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14 results on '"Onieva, Juan Luis"'

3. Contributors

Author

Abi Khalil, Charbel, primary, Akins, Robert E., additional, Alenghat, T., additional, Allen, Emily G, additional, Altorok, N., additional, Altucci, Lucia, additional, Balcerczyk, Aneta, additional, Barragán, Isabel, additional, Biesiekierska, Marta, additional, Biradar, Vinayak S., additional, Blossom, Sarah J., additional, Chaves, Patricia, additional, Chen, D., additional, Chen, Hong, additional, Chen, Shijia Alexia, additional, Cheng, Baoli, additional, Chun, P., additional, Ciesielski, Oskar, additional, Colon-Diaz, Maricarmen, additional, Cox, O.H., additional, Cozma, Angela, additional, Cui, Xiaolong, additional, Dekker, F.J., additional, Dell’Aversana, Carmela, additional, Demirdizen, Engin, additional, Deng, Jiali, additional, Deobagkar, Deepti D., additional, Dvir-Ginzberg, Mona, additional, Ehnes, Devon, additional, Eissenberg, J.C., additional, Elosegui, Perla M., additional, Fodor, Adriana, additional, Ganesan, A., additional, Giorgio, Cristina, additional, Guo, Mengying, additional, Hall, J.G., additional, Hashimoto-Hill, S., additional, Imam, Mustapha Umar, additional, Ismail, Maznah, additional, Jaramillo, Alexander J., additional, Jennings, M.P., additional, Jin, Peng, additional, Johnson, A.C., additional, Kahaleh, B., additional, Kelly, D.R., additional, Koliada, Alexander, additional, Kolliputi, Narasaiah, additional, Kumar, Ashok, additional, Lee, R.S., additional, Levenson, Anait S., additional, Levy, Shiri, additional, Ligon, C.O., additional, Liguori, Maria, additional, Liu, Ji, additional, Louwies, T., additional, Lu, Qianjin, additional, Luo, Shuaihantian, additional, Lushchak, Oleh, additional, Meerveld, B. Greenwood-Van, additional, Miller, Rachel L., additional, Nagaraja, V., additional, Navada, Shyamala C., additional, Nuzziello, Nicoletta, additional, Oh, Jessica, additional, Oltra, Elisa, additional, Onieva, Juan Luis, additional, Ooi, Der Jiun, additional, Pirola, Luciano, additional, Proschinger, S., additional, Rajpathak, Shriram N., additional, Robinson, Karyn G., additional, Roman, Gabriela, additional, Ruohola-Baker, Hannele, additional, Rusu, Adriana, additional, Sanusi, Kamaldeen Olalekan, additional, Schenk, A., additional, Seib, K.L., additional, Sgueglia, Giulia, additional, Shu, Liqi, additional, Singh, J., additional, Sitar-Tăut, Adela, additional, Soto, Edwin Y., additional, Suharoschi, Ramona, additional, Tajbakhsh, J., additional, Tambaro, Francesco Paolo, additional, Taranda, Julian, additional, Thoutam, Akshaya, additional, Tollefsbol, Trygve O., additional, Trojer, P., additional, Turcan, Sevin, additional, Uthman, Yaaqub Abiodun, additional, Vaiserman, Alexander, additional, Vulturar, Romana, additional, Wang, Huan, additional, Wapenaar, H., additional, Weksberg, R., additional, Xiao, Junjie, additional, Xu, Guanying Bianca, additional, Zeng, Chang, additional, Zhang, Wei, additional, Zhang, Zhou, additional, and Zimmer, P., additional

Published
2021
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4. Novel Blood Biomarkers for Response Prediction and Monitoring of Stereotactic Ablative Radiotherapy and Immunotherapy in Metastatic Oligoprogressive Lung Cancer.

