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29 results on '"Payne, Geoffrey W."'

2. Impact of Smoking on Coronary Volume–to–Myocardial Mass Ratio: An ADVANCE Registry Substudy

Author

Holmes, Kenneth R., primary, Gulsin, Gaurav S., additional, Fairbairn, Timothy A., additional, Hurwitz-Koweek, Lynne, additional, Matsuo, Hitoshi, additional, Nørgaard, Bjarne L., additional, Jensen, Jesper M., additional, Sand, Niels-Peter Rønnow, additional, Nieman, Koen, additional, Bax, Jeroen J., additional, Pontone, Gianluca, additional, Chinnaiyan, Kavitha M., additional, Rabbat, Mark G., additional, Amano, Tetsuya, additional, Kawasaki, Tomohiro, additional, Akasaka, Takashi, additional, Kitabata, Hironori, additional, Rogers, Campbell, additional, Patel, Manesh R., additional, Payne, Geoffrey W., additional, Leipsic, Jonathon A., additional, and Sellers, Stephanie L., additional

Published
2024
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6. Redo-TAVI with SAPIEN 3 in SAPIEN XT or SAPIEN 3 – impact of pre- and post-dilatation on final THV expansion

Author

Meier, David, primary, Landes, Uri, additional, Sondergaard, Lars, additional, De Backer, Ole, additional, Lutter, Georg, additional, Puehler, Thomas, additional, Akodad, Mariama, additional, Tzimas, Georgios, additional, Blanke, Philipp, additional, Payne, Geoffrey W., additional, Lai, Althea, additional, Gill, Hacina, additional, Wood, David A., additional, Webb, John G., additional, Sellers, Stephanie L., additional, and Sathananthan, Janarthanan, additional

Published
2023
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9. Neovascularization in Structural Bioprosthetic Valve Dysfunction

Author

Yoon, Joshua, primary, Jelisejevas, Julius, additional, Meier, David, additional, Gill, Hacina, additional, Lai, Althea, additional, Seidman, Michael A., additional, Payne, Geoffrey W., additional, Cheung, Anson, additional, Wood, David A., additional, Leipsic, Jonathon A., additional, Webb, John G., additional, Sathananthan, Janarthanan, additional, and Sellers, Stephanie L., additional

Published
2023
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10. Timing of bioprosthetic valve fracture in transcatheter valve-in-valve intervention:impact on valve durability and leaflet integrity

Author

Meier, David, Payne, Geoffrey W., Mostaço-Guidolin, Leila B., Bouchareb, Rihab, Rich, Courtney, Lai, Althea, Chatfield, Andrew G., Akodad, Mariama, Salcudean, Hannah, Lutter, Georg, Puehler, Thomas, Pibarot, Philippe, Allen, Keith B., Chhatriwalla, Adnan K., Sondergaard, Lars, Wood, David A., Webb, John G., Leipsic, Jonathon A., Sathananthan, Janarthanan, Sellers, Stephanie L., Meier, David, Payne, Geoffrey W., Mostaço-Guidolin, Leila B., Bouchareb, Rihab, Rich, Courtney, Lai, Althea, Chatfield, Andrew G., Akodad, Mariama, Salcudean, Hannah, Lutter, Georg, Puehler, Thomas, Pibarot, Philippe, Allen, Keith B., Chhatriwalla, Adnan K., Sondergaard, Lars, Wood, David A., Webb, John G., Leipsic, Jonathon A., Sathananthan, Janarthanan, and Sellers, Stephanie L.

