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3. Liquid Biopsy in Early-Stage Lung Cancer: Current and Future Clinical Applications

Author

Vandekerckhove, Olivia, CUPPENS, Kristof, Pat, Karin, Du Pont, Bert, FROYEN, Guy, MAES, Brigitte, Vandekerckhove, Olivia, CUPPENS, Kristof, Pat, Karin, Du Pont, Bert, FROYEN, Guy, and MAES, Brigitte

Subjects
circulating tumor DNA, molecular diagnostics, liquid biopsy, screening, review, minimal residual disease, early stage, targeted therapy, non-small cell lung cancer
Abstract

Lung cancer remains the leading cause of cancer death worldwide, with the majority of cases diagnosed in an advanced stage. Early-stage disease non-small cell lung cancer (NSCLC) has a better outcome, nevertheless the 5-year survival rates drop from 60% for stage IIA to 36% for stage IIIA disease. Early detection and optimized perioperative systemic treatment are frontrunner strategies to reduce this burden. The rapid advancements in molecular diagnostics as well as the growing availability of targeted therapies call for the most efficient detection of actionable biomarkers. Liquid biopsies have already proven their added value in the management of advanced NSCLC but can also optimize patient care in early-stage NSCLC. In addition to having known diagnostic benefits of speed, accessibility, and enhanced biomarker detection compared to tissue biopsy, liquid biopsy could be implemented for screening, diagnostic, and prognostic purposes. Furthermore, liquid biopsy can optimize therapeutic management by overcoming the issue of tumor heterogeneity, monitoring tumor burden, and detecting minimal residual disease (MRD), i.e., the presence of tumor-specific ctDNA, post-operatively. The latter is strongly prognostic and is likely to become a guidance in the postsurgical management. In this review, we present the current evidence on the clinical utility of liquid biopsy in early-stage lung cancer, discuss a selection of key trials, and suggest future applications. This research received no external funding.

Published
2023

5. A prospective, multicenter, noninterventional study of decision factors in the first-line treatment of metastatic non-small cell lung cancer.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sibille, Anne, Bustin, Frederique, Carestia, Luciano, Catala, Gaetan, Compère, Christophe, Cuppens, Kristof, Colinet, Benoit, Coulon, Stephanie, De Brucker, Nele, Decoster, Lore, Decoster, Lynn, Demedts, Ingel, Derijcke, Sofie, Deschepper, Koen, Galdermans, Danny, Janssens, Annelies, Ocak, Sebahat, Oyen, Christel, Pat, Karin, Pieters, Thierry, Pruniau, Vincent, Surmont, Veerle, Vandekeere, Saar, Vansteenkiste, Johan, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Sibille, Anne, Bustin, Frederique, Carestia, Luciano, Catala, Gaetan, Compère, Christophe, Cuppens, Kristof, Colinet, Benoit, Coulon, Stephanie, De Brucker, Nele, Decoster, Lore, Decoster, Lynn, Demedts, Ingel, Derijcke, Sofie, Deschepper, Koen, Galdermans, Danny, Janssens, Annelies, Ocak, Sebahat, Oyen, Christel, Pat, Karin, Pieters, Thierry, Pruniau, Vincent, Surmont, Veerle, Vandekeere, Saar, and Vansteenkiste, Johan

Published
2022

6. A prospective, multicenter, noninterventional study of decision factors in the first-line treatment of metastatic non–small cell lung cancer

Author

Sibille, Anne, primary, Bustin, Frederique, additional, Carestia, Luciano, additional, Catala, Gaetan, additional, Compère, Christophe, additional, Cuppens, Kristof, additional, Colinet, Benoit, additional, Coulon, Stephanie, additional, De Brucker, Nele, additional, Decoster, Lore, additional, Decoster, Lynn, additional, Demedts, Ingel, additional, Derijcke, Sofie, additional, Deschepper, Koen, additional, Galdermans, Danny, additional, Janssens, Annelies, additional, Ocak, Sebahat, additional, Oyen, Christel, additional, Pat, Karin, additional, Pieters, Thierry, additional, Pruniau, Vincent, additional, Surmont, Veerle, additional, Vandekeere, Saar, additional, and Vansteenkiste, Johan, additional

