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4. The Role of Vascular Imaging atReferral Centers in the Drip and Ship Paradigm

Author

Flores, Alan, Seró, Laia, Gomez-Choco, Manuel, Ustrell, Xavier, Pellisé, Anna, Viñas, Jaume, Rodriguez, Paula, Monterde, Angela, Castilho, Gislaine, Rubiera, Marta, Amaro, Sergi, Padrós, Maria Angels Font, Cardona, Pedro, Marti-Fabregas, Joan, Molina, Carlos A., Serena, Joaquín, Jimenez-Fábrega, Francesc Xavier, Purroy, Francisco, Zaragoza-Brunet, José, Cocho, Dolores, Palomeras, Ernest, Kuprinski, Jurek, Más, Natalia, Hernández-Perez, Maria, Sanjurjo, Eduard, Carrión, Dolors, Costa, Xavier, Barceló, Miquel, Monedero, Jordi, Catena, Esther, Rybyeba, Maria, Díaz, Gloria, de la Ossa, Natalia Perez, and Ribó, Marc

Published
2022
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5. Prehospital care process and hospital outcomes in stroke-code cases: comparison of basic and advance life support ambulance attendance

Author

Solà-Muñoz, Silvia, primary, Escudero Campillo, María del Mar, additional, Soro Borrega, Cristina, additional, Azeli, Youcef, additional, Querol Gil, Soledad, additional, Ruiz, Antoni, additional, Albacete, Gemma, additional, Peral, Olga, additional, Lluch, Sergi, additional, Amaro Delgado, Sergio, additional, Silva Blas, Yolanda, additional, Urra, Xabier, additional, Cocho Calderón, Dolores, additional, Martí Fàbregas, Joan, additional, Ribó Jacobi, Marc, additional, Cardona Portela, Pere, additional, Purroy García, Francisco, additional, Duarte Oller, Esther, additional, Hidalgo Benítez, Verónica, additional, Flores, Alan, additional, Rubiera, Marta, additional, Palomeras, Ernest, additional, García-Tornel, Álvaro, additional, Suñer Soler, Rosa, additional, Vilar Roquet, Daniel, additional, Salvat-Plana, Mercè, additional, Ramos Pachón, Anna, additional, Pérez de la Ossa Herrero, Natalia, additional, and Jiménez-Fàbrega, Xavier, additional

Published
2024
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8. Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke

Author

Martí-Fàbregas, Joan, Guisado-Alonso, Daniel, Delgado-Mederos, Raquel, Martínez-Domeño, Alejandro, Prats-Sánchez, Luis, Guasch-Jiménez, Marina, Cardona, Pere, Núñez-Guillén, Ana, Requena, Manuel, Rubiera, Marta, Olivé, Marta, Bustamante, Alejandro, Gomis, Meritxell, Amaro, Sergio, Llull, Laura, Ustrell, Xavier, Castilho de Oliveira, Gislaine, Seró, Laia, Gomez-Choco, Manuel, Mena, Luis, Serena, Joaquín, Bashir Viturro, Saima, Purroy, Francisco, Vicente, Mikel, Rodríguez-Campello, Ana, Ois, Angel, Catena, Esther, Carmen Garcia-Carreira, Maria, Barrachina, Oriol, Palomeras, Ernest, Krupinski, Jerzky, Almeria, Marta, Zaragoza, Josep, Esteve, Patricia, Cocho, Dolores, Moreira, Antia, van Eendenburg, Cecile, Emilio Codas, Javier, Pérez de la Ossa, Natalia, Salvat, Mercè, and Camps-Renom, Pol

Published
2021
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9. Thrombolysis in Patients With Large‐Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population‐Based Study

Author

Garcia‐Tornel, Alvaro, primary, Lozano, Prudencio, additional, Rubiera, Marta, additional, Requena, Manuel, additional, Olivé‐Gadea, Marta, additional, Muchada, Marian, additional, Juega, Jesus, additional, Rizzo, Federica, additional, Rodriguez‐Villatoro, Noelia, additional, Pagola, Jorge, additional, Rodriguez‐Luna, David, additional, Boned, Sandra, additional, Dorado, Laura, additional, Jiménez, Xavier, additional, Soto, Angels, additional, Cardona, Pere, additional, Urra, Xabier, additional, Chamorro, Angel, additional, Purroy, Francesc, additional, Terceño, Mikel, additional, Silva, Yolanda, additional, Flores, Alan, additional, Ustrell, Xavier, additional, Zaragoza, Josep, additional, Roquer, Jaume, additional, Kuprinski, Jerzy, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Gomez‐Choco, Manuel, additional, Canovas, David, additional, Martí‐Fabregas, Joan, additional, Mas, Natalia, additional, Abilleira, Sonia, additional, Molina, Carlos, additional, Ribó, Marc, additional, and de la Ossa, Natalia Pérez, additional

Published
2023
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10. Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia

Author

Silva, Yolanda, primary, Sánchez-Cirera, Laura, additional, Terceño, Mikel, additional, Dorado, Laura, additional, Valls, Adrián, additional, Martínez, Marina, additional, Abilleira, Sònia, additional, Rubiera, Marta, additional, Quesada, Helena, additional, Llull, Laura, additional, Rodríguez-Campello, Ana, additional, Martí-Fàbregas, Joan, additional, Seró, Laia, additional, Purroy, Francisco, additional, Payo, Iago, additional, García, Sònia, additional, Cánovas, David, additional, Krupinski, Jurek, additional, Mas, Natalia, additional, Palomeras, Ernest, additional, Cocho, Dolores, additional, Font, Maria Àngels, additional, Catena, Esther, additional, Puiggròs, Elsa, additional, Pedroza, Claudia, additional, Marín, Gemma, additional, Carrión, Dolors, additional, Costa, Xavier, additional, Almendros, Mari Cruz, additional, Torres, Ivan, additional, Colom, Carla, additional, Velasquez, John Alejandro, additional, Diaz, Gloria, additional, Jiménez, Xavier, additional, Subirats, Teresa, additional, Deulofeu, Anna, additional, Hidalgo, Verónica, additional, Salvat-Plana, Mercè, additional, and Pérez de la Ossa, Natalia, additional

Published
2023
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11. MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation

Author

Martí-Fàbregas, Joan, Medrano-Martorell, Santiago, Merino, Elisa, Prats-Sánchez, Luis, Marín, Rebeca, Delgado-Mederos, Raquel, Martínez-Domeño, Alejandro, Camps-Renom, Pol, Jiménez-Xarrié, Elena, Zedde, Mariluisa, Gómez-Choco, Manuel, Lara, Lidia, Boix, Amèlia, Calleja, Ana, De Arce-Borda, Ana María, Bravo, Yolanda, Fuentes, Blanca, Hernández-Pérez, María, Cánovas, David, Llull, Laura, Zandio, Beatriz, Freijo, Marimar, Casado-Naranjo, Ignacio, Sanahuja, Jordi, Cocho, Dolores, Krupinski, Jerzy, Rodríguez-Campello, Ana, Palomeras, Ernest, De Felipe, Alicia, Serrano, Marta, Zapata-Arriaza, Elena, Zaragoza-Brunet, Josep, Díaz-Maroto, Inmaculada, Fernández-Domínguez, Jessica, Lago, Aida, Maestre, José, Rodríguez-Yáñez, Manuel, and Gich, Ignasi

Published
2019
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12. PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

Author

Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Natàlia, Torres-Aguila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Angel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernandez-Guillamon, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Martí-Fàbregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Victor, Ribó, Marc, Molina, Carlos A., Alvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibanez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kristiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, and Jiménez-Conde, Jordi

Published
2019
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13. Abstract TMP70: Relevance Of Persistent Perfusion Deficits On Clinical Outcome After Sucessful Endovascular Treatment

Author

Valls, Adrian, primary, Puig, Josep, additional, Palomar, Alicia, additional, Laredo, Carlos, additional, Werner, Mariano, additional, Remollo Friedemann, Sebastià, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Munuera, Josep, additional, Perez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Bustamante, Alejandro, additional, Carbonell, Jaime, additional, Larrañaga, Clara, additional, Castaño, Carlos, additional, Muñoz, Lucía, additional, Palomeras, Ernest, additional, Domenech, Sira, additional, Terceño, Mikel, additional, Davalos, Antoni, additional, Millan, Monica, additional, and Hernandez-Perez, Maria, additional

Published
2023
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14. Abstract WP99: Impact Of Venous Delay Evaluated Before And After Mechanical Thrombectomy On Stroke Outcome

Author

Zangana, Lara, primary, Valls, Adrian, additional, Munuera, Josep, additional, Werner, Mariano, additional, Remollo, Sebastiàn, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Puig, Josep, additional, Perez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Bustamante, Alejandro, additional, Pina, Belen F., additional, Castaño, Carlos, additional, Muñoz, Lucia, additional, Palomeras, Ernest, additional, Massuet, Anna, additional, Terceño, Mikel, additional, Davalos, Antonio, additional, Millan, Monica, additional, and Hernandez-Perez, Maria, additional

Published
2023
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15. Abstract WP4: Intravenous Thrombolysis And Outcomes In Patients With Large-vessel Stroke Directly Admitted Or Transferred To A Thrombectomy-capable Center