Abstract

BACKGROUND: Bioprosthetic valve fracture (BVF) can be used to improve transcatheter heart valve (THV) haemodynamics following a valve-in-valve (ViV) intervention. However, whether BVF should be performed before or after THV deployment and the implications on durability are unknown. Aims: We sought to assess the impact of BVF timing on long-term THV durability. METHODS: The impact of BVF timing was assessed using small ACURATE neo (ACn) or 23 mm SAPIEN 3 (S3) THV deployed in 21 mm Mitroflow valves compared to no-BVF controls. Valves underwent accelerated wear testing up to 200 million (M) cycles (equivalent to 5 years). At 200M cycles, THV were evaluated by hydrodynamic testing, second-harmonic generation (SHG) microscopy, scanning electron microscopy (SEM) and histology. RESULTS: At 200M cycles, the regurgitant fraction (RF) and effective orifice area (EOA) for the ACn were 8.03±0.30%/1.74±0.01 cm2 (no BVF), 12.48±0.70%/1.97±0.02 cm2 (BVF before ViV) and 9.29±0.38%/2.21±0.0 cm2 (BVF after ViV), respectively. For the S3 these values were 2.63±0.51%/1.26±0.01 cm2, 2.03±0.42%/1.65±0.01 cm2, and 1.62±0.38%/2.22±0.01 cm2, respectively. Further, SHG and SEM revealed a higher degree of superficial leaflet damage when BVF was performed after ViV for the ACn and S3. However, the histological analysis revealed significantly less damage, as determined by matrix density analysis, through the entire leaflet thickness when BVF was performed after ViV with the S3 and a similar but non-significant trend with the ACn. Conclusions: BVF performed after ViV appears to offer superior long-term EOA without increased RF. Ultrastructure leaflet analysis reveals that the timing of BVF can differentially impact leaflets, with more superficial damage but greater preservation of overall leaflet structure when BVF is performed after ViV.

Published
2023

11. Timing of bioprosthetic valve fracture in transcatheter valve-in-valve intervention: impact on valve durability and leaflet integrity

Author

Meier, David, primary, Payne, Geoffrey W., additional, Mostaço-Guidolin, Leila B., additional, Bouchareb, Rihab, additional, Rich, Courtney, additional, Lai, Althea, additional, Chatfield, Andrew G., additional, Akodad, Mariama, additional, Salcudean, Hannah, additional, Lutter, Georg, additional, Puehler, Thomas, additional, Pibarot, Philippe, additional, Allen, Keith B., additional, Chhatriwalla, Adnan K., additional, Sondergaard, Lars, additional, Wood, David A., additional, Webb, John G., additional, Leipsic, Jonathon A., additional, Sathananthan, Janarthanan, additional, and Sellers, Stephanie L., additional

Published
2023
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12. Multimodality Imaging to Assess Leaflet Height in Mitral Bioprosthetic Valves

Author

Akodad, Mariama, primary, Sathananthan, Janarthanan, additional, Tzimas, Georgios, additional, Salcudean, Hannah, additional, Hensey, Mark, additional, Gulsin, Gaurav S., additional, Meier, David, additional, (Anthony) Chuang, Ming-yu, additional, Chatfield, Andrew G., additional, Landes, Uri, additional, Blanke, Philipp, additional, Sondergaard, Lars, additional, Payne, Geoffrey W., additional, Lutter, Georg, additional, Puehler, Thomas, additional, Wood, David A., additional, Webb, John G., additional, Leipsic, Jonathon A., additional, and Sellers, Stephanie L., additional

Published
2022
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13. Multimodality Imaging to Assess Leaflet Height in Mitral Bioprosthetic Valves:Implications for Mitral Valve-in-Valve Procedure

Author

Akodad, Mariama, Sathananthan, Janarthanan, Tzimas, Georgios, Salcudean, Hannah, Hensey, Mark, Gulsin, Gaurav S., Meier, David, (Anthony) Chuang, Ming yu, Chatfield, Andrew G., Landes, Uri, Blanke, Philipp, Sondergaard, Lars, Payne, Geoffrey W., Lutter, Georg, Puehler, Thomas, Wood, David A., Webb, John G., Leipsic, Jonathon A., Sellers, Stephanie L., Akodad, Mariama, Sathananthan, Janarthanan, Tzimas, Georgios, Salcudean, Hannah, Hensey, Mark, Gulsin, Gaurav S., Meier, David, (Anthony) Chuang, Ming yu, Chatfield, Andrew G., Landes, Uri, Blanke, Philipp, Sondergaard, Lars, Payne, Geoffrey W., Lutter, Georg, Puehler, Thomas, Wood, David A., Webb, John G., Leipsic, Jonathon A., and Sellers, Stephanie L.

