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Your search keyword '"Penn-Barwell, Jowan G."' showing total 114 results
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114 results on '"Penn-Barwell, Jowan G."'

4. Open fracture infection following combat trauma : defining the problem and evaluating novel treatments

Author

Penn-Barwell, Jowan G.

Subjects
617.1
Abstract

The British military was engaged in combat operations in Iraq and Afghanistan over a 12-year period from 2003 to 2014. It has been asserted that over this time survival after combat injury improved generating a cohort of patients with complex limb injuries, including open fractures, which are prone to infection and challenging to reconstruct. Using an anatomic measure of injury severity I demonstrate an improvement in survival after combat injury. I further tested this finding by devising a military specific version of an anatomic-physiological injury scoring system, which confirmed the survival improvement. The UK military trauma registry was used to determine that the most frequently fractured bone was the Tibia and 65% of these fractures were open. Of these, 23% were surgically treated for infection in the first year and S. aureus bacteria was the causative organism in 60%. Infection was significantly associated with amputation or unplanned revision surgery. To further investigate open fracture infections in a controlled setting, an established rodent model of a stabilised, S. aureus contaminated, femoral defect was refined. This model was used to investigate the relationship between timing of treatment and infection. The results of this study indicate that delaying antibiotics administration has a greater effect on infection rates than delaying surgery and that early antibiotics can reduce the greater infection seen with surgical delay but not negate its effect entirely. Novel treatments with potential to reduce infection in open fractures were then evaluated. Chlorhexidine was found to be similar to saline for wound irrigation with respect to preventing infection. A novel biodegradable antibiotic gel proved to be superior at preventing infection in the model than the existing clinical standard local antibiotic delivery vehicle: bone cement (Polymethylmethacrylate) beads. Finally Bismuth Thiols were demonstrated to potentiate the effect of antibiotics in preventing infection.

Published
2018

7. Amputation

Author

Penn-Barwell, Jowan G., Kendrew, Jon, Sargeant, Ian D., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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8. The Effect of Projectiles on Tissues

Author

Penn-Barwell, Jowan G., Stevenson, Tom, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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9. Firearms and Bullets

Author

Penn-Barwell, Jowan G., Helliker, Aimee E., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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19. Ballistic Trauma: A Practical Guide

Author

Breeze, John., editor, Penn-Barwell, Jowan G., editor, Keene, Damian., editor, O Reilly, David., editor, Jeyanathan, Jeyasankar., editor, Mahoney, Peter F., editor, Breeze, John., editor, Penn-Barwell, Jowan G., editor, Keene, Damian., editor, O Reilly, David., editor, Jeyanathan, Jeyasankar., editor, and Mahoney, Peter F., editor

Published
2017

20. Extremity injuries sustained by the UK military in the Iraq and Afghanistan conflicts: 2003–2014

Author

Chandler, Henry, primary, MacLeod, Kirsty, additional, Penn-Barwell, Jowan G, additional, Penn-Barwell, J.G., additional, Bennett, P.M., additional, Fries, C.A., additional, Kendrew, J.M., additional, Midwinter, M., additional, Bishop, J., additional, Rickard, R.F., additional, Sargeant, I.D., additional, Porter, K., additional, Rowland, T., additional, Mountain, A., additional, Kay, A., additional, Mortiboy, D., additional, Stevenson, T., additional, and Myatt, R.M., additional

Published
2017
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23. Gun-shot injuries in UK military casualties – Features associated with wound severity

Author

Penn-Barwell, Jowan G., primary, Sargeant, Ian D., additional, Penn-Barwell, J.G., additional, Bennett, P.M., additional, Fries, C.A., additional, Kendrew, J.M., additional, Midwinter, M., additional, Bishop, J., additional, Rickard, R.F., additional, Sargeant, I.D., additional, Porter, K., additional, Rowlands, T., additional, Mountain, A., additional, Kay, A., additional, Mortiboy, D., additional, Stevenson, T., additional, and Myatt, R.M., additional

Published
2016
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29. Pre-clinical evaluation of therapies to prevent or treat bone non-union:a systematic review protocol.

Author

Stewart, Sarah K., Bennett, Philippa M., Stapley, Sarah A., Dretzke, Janine, Bem, Danai, and Penn-Barwell, Jowan G.

Subjects
ORTHOPEDICS, MEDICAL protocols, MEDICAL care
Abstract

Background: Non-union of fractured bone is a major cause of morbidity in the orthopaedic population. Despite this, optimal management of non-union is still unclear and remains a significant clinical challenge. Research continues in animal models in an attempt to identify an effective clinical treatment. The proposed systematic review will evaluate current therapies of bone non-union in animal models, in order to identify those that may translate successfully to clinical therapies. Methods/design: The methodology for the systematic review will be in accordance with standard guidelines. All potential sources for pre-clinical studies will be interrogated and the search strategy written in conjunction with a specialist in this field. Data extraction will be conducted by two reviewers to minimise bias. Analysis will be predominantly qualitative because of the heterogeneity that is likely to exist between the studies. However, quantitative synthesis will be performed where homogeneity in a sub-group of studies exists. Quality assessment will be undertaken utilising a risk of bias tool. Discussion: To date, there has not been a systematic review addressing bone non-union therapies in animal models despite the plethora of pre-clinical research currently being undertaken. This protocol details and outlines the methodology and justification for such a review. [ABSTRACT FROM AUTHOR]

Published
2015
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30. Emergency Department Management

Author

Smith, Jason, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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31. Triage

Author

Barnard, Ed, Vassallo, Jamie, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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33. Suicide Bombs

Author

Page, Piers, Breeze, Johno, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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35. Fragmenting Munitions

Author

Breeze, John, Ramasamy, Arul, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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36. Conflict Rehabilitation

Author

Scott, Alex, Etherington, John, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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37. Soft Tissue Reconstruction

Author

Fries, C. A., Davis, M. R., Rickard, R. F., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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38. Skeletal Reconstruction

Author

Stinner, Daniel J., Tennent, David J., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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39. Transfer and Evacuation

Author

Ewington, Ian, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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41. Critical Care for Ballistic Trauma

Author

Johnston, Andrew McDonald, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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42. Forensic Aspects of Ballistic Injury

Author

Vellema, Jeanine, Scholtz, Hendrik, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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43. Ballistic Trauma in Pregnancy

Author

Appleyard, Tracy-Louise, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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44. Human Factors in Ballistic Trauma

Author

Mercer, Simon J., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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46. Ballistic Genitourinary Trauma

Author

Campbell, Angus, Sharma, Davendra, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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47. A Personal Experience

Author

Vivien, Benoît, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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48. Management of Vascular Trauma

Author

Webster, Claire, König, Thomas C., Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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49. Penetrating Neck Injury

Author

Breeze, Johno, Powers, David, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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50. Ballistic Maxillofacial Trauma

Author

Breeze, Johno, Tong, Darryl, Gibbons, Andrew, Breeze, John, editor, Penn-Barwell, Jowan G., editor, Keene, Damian, editor, O'Reilly, David, editor, Jeyanathan, Jeyasankar, editor, and Mahoney, Peter F., editor

Published
2017
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