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Your search keyword '"Peña-Rodriguez, Luis Manuel"' showing total 15 results
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15 results on '"Peña-Rodriguez, Luis Manuel"'

5. Exploring the potential of deep eutectic solvents (DES) in bioactive natural product research: from DES to NaDES, THEDES, and beyond

Author

Ruesgas Ramon, Mariana, Durand, Erwann, Garcia-Sosa, Karlina, Peña-Rodriguez, Luis Manuel, Ruesgas Ramon, Mariana, Durand, Erwann, Garcia-Sosa, Karlina, and Peña-Rodriguez, Luis Manuel

Abstract

Background: Deep eutectic solvents (DESs) have garnered significant interest in natural products research, owing to their green and natural attributes in comparison to conventional solvents. However, the approach of demonstrating that DESs are superior extractants has led to an underestimation of their full potential in this field. This perspective disregards crucial challenges related to their practical application and potential scalability, mainly the difficulty of target component separation from intermolecular network forming by DESs. Conversely, the DESs unique features can enhance aspects such as solubilization, stabilization, and storage of natural products, as well as improve their biological activities. By addressing key challenges and limitations, we aim to provide valuable insights into the potential of DESs in this domain. Methodology: In this review, we conducted an exhaustive literature search to gather relevant articles about DESs and their applications in bioactive natural product research. The gathered literature was analyzed, and a systematic thematic categorization was performed, emphasizing studies where the use of DESs yielded relevant outcomes that could potentially present an advantage in the exploration of bioactive natural products. The approach in structuring this review aimed to provide an overview of the potential and challenges associated with DESs in the domain of bioactive natural product research, transcending their conventional role as mere extraction solvents. Results: Through this critical analysis of the literature, this review delves into the potential of DESs as effective solvents for the solubilization, stabilization, and storage of bioactive natural products. In addition, it highlights the ability of DESs to improve the biological activities of natural products, as well as to be used as formulation media for the transport of pharmaceutical active ingredients. By revealing these advances, the review contributes to a more comple

Published
2023

7. Crystal structure of methyl 8-hydroxy-3-isopropyl-5a,8-dimethyl-2,3,4,5,5a,6,7,8,10a,10b-decahydrocyclohepta[e]indene-3a(1H)-carboxylate, C21H34O3

Author

Brito Iván, Bórquez Jorge, Simirgiotis Mario, Cárdenas Alejandro, Molina-Salinas Gloria M., Jerz Gerold, Peña-Rodriguez Luis Manuel, and Winterhalter Peter

Subjects
1448533, Physics, QC1-999, Crystallography, QD901-999
Abstract

C21H34O3, orthorhombic, P212121 (no. 19), a = 7.5420(7) Å, b = 11.6929(11) Å, c = 22.657(2) Å, V = 1998.1(3) Å3, Z = 4, Rgt(F) = 0.0383, wRref(F2) = 0.113, T = 293(2) K.

Published
2016
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11. Using 13C‐NMR dereplication to aid in the identification of xanthones present in the stem bark extract of Calophyllum brasiliense.

Author

Silva‐Castro, Lina Fernanda, Derbré, Séverine, Le Ray, Anne Marie, Richomme, Pascal, García‐Sosa, Karlina, and Peña‐Rodriguez, Luis Manuel

Abstract

Introduction: Xanthones are metabolites with a variety of biological properties. The Clusiaceae family, which until recently included the genus Calophyllum, is recognised for its production of monohydroxylated and polyhydroxylated xanthones. Presently, C. brasiliense is the only Calophyllum spp. known to occur in the Yucatan peninsula. Objective: To use a combination of traditional phytochemical methods and carbon‐13 nuclear magnetic resonance (13C‐NMR) dereplication analysis to identify xanthones in the stem bark of C. brasiliense. Material and methods: Initial fractionation and purification of the stem bark extract of C. brasiliense produced macluraxanthone (1). Additional xanthones, together with chromanones and terpenoids, were identified using 13C‐NMR dereplication analysis in different semipurified fractions obtained from the low and medium polarity fractions of the stem bark extract of C. brasiliense. Results: Initial identification of macluraxanthone (1) was confirmed by 13C‐NMR dereplication analysis; additionally, 13C‐NMR dereplication analysis allowed the identification of a number of monohydroxylated and polyhydroxylated xanthones, together with chromanones and terpenoids. Conclusion: This study confirms C. brasiliense as a rich source of xanthones and the 13C‐NMR dereplication analysis as a suitable method to quickly identify the presence of different families of secondary metabolites in semipurified fractions. Calophyllum brasiliense is recognised for its production of xanthones having different biological activities. In this investigation, a combination of phytochemical methods and carbon‐13 nuclear magnetic resonance (13C‐NMR) dereplication analysis allowed the identification of a number of monohydroxylated and polyhydroxylated xanthones, together with chromanones and terpenoids, from the stem bark extract of the plant. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Unusual chemical composition of a Mexican propolis collected in Quintana Roo, Mexico

Author

Boisard, Séverine, Tho Huynh, Thi Huong, Escalante-Erosa, Fabiola, Hernandez-Chavez, Luis Ignacio, Peña-Rodriguez, Luis Manuel, Richomme, Pascal, Substances d'Origine Naturelle et Analogues Structuraux (SONAS), and Université d'Angers (UA)

Subjects
Sterols, pentacyclic triterpenes, [SDV]Life Sciences [q-bio], Mexican propolis, amyrins, Bursera simaruba
Abstract

