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296 results on '"Pap, T"'

24. Sclerostin inhibits osteoclastogenesis by modulating wnt signaling in bone-marrow-derived macrophages

Author

Intemann, J, Wehmeyer, C, Werbenko, E, Kracke, V, Reinhardt, J, Paruzel, P, Kramer, I, Kneissel, M, Pap, T, and Dankbar, B

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Introduction: Sclerostin is a wnt inhibitor and has anti-anabolic effects on bone formation, by negatively regulating osteoblast differentiation. Therefore, pharmacological inhibition of sclerostin is a promising target to treat osteoporosis. Surprisingly, the loss of sclerostin in a TNFα-dependent[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)

Published
2020
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28. BCP and CPPD crystalopathies exhibit distinct effects on the chondrocyte phenotype

Author

Meyer, F, Pap, T, Kornak, U, Bollmann, M, and Bertrand, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Calcification of cartilage with BCP crystals is a common finding during osteoarthritis (OA) and is directly linked to the severity of the disease and hypertrophic differentiation of chondrocytes. In some OA cartilage samples calcium pyrophosphate dihydrate (CPPD) crystals can be found. The[for full text, please go to the a.m. URL], 47. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 33. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 29. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2019
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29. An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis

Author

Severmann, A. -C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J., Pap, T., Hoffmann, D., Vortkamp, A., Severmann, A. -C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J., Pap, T., Hoffmann, D., and Vortkamp, A.

Abstract

Objective: Osteoarthritis (OA) is a progressive degenerative disease of the articular cartilage caused by an unbalanced activity of proteases, cytokines and other secreted proteins. Since heparan sulfate (HS) determines the activity of many extracellular factors, we investigated its role in OA progression. Methods: To analyze the role of the HS level, OA was induced by anterior cruciate ligament transection (ACLT) in transgenic mice carrying a loss-of-function allele of Ext1 in clones of chondrocytes (Col2-rtTA-Cre;Ext1(e2fl/e2fl)). To study the impact of the HS sulfation pattern, OA was surgically induced in mice with a heterozygous (Ndst1(+/-)) or chondrocyte-specific (Col2-Cre;Ndst1(fl/fl)) loss-of-function allele of the sulfotransferase Ndst1. OA progression was evaluated using the OARSI scoring system. To investigate expression and activity of cartilage degrading proteases, femoral head explants of Ndst1(+/-) mutants were analyzed by qRT-PCR, Western Blot and gelatin zymography. Results: All investigated mouse strains showed reduced OA scores (Col2-rtTA-Cre;Ext1(e2fl/e2fl): 0.83; 95% HDI 0.72-0.96; Ndst1(+/-): 0.83, 95% HDI 0.74-0.9; Col2-Cre;Ndst1(fl/fl): 0.87, 95% HDI 0.76-1). Using cartilage explant cultures of Ndst1 animals, we detected higher amounts of aggrecan degradation products in wildtype samples (NITEGE 4.24-fold, 95% HDI 1.05-18.55; VDIPEN 1.54-fold, 95% HDI 1.54-2.34). Accordingly, gelatin zymography revealed lower Mmp2 activity in mutant samples upon RA-treatment (0.77-fold, 95% HDI: 0.60-0.96). As expression of major proteases and their inhibitors was not altered, HS seems to regulate cartilage degeneration by affecting protease activity. Conclusion: A decreased HS content or a reduced sulfation level protect against OA progression by regulating protease activity rather than expression. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-N

Published
2020

32. Programmierter Zelltod und Toll-like Rezeptor Aktivierung im Hyalinen Knorpel

Author

Stolberg-Stolberg, J, Böttcher, A, Sherwood, J, Sambale, M, Raschke, M, Pap, T, and Bertrand, J

Subjects
ddc: 610, Entzündung, Pattern Recognition Receptor, Arthrose, 610 Medical sciences, Medicine, Nekroptose
Abstract

Fragestellung: Die Rolle des programmierten Zelltods in der Pathogenese der Osteoarthrose ist unklar. Im Gegensatz zur Apoptose ist die Nekroptose mit dem Freiwerden von damage associated molecular patterns (DAMPs), insbesondere von Nukleinsäuren assoziiert. Wir beschäftigen uns mit der Fragestellung,[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Published
2018
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44. Der Verlust von Integrin alpha-2/beta-1 führt zu einer veränderten Kollagenstruktur in der der murinen Achillessehne

Author

Michel, P, Kronenberg, D, Ma, W, Hochstrat, E, Neu, G, Pap, T, Raschke, MJ, and Stange, R

Subjects
Sehnenheilung, ddc: 610, Integrin, Kollagen, 610 Medical sciences, Medicine
Abstract

Fragestellung: Sehnengewebe besteht bis zu 90% aus Typ-I Kollagen, welches in Fibrillen und Faszikeln organisiert ist und durch Adhäsionsmoleküle der Extrazellulärmatrix (EZM) verbunden wird. Integrin alpha-2/beta-1 ist ein kollagenbindendes Protein mit hoher Affinität [zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017
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