Published
2022
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8. Does nivolumab for progressed metastatic lung cancer fulfill its promises? An efficacy and safety analysis in 20 general hospitals

Author

Tournoy, Kurt G., primary, Thomeer, Michiel, additional, Germonpré, Paul, additional, Derijcke, Sofie, additional, De Pauw, Rebecca, additional, Galdermans, Daniëlla, additional, Govaert, Karl, additional, Govaerts, Elke, additional, Schildermans, Rob, additional, Declercq, Isabelle, additional, De Brucker, Nele, additional, Pat, Karin, additional, Van Herreweghe, Rika, additional, Van Zandweghe, Luc, additional, Vanmaele, Luc, additional, Van Damme, Valerie, additional, Marien, Heidi, additional, De Craene, Sofie, additional, Fabry, Isabelle, additional, Alexander, Patrick, additional, Vercauter, Piet, additional, and Demedts, Ingel, additional

Published
2018
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9. P2.02-055 Pathologic Mediastinal Nodal and Metabolic Tumor Response to Predict Overall Survival in Stage IIIA-N2 NSCLC after Neoadjuvant Chemotherapy

Author

Dooms, Christophe, primary, Van De Kerkhove, Charlotte, additional, De Leyn, Paul, additional, Verbeken, Eric, additional, Pat, Karin, additional, Stroobanst, Sigrid, additional, Demedts, Ingel, additional, Derijcke, Sofie, additional, Decaluwe, Herbert, additional, Vansteenkiste, Johan, additional, and Deroose, Christophe, additional

Published
2017
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11. A prospective, multicenter, noninterventional study of decision factors in the first-line treatment of metastatic non–small cell lung cancer

Author

Anne Sibille, Frederique Bustin, Luciano Carestia, Gaetan Catala, Christophe Compère, Kristof Cuppens, Benoit Colinet, Stephanie Coulon, Nele De Brucker, Lore Decoster, Lynn Decoster, Ingel Demedts, Sofie Derijcke, Koen Deschepper, Danny Galdermans, Annelies Janssens, Sebahat Ocak, Christel Oyen, Karin Pat, Thierry Pieters, Vincent Pruniau, Veerle Surmont, Saar Vandekeere, Johan Vansteenkiste, Medical Oncology, Clinical sciences, Laboratory of Molecular and Medical Oncology, Faculty of Economic and Social Sciences and Solvay Business School, Cuppens, Kristof/0000-0002-8153-0008, Sibille, Anne, Bustin, Frederique, Carestia, Luciano, Catala, Gaetan, Compere, Christophe, CUPPENS, Kristof, Colinet, Benoit, Coulon, Stephanie, De Brucker, Nele, Decoster, Lore, Decoster, Lynn, Demedts, Ingel, Derijcke, Sofie, Deschepper, Koen, Galdermans, Danny, Janssens, Annelies, Ocak, Sebahat, Oyen, Christel, Pat, Karin, Pieters, Thierry, Pruniau, Vincent, Surmont, Veerle, Vandekeere, Saar, Vansteenkiste, Johan, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie

Subjects
metastatic non-small cell lung cancer, Pulmonary and Respiratory Medicine, Lung Neoplasms, Oncology, Carcinoma, Non-Small-Cell Lung, First-line treatment, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Human medicine, Hematology, General Medicine, respiratory system
Abstract

Medical writing and editorial assistance were provided by Tim Ibbotson, PhD, of ApotheCom (Yardley, PA, USA) and funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Statistical analysis was done by Herbert Thijs, Sofie Van Waes, and Filip Deforce (DICE). This assistance was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. The authors thanks to Hermine Leroi for the operational support and assistance during this project. The authors thank Katrien Willaert for the initiation of the study and its study design.

Published
2022
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