Author

Garcia-Tornel Garcia-Camba, Alvaro, primary, Lozano, Prudencio, additional, Requena, Manuel, additional, Rodriguez-Luna, David, additional, Rodriguez-Villatoro, Noelia, additional, Rubiera, Marta, additional, Muchada, Marian, additional, Olive-Gadea, Marta, additional, Rizzo, Federica, additional, boned, sandra, additional, Ribo, Marc, additional, Molina, Carlos A, additional, Pagola, Jorge, additional, Juega, Jesús, additional, Dorado, Laura, additional, Jimenez-Fabrega, Xavier, additional, Cardona, Pedro, additional, Urra, Xabier, additional, Purroy, Francisco, additional, Terceño, Mikel, additional, Flores, Alan F, additional, Chamorro, Angel, additional, Silva, Yolanda, additional, Ustrell, Xavier, additional, Zaragoza, Jose, additional, Roquer, Jaime, additional, Krupinski, Jerzy, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Gomez-Choco, Manuel J, additional, Canovas, David, additional, Martí-Fàbregas, Joan, additional, Mas, Natalia, additional, Fagundez, Olga, additional, Abilleira, Sonia, additional, and Perez de la Ossa, Natalia, additional

Published
2023
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16. Early and Delayed Infarct Growth in Patients Undergoing Mechanical Thrombectomy: A Prospective, Serial MRI Study

Author

Hernández-Pérez, María, primary, Werner, Mariano, additional, Remollo, Sebastián, additional, Martín, Carlota, additional, Cortés, Jordi, additional, Valls, Adrian, additional, Ramos, Anna, additional, Dorado, Laura, additional, Serena, Joaquin, additional, Munuera, Josep, additional, Puig, Josep, additional, Pérez de la Ossa, Natalia, additional, Gomis, Meritxell, additional, Carbonell, Jaime, additional, Castaño, Carlos, additional, Muñoz-Narbona, Lucia, additional, Palomeras, Ernest, additional, Domenech, Sira, additional, Massuet, Anna, additional, Terceño, Mikel, additional, Davalos, Antoni, additional, and Millán, Monica, additional

Published
2023
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18. sj-docx-1-eso-10.1177_23969873231156260 – Supplemental material for Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia

Author

Silva, Yolanda, Sánchez-Cirera, Laura, Terceño, Mikel, Dorado, Laura, Valls, Adrián, Martínez, Marina, Abilleira, Sònia, Rubiera, Marta, Quesada, Helena, Llull, Laura, Rodríguez-Campello, Ana, Martí-Fàbregas, Joan, Seró, Laia, Purroy, Francisco, Payo, Iago, García, Sònia, Cánovas, David, Krupinski, Jurek, Mas, Natalia, Palomeras, Ernest, Cocho, Dolores, Font, Maria Àngels, Catena, Esther, Puiggròs, Elsa, Pedroza, Claudia, Marín, Gemma, Carrión, Dolors, Costa, Xavier, Almendros, Mari Cruz, Torres, Ivan, Colom, Carla, Velasquez, John Alejandro, Diaz, Gloria, Jiménez, Xavier, Subirats, Teresa, Deulofeu, Anna, Hidalgo, Verónica, Salvat-Plana, Mercè, and Pérez de la Ossa, Natalia

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231156260 for Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia by Yolanda Silva, Laura Sánchez-Cirera, Mikel Terceño, Laura Dorado, Adrián Valls, Marina Martínez, Sònia Abilleira, Marta Rubiera, Helena Quesada, Laura Llull, Ana Rodríguez-Campello-Campello, Joan Martí-Fàbregas, Laia Seró, Francisco Purroy, Iago Payo, Sònia García, David Cánovas, Jurek Krupinski, Natalia Mas, Ernest Palomeras, Dolores Cocho, Maria Àngels Font, Esther Catena, Elsa Puiggròs, Claudia Pedroza, Gemma Marín, Dolors Carrión, Xavier Costa, Mari Cruz Almendros, Ivan Torres, Carla Colom, John Alejandro Velasquez, Gloria Diaz, Xavier Jiménez, Teresa Subirats, Anna Deulofeu, Verónica Hidalgo, Mercè Salvat-Plana and Natalia Pérez de la Ossa in European Stroke Journal

Published
2023
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20. Spontaneous Swallowing Frequency in Post-Stroke Patients with and Without Oropharyngeal Dysphagia : an Observational Study

Author

Alvarez-Larruy, Marta, Tomsen, Noemí, Guanyabens, Nicolau, Palomeras, Ernest, Clavé, Pere, Nascimento, Weslania, Alvarez-Larruy, Marta, Tomsen, Noemí, Guanyabens, Nicolau, Palomeras, Ernest, Clavé, Pere, and Nascimento, Weslania

Abstract

Altres ajuts: Acord transformatiu CRUE-CSIC, Altres ajuts: Generalitat de Catalunya, RIS3CAT, projectes d'especialització i competitivitat territorial (PECT) PRE/161/2019, Oropharyngeal dysphagia (OD) is a frequent complication after stroke (PSOD) that increases morbidity and mortality. Early detection of PSOD is essential to reduce morbidity and mortality in patients with acute stroke. In recent years, an association between reduced spontaneous swallowing frequency (SSF) and OD has been described. Likewise, the reduction of saliva substance P (SP) concentration has been associated with an increased risk of aspiration and a decrease in SSF. In this study we aimed to compare SSF, salivary SP concentration, hydration and nutritional status in post-stroke (PS) patients with and without OD. We included 45 acute PS patients (4.98 ± 2.80 days from stroke onset, 62.22% men, 71.78 ± 13.46 year). The Volume-Viscosity Swallowing Test (V-VST) was performed for clinical diagnosis of OD. SSF/minute was assessed through 10-min neurophysiological surface recordings including suprahyoid-electromyography and cricothyroid-accelerometry. Saliva samples were collected with a Salivette® to determine SP by ELISA. Hydration status was assessed by bioimpedance. Nutritional status was evaluated by Mini Nutritional Assessment Short Form (MNA-sf) and blood analysis. Twenty-seven PS patients (60%) had OD; 19 (40%), impaired safety of swallow. SSF was significantly reduced in PSOD, 0.23 ± 0.18 and PSOD with impaired safety, 0.22 ± 0.18 vs 0.48 ± 0.29 swallows/minute in PS without OD (PSnOD); (both p < 0.005). Nutritional risk was observed in 62.92% PSOD vs 11.11% PSnOD (p = 0.007) and visceral protein markers were also significantly reduced in PSOD (p < 0.05). Bioimpedance showed intracellular dehydration in 37.50% PSOD vs none in PSnOD. There were no differences for saliva SP concentrations. SSF is significantly reduced in PSOD in comparison with PSnOD. Acute PSOD patients present poor nutritional status, hydropenia, and high risk for respiratory complications.

Published
2022

21. Influence of Hospital Type on Outcomes of Individuals Aged 80 and Older with Stroke Treated Using Intravenous Thrombolysis

Author

Purroy, Francisco, Vena, Ana, Cánovas, David, Cardona, Pere, Cocho, Dolores, Cuadrado‐Godia, Elisa, Chamorro, Angel, Dávalos, Antonio, Garcés, Moisés, Gomis, Meritxell, Krupinski, Jerzy, Palomeras, Ernest, Ribó, Marc, Roquer, Jaume, Rubiera, Marta, Sanahuja, Jordi, Saura, Júlia, Serena, Joaquín, Ustrell, Xavier, Vargas, Martha, Benabdelhak, Ikram, Abilleira, Sonia, and Gallofré, Miquel

Published
2017
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22. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Author

Fernández-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafria, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado, Pilar, Ribó, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Marimar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez-Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Perez de la Ossa, Natalia, Martinez-Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Canovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Davalos, Antoni, Roquer, Jaume, Arenillas, Juan Francisco, Martí-Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, and Montaner, Joan

Published
2017
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23. Evolution of quality indicators in acute stroke during the RACECAT Trial: Impact in the general population

Author

Olivé-Gadea, Marta, primary, Pérez de la Ossa, Natalia, additional, Jovin, Tudor, additional, Abilleira, Sonia, additional, Jiménez, Xavier, additional, Cardona, Pere, additional, Chamorro, Angel, additional, Flores, Alan, additional, Silva, Yolanda, additional, Purroy, Francesc, additional, Martí-Fabregas, Joan, additional, Rodríguez-Campello, Ana, additional, Zaragoza, Josep, additional, Krupinski, Jerzy, additional, Canovas, David, additional, Gomez Choco, Manuel, additional, Mas, Natalia, additional, Palomeras, Ernest, additional, Cocho, Dolores, additional, Aragonès, Josep M, additional, Repullo, Carmen, additional, Sanjurjo, Eduard, additional, Carrion, Dolores, additional, Catena, Esther, additional, Costa, Xavier, additional, Almendros, M Cruz, additional, Barceló, Miquel, additional, Monedero, Jordi, additional, Rybyeva, Maria, additional, Diaz, Gloria, additional, and Ribó, Marc, additional

Published
2022
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25. Evolution of quality indicators in acute stroke during the RACECAT Trial: Impact in the general population.

