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Your search keyword '"PRIVITERA, MICHAEL D."' showing total 13 results
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13 results on '"PRIVITERA, MICHAEL D."'

8. Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy

Author

Buono, Russell J., primary, Bradfield, Jonathan P., additional, Wei, Zhi, additional, Sperling, Michael R., additional, Dlugos, Dennis J., additional, Privitera, Michael D., additional, French, Jacqueline A., additional, Lo, Warren, additional, Cossette, Patrick, additional, Schachter, Steven C., additional, Basehore, Heather, additional, Lohoff, Falk W., additional, Grant, Struan F. A., additional, Ferraro, Thomas N., additional, and Hakonarson, Hakon, additional

Published
2021
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9. Genetic variation in PADI6-PADI4 on 1p36.13 is associated with common forms of human generalized epilepsy

Author

Buono, Russell J., Bradfield, Jonathan P., Wei, Zhi, Sperling, Michael R., Dlugos, Dennis J., Privitera, Michael D., French, Jacqueline A., Lo, Warren, Cossette, Patrick, Schachter, Steven C., Basehore, Heather, Lohoff, Falk W., Grant, Struan F.A., Ferraro, Thomas N., Hakonarson, Hakon, Buono, Russell J., Bradfield, Jonathan P., Wei, Zhi, Sperling, Michael R., Dlugos, Dennis J., Privitera, Michael D., French, Jacqueline A., Lo, Warren, Cossette, Patrick, Schachter, Steven C., Basehore, Heather, Lohoff, Falk W., Grant, Struan F.A., Ferraro, Thomas N., and Hakonarson, Hakon

Abstract

We performed a genome-wide association study (GWAS) to identify genetic variation associated with common forms of idiopathic generalized epilepsy (GE) and focal epilepsy (FE). Using a cohort of 2220 patients and 14,448 controls, we searched for single nucleotide polymorphisms (SNPs) associated with GE, FE and both forms combined. We did not find any SNPs that reached genome-wide statistical significance (p ≤ 5 × 10−8) when comparing all cases to all controls, and few SNPs of interest comparing FE cases to controls. However, we document multiple linked SNPs in the PADI6-PADI4 genes that reach genome-wide significance and are associated with disease when comparing GE cases alone to controls. PADI genes encode enzymes that deiminate arginine to citrulline in molecular pathways related to epigenetic regulation of histones and autoantibody formation. Although epilepsy genetics and treatment are focused strongly on ion channel and neurotransmitter mechanisms, these results suggest that epigenetic control of gene expression and the formation of autoantibodies may also play roles in epileptogenesis.

Published
2021

10. Reply to

Author

Alsherbini, Khalid A., primary, Metter, E. Jeffrey, additional, Foreman, Brandon P., additional, and Privitera, Michael D., additional

Published
2019
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11. Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy

Author

Berg, Michel, primary, Welty, Timothy E., additional, Gidal, Barry E., additional, Diaz, Francisco J., additional, Krebill, Ron, additional, Szaflarski, Jerzy P., additional, Dworetzky, Barbara A., additional, Pollard, John R., additional, Elder, Edmund J., additional, Jiang, Wenlei, additional, Jiang, Xiaohui, additional, Switzer, Regina D., additional, and Privitera, Michael D., additional

Published
2017
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13. Commentary-Study Reaffirms FDA Findings.

Author

Krauss, Gregory L. and Privitera, Michael D.

Subjects
*GENERIC drug substitution, *MEDICATION safety
Abstract

The article offers insights on the study related to safety of switching to generic drugs that reaffirms the findings of U.S. Food and Drug Administration (FDA), adapted from the article "More data on the safety of generic substitution: yes, the blue tablet is OK?" by G. L. Krauss and M. Privitera.

Published
2016

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