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Your search keyword '"Park, Y.‐J."' showing total 214 results
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214 results on '"Park, Y.‐J."'

1. 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Published
2022
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2. Investigation of biogenic materials and ferroelectrets for energy harvesting on vibrating aircraft structures

Author

Holzmann, H., Weber, M., Park, Y. J., Perfetto, S., Atzrodt, H., Dafnis, A., Holzmann, H., Weber, M., Park, Y. J., Perfetto, S., Atzrodt, H., and Dafnis, A.

Abstract

In this publication the application of novel piezoelectric materials for energy harvesting on vibrating aircraft structures is investigated. These materials have significant advantages over conventional piezoelectric transducer materials like piezoceramics. In particular, biogenic materials in the form of wood-based materials and ferroelectrets in the form of irradiation cross-linked polypropylene are the subject of the investigation. The material characterization in terms of mechanical and electromechanical properties is shown for both material types. For the wood materials a compression test is used as the material has load-bearing properties. The ferroelectrets provide high compliances and are therefore investigated in a tensile test for material characterisation as well as in a four-point flexural test regarding its behaviour when glued to a dynamically bending surface. Additionally an FE-model of the material model for ferroelectrets is presented, which is validated by experimental results. An estimation of the power output is given for different concepts with both kinds of materials.

Published
2024

22. Computational design of mechanically coupled axle-rotor protein assemblies

Author

Courbet, A., Hansen, J., Hsia, Y., Bethel, N., Park, Y.-J., Xu, C., Moyer, A., Boyken, S.E., Ueda, G., Nattermann, U., Nagarajan, D., Silva, D., Sheffler, W., Quispe, J., Nord, A., King, N., Bradley, P., Veesler, D., Kollman, J., Baker, D., Courbet, A., Hansen, J., Hsia, Y., Bethel, N., Park, Y.-J., Xu, C., Moyer, A., Boyken, S.E., Ueda, G., Nattermann, U., Nagarajan, D., Silva, D., Sheffler, W., Quispe, J., Nord, A., King, N., Bradley, P., Veesler, D., Kollman, J., and Baker, D.

Abstract

Natural molecular machines contain protein components that undergo motion relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge for computational protein design. Here we explore the de novo construction of protein machinery from designed axle and rotor components with internal cyclic or dihedral symmetry. We find that the axle-rotor systems assemble in vitro and in vivo as designed. Using cryo–electron microscopy, we find that these systems populate conformationally variable relative orientations reflecting the symmetry of the coupled components and the computationally designed interface energy landscape. These mechanical systems with internal degrees of freedom are a step toward the design of genetically encodable nanomachines. © 2022 American Association for the Advancement of Science. All rights reserved.

Published
2022

23. Computational design of mechanically coupled axle-rotor protein assemblies

Author

Courbet, A., primary, Hansen, J., additional, Hsia, Y., additional, Bethel, N., additional, Park, Y.-J., additional, Xu, C., additional, Moyer, A., additional, Boyken, S. E., additional, Ueda, G., additional, Nattermann, U., additional, Nagarajan, D., additional, Silva, D., additional, Sheffler, W., additional, Quispe, J., additional, Nord, A., additional, King, N., additional, Bradley, P., additional, Veesler, D., additional, Kollman, J., additional, and Baker, D., additional

Published
2022
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24. A randomized study to evaluate the safety and efficacy of two dosages of lenvatinib – 18 and 24 mg – in patients with radioiodrefract differentiated thyroid cancer

Author

Brose, M. S., primary, Panaseykin, Yu., additional, Konda, B., additional, De la Fouchardiere, C., additional, Hughes, B. G.M., additional, Gianoukakis, A. G., additional, Park, Y. J., additional, Romanov, I., additional, Krzyzanowska, M. K., additional, Leboulleux, S., additional, Binder, T. A., additional, Dutcus, C., additional, Xie, R., additional, and Taylor, M. H., additional

Published
2022
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25. Additional file 5 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 5. Supplementary fig 5

Published
2022
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26. Additional file 2 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 2. Supplementary fig 2

Published
2022
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27. Additional file 10 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 10. Supplementary table 3

Published
2022
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28. Additional file 3 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 3. Supplementary fig 3

Published
2022
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29. Additional file 7 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 7. Supplementary fig 7

Published
2022
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30. Additional file 6 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 6. Supplementary fig 6

Published
2022
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31. Additional file 4 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 4. Supplementary fig 4

Published
2022
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32. Additional file 9 of 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R., Pugh, Derian A., Liu, Yiyuan, Patel, Tulsi, Renton, Alan E., Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, Bertelsen, Sarah, Cherry, Jonathan D., Karch, Celeste M., Frucht, Steven J., Kopell, Brian H., Peter, Inga, Park, Y. J., Charney, Alexander, Raj, Towfique, Crary, John F., and Goate, A. M.

