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Background. Increasing evidence highlights potential associations between varus thrust and health domains associated with knee osteoarthritis (OA). Objective. The aim of this study was to investigate the association between varus thrust and 2 subcategories--'pain and stiffness' and 'activities of daily living (ADI.)'--of the Japanese Knee Osteoarthritis Measure (JKOM). Design. This was a cross-sectional study. Methods. In total, 296 outpatients with knee OA visiting orthopedic clinics were enrolled. The inclusion criteria were age [greater than or equal to]50 years, medial knee OA and Kellgren-Lawrence (K/L) grade [greater than or equal to] 1 in one or both knees, and the ability to walk independently. Standard posterior-anterior knee radiographs were measured for vims alignment. Participants were video recorded while walking and were evaluated for the presence or absence of varus thrust. Pain and stiffness of the knee joint and ADL were evaluated using the JKOM. Multivariate regressions (outcomes: pain and stiffness and ADL; predictor variable: varus thrust) were performed. Results. Varus thrust was present in 46 (16.2%) of 284 patients. Multivariate regression analyses demonstrated that varus thrust is independently associated with pain and stiffness, adjusted for age, sex, body mass index, K/L grade, and varus alignment ([beta] = 17, P =.005). However, the association between varus thrust and ADL was not significant ([beta]=.11, P =.058). Based on sensitivity analyses, including participants of K/I. grade 1 had little influence on this analysis. Limitations. Only 16.2% of participants had a varus thrust. Moreover, a cause-effect relationship between varus thrust and pain and stiffness remains unknown due to the crosssectional design of this study. Conclusions. Varus thrust was associated with pain and stiffness in patients with medial knee OA. However, the association between varus thrust and ADL did not reach significance., Knee osteoarthritis (OA) is the most common joint disease and an important cause of pain and disability among older adults. (1,2) In a 2009 study by Yoshimura et al, (3) [...]