Search

Your search keyword '"Paquin, Ashley"' showing total 23 results
Start Over Author "Paquin, Ashley" Publication Year Range Last 10 years
23 results on '"Paquin, Ashley"'

3. Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance

Author

O’Brien, Thomas R, Pfeiffer, Ruth M, Paquin, Ashley, Kuhs, Krystle A Lang, Chen, Sabrina, Bonkovsky, Herbert L, Edlin, Brian R, Howell, Charles D, Kirk, Gregory D, Kuniholm, Mark H, Morgan, Timothy R, Strickler, Howard D, Thomas, David L, and Prokunina-Olsson, Ludmila

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Hepatitis - C, Emerging Infectious Diseases, Digestive Diseases, Genetics, Hepatitis, Infectious Diseases, Liver Disease, Good Health and Well Being, Alleles, Antiviral Agents, Female, Genotype, Hepacivirus, Hepatitis C, Chronic, Humans, Interferons, Interleukins, Male, Middle Aged, Polymorphism, Genetic, RNA, Viral, IFNL3, IFNL4, IL28B, Innate immunity, Interferon lambda, Treatment, Viral clearance, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsGenetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant'). An IFNL3 3' untranslated region polymorphism (rs4803217) has been proposed as a causal variant that may affect HCV clearance by altering IFNL3 mRNA stability.MethodsWe compared IFNL4-ΔG/TT and rs4803217 for association with response to pegylated-IFN-α/ribavirin in the VIRAHEP-C and HALT-C trials, and spontaneous HCV clearance in the ALIVE, UHS and WIHS studies. Genotyping was performed with TaqMan assays. We compared differences in mean reduction in HCV RNA levels by genotype and haplotype. For HCV clearance, we calculated p-values comparing c-statistics for IFNL4-ΔG/TT and rs4803217 genotypes by a bootstrap approach.ResultsAmong European Americans, linkage disequilibrium between IFNL4-ΔG/TT and rs4803217 was strong (r(2)=0.89-0.99) and there were no significant differences between the variants. In African American (AA) individuals enrolled in VIRAHEP-C, HCV RNA at treatment day 28 was more strongly associated with IFNL4-ΔG/TT than rs4803217 (p=0.003); the IFNL4-ΔG:rs4803217-G haplotype, which includes the putatively favorable IFNL3 allele, was actually associated with the poorest day 28 response (p=0.03, comparison to IFNL4-ΔG:rs4803217-T haplotype). Among AA participants, associations were stronger for IFNL4-ΔG/TT than rs4803217 for undetectable HCV RNA at week 24 in Virahep-C (p=0.03) and week 20 in HALT-C (p=0.03), as well as for spontaneous HCV clearance (p=0.048).ConclusionIFNL4-ΔG/TT is the primary IFN-λ region polymorphism for impaired HCV clearance.

Published
2015

4. Characteristics of exceptional responders to autologous stem cell transplantation in multiple myeloma

Author

Paquin, Ashley, Visram, Alissa, Kumar, Shaji K., Gertz, Morie A., Cantwell, Hafsa, Buadi, Francis K., Lacy, Martha Q., Dispenzieri, Angela, Dingli, David, Hwa, Lisa, Fonder, Amie, Hobbs, Miriam, Hayman, Suzanne R., Lust, John A., Russell, Stephen J., Leung, Nelson, Kapoor, Prashant, Go, Ronald S., Lin, Yi, Gonsalves, Wilson I., Kourelis, Taxiarchis, Warsame, Rahma, Kyle, Robert A., and Rajkumar, S. Vincent

Published
2020
Full Text
View/download PDF

5. Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

6. Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Table 5 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

8. Overall survival of transplant eligible patients with newly diagnosed multiple myeloma: comparative effectiveness analysis of modern induction regimens on outcome

Author

Paquin, Ashley R., Kumar, Shaji K., Buadi, Francis K., Gertz, Morie A., Lacy, Martha Q., Dispenzieri, Angela, Dingli, David, Hwa, Lisa, Fonder, Amie, Hobbs, Miriam, Hayman, Suzanne R., Zeldenrust, Steven R., Lust, John A., Russell, Stephen J., Leung, Nelson, Kapoor, Prashant, Go, Ronald S., Lin, Yi, Gonsalves, Wilson I., Kourelis, Taxiarchis, Warsame, Rahma, Kyle, Robert A., and Rajkumar, S. Vincent

