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3. Moderate hypofractionation and simultaneous integrated boost by helical tomotherapy in prostate cancer: monoinstitutional report of acute tolerability assessment with different toxicity scales

Author

Ferrera, Giuseppe, Mortellaro, Gianluca, Mannino, Mariella, Caminiti, Giovanni, Spera, Antonio, Figlia, Vanessa, Iacoviello, Giuseppina, Di Paola, Gioacchino, Mazzola, Rosario, Lo Casto, Antonio, Alongi, Filippo, Pappalardo, Maria Pia, and Lagalla, Roberto

Published
2015
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5. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

8. Preliminary Experience with a Novel System of Facet Fixation to Treat Patients with Lumbar Degenerative Disease. A New Perspective in Minimally Invasive Spine Surgery?

Author

Francaviglia, Natale, Costantino, Gabriele, Villa, Alessandro, Iacopino, Domenico Gerardo, Pappalardo, Maria Pia, Barone, Fabio, Gallo, Cristina, Contino, Antonino Odierna, Meli, Francesco, and Maugeri, Rosario

Subjects
LAPAROSCOPIC surgery, SPONDYLOLISTHESIS, MAGNETIC resonance imaging, DEGENERATION (Pathology), SURGICAL complications
Abstract

Purpose We report our experience with a novel surgical device for the treatment of lumbar degenerative microinstability. Facet Wedge (DePuy Synthes, Raynham, Massachusetts, United States) is a novel technique of intra-articular lumbar facet fixation that provides a minimally invasive alternative to standard posterior fixation. Materials and Methods From November 2014 to July 2015, 38 patients underwent single-level Facet Wedge implantation. The main surgical indications included herniated disk (18 patients), spinal canal and foraminal stenosis (14 patients), and Meyerding grade I degenerative spondylolisthesis (6 patients). All the patients showed radiologic signs of microinstability: hyperintensity in both facet joints (facet fluid signal) in T2-weighted magnetic resonance imaging and a black disk as a sign of degenerative disease. No slippage was evident at dynamic radiograph. After a period of conservative treatment (minimum of 6 months), surgery was performed. All patients' follow-up lasted over at least 12 months. Results The low back visual analog scale score decreased significantly after surgery (from an average of 8.2 to 3.1 at final follow-up). Postoperatively, the Oswestry Disability Index showed a significant reduction (14.7 on average). No slippage or signs of adjacent segment degeneration was detected in neuroimaging follow-up. Conclusion Facet Wedge allows facet fixation in lumbar degenerative microinstability. To the best of our knowledge, this is the first clinical series reported in the literature on this novel device. [ABSTRACT FROM AUTHOR]

Published
2018
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9. Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review

Author

Caterina Cacace, Rossana Bussani, Mirella Collura, Giovanni Corsello, Aurora Puglisi, Valeria Calcaterra, Maria Pia Pappalardo, Gloria Pelizzo, Emanuele Agolini, Antonio Novelli, Maria Piccione, Pelizzo, Gloria, Collura, Mirella, Puglisi, Aurora, Pappalardo, Maria Pia, Agolini, Emanuele, Novelli, Antonio, Piccione, Maria, Cacace, Caterina, Bussani, Rossana, Corsello, Giovanni, Calcaterra, Valeria, Pelizzo, G., Collura, M., Puglisi, A., Pappalardo, M. P., Agolini, E., Novelli, A., Piccione, M., Cacace, C., Bussani, R., Corsello, G., and Calcaterra, V.

Subjects
Lung Diseases, Male, Pathology, medicine.medical_specialty, Filamins, medicine.medical_treatment, Children, Congenital enphysema, Filamin a, Lung disease, Periventricular nodular heterotopia, Case Report, Filamin, Keywords: Filamin a, Congenital enphysema, Lung disease, Children, Periventricular nodular heterotopia, Lung Disorder, 03 medical and health sciences, 0302 clinical medicine, Neuroimaging, Loss of Function Mutation, 030225 pediatrics, medicine, Humans, FLNA, 030212 general & internal medicine, Lung, Genetic testing, Mechanical ventilation, medicine.diagnostic_test, business.industry, lcsh:RJ1-570, Brain, Infant, lcsh:Pediatrics, respiratory system, Respiration, Artificial, medicine.anatomical_structure, Pulmonary Emphysema, Respiratory failure, Pediatrics, Perinatology and Child Health, Radiography, Thoracic, Respiratory Insufficiency, Tomography, X-Ray Computed, business
Abstract

Background Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases. Case presentation We report a new pathogenic FLNA gene variant (c.7391_7403del; p.Val2464Alafs*5) in a male infant who developed progressive lung disease with emphysematous lesions and interstitial involvement. Following lobar resection, chronic respiratory failure ensued necessitating continuous mechanical ventilation and tracheostomy. Cerebral periventricular nodular heterotopia was also present. Conclusions We report a novel variant of the FLNA gene, associated with a severe lung disorder and PNVH. The lung disorder led to respiratory failure during infancy and these pulmonary complications may be the first sign of this disorder. Early recognition with thoracic imaging is important to guide genetic testing, neuroimaging and to define optimal timing of potential therapies, such as lung transplant in progressive lung disease.

Published
2019
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10. Non-alcoholic Wernicke's encephalopathy: From MRI findings of a case to differential diagnosis checklist

Author

G. La Tona, Carla Cannizzaro, MP Pappalardo, F Barone, Roberto Lagalla, Giuseppe Salvaggio, Cesare Gagliardo, S Arculeo, Gagliardo, Cesare, La Tona, Giuseppe, Arculeo, Simona, Barone, Fabio, Salvaggio, Giuseppe, Pappalardo, Maria Pia, Cannizzaro, Carla, and Lagalla, Roberto

Subjects
medicine.medical_specialty, Diffusion-weighted magnetic resonance imaging, Wernicke Encephalopathy, medicine.diagnostic_test, Wernicke encephalopathy, business.industry, Metabolic brain disease, Medicine (all), Magnetic resonance imaging, Non alcoholic, General Medicine, medicine.disease, Diffusion-Weighted Magnetic Resonance Imaging, Checklist, Wernicke's encephalopathy, Thiamine deficiency, medicine, Radiology, Differential diagnosis, business, Mri findings
Abstract

Wernicke's encephalopathy is a serious neurological disorder secondary to thiamine deficiency in alcoholics. However, rarely it affects non-alcoholics. Here we present a case of Wernicke's encephalopathy in a non-alcoholic 56-year-old female, treated by endoscopic surgery for a duodenal ulcer two years before. She came to our attention for a sudden onset of a neurological syndrome characterized by visual deficits, diplopia, confusion, spatial disorientation and loss of short-term memory. An MRI scan showed the typical MRI findings of Wernicke's encephalopathy, which are discussed together with the possible differential diagnosis.

Published
2018

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