Published
2022

14. Impact of Bioprosthetic Valve Fracture on Potential Embolic Debris Generation

Author

Meier, David, primary, Sreedharan, Subhashaan, additional, Akodad, Mariama, additional, Salcudean, Hannah, additional, Lai, Althea, additional, Chatfield, Andrew G., additional, Ye, Jian, additional, Cheung, Anson, additional, Payne, Geoffrey W., additional, Allen, Keith B., additional, Chhatriwalla, Adnan K., additional, Wood, David A., additional, Webb, John G., additional, Leipsic, Jonathon A., additional, Sathananthan, Janarthanan, additional, and Sellers, Stephanie L., additional

Published
2022
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15. Tricuspid Valve-in-Valve and Bioprosthetic Surgical Tricuspid and Pulmonic Valve Degeneration

Author

Sellers, Stephanie L., primary, Hensey, Mark, additional, Cartlidge, Timothy R.G., additional, Turner, Christopher T., additional, Lau, Karen, additional, Lai, Althea, additional, Salcudean, Hannah, additional, Sathananthan, Janarthanan, additional, McManus, Bruce M., additional, Granville, David J., additional, Payne, Geoffrey W., additional, Pibarot, Philippe, additional, Webb, John G., additional, Newby, David E., additional, Blanke, Philipp, additional, Seidman, Michael A., additional, Dweck, Marc R., additional, and Leipsic, Jonathon A., additional

Published
2020
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18. Impact of sublingual nitroglycerin dosage on FFRCT assessment and coronary luminal volume-to-myocardial mass ratio

Author

Holmes, Kenneth R, Fonte, Tim A, Weir-McCall, Jonathan, Anastasius, Malcolm, Blanke, Philipp, Payne, Geoffrey W, Ellis, Jen, Murphy, Darra T, Taylor, Charles, Leipsic, Jonathon A, Sellers, Stephanie L, Sellers, Stephanie L [0000-0002-3539-5730], and Apollo - University of Cambridge Repository

Subjects
Male, Computed Tomography Angiography, Myocardium, Vasodilator Agents, Administration, Sublingual, Coronary Artery Disease, Organ Size, Middle Aged, Coronary Angiography, Vasodilation, Fractional Flow Reserve, Myocardial, Nitroglycerin, Predictive Value of Tests, Humans, Female, Retrospective Studies
Abstract

