, Lacut, K, De Dedker, L, Piloquet, Fx, Decoulx, E, Derrien, B, Diamand, Jm, Diard, A, Douadi, Y, Dupas, S, Modeliar Remond SS, Sevestre, Ma, Edhery, S, Falvo, N, Farcas Taralunga, C, Ferrari, E, Gaillard, C, Garrigues, D, Gillet, Jl, Giordana, P, Grange, C, Vital-Durand, D, Grare, F, Hadj Henni, A, Heuser, S, Schmidt, J, Hidden-Henic, V, Hottin, D, Imbert, B, Pernod, G, Jakob, D, Jacquinandi, V, Jurus, C, Lacoste, A, Laroche, Jp, Martin, M, Mazollier, C, Mersel, T, Miserey, G, Nedey, C, Nou, M, Quere, I, Ouvry, P, Peuch, B, Pichot, O, Poulain, V, Ray, P, Rifai, A, Roy, Pm, Saby, Jc, Simon, F, Simonot-Lalandec, E, Stephan, D, Tissot, A, Vodoungnon, H, Adamczyk, A, Schnabl, S, Al Ahmad, W, Weber, H, Axthelm, C, Axthelm, P, Bergmann, K, Beschorner, U, Knittel, M, Binias, Kh, Pasligh, M, Boral, M, Girke, F, Bratsch, H, Brauer, G, Burghard, S, Demann, C, Rennebaum, C, Emter, E, Demmig, A, Eberlein, U, Enger, F, Eschenburg, J, Eschenburg, Ju, Forkmann, L, Frank, J, Freischmidt, H, Gassauer, M, Fritsche, I, Kubicek–hofmann, C, Goebels, Mc, Guggenbichler, S, Härtel, D, Hartmann, K, Heilberger, P, Heinsius, A, Held, M, Schnupp, S, Herman, G, Herold, J, Hertrich, F, Hommel, H, Hütte, G, Kalka, C, Jungandreas, K, Ramthor, M, Karcher, J, Werner, N, Karl-Wollweber, S, Keilhau, Da, Kittel, K, Knolinski, T, Köhler, C, Werth, S, Kopplin, U, Körner, I, Wittig, K, Dres, P, Kröger, K, Moysidis, T, Kroschel, U, Leschke, M, zur Nieden, T, Lübbert, G, Lutz, A, Wucherpfennig, P, Marencke, Gh, Mortensen, K, Reppel, M, Nelles, H, Nestler, K, Neumeister, A, Schlosser, A, Oettler, W, Ott, I, Otto, A, Pertermann, A, Pfister, R, Pindur, P, Pourhassan, S, Predel, D, Pudollek, T, Reimer, D, Richter, R, Eberhad Rieker, E, Rothenbücher, G, Rothhagen, B, Rudolff, S, Stücker, M, Schäfer, A, Sonnenschein, K, Schafnitzl, W, Schellong, S, Voigts, B, Schiller, M, Schmeink, T, Schmeink, P, Schneider, H, Schön, N, Schulze, M, Sechtem, U, Sedl, S, Werno, Hs, Stachowitz, J, Thieme, M, Tiefenbacher, C, Tsantilas, D, Vieth, P, vom Dahl, J, Grün-Himmelmann, K, von Bilderling, P, von Maltik, T, Weinrich, K, Weyer, M, Wirtz, P, Wittig, I, Zierock, P, Ageno, W, Caprioli, C, Rancan, E, Guercini, F, Mommi, V, Amitrano, M, Cannavacciuolo, F, Amore, M, D'Antoni, S, Angelini, E, La Forgia, S, Antignani, Pl, Calandra, G, Arone, A, Perticone, F, Sciacqua, A, Asaro, G, Bellisi, M, Attanzio, Mt, Pinto, A, Attinasi, V, Cillari, E, Sorvillo, S, Balbarini, A, Santini, C, Violo, C, Banfi, E, Lodigiani, C, Barcellona, D, Delpin, S, Marongiu, S, Barillari, G, Pasca, S, Bartolini, C, Verdecchia, P, Bartone, M, Mancuso, G, Bellanuova, I, Felis, S, Bellizzi, A, Masotti, L, Bianchi, M, Carugati, A, Bianchini, G, Guarnera, G, Boari, B, Gallerani, M, Pasin, M, Bortoluzzi, C, Parisi, R, Brucoli, C, Palasciano, G, Camporese, G, Tonello, C, Canafoglia, L, Rupoli, S, Cancellieri, E, Paoletti, O, Testa, S, Carlizza, A, Carnovali, M, Sada, S, Samaden, A, Casarsa, C, Mearelli, F, Pivetti, G, Catalini, R, Zingaretti, O, Cavazza, S, Cosmi, B, Cenci, C, Prisco, D, Silvestri, E, Ceresa, F, Patanè, F, Ciampa, A, Siniscalchi, V, Ciarambino, T, De