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We examine the parameter space region of the inverse seesaw model that is consistent with neutrino oscillation data. We focus on the correlation between the current limits from the search of the $\mu\to e\gamma$ lepton flavour violating decay and the non-standard effects associated with the presence of new heavy neutrino states. Unlike what we would expect from an inverse seesaw model, we have found a parametrization for the mass matrices in which the rates of charged lepton flavour-violating processes are negligible. Additionally, we provide a model where the inverse seesaw is obtained naturally, and the mass matrices get this structure with negligible violation of the lepton flavour., Comment: 20 pages, 3 figures and 3 tables

Este artigo tem como objetivo apresentar as possibilidades administrativas e pedagógicas na utilização de um sistema informatizado na gestão escolar com foco na inclusão do aluno com necessidade especial. Nesse sentido, a Secretaria de Estado de Educação e Desporto (SEDUC/AM) desenvolveu e implantou o Sistema Integrado de Gestão Educacional do Amazonas (Sigeam), que traz, dentre outros serviços, um módulo chamado Especial. Esse módulo é composto de serviços e relatórios gerenciais que têm por finalidade subsidiar a gestão escolar e a macrogestão da SEDUC/AM, nas tomadas de decisão sobre o público-alvo da educação especial. É importante destacar que o interesse neste tema surgiu a partir de formações ministradas por esta pesquisadora aos gestores escolares, nas quais foram constatadas que estes, não só, não tinham acesso a todos os serviços deste módulo, como sequer conheciam, na íntegra, aqueles aos quais tinham acesso. Assim sendo, considerando esses fatores como condicionantes para o pleno uso do sistema, pondera-se que não basta ter um sistema informatizado, como também é fundamental que se conheçam as possibilidades administrativas e pedagógicas a ele pertinentes, além de possibilitar acesso pleno aos gestores. No que concerne à pesquisa, utilizou-se metodologia de natureza qualitativa exploratória e descritiva, sendo embasada por estudos bibliográficos da temática educação especial, no uso das NTICs e das possibilidades advindas da utilização de sistemas. Destarte, os achados dessa pesquisa trouxeram informações que podem possibilitar à SEDUC/AM ser mais assertiva nas políticas implementadas na área da educação inclusiva. Palavras-chave: educação especial; Sigeam; gestão escolar.

Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEEP < 10, (II) PaO2/FiO2 ≥ 150 at PEEP ≥ 10, (III) PaO2/FiO2 < 150 at PEEP < 10, and (IV) PaO2/FiO2 < 150 at PEEP ≥ 10. Primary outcome was death in the ICU. Results: ICU mortalities were similar in the testing and confirmatory cohorts (375/1000, 37.5% vs. 112/303, 37.0%, respectively). At baseline, most patients from the testing cohort (n = 792/1000, 79.2%) had a PaO2/FiO2 < 150, with similar mortality among the four subsets (p = 0.23). When assessed at 24 h, ICU mortality increased with an advance in the subset: 17.9%, 22.8%, 40.0%, and 49.3% (p < 0.0001). The findings were replicated in the confirmatory cohort (p < 0.0001). However, independent of the PEEP levels, patients with PaO2/FiO2 < 150 at 24 h followed a distinct 30-day ICU survival compared with patients with PaO2/FiO2 ≥ 150 (hazard ratio 2.8, 95% CI 2.2–3.5, p < 0.0001). Conclusions: Subsets based on PaO2/FiO2 thresholds of 150 mm Hg assessed after 24 h of moderate/severe ARDS diagnosis are clinically relevant for establishing prognosis, and are helpful for selecting adjunctive therapies for hypoxemia and for enrolling patients into therapeutic trials.

Objectives: Incomplete or ambiguous evidence for identifying high-risk patients with acute respiratory distress syndrome for enrollment into randomized controlled trials has come at the cost of an unreasonable number of negative trials. We examined a set of selected variables early in acute respiratory distress syndrome to determine accurate prognostic predictors for selecting high-risk patients for randomized controlled trials. Design: A training and testing study using a secondary analysis of data from four prospective, multicenter, observational studies. Setting: A network of multidisciplinary ICUs. Patients: We studied 1,200 patients with moderate-to-severe acute respiratory distress syndrome managed with lung-protective ventilation. Interventions: None. Measurements and Main Results: We evaluated different thresholds for patient's age, Pao 2 /Fio 2, plateau pressure, and number of extrapulmonary organ failures to predict ICU outcome at 24 hours of acute respiratory distress syndrome diagnosis. We generated 1,000 random scenarios as training (n = 900, 75% of population) and testing (n = 300, 25% of population) datasets and averaged the logistic coefficients for each scenario. Thresholds for age (< 50, 50-70, > 70 yr), Pao 2 /Fio 2 (= 100, 101-150, > 150 mm Hg), plateau pressure (< 29, 29-30, > 30 cm H2O), and number of extrapulmonary organ failure (< 2, 2, > 2) stratified accurately acute respiratory distress syndrome patients into categories of risk. The model that included all four variables proved best to identify patients with the highest or lowest risk of death (area under the receiver operating characteristic curve, 0.86; 95% CI, 0.84-0.88). Decision tree analyses confirmed the accuracy and robustness of this enrichment model. Conclusions: Combined thresholds for patient's age, Pao 2 / Fio 2, plateau pressure, and extrapulmonary organ failure provides prognostic enrichment accuracy for stratifying and selecting acute respiratory distress syndrome patients for randomized controlled trials.