OBJECTIVES: Fractional flow reserve computed tomography (FFRCT) depends upon nitroglycerin (NTG) inducing maximal hyperemia. However, the impact of NTG dosages on FFRCT analysis including coronary volume-to-mass ratio (V/M) is unknown. METHODS: Eighty patients with repeat coronary CT angiograms (CCTAs) with different sublingual spray NTG doses (0.4 mg and 0.8 mg) were retrospectively analyzed with 45 patients excluded. Patient and scan demographics, post-stenosis and nadir FFRCT values, coronary volume, and coronary volume-to-mass ratio (V/M) were compared at initial CCTA (0.4 mg NTG) and follow-up CCTA (0.8 mg NTG). Differences were compared by Wilcoxon signed-rank test. RESULTS: Thirty-five patients were included (time between CCTAs, 3.9 ± 1.6 years). Segment involvement score was 2.4 ± 3.3 and 2.8 ± 3.4 at initial and repeat CCTA (0.4 and 0.8 mg NTG), respectively (p = 0.004). There was similar image quality (4.1 ± 0.7 vs 4.1 ± 0.8; p = 0.51). Nadir FFRCT values did not differ in the left (0.4 mg, 0.80 ± 0.08 vs 0.8 mg, 0.80 ± 0.03; p = 0.66), right (0.4 mg, 0.90 ± 0.04 vs 0.8 mg, 0.90 ± 0.06; p = 0.25), or circumflex coronaries (0.4 mg, 0.87 ± 0.06 vs 0.8 mg, 0.88 ± 0.06; p = 0.34). Post-stenosis FFRCT values did not differ (p = 0.65). Coronary volume increased with 0.8 mg of NTG (2639 ± 753 mm3 vs 2844.8 ± 827 mm3; p = 0.009) but V/M ratio did not (p = 0.20). CONCLUSIONS: Use of 0.8 mg versus 0.4 mg of NTG in routine clinical CCTAs significantly increased coronary volume determined from FFRCT analysis but did not alter FFRCT or V/M. Further evaluation of repeat CCTAs in a more contemporaneous fashion using varied nitrate doses and disease severity is needed. KEY POINTS: • Fractional flow reserve from computed tomography (FFRCT) is a noninvasive method for evaluating the coronary arteries and relies on nitroglycerin (NTG) to induce coronary vasodilation, but the impact of different NTG dosages is unknown. • Retrospective analysis evaluated use of different NTG doses on FFRCT. • Increased NTG dose increased coronary luminal volume on FFRCTanalysis, but did not change FFRCTvalues.

Published
2019
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19. Transcatheter Aortic Heart Valves:Histological Analysis Providing Insight to Leaflet Thickening and Structural Valve Degeneration

Author

Sellers, Stephanie L, Turner, Christopher T, Sathananthan, Janarthanan, Cartlidge, Timothy R G, Sin, Frances, Bouchareb, Rihab, Mooney, John, Nørgaard, Bjarne L, Bax, Jeroen J, Bernatchez, Pascal N, Dweck, Marc R, Granville, David J, Newby, David E, Lauck, Sandra, Webb, John G, Payne, Geoffrey W, Pibarot, Philippe, Blanke, Philipp, Seidman, Michael A, and Leipsic, Jonathon A

Subjects
cardiovascular system
Abstract

OBJECTIVES: This study investigated processes causing leaflet thickening and structural valve degeneration (SVD).BACKGROUND: Although transcatheter aortic valve replacement (TAVR) has changed the treatment of aortic stenosis, concerns remain regarding SVD, potentially related to valve thrombosis and thickening, based on studies using computed tomography (CT). Detailed histological analyses are provided to help attain insights into these processes.METHODS: Explanted transcatheter heart valves (THVs) were evaluated for thrombosis, fibrosis, and calcification for quantification of leaflet thickness. Immunohistochemical and microscopy approaches were used to investigate SVD-associated mechanisms.RESULTS: THVs (n = 23) were obtained from 22 patients (median 81 years of age; 50% male) from 0 to 2,583 days post TAVR. Maximal leaflet thickness increased relative to implant duration (ρ = 0.427; p = 0.027). THVs explanted after >2 years were thicker than those explanted after CONCLUSIONS: There is a time-dependent degeneration of THVs consisting of thrombus formation, endothelial hyperplasia, fibrosis, tissue remodeling, proteinase expression, and calcification. Future investigation is needed to further understand these mechanisms contributing to leaflet thickening and SVD.

