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Your search keyword '"Parks, Jaclyn"' showing total 16 results
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16 results on '"Parks, Jaclyn"'

4. Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity

Author

Peng, Ye, primary, Tun, Hein M, additional, Ng, Siew C, additional, Wai, Hogan Kok-Fung, additional, Zhang, Xi, additional, Parks, Jaclyn, additional, Field, Catherine J, additional, Mandhane, Piush, additional, Moraes, Theo J, additional, Simons, Elinor, additional, Turvey, Stuart E, additional, Subbarao, Padmaja, additional, Brook, Jeffrey R, additional, Takaro, Tim K, additional, Scott, James A, additional, Chan, Francis KL, additional, and Kozyrskyj, Anita L, additional

Published
2024
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5. Association of use of cleaning products with respiratory health in a Canadian birth cohort

Author

Parks, Jaclyn, McCandless, Lawrence, Dharma, Christoffer, Brook, Jeffrey, Turvey, Stuart E., Mandhane, Piush, Becker, Allan B., Kozyrskyj, Anita L., Azad, Meghan B., Moraes, Theo J., Lefebvre, Diana L., Sears, Malcolm R., Subbarao, Padmaja, Scott, James, and Takaro, Tim K.

Subjects
Parenting, Child development, Childhood asthma -- Risk factors, Medical research, Cleaning agents -- Usage, Allergy -- Risk factors, Wheezing, Childhood, Asthma, Diseases, Children, Health
Abstract

BACKGROUND: Comprehensive longitudinal studies are important for understanding the complex risk factors, pathways, exposures and interactions that lead to the development and persistence of asthma. We aimed to examine associations between use of household cleaning products in early life and childhood respiratory and allergic disease using data from the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study. METHODS: We summed responses from parental questionnaires that indicated the frequency of use of 26 household cleaning products in the homes of 2022 children from this birth cohort when they were 3-4 months of age to create a cumulative Frequency of Use Score (FUS). We used multivariable logistic regression models to assess whether frequent compared with less frequent use was associated with recurrent wheeze, atopy or asthma diagnosis, as defined by the questionnaire and clinical assessments at age 3 years. Data were collected between 2008 and 2015. RESULTS: Children in homes with a higher frequency of use of cleaning products in infancy, as determined by an interquartile range increase, had higher odds of recurrent wheeze (adjusted odds ratio [OR] 1.35, 95% confidence interval [CI] 1.11-1.64), recurrent wheeze with atopy (adjusted OR 1.49, 95% CI 1.02-2.16) and asthma diagnosis (adjusted OR 1.37, 95% CI 1.09-1.70), but no increase in the odds of atopy at age 3 years (adjusted OR 1.14, 95% CI 0.96-1.35). Compared with the lowest tertile of FUS exposure, infants in the highest tertile had higher odds of acquiring asthma. Stratification of the results showed that females had higher ORs than males for all outcomes, although the p values for this sex difference did not reach statistical significance. INTERPRETATION: Frequent use of household cleaning products in early life was associated with an increased risk for childhood wheeze and asthma but not atopy at age 3 years. Our findings add to the understanding of how early life exposures to cleaning products may be associated with the development of allergic airway disease and help to identify household behaviours as a potential area for intervention., The prevalence of childhood asthma has steadily increased over the past several decades and is now a leading cause of childhood chronic disease and admissions to hospital in developed countries, [...]

Published
2020
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9. Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants

Author

Obiakor, Chinwe Vivien, primary, Parks, Jaclyn, additional, Takaro, Tim K., additional, Tun, Hein M., additional, Morales-Lizcano, Nadia, additional, Azad, Meghan B., additional, Mandhane, Piushkumar J., additional, Moraes, Theo J., additional, Simons, Elinor, additional, Turvey, Stuart E., additional, Subbarao, Padmaja, additional, Scott, James A., additional, and Kozyrskyj, Anita L., additional

Published
2022
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13. Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning

Author

Parks, Jaclyn, primary, McLean, Kathleen E., additional, McCandless, Lawrence, additional, de Souza, Russell J., additional, Brook, Jeffrey R., additional, Scott, James, additional, Turvey, Stuart E., additional, Mandhane, Piush J., additional, Becker, Allan B., additional, Azad, Meghan B., additional, Moraes, Theo J., additional, Lefebvre, Diana L., additional, Sears, Malcolm R., additional, Subbarao, Padmaja, additional, and Takaro, Tim K., additional

Published
2021
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14. Cotinine, tobacco smoke, and diet: Strengthening our understanding of this biomarker in early life

Author

Parks, Jaclyn

Abstract

There are concerns about the usefulness of cotinine and trans-3’-hydroxycotinine (3HC), as biomarkers of risk in populations with light tobacco smoke exposure. Using CHILD cohort study data, multiple linear and logistic regression was used to determine how well questionnaire responses explained urinary concentrations of cotinine and 3HC in infants, whether these concentrations predicted childhood asthmatic and allergic disease risk, and whether breastmilk facilitated nicotine exposure. Predictive models explained 31% and 41% of the variation in cotinine and 3HC, respectively. Only 23% of the infants had urinary concentrations consistent with second-hand smoke (SHS) exposure. The majority (92%) of household smoking occurred outdoors. While smokers breastfed less often, breastmilk did facilitate nicotine intake. The implications of dietary nicotine sources through breastmilk were inconclusive. Subclinical impacts and the pervasiveness of thirdhand smoke pose a challenge for public health and we should re-evaluate our use and interpretation of nicotine biomarkers in low-smoke exposure settings.

Published
2020

16. A Novel Approach to Examining Multiple Indoor Exposures in Early Childhood on the Inflammatory Pathway and Risk of Intermediate Outcomes for Childhood Asthma in the Canadian Healthy Infant Longitudinal Development (CHILD) Birth Cohort

Author

Takaro, Tim K, primary, Vrijheid, Martine, additional, Basagaña, Xavier, additional, Parks, Jaclyn, additional, Becker, Allan, additional, Scott, James, additional, Lefebvre, Diana, additional, Lou, Wendy, additional, Mandhane, Piush, additional, Subbarao, Padmaja, additional, Turvey, Stuart, additional, Sears, Malcolm, additional, and Brook, Jeffrey, additional

Published
2018
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