Bartolomeo, G, Clemente, M, Conti, F, Paiella, L, D’Avino, M, D'Alessandro, A, Placentino, M, Sollazzo, V, D'Angelo, A, Viganò, S, De Campora, P, Sangiuolo, R, De Franciscis, S, Serra, R, De Gaudenzi, E, De Santis, F, Piccinni, Gc, De Tommaso, I, Di Francesco, L, Vincentelli, Gm, Di Maggio, R, Saccullo, G, Siragusa, S, Di Micco, P, Fontanella, A, Di Michele, D, Di Minno, G, Tufano, A, Di Nisio, M, Porreca, E, Donadio, F, Imberti, D, Enea, I, Fabbian, F, Manfredini, R, Pala, P, Falanga, A, Milesi, V, Fiore, V, Signorelli, Ss, Franco, E, Giudice, G, Frausini, G, Rovinelli, M, Fuorlo, M, Landolfi, R, Morretti, T, Gamberini, S, Salmi, R, Ghirarduzzi, A, Ghizzi, G, Pepe, C, Gianniello, F, Martinelli, I, Iosub, Di, Piovella, F, Iozzi, E, Talerico, A, La Regina, M, Orlandini, F, Marconi, L, Palla, A, Marcucci, R, Poli, D, Margheriti, R, Sala, G, Marra, A, Marrocco, F, Montagna, Es, Silvestris, F, Vallarelli, S, Mos, L, Rossetto, V, Mugno, F, Di Salvo, M, Nitti, C, Pennacchioni, M, Salvi, A, Olivieri, O, Tosi, F, Zorzi, F, Onesta, M, Pagliara, V, Villalta, S, Paolucci, G, Severino, S, Pierri, F, Russo, V, Pizzini, Am, Quintavalla, R, Rubino, P, Ria, L, Schenone, A, Strafino, C, Tropeano, P, Vetrano, V, Zanatta, N, Adarraga Cansino MD, Gutierrez, Ja, de las Revillas FA, Amado Fernández, C, Calvo Mijares, N, Blanco-Molina, Ma, Garcia, Ma, Joya Seijo, D, Aranda Blazquez, R, López-Sáez, Jb, Arellano Rodrigo, E, Villalta Blanch, J, Armengou Arxe, A, García-Bragado Dalmau, F, Ballaz Quincoces, A, García Loizaga, A, Beato Pérez JL, Bedate Díaz, P, Quezada Loaiza, A, Castellote, Mc, Cañas Alcántara, I, Lluís Padierna, M, Carrasco Expósito, M, Millón Caño JA, Carrasco Mas, A, Cereto Castro, F, Castrodeza Sanz, R, Ortiz de Saracho, J, Cisneros de la Fuente, E, de Ancos Aracil, C, Ruiz, J, de Daborenea González MD, Fernández Iglesias, A, de la Fuente Aguado, J, González, Lg, del Carmen Fernández-Capitán, M, Lorenzo Hernández, A, del Toro Cervera, J, Pérez Rus, G, Delgado Bregel JL, Díez Fernández, F, Santalla Valle EA, Elias Hernández, T, Jara Palomares, L, Ferri Bataler, R, Nieto Rodríguez JA, García García JM, Villanueva Montes MA, González Porras JR, Guil García, M, San Román Terán CM, Hernando López, E, Roncero Lázaro, A, Jaras, Mj, Jiménez Castro, D, Jiménez-Rodríguez Madridejos, R, Pedrajas Navas JM, Lecumberri, R, Martínez, N, López Castellanos GT, Manzano Espinosa, L, López Jiménez, L, Madridano Cobo, O, Mainez Saiz, C, Romero Pizarro, Y, Marchena Yglesias PJ, Martín del Pozo, M, Melibovsky, L, Altarriba, Es, Monreal Bosch, M, Monte Secades, R, Mora Luján JM, Riera Mestre, A, Moral Moral, P, Todolí Parra JA, Moreno Flores, A, Sánchez Muñoz-Torrero JF, Muñoz Rodríguez FJ, Núñez Fernández MJ, Oncala Sibajas, E, Vaquero de Sedas, M, Parra Caballero, P, Pons Martín del Campo, I, Portillo Sánchez, J, Rivera Gallego, A, Villaverde Álvarez, I, Rodríguez Beltrán EM, Sánchez Fuentes, D, Roldán Schilling, V, Sánchez Álvarez, J, López, Gt, Suriñach Caralt JM, Tirado Miranda, R, Usandizaga de