Published
2018

22. The Authors Reply

Author

Sellers, Stephanie L., primary, Payne, Geoffrey W., additional, Seidman, Michael A., additional, and Leipsic, Jonathon A., additional

Published
2019
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23. Transcatheter Aortic Heart Valves

Author

Sellers, Stephanie L., primary, Turner, Christopher T., additional, Sathananthan, Janarthanan, additional, Cartlidge, Timothy R.G., additional, Sin, Frances, additional, Bouchareb, Rihab, additional, Mooney, John, additional, Nørgaard, Bjarne L., additional, Bax, Jeroen J., additional, Bernatchez, Pascal N., additional, Dweck, Marc R., additional, Granville, David J., additional, Newby, David E., additional, Lauck, Sandra, additional, Webb, John G., additional, Payne, Geoffrey W., additional, Pibarot, Philippe, additional, Blanke, Philipp, additional, Seidman, Michael A., additional, and Leipsic, Jonathon A., additional

Published
2019
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24. Impact of sublingual nitroglycerin dosage on FFRCT assessment and coronary luminal volume-to-myocardial mass ratio.

Author

Holmes, Kenneth R., Fonte, Tim A., Weir-McCall, Jonathan, Anastasius, Malcolm, Blanke, Philipp, Payne, Geoffrey W., Ellis, Jen, Murphy, Darra T., Taylor, Charles, Leipsic, Jonathon A., and Sellers, Stephanie L.

Subjects
NITROGLYCERIN, WILCOXON signed-rank test, HYPEREMIA, DRUG dosage, CORONARY vasospasm, COMPUTED tomography, CORONARY arteries
Abstract

Objectives: Fractional flow reserve computed tomography (FFRCT) depends upon nitroglycerin (NTG) inducing maximal hyperemia. However, the impact of NTG dosages on FFRCT analysis including coronary volume-to-mass ratio (V/M) is unknown.Methods: Eighty patients with repeat coronary CT angiograms (CCTAs) with different sublingual spray NTG doses (0.4 mg and 0.8 mg) were retrospectively analyzed with 45 patients excluded. Patient and scan demographics, post-stenosis and nadir FFRCT values, coronary volume, and coronary volume-to-mass ratio (V/M) were compared at initial CCTA (0.4 mg NTG) and follow-up CCTA (0.8 mg NTG). Differences were compared by Wilcoxon signed-rank test.Results: Thirty-five patients were included (time between CCTAs, 3.9 ± 1.6 years). Segment involvement score was 2.4 ± 3.3 and 2.8 ± 3.4 at initial and repeat CCTA (0.4 and 0.8 mg NTG), respectively (p = 0.004). There was similar image quality (4.1 ± 0.7 vs 4.1 ± 0.8; p = 0.51). Nadir FFRCT values did not differ in the left (0.4 mg, 0.80 ± 0.08 vs 0.8 mg, 0.80 ± 0.03; p = 0.66), right (0.4 mg, 0.90 ± 0.04 vs 0.8 mg, 0.90 ± 0.06; p = 0.25), or circumflex coronaries (0.4 mg, 0.87 ± 0.06 vs 0.8 mg, 0.88 ± 0.06; p = 0.34). Post-stenosis FFRCT values did not differ (p = 0.65). Coronary volume increased with 0.8 mg of NTG (2639 ± 753 mm3 vs 2844.8 ± 827 mm3; p = 0.009) but V/M ratio did not (p = 0.20).Conclusions: Use of 0.8 mg versus 0.4 mg of NTG in routine clinical CCTAs significantly increased coronary volume determined from FFRCT analysis but did not alter FFRCT or V/M. Further evaluation of repeat CCTAs in a more contemporaneous fashion using varied nitrate doses and disease severity is needed.Key Points: • Fractional flow reserve from computed tomography (FFRCT) is a noninvasive method for evaluating the coronary arteries and relies on nitroglycerin (NTG) to induce coronary vasodilation, but the impact of different NTG dosages is unknown. • Retrospective analysis evaluated use of different NTG doses on FFRCT. • Increased NTG dose increased coronary luminal volume on FFRCTanalysis, but did not change FFRCTvalues. [ABSTRACT FROM AUTHOR]

Published
2019
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28. Redo-TAVI with SAPIEN 3 in SAPIEN XT or SAPIEN 3 - impact of pre- and post-dilatation on final THV expansion.