Author

Olivé-Gadea, Marta, Pérez de la Ossa, Natalia, Jovin, Tudor, Abilleira, Sonia, Jiménez, Xavier, Cardona, Pere, Chamorro, Angel, Flores, Alan, Silva, Yolanda, Purroy, Francesc, Martí-Fabregas, Joan, Rodríguez-Campello, Ana, Zaragoza, Josep, Krupinski, Jerzy, Canovas, David, Gomez Choco, Manuel, Mas, Natalia, Palomeras, Ernest, Cocho, Dolores, and Aragonès, Josep M

Subjects
STROKE, STROKE patients, WATERSHEDS, EMERGENCY medical services, ENDOVASCULAR surgery
Abstract

Background: Acute ischemic stroke patients not referred directly to a comprehensive stroke center (CSC) have reduced access to endovascular treatment (EVT). The RACECAT trial is a population-based cluster-randomized trial, designed to compare mothership and drip-and-ship strategies in acute ischemic stroke patients outside the catchment area of a CSC. Aims: To analyze the evolution of performance indicators in the regions that participated in RACECAT. Methods: This retrospective longitudinal observational study included all stroke alerts evaluated by emergency medical services in Catalonia between February 2016 and February 2020. Cases were classified geographically according to the nearest SC: local SC (Local-SC) and CSC catchment areas. We analyzed the evolution of EVT rates and relevant workflow times in Local-SC versus CSC catchment areas over three study periods: P1 (February 2016 to April 2017: before RACECAT initiation), P2 (May 2017 to September 2018), and P3 (October 2018 to February 2020). Results: We included 20603 stroke alerts, 10,694 (51.9%) of which were activated within Local-SC catchment areas. The proportion of patients receiving EVT within Local-SC catchment areas increased (P1 vs. P3: 7.5% (95% confidence interval (CI), 6.4–8.7) to 22.5% (95% CI, 20.8–24.4) p < 0.001). Inequalities in the odds of receiving EVT were reduced for patients from CSC versus Local-SC catchment areas (P1: odds ratio (OR) 3.9 (95% CI, 3.2–5) vs. P3: OR 1.5 (95% CI, 1.3–1.7) In Local-SC, door-to-image (P1: 24 (interquartile range (IQR) 15–36), P2: 24 (15–35), P3: 21 (13–32) min, p < 0.001) and door-to-needle times (P1: 42 (31–60), P2: 41 (29–58), P3: 35 (25–50) p < 0.001) reduced. Time from Local-SC arrival to groin puncture also decreased over time (P1: 188 [151–229], P2: 190 (157–233), P3: 168 (127–215) min, p < 0.001). Conclusion: An increase in EVT rates in Local-SC regions with a significant decrease in workflow times occurred during the period of the RACECAT trial. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Workflow Times and Outcomes in Patients Triaged for a Suspected Severe Stroke.

Author

García‐Tornel, Álvaro, Seró, Laia, Urra, Xabier, Cardona, Pere, Zaragoza, Josep, Krupinski, Jerzy, Gómez‐Choco, Manuel, Sala, Natalia Mas, Catena, Esther, Palomeras, Ernest, Serena, Joaquin, Hernandez‐Perez, Maria, Boned, Sandra, Olivé‐Gadea, Marta, Requena, Manuel, Muchada, Marian, Tomasello, Alejandro, Molina, Carlos A., Salvat‐Plana, Mercè, and Escudero, Mar

Subjects
WORKFLOW, EMERGENCY medical services, TREATMENT effectiveness, STROKE
Abstract

Introduction: Current recommendations for regional stroke destination suggest that patients with severe acute stroke in non‐urban areas should be triaged based on the estimated transport time to a referral thrombectomy‐capable center. Methods: We performed a post hoc analysis to evaluate the association of pre‐hospital workflow times with neurological outcomes in patients included in the RACECAT trial. Workflow times evaluated were known or could be estimated before transport allocation. Primary outcome was the shift analysis on the modified Rankin score at 90 days. Results: Among the 1,369 patients included, the median time from onset to emergency medical service (EMS) evaluation, the estimated transport time to a thrombectomy‐capable center and local stroke center, and the estimated transfer time between centers were 65 minutes (interquartile ratio [IQR] = 43–138), 61 minutes (IQR = 36–80), 17 minutes (IQR = 9–27), and 62 minutes (IQR = 36–73), respectively. Longer time intervals from stroke onset to EMS evaluation were associated with higher odds of disability at 90 days in the local stroke center group (adjusted common odds ratio (acOR) for each 30‐minute increment = 1.03, 95% confidence interval [CI] = 1.01–1.06), with no association in the thrombectomy‐capable center group (acOR for each 30‐minute increment = 1.01, 95% CI = 0.98–1.01, pinteraction = 0.021). No significant interaction was found for other pre‐hospital workflow times. In patients evaluated by EMS later than 120 minutes after stroke onset, direct transport to a thrombectomy‐capable center was associated with better disability outcomes (acOR = 1.49, 95% CI = 1.03–2.17). Conclusion: We found a significant heterogeneity in the association between initial transport destination and neurological outcomes according to the elapse of time between the stroke onset and the EMS evaluation (ClinicalTrials.gov: NCT02795962). ANN NEUROL 2022;92:931–942 [ABSTRACT FROM AUTHOR]

Published
2022
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27. Reasons for Not Performing Mechanical Thrombectomy: A Population-Based Study of Stroke Codes

Author

Guisado-Alonso, Daniel, primary, Martínez-Domeño, Alejandro, additional, Prats-Sánchez, Luis, additional, Delgado-Mederos, Raquel, additional, Camps-Renom, Pol, additional, Abilleira, Sònia, additional, de la Ossa, Natalia Pérez, additional, Ramos-Pachón, Anna, additional, Cardona, Pere, additional, Rodríguez-Campello, Ana, additional, Molina, Carlos A., additional, Rudilosso, Salvatore, additional, Martí-Fàbregas, Joan, additional, Marín, Rebeca, additional, Purroy, Francisco, additional, Serena, Joaquín, additional, Canovas, David, additional, Gómez- Choco, Manuel, additional, Ustrell, Xavier, additional, Zaragoza, Josep, additional, Krupinski, Jerzy, additional, Mas Sala, Natalia, additional, Palomeras, Ernest, additional, Cocho, Dolors, additional, Maria Aragonés, Josep, additional, López, Núria, additional, Sanjurjo, Eduard, additional, Carrión Duch, Dolors, additional, López, Mercè, additional, Almendros Rivas, M.Cruz, additional, Monedero Boado, Jordi, additional, Catena, Esther, additional, Rybyeba, Maria, additional, and Diaz, Gloria, additional

Published
2021
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28. Determinants and Trends of the Use of Intravenous Thrombolysis for Minor Stroke: A Population-Based Study, 2016 to 2020.

Author

Font, Maria Àngels, García-Sánchez, Sonia María, Mengual, Juan José, Mena, Luis, Avellaneda, Carla, Serena, Joaquín, Valls-Carbó, Adrián, Chamorro, Ángel, Ustrell, Xavier, Molina, Carlos, Cardona, Pere, Guasch-Jiménez, Marina, Purroy, Francisco, Rodríguez-Campello, Ana, Palomeras, Ernest, Cocho, Dolores, Krupinski, Jerzy, Cánovas, David, García-Alhama, Jessica, and Zaragoza, José

Published
2022
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30. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors : Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry

Author

Rudilosso, Salvatore, Ríos, José, Rodríguez, Alejandro, Gomis, Meritxell, Vera, Víctor, Gómez-Choco, Manuel, Renú, Arturo, Matos, Núria, Llull, Laura, Purroy, Francisco, Amaro, Sergio, Terceño, Mikel, Obach, Víctor, Serena, Joaquim, Martí-Fàbregas, Joan, Cardona, Pedro, Molina, Carlos, Rodríguez-Campello, Ana, Cánovas, David, Krupinski, Jerzy, Ustrell, Xavier, Torres, Ferran, Román, Luis San, Salvat-Plana, Mercè, Jiménez-Fàbrega, Francesc Xavier, Palomeras, Ernest, Catena, Esther, Colom, Carla, Cocho, Dolores, Baiges, Juanjo, Aragones, Josep Maria, Diaz, Gloria, Costa, Xavier, Almendros, María Cruz, Rybyeba, Maria, Barceló, Miquel, Carrión, Dolors, Lòpez, Matilde Núria, Sanjurjo, Eduard, Pérez de la Ossa, Natalia, Urra, Xabier, Chamorro, Ángel, Rudilosso, Salvatore, Ríos, José, Rodríguez, Alejandro, Gomis, Meritxell, Vera, Víctor, Gómez-Choco, Manuel, Renú, Arturo, Matos, Núria, Llull, Laura, Purroy, Francisco, Amaro, Sergio, Terceño, Mikel, Obach, Víctor, Serena, Joaquim, Martí-Fàbregas, Joan, Cardona, Pedro, Molina, Carlos, Rodríguez-Campello, Ana, Cánovas, David, Krupinski, Jerzy, Ustrell, Xavier, Torres, Ferran, Román, Luis San, Salvat-Plana, Mercè, Jiménez-Fàbrega, Francesc Xavier, Palomeras, Ernest, Catena, Esther, Colom, Carla, Cocho, Dolores, Baiges, Juanjo, Aragones, Josep Maria, Diaz, Gloria, Costa, Xavier, Almendros, María Cruz, Rybyeba, Maria, Barceló, Miquel, Carrión, Dolors, Lòpez, Matilde Núria, Sanjurjo, Eduard, Pérez de la Ossa, Natalia, Urra, Xabier, and Chamorro, Ángel

Abstract

In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups' criteria). Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.

