13 results on '"Peng‐Fei, Luo"'
Search Results
2. Alloyed triple half-Heuslers: a route toward high-performance thermoelectrics with intrinsically low lattice thermal conductivity
- Author
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Peng-Fei Luo, Shengnan Dai, Yuting Zhang, Xin Liu, Zhili Li, Jiye Zhang, Jiong Yang, and Jun Luo
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Renewable Energy, Sustainability and the Environment ,General Materials Science ,General Chemistry - Abstract
Alloyed triple half-Heusler Ti(Fe0.5+xCo0.25Cu0.25−x)Sb with intrinsically low thermal conductivity have been successfully designed and synthesized based on a valence balanced strategy.
- Published
- 2023
3. Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
- Author
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Chen-Jian Zhong, Xi-Le Hu, Xiao-Lan Yang, Hui-Qi Gan, Kai-Cheng Yan, Fu-Ting Shu, Pei Wei, Teng Gong, Peng-Fei Luo, Tony D. James, Zhao-Hong Chen, Yong-Jun Zheng, Xiao-Peng He, and Zhao-Fan Xia
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General Materials Science - Published
- 2022
4. Hexaarylbiimidazole-based polyurethane positive photoresists for UV lithography
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Peng-Fei Luo, Shi-Li Xiang, Ying-Yi Ren, Ling-Yan Peng, Jun-Dan Huang, Pan Hong, Qi Yu, Chong Li, and Ming-qiang Zhu
- Abstract
Photochromic hexaarylbiimidazoles (HABIs) enable reversible transformation between HABI and triphenylimidazole radicals (TPIRs) upon UV light irradiation, which have been applied in photo-patterning, super-resolution imaging, photoinduced self-healing materials and photomechanical hydrogels. Here, we designed and prepared a novel kind of polyurethane (PU) photoresist based on photo-cleavable HABI cross-linkers (HABI-PU), linear PU backbone and additive tert-butylhydroquinone (TBHQ) radical quencher. Upon UV light irradiation, the C-N bond inside HABI unit is broken, causing the transformation of HABI into two TPIRs which are subsequently quenched by TBHQ. Therefore, the cross-linking points of HABI-PU in UV irradiation area were broken, forming flexible PU polymer chains with declined molecular weight, which can be dissolved in developer. HABI-PU films show excellent photosensitivity as a positive photoresist in photolithography. The reaction mechanism between HABI and TBHQ was studied by UV-vis absorption spectra, electron paramagnetic resonance (EPR), mass spectra and nuclear magnetic resonance spectra. The lithographic patterns were characterized through metallurgical microscope and scanning electron microscope with a resolution at about 5 µm.
- Published
- 2022
5. Targeted release of stromal cell-derived factor-1α by reactive oxygen species-sensitive nanoparticles results in bone marrow stromal cell chemotaxis and homing, and repair of vascular injury caused by electrical burns.
- Author
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Fang He, Peng-Fei Luo, Tao Tang, Fang Zhang, He Fang, Shi-Zhao Ji, Yu Sun, Guo-Sheng Wu, Bo-Han Pan, Zhi-Bao Huo, Guang-Yi Wang, and Zhao-Fan Xia
- Subjects
Medicine ,Science - Abstract
Rapid repair of vascular injury is an important prognostic factor for electrical burns. This repair is achieved mainly via stromal cell-derived factor (SDF)-1α promoting the mobilization, chemotaxis, homing, and targeted differentiation of bone marrow mesenchymal stem cells (BMSCs) into endothelial cells. Forming a concentration gradient from the site of local damage in the circulation is essential to the role of SDF-1α. In a previous study, we developed reactive oxygen species (ROS)-sensitive PPADT nanoparticles containing SDF-1α that could degrade in response to high concentration of ROS in tissue lesions, achieving the goal of targeted SDF-1α release. In the current study, a rat vascular injury model of electrical burns was used to evaluate the effects of targeted release of SDF-1α using PPADT nanoparticles on the chemotaxis of BMSCs and the repair of vascular injury. Continuous exposure to 220 V for 6 s could damage rat vascular endothelial cells, strip off the inner layer, significantly elevate the local level of ROS, and decrease the level of SDF-1α. After injection of Cy5-labeled SDF-1α-PPADT nanoparticles, the distribution of Cy5 fluorescence suggested that SDF-1α was distributed primarily at the injury site, and the local SDF-1α levels increased significantly. Seven days after injury with nanoparticles injection, aggregation of exogenous green fluorescent protein-labeled BMSCs at the injury site was observed. Ten days after injury, the endothelial cell arrangement was better organized and continuous, with relatively intact vascular morphology and more blood vessels. These results showed that SDF-1α-PPADT nanoparticles targeted the SDF-1α release at the site of injury, directing BMSC chemotaxis and homing, thereby promoting vascular repair in response to electrical burns.
