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Your search keyword '"Park, Y.M."' showing total 41 results
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41 results on '"Park, Y.M."'

1. Diagnostic Yield and Synergistic Impact of Needle Aspiration and Forceps Biopsy With Electromagnetic Navigation Bronchoscopy for Pulmonary Lesions: A Randomized Trial

Author

Kim, Y.W., primary, Kim, H.-J., additional, Kwon, B.S., additional, Lee, Y.J., additional, Song, M.J., additional, Yoon, S.H., additional, Lim, S.Y., additional, Park, J.S., additional, Cho, Y.-J., additional, Lee, K.H., additional, Chung, J.-H., additional, Han, Y.B., additional, Maldonado, F., additional, Park, Y.M., additional, Ahn, S.Y., additional, Joo, D.-H., additional, Lee, J.H., additional, and Lee, C.-T., additional

Published
2024
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4. 895P Disproportional enrichment of FoxP3+CD4+ regulatory T-cells shapes a suppressive tumor microenvironment and provokes anti–PD-1 resistance in head and neck squamous cell carcinoma

Author

Kim, C.G., primary, Park, S., additional, Kim, D.H., additional, Hong, M.H., additional, Choi, E.C., additional, Kim, S.H., additional, Park, Y.M., additional, Kim, J., additional, Yoon, S.O., additional, Kim, G., additional, Shin, S., additional, Koh, Y.W., additional, Ha, S-J., additional, and Kim, H.R., additional

Published
2021
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6. DeepTetrad: high-throughput image analysis of meiotic tetrads by deep learning in Arabidopsis thaliana

Author

Kim, J., Choi, K., Byun, D., Henderson, I.R., Kim, E.-J., Lim, E.-C., Park, Y.M., Cho, H.S., Park, J., Hwang, I., and Copenhaver, G.P.

Subjects
fungi, food and beverages
Abstract

Meiotic crossovers facilitate chromosome segregation and create new combinations of alleles in gametes. Crossover frequency varies along chromosomes and crossover interference limits the coincidence of closely spaced crossovers. Crossovers can be measured by observing the inheritance of linked transgenes expressing different colors of fluorescent protein in Arabidopsis pollen tetrads. Here we establish DeepTetrad, a deep learning-based image recognition package for pollen tetrad analysis that enables high-throughput measurements of crossover frequency and interference in individual plants. DeepTetrad will accelerate the genetic dissection of mechanisms that control meiotic recombination.

Published
2020
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15. Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis.

Author

Bae, J.M., Kim, Y.‐S., Choo, E.H., Kim, M.‐Y., Lee, J.Y., Kim, H.‐O., and Park, Y.M.

Subjects
PROPENSITY score matching, PHOTOTHERAPY, CARDIOVASCULAR diseases, PROPORTIONAL hazards models, VITILIGO
Abstract

Background: Systemic effects of long‐term narrowband ultraviolet B (NB‐UVB) phototherapy have not been well studied in vitiligo patients. An 11‐year nationwide population‐based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007–2017). Objectives: To investigate the effects of long‐term NB‐UVB phototherapy on the risk of cardiovascular and cerebrovascular events in vitiligo patients. Methods: This study included vitiligo patients with ≥100 phototherapy sessions (phototherapy group, n = 3229) and <3 phototherapy sessions (no phototherapy group, n = 9687), in which covariables with age, sex, insurance type and comorbidities such as diabetes, hypertension and hyperlipidemia were matched by 1 : 3 propensity score matching. The outcomes of interest were cardiovascular (ischaemic heart disease and myocardial infarction) and cerebrovascular events (cerebrovascular infraction and haemorrhage). Cox proportional hazards models were used to assess the associations between NB‐UVB phototherapy and each event. Results: The risk of cardiovascular or cerebrovascular events was significantly decreased in the phototherapy group compared with the no phototherapy group [hazard ratio (HR) 0.637, 95% confidence interval (CI) 0.523–0.776]. Subgroup analysis revealed that the risk of cardiovascular (HR: 0.682, 95% CI: 0.495–0.940) and cerebrovascular events (HR: 0.601, 95% CI: 0.470–0.769) were significantly lower in the phototherapy group than the no phototherapy group, respectively. Conclusions: Our findings suggest that long‐term NB‐UVB phototherapy could decrease the risk of cardiovascular and cerebrovascular events in patients with vitiligo. Linked Commentary: B. Eberlein. J Eur Acad Dermatol Venereol 2021; 35: 11–12. https://doi.org/10.1111/jdv.17073. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Periodontal Antibodies and All-Cause and Cardiovascular Disease Mortality.