Published
2021

31. Healthcare costs of post-stroke oropharyngeal dysphagia and its complications : malnutrition and respiratory infections

Author

Marin, Sergio, Serra-Prat, Mateu, Ortega, Omar, Audouard Fericgla, Monica, Valls, Jordi, Palomera, Elisabet, Cunillera, Ramon, Palomeras, Ernest, Ibàñez, Josep Maria, Clavé, Pere, Marin, Sergio, Serra-Prat, Mateu, Ortega, Omar, Audouard Fericgla, Monica, Valls, Jordi, Palomera, Elisabet, Cunillera, Ramon, Palomeras, Ernest, Ibàñez, Josep Maria, and Clavé, Pere

Abstract

Altres ajuts: Acord transformatiu CRUE-CSIC, Financial support received from research grants from Nutricia Danone Advanced Medical Nutrition (HESDY Grant); Fundació Salut del CSdM, Strategic Action Grant in Oropharyngeal Dysphagia provided by the Centro de Investigación Biomédica en Red en el Área de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, DJO Global, and la Fundació la Marató de TV3 (11/2310)., Background and purpose: The healthcare economic costs of post-stroke oropharyngeal dysphagia (OD) are not fully understood. The purpose of this study was to assess the acute, subacute and long-term costs related to post-stroke OD and its main complications (malnutrition and respiratory infections). Methods: A cost of illness study of patients admitted to Mataró Hospital (Catalonia, Spain) from May 2010 to September 2014 with a stroke diagnosis was performed. OD, malnutrition and respiratory infections were assessed during hospitalization and follow-up (3 and 12 months). Hospitalization and long-term costs were measured from hospital and healthcare system perspectives. Multivariate linear regression analysis was performed to assess the independent effect of OD, malnutrition and respiratory infections on healthcare costs during hospitalization, and at 3 and 12 months' follow-up. Results: In all, 395 patients were included of whom 178 had OD at admission. Patients with OD incurred major total in-hospital costs (€5357.67 ± €3391.62 vs. €3976.30 ± €1992.58, p < 0.0001), 3-month costs (€8242.0 ± €5376.0 vs. €5320.0 ± €4053.0, p < 0.0001) and 12-month costs (€11,617.58 ± €12,033.58 vs. €7242.78 ± €7402.55, p < 0.0001). OD was independently associated with a cost increase of €789.68 (p = 0.011) during hospitalization and of €873.5 (p = 0.084) at 3 months but not at 12 months. However, patients with OD who were at risk of malnutrition or malnourished and suffered respiratory infections incurred major mean costs compared with those patients without OD (€19,817.58 ± €13,724.83 vs. €7242.8 ± €7402.6, p < 0.0004) at 12 months' follow-up. Conclusion: Oropharyngeal dysphagia causes significant high economic costs during hospitalization that strongly and significantly increase with the development of malnutrition and respiratory infections at long-term follow-up.

Published
2021

32. Abstract 18: The Role of Vascular Imaging at Primary Stroke Centers in the Drip and Ship Paradigm

Author

Flores, Alan, primary, Seró, Laia, additional, Ustrell, Xavier, additional, Pellisé, Anna, additional, Gomez Choco, Manuel, additional, Viñas, Jaume, additional, Palomeras, Ernest, additional, Krupinski, Jurek, additional, Más, Natalia, additional, Cocho, Dolores, additional, Purroy, Francisco, additional, Zaragoza-brunet, Jose, additional, Cardona, Pedro, additional, Serena, Joaquin, additional, Ribó, Marc, additional, Obach, Victor, additional, Rubiera, Marta, additional, and Perez de la Ossa, Natalia, additional

Published
2021
Full Text
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33. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author