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- 2018
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6. Photomechanical polymer hydrogels based on molecular photoswitches
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Shi-Li Xiang, Chong Li, Peng-Fei Luo, and Ming-Qiang Zhu
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chemistry.chemical_classification ,Photochromism ,Materials science ,Polymers and Plastics ,chemistry ,Self-healing hydrogels ,Materials Chemistry ,Nanotechnology ,Artificial muscle ,Polymer ,Physical and Theoretical Chemistry - Published
- 2021
7. Metabolically Specific
- Author
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Chen-Jian, Zhong, Xi-Le, Hu, Xiao-Lan, Yang, Hui-Qi, Gan, Kai-Cheng, Yan, Fu-Ting, Shu, Pei, Wei, Teng, Gong, Peng-Fei, Luo, Tony D, James, Zhao-Hong, Chen, Yong-Jun, Zheng, Xiao-Peng, He, and Zhao-Fan, Xia
- Subjects
Mammals ,Dihydropteroate Synthase ,Mice ,Folic Acid ,Animals ,Humans ,Bacterial Infections ,4-Aminobenzoic Acid - Abstract
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells
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- 2022
8. Use of Amniotic Microparticles Coated with Fibroblasts Overexpressing SDF-1a to Create an Environment Conducive to Neovascularization for Repair of Full-Thickness Skin Defects
- Author
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Yun-Qing Zhang, Shi-Zhao Ji, He Fang, Yong-Jun Zheng, Peng-Fei Luo, Hai-Bin Wu, Min-Juan Wu, Zhi-Hong Wang, Shi-Chu Xiao, and Zhao-Fan Xia
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Medicine - Abstract
As angiogenesis and vasculogenesis involve the complex network structures of various types of cells, extracellular matrix components, and cytokines, it is still difficult to exactly mimic the microenvironment of vascularization in vivo. In our study, we constructed a complex containing highly proliferative fibroblasts that can secrete extracellular matrix components and growth factors to chemotaxize endothelial progenitor cells (EPCs) in an attempt to create an ideal microenvironment for quick vascularization. Amniotic membrane microparticles (mAM) rich in type IV collagen (COL IV) and laminin (LN) were prepared, and human dermal fibroblasts (HDF) were infected with lentivirus (LV) of overexpression of SDF-1α to construct SDF-1α ov HDF. Using the rotary cell culture system (RCCS), mAM was loaded with HDF or SDF-1α ov HDF to construct HDF-mAM and SDF-1α ov HDF-mAM complexes. The complexes were able to secrete various types of active peptides (IL-6, IL-8, TGF-β, and bFGF) during in vitro culture. In addition, SDF-1α ov HDF-mAM complex highly expressed SDF-1α. Transwell assay showed SDF-1α ov HDF-mAM complex had an apparent chemotactic effect on EPCs. Transplantation of complexes onto full-thickness skin defects of C57BL mice further demonstrated that SDF-1α expression and the number of peripheral EPCs at days 3, 5, and 7 in the SDF-1α ov HDF-mAM group were significantly higher than that in other groups ( p < 0.01). The local microvascular density at day 10 of transplantation showed that the microvascular density in the SDF-1α ov HDF-mAM group was significantly higher than that in HDF-mAM group ( p < 0.01). In conclusion, HDF-mAM had a strong proliferative activity and could be used to create a sound microenvironment for quick vascularization by secreting multiple cytokines and extracellular matrix components. Overexpression of SDF-1α could chemotaxize EPCs to reach local wounds, thus further accelerating angiogenesis in the transplant site. The technique described may prove to be a new model for accelerating vascularization of tissue and organ transplants and chronic ischemic wounds.