Author

Zafra, Juan, Onieva, Juan Luis, Oliver, Javier, Garrido-Barros, María, González-Hernández, Andrea, Martínez-Gálvez, Beatriz, Román, Alicia, Ordóñez-Marmolejo, Rafael, Pérez-Ruiz, Elisabeth, Benítez, José Carlos, Mesas, Andrés, Vera, Andrés, Chicas-Sett, Rodolfo, Rueda-Domínguez, Antonio, and Barragán, Isabel

Subjects
*STEREOTACTIC radiotherapy, *CIRCULATING tumor DNA, *MONONUCLEAR leukocytes, *NON-small-cell lung carcinoma, *LUNG cancer, *IMMUNE checkpoint inhibitors, *DACARBAZINE
Abstract

Up to 80% of patients under immune checkpoint inhibitors (ICI) face resistance. In this context, stereotactic ablative radiotherapy (SABR) can induce an immune or abscopal response. However, its molecular determinants remain unknown. We present early results of a translational study assessing biomarkers of response to combined ICI and SABR (I-SABR) in liquid biopsy from oligoprogressive patients in a prospective observational multicenter study. Cohort A includes metastatic patients in oligoprogression to ICI maintaining the same ICI due to clinical benefit and who receive concomitant SABR. B is a comparative group of oligometastatic patients receiving only SABR. Blood samples are extracted at baseline (T1), after the first (T2) and last (T3) fraction, two months post-SABR (T4) and at further progression (TP). Response is evaluated by iRECIST and defined by the objective response rate (ORR)—complete and partial responses. We assess peripheral blood mononuclear cells (PBMCs), circulating cell-free DNA (cfDNA) and small RNA from extracellular vesicles. Twenty-seven patients could be analyzed (cohort A: n = 19; B: n = 8). Most were males with non-small cell lung cancer and one progressing lesion. With a median follow-up of 6 months, the last ORR was 63% (26% complete and 37% partial response). A decrease in cfDNA from T2 to T3 correlated with a good response. At T2, CD8+PD1+ and CD8+PDL1+ cells were increased in non-responders and responders, respectively. At T2, 27 microRNAs were differentially expressed. These are potential biomarkers of response to I-SABR in oligoprogressive disease. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Fluorometric Quantification of Total Cell-Free DNA as a Prognostic Biomarker in Non-Small-Cell Lung Cancer Patients Treated with Immune Checkpoint Blockade

Author

Oliver, Javier, primary, Onieva, Juan Luis, additional, Garrido-Barros, María, additional, Cobo-Dols, Manuel, additional, Martínez-Gálvez, Beatriz, additional, García-Pelícano, Ana Isabel, additional, Dubbelman, Jaime, additional, Benítez, José Carlos, additional, Martín, Juan Zafra, additional, Cantero, Alejandra, additional, Pérez-Ruiz, Elisabeth, additional, Rueda-Domínguez, Antonio, additional, and Barragán, Isabel, additional

Published
2023
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6. Abstract 3746: Dynamic characterization of small RNAs in non small cell lung cancer exosomes under immune-checkpoint inhibitor treatments

Author

Garrido-Barros, Maria, primary, Oliver, Javier, additional, Onieva, Juan Luis, additional, Martinez-Galvez, Beatriz, additional, Duddelman, Jaime, additional, Rueda, Antonio, additional, Perez, Elisabeth, additional, Alba, Emilio, additional, Ramos, Inmaculada, additional, Zafra, Juan, additional, Cobo, Manuel, additional, and Barragán, Isabel, additional

Published
2023
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7. Abstract 1044: Cell-free DNA concentration as a prognostic biomarker in patients with non-small cell lung cancer under immunotherapy treatment

Author

Barragan, Isabel, primary, Perez-Ruiz, Elisabeth, additional, Onieva, Juan Luis, additional, Garrido-Ramos, Maria, additional, Martinez-Galvez, Beatriz, additional, Dubbelman, Jaime, additional, Alba, Emilio, additional, Zafra, Juan, additional, Cobo, Manuel, additional, Oliver, Javier, additional, and Rueda-Dominguez, Antonio, additional

Published
2023
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8. Association of Circular RNA and Long Non-Coding RNA Dysregulation with the Clinical Response to Immune Checkpoint Blockade in Cutaneous Metastatic Melanoma