Thomalla, Götz, primary, Boutitie, Florent, additional, Ma, Henry, additional, Koga, Masatoshi, additional, Ringleb, Peter, additional, Schwamm, Lee H, additional, Wu, Ona, additional, Bendszus, Martin, additional, Bladin, Christopher F, additional, Campbell, Bruce C V, additional, Cheng, Bastian, additional, Churilov, Leonid, additional, Ebinger, Martin, additional, Endres, Matthias, additional, Fiebach, Jochen B, additional, Fukuda-Doi, Mayumi, additional, Inoue, Manabu, additional, Kleinig, Timothy J, additional, Latour, Lawrence L, additional, Lemmens, Robin, additional, Levi, Christopher R, additional, Leys, Didier, additional, Miwa, Kaori, additional, Molina, Carlos A, additional, Muir, Keith W, additional, Nighoghossian, Norbert, additional, Parsons, Mark W, additional, Pedraza, Salvador, additional, Schellinger, Peter D, additional, Schwab, Stefan, additional, Simonsen, Claus Z, additional, Song, Shlee S, additional, Thijs, Vincent, additional, Toni, Danilo, additional, Hsu, Chung Y, additional, Wahlgren, Nils, additional, Yamamoto, Haruko, additional, Yassi, Nawaf, additional, Yoshimura, Sohei, additional, Warach, Steven, additional, Hacke, Werner, additional, Toyoda, Kazunori, additional, Donnan, Geoffrey A, additional, Davis, Stephen M, additional, Gerloff, Christian, additional, Acosta, Boris Raul, additional, Aegidius, Karen, additional, Albiker, Christian, additional, Alegiani, Anna, additional, Almendrote, Miriam, additional, Alonso, Angelika, additional, Althaus, Katharina, additional, Amarenco, Pierre, additional, Amiri, Hemasse, additional, Anders, Bettina, additional, Aniculaesei, Adriana, additional, Appleton, Jason, additional, Arenillas, Juan, additional, Back, Christina, additional, Bähr, Christian, additional, Bardutzky, Jürgen, additional, Baronnet-Chauvet, Flore, additional, Bathe-Peters, Rouven, additional, Bayer-Karpinska, Anna, additional, Becerra, Juan L., additional, Beck, Christoph, additional, Belchí Guillamon, Olga, additional, Benoit, Amandine, additional, Berhoune, Nadia, additional, Bindila, Daniela, additional, Birchenall, Julia, additional, Blanc-Lasserre, Karine, additional, Blanco Gonzales, Miguel, additional, Bobinger, Tobias, additional, Bodechtel, Ulf, additional, Bodiguel, Eric, additional, Bojaryn, Urszula, additional, Bonnet, Louise, additional, Bouamra, Benjamin, additional, Bourgeois, Paul, additional, Breuer, Lorenz, additional, Breynaert, Ludovic, additional, Broughton, David, additional, Brouns, Raf, additional, Brugirard, Sébastian, additional, Bruneel, Bart, additional, Buggle, Florian, additional, Cakmak, Serkan, additional, Calleja, Ana, additional, Calvet, David, additional, Carrera, David, additional, Chen, Hsin-Chieh, additional, Cheripelli, Bharath, additional, Cho, Tae-Hee, additional, Choe, Chi-un, additional, Choy, Lillian, additional, Christensen, Hanne, additional, Ciatipis, Mareva, additional, Cloud, Geoffrey, additional, Cogez, Julien, additional, Cortijo, Elisa, additional, Crozier, Sophie, additional, Damgaard, Dorte, additional, Dani, Krishna, additional, De Coene, Beatrijs, additional, De Hollander, Isabel, additional, De Keyser, Jacques, additional, De Klippel, Nina, additional, De Maeseneire, Charlotte, additional, De Smedt, Ann, additional, del Mar Castellanos Rodrigo, Maria, additional, Deltour, Sandrine, additional, Demeestere, Jelle, additional, Derex, Laurent, additional, Desfontaines, Philippe, additional, Dittrich, Ralf, additional, Dixit, Anand, additional, Dobbels, Laurens, additional, Domigo, Valérie, additional, Dorado, Laura, additional, Druart, Charlotte, additional, Dupont, Kristina Hougaard, additional, Dusart, Anne, additional, Dziewas, Rainer, additional, Ebner, Matthias, additional, Edjali-Goujon, Myriam, additional, Eisele, Philipp, additional, El Tawil, Salwa, additional, Elhfnawy, Ahmed, additional, Etexberria, Ana, additional, Evans, Nicholas, additional, Fandler, Simon, additional, Fazekas, Franz, additional, Felix, Sandra, additional, Fiebach, Jochen B., additional, Fiehler, Jens, additional, Filipov, Alexandra, additional, Filipski, Katharina, additional, Fleischmann, Robert, additional, Foerch, Christian, additional, Ford, Ian, additional, Gaenslen, Alexandra, additional, Galinovic, Ivana, additional, Gancedo, Elena Meseguer, additional, Ganeshan, Ramanan, additional, García Esperón, Carlos, additional, Garrido, Alicia, additional, Gattringer, Thomas, additional, Geraghty, Olivia, additional, Geran, Rohat, additional, Gerner, Stefan, additional, Godon-Hardy, Sylvie, additional, Göhler, Jos, additional, Golsari, Amir, additional, Gomis, Meritxell, additional, Gorriz, David, additional, Gramse, Verena, additional, Grau, Laia, additional, Griebe, Martin, additional, Guerrero, Cristina, additional, Guerzoglu, Damla, additional, Guettier, Sophie, additional, Guiraud, Vincent, additional, Gumbinger, Christoph, additional, Gunreben, Ignaz, additional, Haertig, Florian, additional, Hametner, Christian, additional, Hanseeuw, Bernard, additional, Hansen, Andreas, additional, Hansen, Jakob, additional, Harbo, Thomas, additional, Harloff, Andreas, additional, Harmel, Peter, additional, Häusler, Karl Georg, additional, Heinen, Florian, additional, Held, Valentin, additional, Hellwig, Simon, additional, Hemelsoet, Dimitri, additional, Hennerici, Michael, additional, Herm, Juliane, additional, Hermans, Sylvia, additional, Hernández, María, additional, Hervas Vicente, Jose, additional, Hjort, Niels, additional, Hobeanu, Cristina, additional, Hobohm, Carsten, additional, Höfner, Elmar, additional, Hohenbichler, Katharina, additional, Hommel, Marc, additional, Hoppe, Julia, additional, Hornberger, Eva, additional, Hoyer, Carolin, additional, Huang, Xuya, additional, Ipsen, Nils, additional, Isern, Irina, additional, Ispierto, Lourdes, additional, Iversen, Helle, additional, Jeppesen, Lise, additional, Jimenez, Marta, additional, Jungehülsing, Jan, additional, Jüttler, Eric, additional, Kalladka, Dheeraj, additional, Kallmünzer, Bernd, additional, Kar, Arindam, additional, Kellert, Lars, additional, Kemmling, André, additional, Kessler, Tobias, additional, Khan, Usman, additional, Klein, Matthias, additional, Kleinschnitz, Christoph, additional, Klockziem, Matti, additional, Knops, Michael, additional, Koehler, Luzie, additional, Koehrmann, Martin, additional, Kohlfürst, Heinz, additional, Kollmar, Rainer, additional, Kraft, Peter, additional, Krause, Thomas, additional, Kristensen, Bo, additional, Kröber, Jan M., additional, Kurka, Natalia, additional, Ladoux, Alexandre, additional, Laloux, Patrice, additional, Lamy, Catherine, additional, Landrault, Emmanuelle, additional, Lauer, Arne, additional, Lebely, Claire, additional, Leempoel, Jonathan, additional, Lees, Kennedy, additional, Leger, Anne, additional, Legrand, Laurence, additional, Li, Lin, additional, Löbbe, Anna-Mareike, additional, London, Frederic, additional, Lopez-cancio, Elena, additional, Lorenz, Matthias, additional, Louw, Stephen, additional, Lovelock, Caroline, additional, Lozano Sánchez, Manuel, additional, Lucente, Giuseppe, additional, Lückl, Janos, additional, Luna, Alain, additional, Macha, Kosmas, additional, Machet, Alexandre, additional, Mackenrodt, Daniel, additional, Madzar, Dominik, additional, Majoie, Charles, additional, Männer, Anika, additional, Maqueda, Vicky, additional, Marstrand, Jacob, additional, Martinez, Alicia, additional, Marzina, Annika, additional, Mechthouff, Laura, additional, Meden, Per, additional, Meersman, Guy, additional, Meier, Julia, additional, Mellerio, Charles, additional, Menn, Oliver, additional, Meyer, Nadja, additional, Michalski, Dominik, additional, Michels, Peter, additional, Michelsen, Lene, additional, Millán Torne, Monica, additional, Minnerup, Jens, additional, Modrau, Boris, additional, Moeller, Sebastian, additional, Møller, Anette, additional, Morel, Nathalie, additional, Moreton, Fiona, additional, Morin, Ludovic, additional, Moulin, Thierry, additional, Moynihan, Barry, additional, Mueller, Anne K., additional, Muir, Keith W., additional, Mulero, Patricia, additional, Mundiyanapurath, Sibu, additional, Mutzenbach, Johannes, additional, Nagel, Simon, additional, Naggara, Oliver, additional, Nallasivan, Arumugam, additional, Navalpotro, Irene, additional, Nave, Alexander H., additional, Nederkoorn, Paul, additional, Neeb, Lars, additional, Neugebauer, Hermann, additional, Neumann-Haefelin, Tobias, additional, Oberndorfer, Stefan, additional, Opherk, Christian, additional, Oppel, Lorenz, additional, Oppenheim, Catherine, additional, Orthgieß, Johannes, additional, Ostergaard, Leif, additional, Paindeville, Perrine, additional, Palomeras, Ernest, additional, Panitz, Verena, additional, Patel, Bhavni, additional, Peeters, Andre, additional, Peeters, Dirk, additional, Pellisé, Anna, additional, Pelz, Johann, additional, Pereira, Anthony, additional, Pérez de la Ossa, Natalia, additional, Perry, Richard, additional, Petraza, Salvador, additional, Peysson, Stéphane, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pierskalla, Alexandra, additional, Pledl, Hans-Werner, additional, Poli, Sven, additional, Pomrehn, Katrin, additional, Poulsen, Marika, additional, Prats, Luis, additional, Presas, Silvia, additional, Prohaska, Elisabeth, additional, Puetz, Volker, additional, Puig, Josep, additional, Puig Alcántara, Josep, additional, Purrucker, Jan, additional, Quenardelle, Veronique, additional, Ramachandran, Sankaranarayanan, additional, Raphaelle, Soulliard, additional, Raposo, Nicolas, additional, Reiff, Tilman, additional, Remmers, Michel, additional, Renou, Pauline, additional, Ribitsch, Martin, additional, Richter, Hardy, additional, Ritter, Martin, additional, Ritzenthaler, Thomas, additional, Rodier, Gilles, additional, Rodriguez-Regent, Christine, additional, Rodríguez-Yáñez, Manuel, additional, Roennefarth, Maria, additional, Roffe, Christine, additional, Rosenbaum, Sverre, additional, Rosso, Charlotte, additional, Röther, Joachim, additional, Rozanski, Michal, additional, Ruiz de Morales, Noelia, additional, Russo, Francesca, additional, Rutgers, Matthieu, additional, Sagnier, Sharmilla, additional, Samson, Yves, additional, Sánchez, Josep, additional, Sauer, Tamara, additional, Schäfer, Jan H., additional, Schieber, Simon, additional, Schill, Josef, additional, Schlak, Dennis, additional, Schlemm, Ludwig, additional, Schmidt, Sein, additional, Schonewille, Wouter, additional, Schröder, Julian, additional, Schulz, Andreas, additional, Schurig, Johannes, additional, Schwarting, Sönke, additional, Schwarz, Alexander, additional, Schwarzbach, Christopher, additional, Seidel, Matthias, additional, Seiler, Alexander, additional, Sembill, Jochen, additional, Serena Leal, Joaquin, additional, Shetty, Ashit, additional, Sibon, Igor, additional, Simonsen, Claus