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- 2016
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9. Overexpression of Hypo-Phosphorylated IκBβ at Ser313 Protects the Heart against Sepsis.
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Guang-Qing Wang, Tao Tang, Zhong-Shan Wang, Ying-Ying Liu, Li Wang, Peng-Fei Luo, and Zhao-Fan Xia
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Medicine ,Science - Abstract
IκBβis an inhibitor of nuclear factor kappa B(NF-κB) and participates in the cardiac response to sepsis. However, the role of the hypo-phosphorylated form of IκBβ at Ser313, which can be detected during sepsis, is unknown. Here, we examined the effects of IκBβ with a mutation at Ser313→Ala313 on cardiac damage induced by sepsis. Transgenic (Tg) mice were generated to overexpress IκBβ, in which Ser-313 is replaced with alanine ubiquitously, in order to mimic the hypo-phosphorylated form of IκBβ. Survival analysis showed that Tg mice exhibited decreased inflammatory cytokine levels and decreased rates of mortality in comparison to wild type (WT) mice, after sepsis in a cecal-ligation and puncture model (CLP). Compared to WT septic mice, sepsis in Tg mice resulted in improved cardiac functions, lower levels of troponin I and decreased rates of cardiomyocyte apoptosis, compared to WT mice. The increased formation of autophagicvacuoles detected with electron microscopy demonstrated the enhancement of cardiac autophagy. This phenomenon was further confirmed by the differential expression of genes related to autophagy, such as LC3, Atg5, Beclin-1, and p62. The increased expression of Cathepsin L(Ctsl), a specific marker for mitochondrial stress response, may be associated with the beneficial effects of the hypo-phosphorylated form of IκBβ. Our observations suggest that the hypo-phosphorylated form of IκBβ at Ser313 is beneficial to the heart in sepsis through inhibition of apoptosisand enhancement of autophagy in mutated IκBβ transgenic mice.
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- 2016
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10. [Comparison of clinical effect of two different Kirschner wire fixations after closed reduction on supracondylar fracture of humerus in children with GartlandⅡand Ⅲ]
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Jin, Huang, Peng-Fei, Luo, and Chun-E, Liu
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Male ,Humeral Fractures ,Child, Preschool ,Humans ,Infant ,Female ,Humerus ,Range of Motion, Articular ,Child ,Bone Wires ,Retrospective Studies - Abstract
To compare clinical effect of Kirschner wire radial sector fixation and bilateral ulnar radial cross fixation in treating supracondylar fracture of humerus in children after closed reduction.From March 2017 to December 2018, 60 children with supracondylar fracture of humerus treated with closed reduction and Kirschner wire fixation were analyzed retrospectively, and divided into two groups according to different needling methods. Thirty patients in radial three needles fan fixation group (group A), including 19 males and 11 females, aged from 2 to 10 years old with an average of (5.00±2.10) years old, 21 patients were typeⅡ and 9 patients were typeⅢ according to Gartland classification. Thirty patients in cross fixationwith 3 needles on both ulnar and radial side group(group B), including 22 males and 8 females, aged from 1 to 9 years old with an average of(5.13±2.08) years old, 19 patients were typeⅡand 11 patients were typeⅢ. Healing time of fracture, postoperative complications, elbow flexion and extension activity, forearm rotation activity recovery, elbow carrying angle and angle loss after operation between two groups were observed and compared. Mayo Elbow function score at the final following up was used to evaluate clinical efficacy.All patients were followed up, while there were no significant difference in follow-up time and fracture healing time between two groups (Closed reduction and Kirschner wire at the early stage of fracture has advantages of less trauma, easy reduction, stable fixation, and early functional exercise. The risk of iatrogenic ulnar nerve injury caused by fan-shaped fixation of three radial needles is less than that of cross fixation of three radial needles.
