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4. The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species

Author

Sakai, Tomoko, Hata, Junichi, Ohta, Hiroki, Shintaku, Yuta, Kimura, Naoto, Ogawa, Yuki, Sogabe, Kazumi, Mori, Susumu, Okano, James, Hirotaka, Hamada, Yuzuru, Shibata, Shinsuke, Okano, Hideyuki, and Oishi, Kenichi

Subjects
Database, Diffusion tensor imaging, Magnetic resonance imaging, Evolution, Primate, Brain samples, Comparative neuroscience, Endangered species
Abstract

Advances in magnetic resonance imaging (MRI) and computational analysis technology have enabled comparisons among various primate brains in a three-dimensional electronic format. Results from comparative studies provide information about common features across primates and species-specific features of neuroanatomy. Investigation of various species of non-human primates is important for understanding such features, but the majority of comparative MRI studies have been based on experimental primates, such as common marmoset, macaques, and chimpanzee. A major obstacle has been the lack of a database that includes non-experimental primates’ brain MRIs. To facilitate scientific discoveries in the field of comparative neuroanatomy and brain evolution, we launched a collaborative project to develop an open-resource repository of non-human primate brain images obtained using ex vivo MRI. As an initial open resource, here we release a collection of structural MRI and diffusion tensor images obtained from 12 species: pygmy marmoset, owl monkey, white-fronted capuchin, crab-eating macaque, Japanese macaque, bonnet macaque, toque macaque, Sykes’ monkey, red-tailed monkey, Schmidt’s guenon, de Brazza’s guenon, and lar gibbon. Sixteen postmortem brain samples from the 12 species, stored in the Japan Monkey Centre (JMC), were scanned using a 9.4-T MRI scanner and made available through the JMC collaborative research program (http://www.j-monkey.jp/BIR/index_e.html). The expected significant contributions of the JMC Primates Brain Imaging Repository include (1) resources for comparative neuroscience research, (2) preservation of various primate brains, including those of endangered species, in a permanent digital form, (3) resources with higher resolution for identifying neuroanatomical features, compared to previous MRI atlases, (4) resources for optimizing methods of scanning large fixed brains, and (5) references for veterinary neuroradiology. User-initiated research projects beyond these contributions are also anticipated.

Published
2018

7. ヒトiPS細胞と小型霊長類コモンマーモセットを用いた蝸牛有毛細胞再生の前臨床検討

Author

慶應義塾大学・医学部(信濃町)・講師, 慶應義塾大学・医学部(信濃町)・教授, 東京慈恵会医科大学・医学部・教授, 防衛医科大学校・医学教育部医学科進学課程及び専門課程, 動物実験施設, 共同利用研究・病院 耳鼻咽喉科科・講師, 国際医療福祉大学・大学病院・教授, 慶應義塾大学・医学部(信濃町)・助教, フジオカ, マサト, オガワ, カオル, オカノ, ジェイムス ヒロタカ, ミズタリ, クニオ, ハラダ, タツヒコ, ホソヤ, マコト, Fujioka, Masato, Ogawa, Kaoru, Okano, James Hirotaka, Mizutari, Kunio, Harada, Tatsuhiko, Hosoya, Makoto, 藤岡, 正人, 小川, 郁, 岡野, ジェイムス 洋尚, 水足, 邦雄, 原田, 竜彦, 細谷, 誠, 慶應義塾大学・医学部(信濃町)・講師, 慶應義塾大学・医学部(信濃町)・教授, 東京慈恵会医科大学・医学部・教授, 防衛医科大学校・医学教育部医学科進学課程及び専門課程, 動物実験施設, 共同利用研究・病院 耳鼻咽喉科科・講師, 国際医療福祉大学・大学病院・教授, 慶應義塾大学・医学部(信濃町)・助教, フジオカ, マサト, オガワ, カオル, オカノ, ジェイムス ヒロタカ, ミズタリ, クニオ, ハラダ, タツヒコ, ホソヤ, マコト, Fujioka, Masato, Ogawa, Kaoru, Okano, James Hirotaka, Mizutari, Kunio, Harada, Tatsuhiko, Hosoya, Makoto, 藤岡, 正人, 小川, 郁, 岡野, ジェイムス 洋尚, 水足, 邦雄, 原田, 竜彦, and 細谷, 誠

Abstract

Research team head, Research team member, Publisher, 私達はこれまで, 自発的再生能のない蝸牛有毛細胞の薬剤による再生と聴力改善を報告してきた(Neuron, 2013)。この"内耳再生医療"の臨床応用に向け, (1)ヒトiPS細胞由来内耳幹細胞を用いた人工蝸牛感覚上皮での薬剤スクリーニングにより臨床試験への橋渡しが可能な薬剤2剤を同定し, (2)小型霊長類コモンマーモセットモデル(特許出願)での治療効果を確認した。また, iPS研究では, ヒト内耳幹細胞においてその幹細胞性の維持と有毛細胞の成熟化の双方にWntシグナルが必須であることを見出し, マーモセットを用いて成体霊長類蝸牛における新たな再生医療の標的分子候補を複数同定した。 We previously reported auditory hair cell regeneration with a hearing improvement in mouse (Neuron, 2013). Towards translation to the clinical trials, we selected better compounds by using otic progenitor cells derived from human iPS cells. We also examined the effect of above mentioned regenerative therapy in a non-human primate common marmoset., 研究種目 : 基盤研究(B)(一般) 研究期間 : 2015～2017 課題番号 : 15H04991 研究分野 : 耳科学

Published
2018

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