Z., additional, Singer, Oliver, additional, Sivagnanaratham, Aravinth, additional, Smets, Ide, additional, Smith, Craig, additional, Soors, Peter, additional, Sprigg, Nikola, additional, Spruegel, Maximilian, additional, Stark, David, additional, Steinert, Susanne, additional, Stösser, Sebastian, additional, Stuermlinger, Markus, additional, Swinnen, Bart, additional, Tamazyan, Ruben, additional, Tembl, Jose, additional, Terceno Izaga, Mikel, additional, Thomalla, Götz, additional, Touze, Emmanuel, additional, Truelsen, Thomas, additional, Turc, Guillaume, additional, Turine, Gaetane, additional, Tütüncü, Serdar, additional, Tyrell, Pippa, additional, Ustrell, Xavier, additional, Vadot, Wilfried, additional, Vallet, Anne-Evelyne, additional, Vallet, Pauline, additional, van den Berg, Lucie, additional, van den Berg, Sophie, additional, van Eendenburg, Cecile, additional, Van Hooff, Robbert-Jan, additional, van Sloten, Isabelle, additional, Vanacker, Peter, additional, Vancaester, Evelien, additional, Vanderdonckt, Patrick, additional, Vandermeeren, Yves, additional, Vanhee, Frederik, additional, Veltkamp, Roland, additional, Vestergaard, Karsten, additional, Viguier, Alain, additional, Vilas, Dolores, additional, Villringer, Kersten, additional, Voget, Dieke, additional, von Schrader, Jörg, additional, von Weitzel, Paul, additional, Warburton, Elisabeth, additional, Weber, Claudia, additional, Weber, Jörg, additional, Wegscheider, Karl, additional, Wegscheider, Mirko, additional, Weimar, Christian, additional, Weinstich, Karin, additional, Weise, Christopher, additional, Weise, Gesa, additional, Willems, Chris, additional, Winder, Klemens, additional, Wittayer, Matthias, additional, Wolf, Marc, additional, Wolf, Martin, additional, Wolff, Valerie, additional, Wollboldt, Christian, additional, Wollenweber, Frank, additional, Wouters, Anke, additional, Yalo, Bertrand, additional, Yger, Marion, additional, Younan, Nadia, additional, Yperzeele, Laetita, additional, Zegarac, Vesna, additional, Zeiner, Pia, additional, Ziemann, Ulf, additional, Zonneveld, Thomas, additional, Zuber, Mathieu, additional, Akutsu, Tsugio, additional, Aoki, Junya, additional, Arakawa, Shuji, additional, Doijiri, Ryosuke, additional, Egashira, Yusuke, additional, Enomoto, Yukiko, additional, Furui, Eisuke, additional, Furuta, Konosuke, additional, Gotoh, Seiji, additional, Hamasaki, Toshimitsu, additional, Hasegawa, Yasuhiro, additional, Hirano, Teryuki, additional, Homma, Kazunari, additional, Ichijyo, Masahiko, additional, Ide, Toshihiro, additional, Igarashi, Shuichi, additional, Iguchi, Yasuyuki, additional, Ihara, Masafumi, additional, Ikenouchi, Hajime, additional, Inoue, Tsuyoshi, additional, Itabashi, Ryo, additional, Ito, Yasuhiro, additional, Iwama, Toru, additional, Kamiyama, Kenji, additional, Kamiyoshi, Shoko, additional, Kanai, Haruka, additional, Kanematsu, Yasuhisa, additional, Kanzawa, Takao, additional, Kimura, Kazumi, additional, Kitayama, Jiro, additional, Kitazono, Takanari, additional, Kondo, Rei, additional, Kudo, Kohsuke, additional, Kusumi, Masayoshi, additional, Kuwahara, Ken, additional, Matsumoto, Shoji, additional, Matsuoka, Hideki, additional, Mihara, Ban, additional, Minematsu, Kazuo, additional, Miura, Ken, additional, Morita, Naomi, additional, Mouri, Wataru, additional, Murata, Kayo, additional, Nagakane, Yoshinari, additional, Nakase, Taizen, additional, Ohara, Hiromi, additional, Ohara, Nobuyuki, additional, Ohnishi, Hideyuki, additional, Ohta, Hajime, additional, Ohtaki, Masafumi, additional, Ohtani, Ryo, additional, Ohtsuki, Toshiho, additional, Ohyama, Hideo, additional, Okada, Takashi, additional, Okada, Yasushi, additional, Osaki, Masato, additional, Sakai, Nobuyuki, additional, Sanbongi, Yoshiki, additional, Sasaki, Naoshi, additional, Sasaki, Makoto, additional, Sato, Shoichiro, additional, Seki, Kenta, additional, Shimizu, Wataru, additional, Shiokawa, Yoshiaki, additional, Sozu, Takashi, additional, Suzuki, Junichiro, additional, Suzuki, Rieko, additional, Takagi, Yasushi, additional, Takizawa, Shunya, additional, Tanahashi, Norio, additional, Tanaka, Eijiro, additional, Tanaka, Ryota, additional, Tateishi, Yohei, additional, Terada, Tomoaki, additional, Terasaki, Tadashi, additional, Todo, Kenichi, additional, Tokunaga, Azusa, additional, Tsujino, Akira, additional, Ueda, Toshihiro, additional, Uesaka, Yoshikazu, additional, Uotani, Mihoko, additional, Urabe, Takao, additional, Watanabe, Masao, additional, Yagita, Yoshiki, additional, Yakushiji, Yusuke, additional, Yasui, Keizo, additional, Yonehara, Toshiro, additional, Yoshimura, Shinichi, additional, Aarnio, K., additional, Alemseged, F., additional, Anderson, C., additional, Ang, T., additional, Archer, M.L., additional, Attia, J., additional, Bailey, P., additional, Balabanski, A., additional, Barber, A., additional, Barber, P.A., additional, Bernhardt, J., additional, Bivard, A., additional, Blacker, D., additional, Bladin, C.F., additional, Brodtmann, A., additional, Cadilhac, D., additional, Campbell, B.C.V., additional, Carey, L., additional, Celestino, S., additional, Chan, L., additional, Chang, W.H., additional, ChangI, A., additional, Chen, C.H., additional, Chen, C.-I., additional, Chen, H.F., additional, Chen, T.C., additional, Chen, W.H., additional, Chen, Y.Y., additional, Cheng, C.A., additional, Cheong, E., additional, Chiou, Y.W., additional, Choi, P.M., additional, Chu, H.J., additional, Chuang, C.S., additional, Chung, T.C., additional, Churilov, L., additional, Clissold, B., additional, Connelly, A., additional, Coote, S., additional, Coulton, B., additional, Cowley, E., additional, Cranefield, J., additional, Curtze, S., additional, D'Este, C., additional, Davis, S.M., additional, Day, S., additional, Desmond, P.M., additional, Dewey, H.M., additional, Ding, C., additional, Donnan, G.A., additional, Drew, R., additional, Eirola, S., additional, Field, D., additional, Frost, T., additional, Garcia-Esperon, C., additional, George, K., additional, Gerraty, R., additional, Grimley, R., additional, Guo, Y.C., additional, Hankey, G., additional, Harvey, J., additional, Ho, S.C., additional, Hogan, K., additional, Howells, D., additional, Hsiao, P.M., additional, Hsu, C.H., additional, Hsu, C.T., additional, Hsu, C.-S., additional, Hsu, J.P., additional, Hsu, Y.D., additional, Hsu, Y.T., additional, Hu, C.J., additional, Huang, C.C., additional, Huang, H.Y., additional, Huang, M.Y., additional, Huang, S.C., additional, Huang, W.S., additional, Jackson, D., additional, Jeng, J.S., additional, Jiang, S.K., additional, Kaauwai, L., additional, Kasari, O., additional, King, J., additional, Kleinig, T.J., additional, Koivu, M., additional, Kolbe, J., additional, Krause, M., additional, Kuan, C.W., additional, Kung, W.L., additional, Kyndt, C., additional, Lau, C.L., additional, Lee, A., additional, Lee, C.Y., additional, Lee, J.T., additional, Lee, Y., additional, Lee, Y.C., additional, Levi, C., additional, Levi, C.R., additional, Lien, L.M., additional, Lim, J.C., additional, Lin, C.C., additional, Lin, C.H., additional, Lin, C.M., additional, Lin, D., additional, Liu, C.H., additional, Liu, J., additional, Lo, Y.C., additional, Loh, P.S., additional, Low, E., additional, Lu, C.H., additional, Lu, C.J., additional, Lu, M.K., additional, Ly, J., additional, Ma, H., additional, Macaulay, L., additional, Macdonnell, R., additional, Mackey, E., additional, Macleod, M., additional, Mahadevan, J., additional, Maxwell, V., additional, McCoy, R., additional, McDonald, A., additional, McModie, S., additional, Meretoja, A., additional, Mishra, S., additional, Mitchell, P.J., additional, Miteff, F., additional, Moore, A., additional, Muller, C., additional, Ng, F., additional, Ng, F.C., additional, Ng, J-L., additional, O'Brian, W., additional, O'Collins, V., additional, Oxley, T.J., additional, Parsons, M.W., additional, Patel, S., additional, Peng, G.S., additional, Pesavento, L., additional, Phan, T., additional, Rodrigues, E., additional, Ross, Z., additional, Sabet, A., additional, Sallaberger, M., additional, Salvaris, P., additional, Shah, D., additional, Sharma, G., additional, Sibolt, G., additional, Simpson, M., additional, Singhal, S., additional, Snow, B., additional, Spratt, N., additional, Stark, R., additional, Sturm, J., additional, Sun, M.C., additional, Sun, Y., additional, Sung, P.S., additional, Sung, Y.F., additional, Suzuki, M., additional, Tan, M., additional, Tang, S.C., additional, Tatlisumak, T., additional, Thijs, V., additional, Tiainen, M., additional, Tsai, C.H., additional, Tsai, C.K., additional, Tsai, C.L., additional, Tsai, H.T., additional, Tsai, L.K., additional, Tseng, C.H., additional, Tseng, L.T., additional, Tsoleridis, J., additional, Tu, H., additional, Tu, H.T-H., additional, Vallat, W., additional, Virta, J., additional, Wang, W.C., additional, Wang, Y.T., additional, Waters, M., additional, Weir, L., additional, Wijeratne, T., additional, Williams, C., additional, Wilson, W., additional, Wong, A.A., additional, Wong, K., additional, Wu, T.Y., additional, Wu, Y.H., additional, Yan, B., additional, Yang, F.C., additional, Yang, Y.W., additional, Yassi, N., additional, Yeh, H.L., additional, Yeh, J.H., additional, Yeh, S.J., additional, Yen, C.H., additional, Young, D., additional, Ysai, C.L., additional, Zhang, W.W., additional, Zhao, H., additional, Zhao, L., additional, Althaus-Knaurer, Katharina, additional, Berrouschot, Jörg, additional, Bluhmki, Erich, additional, Bovi, Paolo, additional, Chatellier, Gilles, additional, Cove, Lynda, additional, Davis, Stephen, additional, Dixit, A., additional, Donnan, Geoffrey, additional, Ehrenkrona, Christina, additional, Eschenfelder, Christoph, additional, Fatar, Marc, additional, Francisco Arenillas, Juan, additional, Gruber, Franz, additional, Kala, Lalit, additional, Kapeller, Peter, additional, Kaste, Markku, additional, Kessler, Christof, additional, Köhrmann, Martin, additional, Laage, Rico, additional, Lees, Kennedy R., additional, Luna Rodriguez, Alain, additional, Mas, Jean-Louis, additional, Mikulik, Robert, additional, Molina, Carlos, additional, Muddegowda, Girish, additional, Muir, Keith, additional, Niederkorn, Kurt, additional, Nuñez, Xavier, additional, Schellinger, Peter, additional, Serena, Joaquin, additional, Sobesky, Jan, additional, Steiner, Thorsten, additional, Svenson, Ann-Sofie, additional, von Kummer, Rüdiger, additional, Wardlaw, Joanna, additional, Betensky, Rebecca A., additional, Boulouis, Gregoire, additional, Carandang, Raphael A., additional, Copen, William A., additional, Cougo, Pedro, additional, Cutting, Shawna, additional, Drake, Kendra, additional, Ford, Andria L., additional, Hallenbeck, John, additional, Harris, Gordon J., additional, Hoesch, Robert, additional, Hsia, Amie, additional, Kase, Carlos, additional, Latour, Lawrence, additional, Lev, Michael H., additional, Muzikansky, Alona, additional, Nagaraja, Nandakumar, additional, Schwamm, Lee H., additional, Searls, Eric, additional, Song, Shlee S., additional, Starkman, Sidney, additional, Yoo, Albert J., additional, and Zand, Ramin, additional