Antonio, E, Banyai, M, Frank, U, Jörg, Gr, Jeanneret, C, Staub, D, Ackroyd, A, Agarwal, G, Mearns, B, Alikhan, R, Allameddine, A, Al-Refaie, F, Arden, C, Austin, A, Bakhai, A, Barton, T, Ewad, H, Body, R, Thachil, J, Chacko, J, Chandra, D, Charters, F, Church, A, Mcgrane, F, Clements, J, Clifford, P, Cox, D, Crouch, M, Crowther, M, Davies, E, Davies, M, Dimitri, S, Drebes, A, Franklin, S, George, J, Irvine, N, Gerofke, H, Gibbs, C, Goh, T, Gupta, S, Holmes, J, Jackson-Voyzey, E, Jones, N, Kallat, A, Kerr, P, Kesteven, P, Lench, T, Lester, W, Lowe, G, Lewis, M, Mccormack, T, Mccoye, A, Moriarty, A, Morris, W, Narayanan, M, Oo, N, Reed, M, Rose, P, Saja, K, Sivakumaran, M, Sohal, M, Solomons, G, Sultanzadeh, Sj, Venton, T, Wakeling, J, Walby, C, Waldron, M, Watt, S, Willcock, W, and Zafar, A.
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Male ,Time Factors ,Databases, Factual ,Administration, Oral ,Disease ,Comorbidity ,030204 cardiovascular system & hematology ,registry ,Direct oral anticoagulants ,0302 clinical medicine ,Recurrence ,Risk Factors ,Epidemiology ,030212 general & internal medicine ,Prospective Studies ,Registries ,anticoagulation ,LS4_7 ,Venous Thrombosis ,Hematology ,Venous Thromboembolism ,Vitamin K antagonist ,Middle Aged ,Thrombosis ,Pulmonary embolism ,Europe ,vitamin K antagonists ,Treatment Outcome ,Administration ,Female ,Coagulation and Fibrinolysis ,Venous thromboembolism ,Oral ,Adult ,medicine.medical_specialty ,Registry ,medicine.drug_class ,Socio-culturale ,Hemorrhage ,direct oral anticoagulants ,Venous thromboembolism, anticoagulation, direct oral anticoagulants, registry, vitamin K antagonists ,Anticoagulation ,Vitamin K antagonists ,Aged ,Anticoagulants ,Humans ,Pulmonary Embolism ,03 medical and health sciences ,Databases ,Disease registry ,Internal medicine ,medicine ,cardiovascular diseases ,Intensive care medicine ,Factual ,business.industry ,medicine.disease ,equipment and supplies ,Clinical trial ,business - Abstract
SummaryVenous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0% were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5%). The diagnosis was deep-vein thrombosis (DVT) in 59.5% and pulmonary embolism (PE) in 40.5%. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5%), hypertension (42.3%) and dyslipidaemia (21.1%). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2%), almost half received a vitamin K antagonist (48.7%) and nearly a quarter received a DOAC (24.5%). Almost a quarter of all presentations were for recurrent VTE, with >80% of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.
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- 2016
5. Bone and body composition analyses by DXA in adults with GH deficiency: effects of long-term replacement therapy
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Marcella Sirtori, Alessandro Rossini, Francesca Perticone, Alessandro Rubinacci, Roberto Lanzi, Mario Pennacchioni, Marco Losa, Carlotta Galeone, Claudio Pelucchi, Rossini, A., Lanzi, R., Galeone, C., Pelucchi, C., Pennacchioni, M., Perticone, F., Sirtori, M., Losa, M., and Rubinacci, A.