A Secretaria de Estado da Educação e Qualidade do Ensino do Amazonas (SEDUC/AM) desenvolveu e implantou o Sistema de Gestão Educacional do Amazonas (SIGEAM). Integra esse sistema, dentre diversos outros, um módulo chamado ESPECIAL. Esse módulo é composto de serviços e relatórios gerenciais que têm por finalidade subsidiar a gestão escolar e a macrogestão da SEDUC/AM, nas tomadas de decisão sobre o público-alvo da Educação Especial. A partir de capacitações ministradas aos gestores escolares, percebi que estes não só não tinham acesso a todos os serviços desse como módulo, como sequer o conheciam na íntegra aqueles aos quais tinham acesso. Considerando esses fatores como condicionantes para o pleno uso do sistema, o objetivo geral deste trabalho é pesquisar os fatores que limitam a utilização do Módulo Especial pelos gestores escolares, para promover intervenções pedagógicas e administrativas. Tal cenário despertou o interesse desta pesquisadora, levando a debruçar-me sobre o tema. Percorri os caminhos históricos dessa temática no Brasil e descrevi esse percurso. Consultei a legislação sobre o tema e destaquei os marcos legais mais relevantes. Voltei-me para a minha realidade, estudando esse contexto na rede estadual de ensino de Manaus. A partir da aplicação de questionários com roteiro semiestruturado e de entrevistas com os principais atores da Educação Especial em Manaus, examinei, de modo mais aprofundado, por meio de uma revisão teórica da temática Educação Especial, com foco nas NTICs, principalmente sob a ótica de Almeida (2007), Moran (2007), Mantoan (2006), Sassaki (2005), as possibilidades advindas da utilização de sistemas informatizados de gestão, com foco na gestão da Educação Especial. Por fim, os achados dessa pesquisa trouxeram informações para a proposição de um Plano de Ação Educacional (PAE) que possibilite à SEDUC/AM ser mais assertiva nas políticas implementadas na área de Educação Especial. The State Education and Quality Secretariat of Amazonas (SEDUC/AM) developed and implemented the Amazon Educational Management System (SIGEAM). It integrates this system, among several others, a module called SPECIAL. This module is composed by services and management reports that aim to subsidize the school management and the macro management of SEDUC/AM, in the decision making about the target audience of Special Education. According to the research, from the training provided to the school managers, I realized that they not only did not have access to all the services of this module, but they also did not know the full ones to which they had access. Considering these factors due to this research, as conditioners for the full use of the system, the general objective of this work is to investigate the factors that limit the use of the Special Module by school administrators to promote pedagogical and administrative interventions. So, such a scenario aroused the interest of this researcher, leading me to look at the subject. I went through the historical paths of this subject in Brazil, and I described this path. I consulted legislation on the subject and highlighted the most relevant legal frameworks. I returned to my reality, studying this context in the state school system of Manaus. Concerning this context, from the application of semi-structured questionnaires and interviews, with the main actors of Special Education in Manaus, I will examine in a more detailed way, through a theoretical revision of the Special Education theme, with a focus on ICT, mainly from the perspective of Almeida (2007), Moran (2007), Mantoan (2006), Sassaki (2005), the possibilities that come from the use of computerized management systems, focusing on the management of special education. Finally, the findings of this research, provided information for the proposition of an Educational Action Plan (PAE), which allows SEDUC/AM to be more assertive in the policies implemented concerning Special Education.

In this letter we present a model for quarks and leptons based on T7 as flavour symmetry, predicting a canonical mass relation between charged leptons and down-type quarks proposed earlier. Neutrino masses are generated through a Type-I seesaw mechanism, with predicted correlations between the atmospheric mixing angle and neutrino masses. Compatibility with oscillation results lead to lower bounds for the lightest neutrino mass as well as for the neutrinoless double beta decay rates, even for normal neutrino mass hierarchy., 17 pages, 3 figures. references added, one appendix with the discussion of the vacuum alignments added