International audience; Propolis is a resinous natural substance collected by honeybees from buds and exudates of various trees and plants; it is widely accepted that the composition of propolis depends on the phytogeographic characteristics of the site of collection. In this study we have analyzed the chemical composition of a propolis collected in Quintana Roo, Mexico, and evaluated its antioxidant, antifungal and antibacterial activities. Unexpectedly, the chemical analysis showed that the main components of the ethanolic extract of a Mexican propolis appeared to be pentacyclic triterpenoids, such as α and β-amyrin derivatives, and sterols. The crude extract did not show antioxidant activity when tested using the DPPH-reduction assay, and it also proved inactive when tested for antifungal and antibacterial activities using microdilution and agar diffusion assays, respectively. The fact that the presence of both α and β-amyrins and their derivatives have been reported from the resin of Bursera simaruba, one of the plants used by the bees for propolis production in Quintana Roo, Mexico, confirms the relationship that exists between the flora available to bees in a given region and the chemical composition of the propolis that they produce.; El propóleo es un producto natural resinoso colectado por abejas a partir de brotes y exudados de diferentes plantas y árboles; es ampliamente aceptado que la composición del propóleo depende de las características fitogeográficas del sitio de colecta. En este estudio analizamos la composición química de un propóleo colectado en Quintana Roo, México, y evaluamos sus actividades antioxidante, antifúngica y antibacteriana. Inesperadamente, el análisis químico mostró que los principales componentes del extracto etanólico del propóleo mexicano parecían ser triterpenoides pentacíclicos, tales como derivados de α y β-amyrina y esteroles. El extracto crudo no mostró actividad antioxidante al ser evaluado en el ensayo de reducción de DPPH, y también se mostró inactivo al ser evaluado en cuanto a su actividad antifúngica y antibacteriana utilizando los ensayos de microdilución y de difusión en agar, respectivamente. El hecho de que la presencia de α y β-amyrina y sus derivados ya se ha reportado en la resina de Bursera simaruba, una de las plantas utilizadas por las abejas para su producción de propóleo en Quintana Roo, México, confirma la relación que existe entre la flora disponible para las abejas en una región en particular y la composición química del propóleo que producen.

Published
2015

13. Crystal structure of methyl 8-hydroxy-3-isopropyl-5a,8-dimethyl-2,3,4,5,5a,6,7,8,10a,10b-decahydrocyclohepta[ e]indene-3a(1H)-carboxylate, C21H34O3.

Author

Brito, Iván, Bórquez, Jorge, Simirgiotis, Mario, Cárdenas, Alejandro, Molina-Salinas, Gloria M., Jerz, Gerold, Peña-Rodriguez, Luis Manuel, and Winterhalter, Peter

Subjects
CRYSTAL structure, METHYL formate, CHEMICAL derivatives, CHROMATOGRAPHIC analysis, CHEMICAL yield, SOLVENTS
Abstract

C21H34O3, orthorhombic, P212121 (no. 19), a=7.5420(7) Å, b=11.6929(11) Å, c=22.657(2) Å, V=1998.1(3) ų, Z=4, Rgt(F)=0.0383, wRref(F²)=0.113, T=293(2) K. [ABSTRACT FROM AUTHOR]

Published
2016
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14. Crystal structure of methyl 8-hydroxy-3-isopropyl-5a,8-dimethyl-2,3,4,5,5a,6,7,8,10a,10b-decahydrocyclohepta[ e]indene-3a(1H)-carboxylate, C21H34O3.

Author

Brito, Iván, Bórquez, Jorge, Simirgiotis, Mario, Cárdenas, Alejandro, Molina-Salinas, Gloria M., Jerz, Gerold, Peña-Rodriguez, Luis Manuel, and Winterhalter, Peter

Subjects
*CRYSTAL structure, *METHYL formate, *CHEMICAL derivatives, *CHROMATOGRAPHIC analysis, *CHEMICAL yield, *SOLVENTS
Abstract

C21H34O3, orthorhombic, P212121 (no. 19), a=7.5420(7) Å, b=11.6929(11) Å, c=22.657(2) Å, V=1998.1(3) ų, Z=4, Rgt(F)=0.0383, wRref(F²)=0.113, T=293(2) K. [ABSTRACT FROM AUTHOR]

Published
2016
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15. Using 13 C-NMR dereplication to aid in the identification of xanthones present in the stem bark extract of Calophyllum brasiliense.

Author

Silva-Castro LF, Derbré S, Le Ray AM, Richomme P, García-Sosa K, and Peña-Rodriguez LM

Subjects
Magnetic Resonance Spectroscopy, Molecular Structure, Plant Bark, Plant Extracts, Calophyllum, Xanthones
Abstract

Introduction: Xanthones are metabolites with a variety of biological properties. The Clusiaceae family, which until recently included the genus Calophyllum, is recognised for its production of monohydroxylated and polyhydroxylated xanthones. Presently, C. brasiliense is the only Calophyllum spp. known to occur in the Yucatan peninsula., Objective: To use a combination of traditional phytochemical methods and carbon-13 nuclear magnetic resonance ( 13 C-NMR) dereplication analysis to identify xanthones in the stem bark of C. brasiliense., Material and Methods: Initial fractionation and purification of the stem bark extract of C. brasiliense produced macluraxanthone (1). Additional xanthones, together with chromanones and terpenoids, were identified using 13 C-NMR dereplication analysis in different semipurified fractions obtained from the low and medium polarity fractions of the stem bark extract of C. brasiliense., Results: Initial identification of macluraxanthone (1) was confirmed by 13 C-NMR dereplication analysis; additionally, 13 C-NMR dereplication analysis allowed the identification of a number of monohydroxylated and polyhydroxylated xanthones, together with chromanones and terpenoids., Conclusion: This study confirms C. brasiliense as a rich source of xanthones and the 13 C-NMR dereplication analysis as a suitable method to quickly identify the presence of different families of secondary metabolites in semipurified fractions., (© 2021 John Wiley & Sons, Ltd.)

Published
2021
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