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Adult ,Male ,Hormone Replacement Therapy ,Endocrinology, Diabetes and Metabolism ,Physiology ,Body composition ,Growth hormone deficiency ,Endocrinology ,Bone Density ,Diabetes mellitus ,GH replacement therapy ,Medicine ,Humans ,Femur ,Bone ,Dwarfism, Pituitary ,Retrospective Studies ,Bone mineral ,Lumbar Vertebrae ,business.industry ,Human Growth Hormone ,medicine.disease ,Sexual dimorphism ,Cohort ,Lean body mass ,Body Composition ,Female ,business ,GH Deficiency - Abstract
Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD.Methods: Data from 138 patients with AGHD (34.3 ± 14.3 years, 48 women and 90 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and radius, and total and truncular body composition were evaluated by dual energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis.Results: Lumbar spine BMD consistently increased in males, while in females decreased after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral BMD in either sexes, while a progressive increase at radius was observed only in males. Lean mass significantly increased in both sexes, while fat mass decreased only in males.Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying more favorable outcome.
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- 2021
6. From Neandertals to modern humans: New data on the Uluzzian
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Jacopo Conforti, Carlo Tozzi, Massimo Pennacchioni, Emanuela Sibilia, Jeannette J. Lucejko, Fabrizio Marra, Paola Villa, Laura Panzeri, Giovanni Zanchetta, Marco Martini, Cristian Biagioni, Luca Pollarolo, Cristiano Nicosia, Ilaria Degano, Villa, P, Pollarolo, L, Conforti, J, Marra, F, Biagioni, C, Degano, I, Lucejko, J, Tozzi, C, Pennacchioni, M, Zanchetta, G, Nicosia, C, Martini, M, Sibilia, E, and Panzeri, L
- Subjects
Genetics and Molecular Biology (all) ,History ,Hominids ,Raw Materials ,Stratigraphy ,Animals ,Cooking ,History, Ancient ,Humans ,Italy ,Minerals ,Weapons ,Neanderthals ,Biochemistry, Genetics and Molecular Biology (all) ,Agricultural and Biological Sciences (all) ,Social Sciences ,Stone Age ,lcsh:Medicine ,Neandertals ,01 natural sciences ,Biochemistry ,ddc:590 ,0601 history and archaeology ,Paleolithic Period ,Stratigraphy (archaeology) ,lcsh:Science ,Palaeolithic ,education.field_of_study ,Multidisciplinary ,060102 archaeology ,Ancient DNA ,Mousterian ,Geology ,06 humanities and the arts ,Radioactive Carbon Dating ,Geography ,Archaeology ,Physical Sciences ,Physical Anthropology ,Research Article ,Uluzzian, Colle Rotondo, Grotta La Fabbrica, OSL dating ,010506 paleontology ,Prehistory ,Population ,Materials Science ,Context (language use) ,Research and Analysis Methods ,Ancient ,Paleoanthropology ,Hominins ,education ,Chemical Characterization ,0105 earth and related environmental sciences ,Isotope Analysis ,Modern Human ,lcsh:R ,Biology and Life Sciences ,Paleontology ,Geologic Time ,Châtelperronian ,Anthropology ,Archaeological Dating ,Upper Paleolithic ,Earth Sciences ,lcsh:Q ,Aurignacian - Abstract
Having thrived in Eurasia for 350,000 years Neandertals disappeared from the record around 40,000–37,000 years ago, after modern humans entered Europe. It was a complex process of population interactions that included cultural exchanges and admixture between Neandertals and dispersing groups of modern humans. In Europe Neandertals are always associated with the Mousterian while the Aurignacian is associated with modern humans only. The onset of the Aurignacian is preceded by “transitional” industries which show some similarities with the Mousterian but also contain modern tool forms. Information on these industries is often incomplete or disputed and this is true of the Uluzzian. We present the results of taphonomic, typological and technological analyses of two Uluzzian sites, Grotta La Fabbrica (Tuscany) and the newly discovered site of Colle Rotondo (Latium). Comparisons with Castelcivita and Grotta del Cavallo show that the Uluzzian is a coherent cultural unit lasting about five millennia, replaced by the Protoaurignacian before the eruption of the Campanian Ignimbrite. The lack of skeletal remains at our two sites and the controversy surrounding the stratigraphic position of modern human teeth at Cavallo makes it difficult to reach agreement about authorship of the Uluzzian, for which alternative hypotheses have been proposed. Pending the discovery of DNA or further human remains, these hypotheses can only be evaluated by archaeological arguments, i.e. evidence of continuities and discontinuities between the Uluzzian and the preceding and succeeding culture units in Italy. However, in the context of “transitional” industries with disputed dates for the arrival of modern humans in Europe, and considering the case of the Châtelperronian, an Upper Paleolithic industry made by Neandertals, typo-technology used as an indicator of hominin authorship has limited predictive value. We corroborate previous suggestions that the Middle-to-Upper Paleolithic transition occurred as steps of rapid changes and geographically uneven rates of spread.