Published
2020
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35. A Genome-Wide Meta-Analysis

Author

Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)

Subjects
Allele, Genome-wide association study, Ischemic stroke, Genetic loci, cardiovascular diseases, Genetic variant
Abstract

[Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome., [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date., [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9)., [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci., Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.

Published
2019

36. A Genome-Wide Meta-Analysis

Author

Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)

Subjects
genetic variant, genome-wide association study, Tight Junction Proteins, allele, Stroke Rehabilitation, genetic loci, Recovery of Function, Polymorphism, Single Nucleotide, Brain Ischemia, Stroke, Disability Evaluation, Phenotype, Treatment Outcome, Gene Frequency, Risk Factors, ischemic stroke, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract

[Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9). [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci. Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.

Published
2018

37. Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia.

Author

Ramos-Pachón, Anna, García-Tornel, Álvaro, Millán, Mònica, Ribó, Marc, Amaro, Sergi, Cardona, Pere, Martí-Fàbregas, Joan, Roquer, Jaume, Silva, Yolanda, Ustrell, Xavier, Purroy, Francisco, Gómez-Choco, Manuel, Zaragoza-Brunet, José, Cánovas, David, Krupinski, Jurek, Sala, Natalia Mas, Palomeras, Ernest, Cocho, Dolores, Redondo, Laura, and Repullo, Carmen

Subjects
COVID-19 pandemic, STROKE, COVID-19, TREATMENT effectiveness, STROKE units, MEDICAL care standards, FUNCTIONAL assessment
Abstract

Introduction: The COVID-19 pandemic resulted in significant healthcare reorganizations, potentially striking standard medical care. We investigated the impact of the COVID-19 pandemic on acute stroke care quality and clinical outcomes to detect healthcare system's bottlenecks from a territorial point of view. Methods: Crossed-data analysis between a prospective nation-based mandatory registry of acute stroke, Emergency Medical System (EMS) records, and daily incidence of COVID-19 in Catalonia (Spain). We included all stroke code activations during the pandemic (March 15–May 2, 2020) and an immediate prepandemic period (January 26–March 14, 2020). Primary outcomes were stroke code activations and reperfusion therapies in both periods. Secondary outcomes included clinical characteristics, workflow metrics, differences across types of stroke centers, correlation analysis between weekly EMS alerts, COVID-19 cases, and workflow metrics, and impact on mortality and clinical outcome at 90 days. Results: Stroke code activations decreased by 22% and reperfusion therapies dropped by 29% during the pandemic period, with no differences in age, stroke severity, or large vessel occlusion. Calls to EMS were handled 42 min later, and time from onset to hospital arrival increased by 53 min, with significant correlations between weekly COVID-19 cases and more EMS calls (rho = 0.81), less stroke code activations (rho = −0.37), and longer prehospital delays (rho = 0.25). Telestroke centers were afflicted with higher reductions in stroke code activations, reperfusion treatments, referrals to endovascular centers, and increased delays to thrombolytics. The independent odds of death increased (OR 1.6 [1.05–2.4], p 0.03) and good functional outcome decreased (mRS ≤2 at 90 days: OR 0.6 [0.4–0.9], p 0.015) during the pandemic period. Conclusion: During the COVID-19 pandemic, Catalonia's stroke system's weakest points were the delay to EMS alert and a decline of stroke code activations, reperfusion treatments, and interhospital transfers, mostly at local centers. Patients suffering an acute stroke during the pandemic period had higher odds of poor functional outcome and death. The complete stroke care system's analysis is crucial to allocate resources appropriately. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Neurophysiological and Biomechanical Evaluation of the Mechanisms Which Impair Safety of Swallow in Chronic Post-stroke Patients

Author

Cabib, Christopher, primary, Nascimento, Weslania, additional, Rofes, Laia, additional, Arreola, Viridiana, additional, Tomsen, Noemí, additional, Mundet, Lluis, additional, Muriana, Desiree, additional, Palomeras, Ernest, additional, Michou, Emilia, additional, Clavé, Pere, additional, and Ortega, Omar, additional

Published
2019
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40. Age- and Sex-Specific Risk Profiles and In-Hospital Mortality in 13,932 Spanish Stroke Patients

Author

Purroy, Francisco, primary, Vena, Ana, additional, Forné, Carles, additional, de Arce, Ana María, additional, Dávalos, Antonio, additional, Fuentes, Blanca, additional, Arenillas, Juan Francisco, additional, Krupinski, Jerzy, additional, Gómez-Choco, Manuel, additional, Palomeras, Ernest, additional, Martí-Fábregas, Joan, additional, Castillo, José, additional, Ustrell, Xavier, additional, Tejada, Javier, additional, Masjuan, Jaime, additional, Garcés, Moisés, additional, Benabdelhak, Ikram, additional, and Serena, Joaquin, additional

Published
2019
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41. Statins do not increase Markers of Cerebral Angiopathies in patients with Cardioembolic Stroke

Author

Martí-Fàbregas, Joan, primary, Medrano-Martorell, Santiago, additional, Merino, Elisa, additional, Prats-Sánchez, Luis, additional, Marín, Rebeca, additional, Delgado-Mederos, Raquel, additional, Camps-Renom, Pol, additional, Martínez-Domeño, Alejandro, additional, Gómez-Choco, Manuel, additional, Lara, Lidia, additional, Casado-Naranjo, Ignacio, additional, Cánovas, David, additional, Torres, Maria José, additional, Freijo, Marimar, additional, Calleja, Ana, additional, Bravo, Yolanda, additional, Cocho, Dolores, additional, Rodríguez-Campello, Ana, additional, Zandio, Beatriz, additional, Fuentes, Blanca, additional, de Felipe, Alicia, additional, Llull, Laura, additional, Maestre, José, additional, Hernández, María, additional, Garcés, Moisès, additional, De Arce-Borda, Ana Maria, additional, Palomeras, Ernest, additional, Rodríguez-Yáñez, Manuel, additional, Díaz-Maroto, Inma, additional, Serrano, Marta, additional, Fernández-Domínguez, Jéssica, additional, Sanahuja, Jordi, additional, Purroy, Francisco, additional, Zedde, Marialuisa, additional, Delgado-Mengual, Jordi, additional, and Gich, Ignasi, additional

Published
2018
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42. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

Author

Fernandez-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafría, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado Martínez, María Pilar, Ribo, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Mari Mar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez Sabín, José, Molina, Carlos A., Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Pérez de la Ossa, Natalia, Martinez Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Cánovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Dávalos, Antoni, Roquer González, Jaume, Arenillas, Juan F., Martí Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, Montaner, Joan, GRECOSstudy group, and Universitat Autònoma de Barcelona

Subjects
0301 basic medicine, Male, Risk, Candidate gene, recurrence, Genotype, Polymorphism, Single Nucleotide, Article, Brain Ischemia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Recurrence, Genetics, Medicine, risk factors, Humans, Genetic variability, Genotyping, Stroke, Aged, Advanced and Specialized Nursing, business.industry, Proportional hazards model, Stroke recurrence, Hazard ratio, medicine.disease, Prognosis, stroke, 030104 developmental biology, Scotland, Cardiovascular Diseases, Ischemic Attack, Transient, Spain, Cohort, North America, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Altres ajuts: This study was funded by Marato TV3, by the Spanish stroke research network (INVICTUS-PLUS) and by Generacion project (PI15/01978) Instituto de Salud Carlos III. Dr Fernández-Cadenas is supported by the Miguel Servet program (CP12/03298), Instituto de Salud Carlos III. Several groups participate in the International Stroke Genetics Consortium and the Spanish Stroke Genetics Consortium. The Hospital del Mar is supported by Spain's Ministry of Health (III FEDER, RD12/0042/0020). Study recruitment and collection of data sets for the VISP trial were supported by a grant (R01 NS34447; PI James Toole) from the National Institute of Neurological Disorders and Stroke (NINDS). Genome-wide association studies genotyping (U01 HG004438l; PI David Valle), funded by the National Human Genome Research Institute and the Genomics and Randomized Trials (GARNET) Network (U01HG00516-03; co-PI Michèle M. Sale and Bradford B. Worrall), and genetic data cleaning was provided by the GARNET Coordinating Center (U01HG005157; PI Bruce S. Weir) Background and Purpose-Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. Methods-We analyzed 256 polymorphisms from 115 candidate genes in three patient cohorts comprising 4,482 IS or TIA patients. The discovery cohort was prospectively recruited and included 1,494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2,988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score), and generated risk groups using a classification tree method. Results-The analyses revealed that rs1800801 in the MGP gene (HR: 1.33, p= 9×10−03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305), however it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (p=3.2×10−09) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared to previous SPI-II score (p=0.03). Conclusions-The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.