Author

Meier D, Landes U, Sondergaard L, De Backer O, Lutter G, Puehler T, Akodad M, Tzimas G, Blanke P, Payne GW, Lai A, Gill H, Wood DA, Webb JG, Sellers SL, and Sathananthan J

Subjects
Humans, X-Ray Microtomography, Dilatation, Treatment Outcome, Aortic Valve diagnostic imaging, Aortic Valve surgery, Prosthesis Design, Transcatheter Aortic Valve Replacement methods, Aortic Valve Insufficiency surgery, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis
Abstract

Background: When a balloon-expandable transcatheter heart valve (THV) is chosen to treat a failed balloon-expandable THV, there is a risk of underexpansion with a potential impact on performance., Aims: We aimed to assess the impact of pre- and post-dilatation on the expansion of balloon-expandable THVs after redo-transcatheter aortic valve implantation (TAVI)., Methods: Redo-TAVI was performed on the bench with a 23 mm SAPIEN 3 (S3) implanted within a 23 mm SAPIEN XT (SXT) or a 23 mm S3, both of which served as the "failed" THVs. Pre- and/or post-dilatation was performed using a 23 mm non-compliant TRUE balloon. Expansion of the index and redo-THVs were assessed before and after pre-/post-dilatation using microcomputed tomography (micro-CT), and THV hydrodynamic testing was conducted., Results: Without pre- or post-dilatation, the S3 was underexpanded, for all combinations, particularly in the mid-portion of the THV (18.6 mm and 19.7 mm representing 81% and 86% of the nominal diameter inside the SXT and S3, respectively). Pre- and post-dilatation had an additive effect on diameter expansion of the redo-THV, which remained constrained in most combinations. The only combination to achieve nominal expansion was the S3 in S3 when both pre- and post-dilatation were performed. The S3 remained underexpanded inside the SXT despite pre- and post-dilatation (93% in the mid-portion). Improved redo-THV expansion was accompanied by 2.7 mm (12%) overexpansion of the index THV. While all samples had acceptable hydrodynamic performance, the underexpanded samples had worse leaflet pinwheeling., Conclusions: When performing redo-TAVI with a 23 mm S3 inside a 23 mm SXT or S3, only the S3 in S3 with the use of pre- and post-dilatation reached full expansion. This underlines the importance of CT assessment of THV expansion and the role of pre-/post-dilatation.

Published
2023
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29. Modified Intravital Microscopy to Assess Vascular Health and T-Cell Motility.

Author

Payne GW, Mitchell K, and Sellers SL

Subjects
Animals, Cell Communication, Mice, Cell Movement, Cell Tracking methods, Intravital Microscopy methods, Lymph Nodes blood supply, Lymph Nodes immunology, Microcirculation, T-Lymphocytes immunology
Abstract

The ability to study the microcirculation in real time is key to elucidating how the immune system and the associated microvasculature interact and influence one another within the lymph node (LN). Here, we present a method for near in-situ imaging of the inguinal LN. In particular, this method is ideal for the assessment of overall vascular health that influences immune functions and for the evaluation of T-cell motility. We focus on imaging of the microvasculature of the LN, paying particular attention to methods that ensure the study of healthy vessels, the ability to maintain imaging of viable vessels over a number of hours, quantification of vessel magnitude and vessel integrity. Modified intravital microscopy (M-IVM) of the LNs allows direct evaluation of microvascular functions as well as real-time imaging of the direct interface between immune cells, the LN, and the microcirculation. Importantly, M-IVM technique can be readily combined with many other vascular and immunological techniques such as fluorescent cell labeling and assessment of sticking and rolling time as descripted. Furthermore, it can be adapted to study vasculature of other than the inguinal LN. Overall, this chapter provides a dependable method for fundamental vascular immunological assessment of LNs that is decidedly useful in a diverse range of investigations.

Published
2019
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