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- 2020
11. Effects of depression on healing and inflammatory responses of acute wounds in rats
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Jian, Jin, primary, Yi‐Heng, Huang, additional, Bang‐Hui, Zhu, additional, Jian‐Hua, Chen, additional, Xu‐Dong, Zhang, additional, Shi‐Chu, Xiao, additional, Peng‐Fei, Luo, additional, Xiao‐Yan, Hu, additional, and Zhao‐Fan, Xia, additional
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- 2019
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12. Epidemiological and Molecular Characteristics of the PB1-F2 Proteins in H7N9 Influenza Viruses, Jiangsu
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Peng-fei Luo, Yang Xuan, Hairong Zi, Pingmin Wei, Yan Guo, Michael Cunningham, Taha Hussein Musa, and Wei Li
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Adult ,Male ,Adolescent ,Article Subject ,viruses ,Molecular Sequence Data ,lcsh:Medicine ,Sequence alignment ,Biology ,medicine.disease_cause ,Influenza A Virus, H7N9 Subtype ,General Biochemistry, Genetics and Molecular Biology ,Virus ,Avian Influenza A Virus ,Cohort Studies ,Viral Proteins ,Young Adult ,Phylogenetics ,Influenza, Human ,Influenza A virus ,medicine ,Humans ,Amino Acid Sequence ,Selection, Genetic ,Phylogeny ,Aged ,Genetics ,Aged, 80 and over ,Molecular Epidemiology ,Models, Statistical ,General Immunology and Microbiology ,Molecular epidemiology ,Human evolutionary genetics ,Host (biology) ,lcsh:R ,General Medicine ,Middle Aged ,Virology ,Female ,Sequence Alignment ,Research Article - Abstract
The recent sporadic infections of humans in China with previously unrecognized avian influenza A virus of the H7N9 subtype (A(H7N9)) have caused concern. The aim is to find out the epidemiological and molecular analysis of the PB1-F2 proteins in H7N9 influenza viruses, in Jiangsu province. Sequences were obtained from GISAID database. Data were analyzed by using Molecular Evolutionary Genetics Analysis software and Bayesian Markov chain Monte Carlo method. From March 1, 2013, to May 31, 2014, 53 patients were confirmed to be infected with the H7N9 virus; one was a retrospective case in Jiangsu province. 38 sequences of PB1 in H7N9 of Jiangsu were obtained from the GISAID online and were then divided into three lineages. Of these sequences, 4 sequences and 3 sequences encode an N-terminally truncated PB1-F2 (52aa)polypeptide and C-terminally truncated PB1-F2 (76aa) polypeptide, respectively. The remaining sequences encode a full-length PB1-F2 (90aa). We estimated a mean evolutionary rate of 3.053 × 10−3 subs/site/year (95% HPD: 2.021 × 10−3–4.051 × 10−3). The site-by-site analysis of selection pressure analysis revealed positively and negatively (12, 3), respectively, selected sites. Influenza A (H7N9) virus adapting into new host, PB1-F2 of H7N9, might be faced with higher selection pressures.
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- 2015
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13. Using negative pressure wound therapy on microskin autograft wounds.
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Fang Zhang, Kai-Yang Lv, Xiao-Chen Qiu, Peng-Fei Luo, Xing-Feng Zheng, Shi-Hui Zhu, and Zhao-Fan Xia
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CASE-control method , *COMPARATIVE studies , *AUTOTRANSPLANTATION , *CONTROL groups , *POSTOPERATIVE care - Abstract
Background Microskin autografts with conventional wrap and compression are used extensively in the treatment of skin and tissue defects. This comparative study aimed at investigation of the clinical application of negative pressure wound therapy (NPWT) in combination with microskin autografts for repair of acute and chronic wounds. Methods A prospective case-control study was performed from December 1, 2010-December 31, 2013 in Changhai Hospital, Shanghai. We compared a study group of patients received microskin autografting covered by NPWT with that of a control group of patients received microskin autografting covered by a conventional gauze. Results A total of 81 patients were in this study, 27 patients were allocated to the study group and 54 patients to the control group. The study group exhibited significant low infection rate and pain score during removal of inner layer at first dressing change after skin grafting compared with those of the control group (P < 0.05). The time interval between skin grafting and first postoperative change was longer in the study group than that in the control group (P < 0.01), the study group showed a significant shorter 95% wound healing time (P < 0.05), and survival rate of microskin autografts in the study group was higher than that in the control group (P < 0.05). Conclusions NPWT is beneficial for wound closure after microskin autografts, which prolongs the interval between skin transplantation and first postoperative dressing change, reduces pain during removal of inner layer dressing, increases skin graft survival rate, and shortens wound healing time. Therefore, NPWT can be recommended for repair of acute and chronic wounds with microskin autografts. [ABSTRACT FROM AUTHOR]
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- 2015
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