Author

Qi, J., Zihang, Z., Zhang, J., Park, Y.M., Shrestha, D., Jianling, B., and Merchant, A.T.

Subjects
IMMUNOGLOBULIN G, CARDIOVASCULAR disease related mortality, PERIODONTITIS, ORAL microbiology, CLUSTER analysis (Statistics), RESEARCH, HYPERGLYCEMIA, RESEARCH methodology, CARDIOVASCULAR diseases, DIABETES, BACTERIAL antibodies, EVALUATION research, MEDICAL cooperation, SURVEYS, COMPARATIVE studies, QUESTIONNAIRES, GRAM-positive bacteria, DISEASE complications
Abstract

Periodontitis is positively linked to cardiovascular disease (CVD), diabetes, cancer, and increased mortality. Empirically derived clusters of IgG antibodies against 19 selected periodontal microorganisms have been associated with hyperglycemia. We further investigated associations between these serum IgG antibody clusters and all-cause and CVD mortality in a representative US population. Participants free of CVD and cancer and aged ≥40 y at baseline (N = 6,491) from the Third National Health and Nutrition Examination Survey (1988 to 1994) were followed up until December 31, 2011. Antibodies were categorized into 4 clusters: red-green, orange-red, yellow-orange, and orange-blue. Over a 23-y follow-up, 2,702 deaths occurred, including 810 CVD-related deaths. In fully adjusted Cox proportional hazard models, the red-green cluster was positively associated with all-cause mortality (tertile 3 vs. tertile 1: hazard ratio [HR] = 1.43, 95% CI = 1.08 to 1.90, P = 0.015). The yellow-orange cluster was inversely associated with all-cause mortality (tertile 3 vs. tertile 1: HR = 0.78, 95% CI = 0.63 to 0.97, P = 0.028) and CVD mortality (tertile 2 vs. tertile 1: HR = 0.57, 95% CI = 0.42 to 0.77, P = 0.005). The orange-blue cluster (composed of antibodies against Eubacterium nodatum and Actinomyces naeslundii) was inversely associated with all-cause mortality (tertile 3 vs. tertile 1: HR = 0.65, 95% CI = 0.55 to 0.78, P < 0.0001) and CVD mortality (tertile 3 vs. tertile 1: HR = 0.65, 95% CI = 0.47 to 0.88, P = 0.007). These antibodies could predict prognosis or be potential intervention targets to prevent systemic effects of periodontal disease if further studies establish a causal relationship. [ABSTRACT FROM AUTHOR]

Published
2020
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22. Real-world rates of hepatitis B surface antigen seroclearance in patients with chronic hepatitis B: a systematic review, conventional aggregated data meta-analysis and individual patient data meta-analysis

Author

Yeo, Y.H., primary, Ho, H.J., additional, Yang, H.-I., additional, Tseng, T.-C., additional, Kwak, M.-S., additional, Park, Y.M., additional, Fung, Y.Y.J., additional, Ferret, M.B., additional, Rodríguez, M., additional, Preda, C.M., additional, Ungtrakul, T., additional, Charatcharoenwitthaya, P., additional, Li, X., additional, Huan Le, M., additional, Wei, B., additional, Zou, B., additional, Le, A., additional, Jeong, D., additional, Chien, N., additional, Kam, L., additional, Hosaka, T., additional, Barciela, M.R., additional, Suzuki, F., additional, Kobayashi, M., additional, Sriprayoon, T., additional, Chong, Y., additional, Tanwandee, T., additional, Yuen, M.-F., additional, Lee, H.-S., additional, Kao, J.-H., additional, Lok, A., additional, Wu, C.-Y., additional, and Nguyen, M., additional

Published
2018
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34. FRI-266 - Real-world rates of hepatitis B surface antigen seroclearance in patients with chronic hepatitis B: a systematic review, conventional aggregated data meta-analysis and individual patient data meta-analysis

Author

Yeo, Y.H., Ho, H.J., Yang, H.-I., Tseng, T.-C., Kwak, M.-S., Park, Y.M., Fung, Y.Y.J., Ferret, M.B., Rodríguez, M., Preda, C.M., Ungtrakul, T., Charatcharoenwitthaya, P., Li, X., Huan Le, M., Wei, B., Zou, B., Le, A., Jeong, D., Chien, N., Kam, L., Hosaka, T., Barciela, M.R., Suzuki, F., Kobayashi, M., Sriprayoon, T., Chong, Y., Tanwandee, T., Yuen, M.-F., Lee, H.-S., Kao, J.-H., Lok, A., Wu, C.-Y., and Nguyen, M.