- Published
- 2018
7. Bone and body composition analyses by DXA in adults with GH deficiency: effects of long-term replacement therapy.
- Author
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Rossini A, Lanzi R, Galeone C, Pelucchi C, Pennacchioni M, Perticone F, Sirtori M, Losa M, and Rubinacci A
- Subjects
- Adult, Body Composition, Bone Density, Female, Hormone Replacement Therapy, Humans, Lumbar Vertebrae diagnostic imaging, Male, Retrospective Studies, Dwarfism, Pituitary, Human Growth Hormone
- Abstract
Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of the gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD., Methods: Data from 118 patients with AGHD (34.8 ± 14.4 years, 43 women and 75 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and 1/3 radius, and total and truncular body composition were evaluated by dual-energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis., Results: Lumbar spine BMD consistently increased in males, while it decreased in females after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral and 1/3 radial BMD in either sexes. Lean mass significantly increased in both sexes, while fat mass only decreased in males., Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying a more favorable outcome., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF
8. Multi-resolution visualization and analysis of biomolecular networks through hierarchical community detection and web-based graphical tools.
- Author
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Perlasca P, Frasca M, Ba CT, Gliozzo J, Notaro M, Pennacchioni M, Valentini G, and Mesiti M
- Subjects
- Algorithms, COVID-19 metabolism, COVID-19 virology, Humans, Proteins genetics, Proteins metabolism, SARS-CoV-2 metabolism, SARS-CoV-2 pathogenicity, COVID-19 genetics, Internet, Metabolic Networks and Pathways genetics, SARS-CoV-2 genetics
- Abstract
The visual exploration and analysis of biomolecular networks is of paramount importance for identifying hidden and complex interaction patterns among proteins. Although many tools have been proposed for this task, they are mainly focused on the query and visualization of a single protein with its neighborhood. The global exploration of the entire network and the interpretation of its underlying structure still remains difficult, mainly due to the excessively large size of the biomolecular networks. In this paper we propose a novel multi-resolution representation and exploration approach that exploits hierarchical community detection algorithms for the identification of communities occurring in biomolecular networks. The proposed graphical rendering combines two types of nodes (protein and communities) and three types of edges (protein-protein, community-community, protein-community), and displays communities at different resolutions, allowing the user to interactively zoom in and out from different levels of the hierarchy. Links among communities are shown in terms of relationships and functional correlations among the biomolecules they contain. This form of navigation can be also combined by the user with a vertex centric visualization for identifying the communities holding a target biomolecule. Since communities gather limited-size groups of correlated proteins, the visualization and exploration of complex and large networks becomes feasible on off-the-shelf computer machines. The proposed graphical exploration strategies have been implemented and integrated in UNIPred-Web, a web application that we recently introduced for combining the UNIPred algorithm, able to address both integration and protein function prediction in an imbalance-aware fashion, with an easy to use vertex-centric exploration of the integrated network. The tool has been deeply amended from different standpoints, including the prediction core algorithm. Several tests on networks of different size and connectivity have been conducted to show off the vast potential of our methodology; moreover, enrichment analyses have been performed to assess the biological meaningfulness of detected communities. Finally, a CoV-human network has been embedded in the system, and a corresponding case study presented, including the visualization and the prediction of human host proteins that potentially interact with SARS-CoV2 proteins., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
- Full Text
- View/download PDF
9. Clinical effects of robot-assisted gait training and treadmill training for Parkinson's disease. A randomized controlled trial.