Abstract

Additional file 9. Supplementary table 2

Published
2022
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33. 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes

Author

Bowles, Kathryn R, Pugh, Derian A, Cherry, Jonathan D, Karch, Celeste M, Frucht, Steven J, Kopell, Brian H, Peter, Inga, Park, Y. J., Consortium, International Parkinson’s Disease Genomics, Charney, Alexander, Raj, Towfique, Crary, John F, Liu, Yiyuan, Goate, A. M., Patel, Tulsi, Renton, Alan E, Bandres-Ciga, Sara, Gan-Or, Ziv, Heutink, Peter, Siitonen, Ari, and Bertelsen, Sarah

Subjects
DNA Copy Number Variations, genetics [DNA Copy Number Variations], Copy number variation, LRRC37A, 17q21.31, Parkinson Disease, tau Proteins, Polymorphism, Single Nucleotide, pathology [Parkinson Disease], genetics [tau Proteins], Haplotypes, genetics [Parkinson Disease], ddc:570, Astrocytes, genetics [alpha-Synuclein], Parkinson’s disease, alpha-Synuclein, Humans, Genetic Predisposition to Disease, pathology [Astrocytes]
Abstract

Parkinson's disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified.To better understand the genetic contribution of this region to PD and to identify novel mechanisms conferring risk for the disease, we fine-mapped the 17q21.31 locus by constructing discrete haplotype blocks from genetic data. We used digital PCR to assess copy number variation associated with PD-associated blocks, and used human brain postmortem RNA-seq data to identify candidate genes that were then further investigated using in vitro models and human brain tissue.We identified three novel H1 sub-haplotype blocks across the 17q21.31 locus associated with PD risk. Protective sub-haplotypes were associated with increased LRRC37A/2 copy number and expression in human brain tissue. We found that LRRC37A/2 is a membrane-associated protein that plays a role in cellular migration, chemotaxis and astroglial inflammation. In human substantia nigra, LRRC37A/2 was primarily expressed in astrocytes, interacted directly with soluble α-synuclein, and co-localized with Lewy bodies in PD brain tissue.These data indicate that a novel candidate gene, LRRC37A/2, contributes to the association between the 17q21.31 locus and PD via its interaction with α-synuclein and its effects on astrocytic function and inflammatory response. These data are the first to associate the genetic association at the 17q21.31 locus with PD pathology, and highlight the importance of variation at the 17q21.31 locus in the regulation of multiple genes other than MAPT and KANSL1, as well as its relevance to non-neuronal cell types.

Published
2021

43. General Colloidal Synthesis of Transition-Metal Disulfide Nanomaterials as Electrocatalysts for Hydrogen Evolution Reaction

Author

Meerbach, C., Klemmed, B., Spittel, D., Bauer, C., Park, Y. J., Hübner, R., Jeong, H. Y., Erb, D., Shin, H. S., Lesnyak, V., Eychmüller, A., Meerbach, C., Klemmed, B., Spittel, D., Bauer, C., Park, Y. J., Hübner, R., Jeong, H. Y., Erb, D., Shin, H. S., Lesnyak, V., and Eychmüller, A.

Abstract

The material-efficient monolayers of transition-metal dichalcogenides (TMDs) are a promising class of ultrathin nanomaterials with properties ranging from insulating through semiconducting to metallic, opening a wide variety of their potential applications from catalysis and energy storage to optoelectronics, spintronics, and valleytronics. In particular, TMDs have a great potential as emerging inexpensive alternatives to noble metal-based catalysts in electrochemical hydrogen evolution. Herein, we report a straightforward, low-cost, and general colloidal synthesis of various 2D transition-metal disulfide nanomaterials, such as MoS2, WS2, NiSx, FeSx, and VS2, in the absence of organic ligands. This new preparation route provides many benefits including relatively mild reaction conditions, high reproducibility, high yields, easy upscaling, no post-thermal annealing/treatment steps to enhance the catalytic activity, and, finally, especially for molybdenum disulfide nanosheets, high activity in the hydrogen evolution reaction. To underline the universal application of the synthesis, we prepared mixed CoxMo1-xS2 nanosheets in one step to optimize the catalytic activity of pure undoped MoS2, which resulted in an enhanced hydrogen evolution reaction performance characterized by onset potentials as low as 134 mV and small Tafel slopes of 55 mV/dec.

Published
2020

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