Published
2016

44. Abstract 153: Prior Statin Therapy is Not Associated With Cerebral Bleeding-prone Angiopathies in Patients With Ischemic Stroke Who Start Long-term Oral Anticoagulation

Author

Martí-Fàbregas, Joan, primary, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Marín, Rebeca, additional, Delgado-Mederos, Raquel, additional, Martínez-Domeño, Alejandro, additional, Medrano, Santiago, additional, Merino, Elisa, additional, González de Echavarri, José María, additional, Rodriguez-Campello, Ana, additional, Cocho, Dolores, additional, Casado-Naranjo, Ignacio, additional, Fuentes, Blanca, additional, Gómez-Choco, Manuel, additional, Freijo, Mari Mar, additional, De Felipe, Alicia, additional, Canovas, David, additional, Bravo, Yolanda, additional, Lara, Lidia, additional, Calleja, Ana, additional, Sanahuja, Jordi, additional, Llull, Laura, additional, Hernández, María, additional, Zandio, Beatriz, additional, Lago, Aida, additional, Zedde, Marialuisa, additional, Boix, Amelia, additional, Reverté, Silvia, additional, De Arce-Bordas, Ana María, additional, and Palomeras, Ernest, additional

Published
2017
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45. Abstract WP251: Telestroke 2.0 in Catalonia: More Patients Treated and Secondary Transfers Reduced

Author

Gomis, Meritxell, primary, López-Cancio, Elena, additional, Perez de la Ossa, Natalia, additional, Cardona, Pere, additional, Ribó, Marc, additional, Serena, Joaquin, additional, Purroy, Francisco, additional, Garcés, Moisés, additional, López, Mercè, additional, Soteras, Iñigo, additional, Aragonés, Josep Maria, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Villagrasa, David, additional, Puiggrós, Elsa, additional, Catena, Ester, additional, Sanjurjo, Eduard, additional, López Claverol, Núria, additional, Carrión, Dolors, additional, Abilleira, Sònia, additional, and Dávalos, Antoni, additional

Published
2017
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46. Neurorehabilitation strategies for poststroke oropharyngeal dysphagia: from compensation to the recovery of swallowing function

Author

Cabib, Christopher, primary, Ortega, Omar, additional, Kumru, Hatice, additional, Palomeras, Ernest, additional, Vilardell, Natalia, additional, Alvarez-Berdugo, Daniel, additional, Muriana, Desirée, additional, Rofes, Laia, additional, Terré, Rosa, additional, Mearin, Fermín, additional, and Clavé, Pere, additional

Published
2016
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47. Abstract TP19: Charlson Comorbidity Index Predicts Mortality and Functional Outcome in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy

Author

Samaniego, Daniela, primary, Hernandez-Perez, Maria, additional, Planas, Anna, additional, Martin, Lorena, additional, Dorado, Laura, additional, Lopez-Cancio, Elena, additional, Gomis, Meritxell, additional, Perez de la Ossa, Natalia, additional, Palomeras, Ernest, additional, Castaño, Carlos, additional, and Davalos, Antoni, additional

Published
2016
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48. Telestroke in Catalonia: Increasing Thrombolysis Rate and Avoiding Interhospital Transfers.

Author

López-Cancio, Elena, Ribó, Marc, Cardona, Pere, Serena, Joaquín, Purroy, Francisco, Palomeras, Ernest, Aragonès, Josep Maria, Cocho, Dolores, Garcés, Moisés, Puiggròs, Elsa, Soteras, Iñigo, Cabanelas, Ana, Villagrasa, David, Catena, Ester, Sanjurjo, Eduard, López Claverol, Nuria, Carrión, Dolors, López, Mercè, Abilleira, Sònia, and Dávalos, Antoni

Subjects
STROKE treatment, THROMBOLYTIC therapy, TELEMEDICINE
Abstract

Objectives: The study aimed to evaluate the impact of a telestroke network on acute stroke care in Catalonia, by measuring thrombolysis rates, access to endovascular treatment, and clinical outcome of telestroke patients in a population-based study. Methods: Telestroke network was implemented on March 2013 and consists of 12 community hospitals and 1 expert stroke neurologist 24 h/7 day, covering a population of 1.3 million inhabitants. Rest of the population (6.2 million) of Catalonia is covered by 8 primary stroke centers (PSC) and 6 comprehensive stroke centers (CSC). After a 2-way videoconference and visualization of neuroimaging on a web platform, the stroke neurologist decides the therapeutic approach and/or to transfer the patient to another facility, entering these data in a mandatory registry. Simultaneously, all patients treated with reperfusion therapies in all centers of Catalonia are prospectively recorded in a mandatory and audited registry. Results: From March 2013 to December 2015, 1,206 patients were assessed by telestroke videoconference, of whom 322 received intravenous thrombolysis (IVT; 33.8% of ischemic strokes). Baseline and 24 h NIHSS, rate of symptomatic hemorrhage, mortality, and good outcome at 3 months were similar compared to those who received IVT in PSC or CSC (2,897 patients in the same period). The door-to-needle time was longer in patients treated through telestroke, but was progressively reduced from 2013 to 2015. Percentage of patients receiving thrombectomy after IVT was similar in patients treated through telestroke circuit, compared to those treated in PSC or CSC (conventional circuit). Population rates of IVT*100,000 inhabitants in Catalonia increased from 2011 to 2015, especially in areas affected by the implementation of telestroke network, achieving rates as high as 16 per 100,000 inhabitants. Transfers to another facility were avoided after telestroke consultation in 46.8% of ischemic, 76.5% of transient ischemic attacks, and 23.5% of hemorrhages. Conclusions: Telestroke favors safe and effective thrombolysis, helps to increase the population rate of IVT, and avoids a large number of interhospital transfers. [ABSTRACT FROM AUTHOR]

Published
2018
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49. Prehospital care process and hospital outcomes in stroke-code cases: comparison of basic and advance life support ambulance attendance.

Author

Solà Muñoz S, Escudero Campillo MDM, Soro Borrega C, Azeli Y, Querol Gil S, Ruiz A, Albacete G, Moreno Peral O, Lluch S, Amaro Delgado S, Silva Blas Y, Urra X, Cocho Calderón D, Martí Fàbregas J, Ribó Jacobi M, Cardona Portela P, Purroy García F, Duarte Oller E, Hidalgo Benítez V, Flores A, Rubiera M, Palomeras E, García-Tornel Á, Suñer Soler R, Vilar Roquet D, Salvat-Plana M, Ramos Pachón A, Pérez de la Ossa Herrero N, and Jiménez Fàbrega X

Subjects
Humans, Prospective Studies, Ambulances, Hospitals, Emergency Medical Services, Stroke diagnosis, Ischemic Stroke
Abstract

Objectives: To study prehospital care process in relation to hospital outcomes in stroke-code cases first attended by 2 different levels of ambulance. To analyze factors associated with a satisfactory functional outcome at 3 months., Material and Methods: Prospective multicenter observational cohort study. All stroke-code cases attended by prehospital emergency services from January 2016 to April 2022 were included. Prehospital and hospital variables were collected. The classificatory variable was type of ambulance attending (basic vs advanced life support). The main outcome variables were mortality and functional status after ischemic strokes in patients who underwent reperfusion treatment 90 days after the ischemic episode., Results: Out of 22 968 stroke-code activations, ischemic stroke was diagnosed in 12 467 patients (54.3%) whose functional status was good before the episode. Basic ambulances attended 93.1%; an advanced ambulance was ordered in 1.6% of the patients. Even though there were differences in patient and clinical characteristics recorded during the prehospital process, type of ambulance was not independently associated with mortality (adjusted odds ratio [aOR], 1.1; 95% CI, 0.77-1.59) or functional status at 3 months (aOR, 1.05; 95% CI, 0,72-1,47)., Conclusion: The percentage of patient complications in stroke-code cases attended by basic ambulance teams is low. Type of ambulance responding was not associated with either mortality or functional outcome at 3 months in this study.

Published
2023
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50. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population-Based Registry.

Author

Rudilosso S, Ríos J, Rodríguez A, Gomis M, Vera V, Gómez-Choco M, Renú A, Matos N, Llull L, Purroy F, Amaro S, Terceño M, Obach V, Serena J, Martí-Fàbregas J, Cardona P, Molina C, Rodríguez-Campello A, Cánovas D, Krupinski J, Ustrell X, Torres F, Román LS, Salvat-Plana M, Jiménez-Fàbrega FX, Palomeras E, Catena E, Colom C, Cocho D, Baiges J, Aragones JM, Diaz G, Costa X, Almendros MC, Rybyeba M, Barceló M, Carrión D, Lòpez MN, Sanjurjo E, de la Ossa NP, Urra X, and Chamorro Á

Abstract

Background and Purpose:  In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors., Methods:  Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups' criteria)., Results:  Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3)., Conclusions:  Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.

Published
2021
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