- Author
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Capecci M, Pournajaf S, Galafate D, Sale P, Le Pera D, Goffredo M, De Pandis MF, Andrenelli E, Pennacchioni M, Ceravolo MG, and Franceschini M
- Subjects
- Aged, Aged, 80 and over, Disability Evaluation, Exercise Test, Female, Gait Disorders, Neurologic etiology, Gait Disorders, Neurologic physiopathology, Humans, Male, Middle Aged, Mobility Limitation, Parkinson Disease physiopathology, Quality of Life, Surveys and Questionnaires, Time and Motion Studies, Treatment Outcome, Exercise Therapy methods, Gait physiology, Gait Disorders, Neurologic therapy, Parkinson Disease complications, Robotics methods
- Abstract
Background: Although gait disorders strongly contribute to perceived disability in people with Parkinson's disease, clinical trials have failed to identify which task-oriented gait training method can provide the best benefit. Freezing of gait remains one of the least investigated and most troublesome symptoms., Objective: We aimed to compare the effects of robot-assisted gait training and treadmill training on endurance and gait capacity in people with Parkinson disease; the secondary aim was to compare the effect of the treatments in people with freezing and/or severe gait disability and assess changes in overall disease-related disability and quality of life., Methods: Outpatients with Parkinson disease (Hoehn and Yahr stage≥2) were randomly assigned to receive 20 sessions of 45-min gait training assisted by an end-effector robotic device (G-EO System) or treadmill training. Outcome assessments were the 6-min walk test, Timed Up and Go test, Freezing of Gait Questionnaire, Unified Parkinson's Disease Rating Scales and Parkinson's Disease Quality of Life Questionnaire-39 administered before (T0) and after treatment (T1)., Results: We included 96 individuals with Parkinson disease: 48 with robot-assisted gait training and 48 treadmill training. Both groups showed significant improvement in all outcomes. As compared with baseline, with robot-assisted gait training and treadmill training, endurance and gait capacity were enhanced by 18% and 12%, respectively, and motor symptoms and quality of life were improved by 17% and 15%. The maximum advantage was observed with the Freezing of Gait Questionnaire score, which decreased by 20% after either treatment. On post-hoc analysis, dependent walkers benefited more than independent walkers from any gait training, whereas freezers gained more from robot-assisted than treadmill training in terms of freezing reduction., Conclusions: Repetitive intensive gait training is an effective treatment for people with Parkinson disease and can increase endurance and gait velocity, especially for those with severe walking disability. Advantages are greater with robot-assisted gait training than treadmill training for individuals with freezing of gait - related disability., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
10. From Neandertals to modern humans: New data on the Uluzzian.
- Author
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Villa P, Pollarolo L, Conforti J, Marra F, Biagioni C, Degano I, Lucejko JJ, Tozzi C, Pennacchioni M, Zanchetta G, Nicosia C, Martini M, Sibilia E, and Panzeri L
- Subjects
- Animals, Cooking history, Cooking instrumentation, History, Ancient, Humans, Italy, Minerals analysis, Weapons history, Neanderthals
- Abstract
Having thrived in Eurasia for 350,000 years Neandertals disappeared from the record around 40,000-37,000 years ago, after modern humans entered Europe. It was a complex process of population interactions that included cultural exchanges and admixture between Neandertals and dispersing groups of modern humans. In Europe Neandertals are always associated with the Mousterian while the Aurignacian is associated with modern humans only. The onset of the Aurignacian is preceded by "transitional" industries which show some similarities with the Mousterian but also contain modern tool forms. Information on these industries is often incomplete or disputed and this is true of the Uluzzian. We present the results of taphonomic, typological and technological analyses of two Uluzzian sites, Grotta La Fabbrica (Tuscany) and the newly discovered site of Colle Rotondo (Latium). Comparisons with Castelcivita and Grotta del Cavallo show that the Uluzzian is a coherent cultural unit lasting about five millennia, replaced by the Protoaurignacian before the eruption of the Campanian Ignimbrite. The lack of skeletal remains at our two sites and the controversy surrounding the stratigraphic position of modern human teeth at Cavallo makes it difficult to reach agreement about authorship of the Uluzzian, for which alternative hypotheses have been proposed. Pending the discovery of DNA or further human remains, these hypotheses can only be evaluated by archaeological arguments, i.e. evidence of continuities and discontinuities between the Uluzzian and the preceding and succeeding culture units in Italy. However, in the context of "transitional" industries with disputed dates for the arrival of modern humans in Europe, and considering the case of the Châtelperronian, an Upper Paleolithic industry made by Neandertals, typo-technology used as an indicator of hominin authorship has limited predictive value. We corroborate previous suggestions that the Middle-to-Upper Paleolithic transition occurred as steps of rapid changes and geographically uneven rates of spread.
- Published
- 2018
- Full Text
- View/download PDF
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