Published
2018
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40. Cross-Sectional Analysis of Alcohol Intake and Serum Antibodies to Oral Microorganisms

Author

Merchant, A.T., Park, Y.M., Dodhia, S., Shrestha, D., Choi, Y.H., and Pitiphat, W.

Abstract

The objective of this study was to evaluate the relation between alcohol intake and groups of periodontal antibody titers among individuals with normal glucose tolerance (NGT), prediabetes and diabetes. This was a cross-sectional analysis of the National Health and Nutrition Examination Survey III (NHANES III) 1988–1994 data, among individuals 40 y and older with information on alcohol intake and serum immunoglobulin G (IgG) antibody data against 19 oral microorganisms. Participants were excluded if they did not have teeth, reported that they were taking insulin, or having gestational diabetes. The sample size for this analysis was 3,219. Periodontal antibodies were grouped into four clusters using cluster analysis: Orange-Red, Red-Green, Yellow- Orange, and Orange-Blue. Cluster scores were computed for each individual by summing z-scores of standardized log-transformed IgG titers of antibodies against periodontal microorganisms making up each respective cluster. Each cluster score was modeled as an outcome. Alcohol consumption was assessed in g/day using self-reported number of days of drinking in the past 12 mo and the average number of drinks consumed per day on days when they drank. Overall, alcohol intake was positively associated with periodontal antibodies of the Orange-Red cluster (P. melaninogenica, P. intermedia, P. nigrescens, and P. gingivalis), and inversely associated with the Yellow-Orange cluster (S. intermedius, S. oralis, S. mutans, F. nucleatum, P. micra, C. ochracea) after multivariable adjustment. The association between alcohol intake and the Orange-Red cluster was strongest among individuals with diabetes; this relation was seen among individuals with and without periodontal damage. The Orange-Red cluster was positively associated with periodontal damage among individuals with diabetes. Alcohol intake was not associated with any antibody cluster among individuals with NGT or prediabetes. The effect of alcohol intake on periodontal disease may be greater among individuals with diabetes but this finding needs to be confirmed in prospective studies.Knowledge Transfer Statement:The results of this study can be used by clinicians when treating patients with periodontal disease and diabetes.

Published
2017
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41. Double-blind, randomized non-inferiority trial of a novel botulinum toxin A processed from the strain CBFC26, compared with onabotulinumtoxin A in the treatment of glabellar lines.

Author

Kim, B.J., Kwon, H.H., Park, S.Y., Min, S.U., Yoon, J.Y., Park, Y.M., Seo, S.H., Ahn, J.Y., Lee, H.K., and Suh, D.H.

Subjects
RANDOMIZED controlled trials, BOTULINUM A toxins, DEGENERATION (Pathology), BLIND experiment, COSMETIC dermatology
Abstract

Background Botulinum toxins have been widely used in cosmetic dermatology. Neurotoxin from the CBFC26 strain ( NTC) is a recently developed botulinum toxin type A product manufactured through refined procedures. Objective A double-blinded, randomized, multicentre-designed, phase III trial to investigate the non-inferiority of NTC to existing botulinum toxin A, onabotulinumtoxin A in the treatment of moderate to severe glabellar lines. Methods A total of 272 subjects were randomized in a 1 : 1 ratio to receive 20 U of NTC or onabotulinumtoxin A. The primary endpoint was the response rate of physicians' assessment ( PA) using the Facial Wrinkle Scale at week 4. The secondary endpoints included the response rate of PA at weeks 8, 12 and 16, and photographic assessment at weeks 4, 8, 12 and 16. Subjects' improvement assessment and subjective self-satisfaction levels were also investigated. Results Response rates for maximum frown were 89.3% in the NTC group and 81.9% in the onabotulinumtoxin A group at week 4. NTC also resulted in comparable results for both the response rates of the other evaluation points and incidence of adverse events compared to those of onabotulinumtoxin A. In subjects' improvement assessment and photographic evaluations, NTC even demonstrated better results compared with onabotulinumtoxin A in the early phase after treatment. Analysis of these results strongly supports the non-inferiority of NTC to onabotulinumtoxin A in the efficacy and safety. Conclusion NTC is as effective as onabotulinumtoxin A in the treatment of glabellar lines, and both products were well tolerated. [ABSTRACT FROM AUTHOR]

Published
2014
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