Published
2018
Full Text
View/download PDF

11. Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms

Author

Figueroa, Jonine D., Koutros, Stella, Colt, Joanne S., Kogevinas, Manolis, Garcia-Closas, Montserrat, Real, Francisco X., Friesen, Melissa C., Baris, Dalsu, Stewart, Patricia, Schwenn, Molly, Johnson, Alison, Karagas, Margaret R., Armenti, Karla R., Moore, Lee E., Schned, Alan, Lenz, Petra, Prokunina-Olsson, Ludmila, Banday, A. Rouf, Paquin, Ashley, Ylaya, Kris, Chung, Joon-Yong, Hewitt, Stephen M., Nickerson, Michael L., Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Malats, Núria, Fraumeni, Joseph F., Jr., Chanock, Stephen J., Chatterjee, Nilanjan, Rothman, Nathaniel, and Silverman, Debra T.

Published
2015
Full Text
View/download PDF

13. The diagnosis and management of suspected lymphoma in general practice.

Author

Paquin, Ashley R., Oyogoa, Emmanuella, McMurry, Hannah Stowe, Kartika, Thomas, West, Malinda, and Shatzel, Joseph J.

Subjects
*BLOOD cell count, *LYMPHOMAS, *BLOOD flow, *SYMPTOMS
Abstract

With rapid advancements in diagnosis and treatment of malignancies, the gap between generalists and subspecialists continues to widen, particularly in cancers like lymphoma where the spectrum of disease varies from indolent to rapidly progressive. Prior to establishing with a hematologist/oncologist, patients must be accurately and comprehensively diagnosed and managed for lymphoma in the generalist setting. In the following manuscript, we review the common clinical presentations in which should raise concern for lymphoma. We summarize the literature regarding the role of laboratory studies including complete blood count and peripheral blood flow cytometry, the recommendations for lymph node sampling, the role and selection of imaging modalities, and ideal patient monitoring for high‐risk clinical syndromes that may be encountered in lymphoma. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

14. Characterization of Exceptional Responders to Autologous Stem Cell Transplantation in Multiple Myeloma

Author

Paquin, Ashley, primary, Gertz, Morie A., additional, Chaudhry, Hafsa, additional, Kumar, Shaji K., additional, Buadi, Francis K., additional, Dispenzieri, Angela, additional, Dingli, David, additional, Hwa, Yi, additional, Fonder, Amie, additional, Hobbs, Miriam, additional, Hayman, Suzanne R., additional, Zeldenrust, Steven, additional, Lust, John A., additional, Russell, Stephen J., additional, Leung, Nelson, additional, Kapoor, Prashant, additional, Go, Ronald S., additional, Lin, Yi, additional, Gonsalves, Wilson I, additional, Kourelis, Taxiarchis, additional, Warsame, Rahma, additional, Kyle, Robert A., additional, and Rajkumar, S. Vincent, additional

Published
2018
Full Text
View/download PDF

16. Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

Author

Middlebrooks, Candace D, primary, Banday, A Rouf, additional, Matsuda, Konichi, additional, Udquim, Krizia-Ivana, additional, Onabajo, Olusegun O, additional, Paquin, Ashley, additional, Figueroa, Jonine D, additional, Zhu, Bin, additional, Koutros, Stella, additional, Kubo, Michiaki, additional, Shuin, Taro, additional, Freedman, Neal D, additional, Kogevinas, Manolis, additional, Malats, Nuria, additional, Chanock, Stephen J, additional, Garcia-Closas, Montserrat, additional, Silverman, Debra T, additional, Rothman, Nathaniel, additional, and Prokunina-Olsson, Ludmila, additional

Published
2016
Full Text
View/download PDF

19. ID: 89

Author

O’Brien, Thomas, primary, Pfeiffer, Ruth, additional, Paquin, Ashley, additional, Kuhs, Krystle Lang, additional, Chen, Sabrina, additional, Howell, Charles, additional, and Prokunina-Olsson, Ludmila, additional

Published
2015
Full Text
View/download PDF

22. Overall Survival of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma: Comparative Effectiveness Analysis of Modern Induction Regimens on Outcome

Author

Paquin, Ashley, Kumar, Shaji K, Buadi, Francis K, Gertz, Morie A., Lacy, Martha Q, Dispenzieri, Angela, Dingli, David, Hwa, Lisa, Fonder, Amie, Hobbs, Miriam, Hayman, Suzanne R., Zeldenrust, Steven, Lust, John A., Russell, Stephen J., Leung, Nelson, Kapoor, Prashant, Go, Ronald S, Lin, Yi, Gonsalves, Wilson I, Kourelis, Taxiarchis, Warsame, Rahma, Kyle, Robert A, and Rajkumar, S. Vincent

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results