Author

Oliver, Javier, primary, Onieva, Juan Luis, additional, Garrido-Barros, Maria, additional, Berciano-Guerrero, Miguel-Ángel, additional, Sánchez-Muñoz, Alfonso, additional, José Lozano, María, additional, Farngren, Angela, additional, Álvarez, Martina, additional, Martínez-Gálvez, Beatriz, additional, Pérez-Ruiz, Elisabeth, additional, Alba, Emilio, additional, Cobo, Manuel, additional, Rueda-Domínguez, Antonio, additional, and Barragán, Isabel, additional

Published
2022
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9. High IGKC-Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade

Author

Onieva, Juan Luis, primary, Xiao, Qingyang, additional, Berciano-Guerrero, Miguel-Ángel, additional, Laborda-Illanes, Aurora, additional, de Andrea, Carlos, additional, Chaves, Patricia, additional, Piñeiro, Pilar, additional, Garrido-Aranda, Alicia, additional, Gallego, Elena, additional, Sojo, Belén, additional, Gálvez, Laura, additional, Chica-Parrado, Rosario, additional, Prieto, Daniel, additional, Pérez-Ruiz, Elisabeth, additional, Farngren, Angela, additional, Lozano, María José, additional, Álvarez, Martina, additional, Jiménez, Pedro, additional, Sánchez-Muñoz, Alfonso, additional, Oliver, Javier, additional, Cobo, Manuel, additional, Alba, Emilio, additional, and Barragán, Isabel, additional

Published
2022
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11. Association of Circular RNA and Long Noncoding RNA Dysregulation to Clinical Response to Immunotherapy in Cutaneous Metastatic Melanoma

Author

Oliver, Javier, primary, Onieva, Juan Luis, additional, Garrido-Barros, Maria, additional, Berciano-Guerrero, Miguel, additional, Sánchez, Alfonso, additional, Lozano, Maria Jose, additional, Farngren, Angela, additional, Álvarez, Martina, additional, Martinez-Galvez, Beatriz, additional, Pérez, Elisabeth, additional, Alba, Emilio, additional, Cobo-Dols, Manuel, additional, Rueda-Dominguez, Antonio, additional, and Barragán, Isabel, additional

Published
2022
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12. Abstract 1910: flowTOTAL: A comprehensive bioinformatics workflow for flow cytometry automatic analysis

Author

Onieva, Juan Luis, primary, Cháves, Patricia, additional, Oliver, Javier, additional, Garrido-Barros, María, additional, Zafra, Juan, additional, Sojo, Belén, additional, Sánchez, Alfonso, additional, Álvarez, Martina, additional, Jiménez, Pedro, additional, Alba, Emilio, additional, Berciano, Miguel, additional, Rueda, Antonio, additional, Cobo-Dols, Manuel, additional, Pérez, Elisabeth, additional, and Barragán, Isabel, additional

Published
2022
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13. Abstract 1538: Association of ceRNA dysregulation with clinical Response to Immunotherapy in cutaneous melanoma (CM)

Author

Oliver, Javier, primary, Onieva, Juan Luis, additional, Garrido-Barros, Maria, additional, Garrido-Aranda, Alicia, additional, De Luque, Vanessa, additional, Alvarez, Martina, additional, Sanchez, Alfonso, additional, Perez, Elisabeth, additional, Chaves, Patricia, additional, Lozano, Maria Jose, additional, Berciano, Miguel, additional, Cobo, Manolo, additional, Alba, Emilio, additional, Rueda, Antonio, additional, and Barragan, Isabel, additional

Published
2022
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14. Abstract 281: Evaluation of circular RNA profiling in metastatic melanoma patients treated with immune checkpoint blockade

Author

Onieva, Juan Luis, primary, Oliver, Javier, additional, Laborda-Illanes, Aurora, additional, Chica-Parrado, Maria Rosario, additional, Garrido-Aranda, Alicia, additional, Robles-Podadera, Cynthia, additional, Prieto, Daniel, additional, Gallego, Elena, additional, Sanchez, Alfonso, additional, Comino, Iñaki, additional, De Luque, Vanessa, additional, Alvarez, Martina, additional, Lozano, Maria Jose, additional, Jimenez, Pedro, additional, Berciano-Guerrero, Miguel Angel, additional, Alba, Emilio, additional, Cobo, Manuel, additional, and Barragan, Isabel, additional

Published
2020
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