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26 results on '"Nixdorff, Uwe"'

1. High-Risk Atherosclerosis and Metabolic Phenotype: The Roles of Ectopic Adiposity, Atherogenic Dyslipidemia, and Inflammation

Author

Lechner, Katharina, McKenzie, Amy L, Kränkel, Nicolle, Von Schacky, Clemens, Worm, Nicolai, Nixdorff, Uwe, Lechner, Benjamin, Scherr, Johannes, Weingärtner, Oliver, and Krauss, Ronald M

Subjects
Clinical Research, Aging, Patient Safety, Obesity, Cardiovascular, Prevention, Atherosclerosis, Diabetes, Nutrition, Heart Disease, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Good Health and Well Being, Adiposity, Biomarkers, Cardiometabolic Risk Factors, Cardiovascular Diseases, Choristoma, Dyslipidemias, Humans, Inflammation, Metabolic Syndrome, Phenotype, Risk Factors, atherosclerosis, metabolic syndrome, ectopic adipose tissue, dyslipidemia, inflammation, lifestyle, Medical Biotechnology, Clinical Sciences, Public Health and Health Services, Endocrinology & Metabolism
Abstract

Current algorithms for assessing risk of atherosclerotic cardiovascular disease (ASCVD) and, in particular, the reliance on low-density lipoprotein (LDL) cholesterol in conditions where this measurement is discordant with apoB and LDL-particle concentrations fail to identify a sizeable part of the population at high risk for adverse cardiovascular events. This results in missed opportunities for ASCVD prevention, most notably in those with metabolic syndrome, prediabetes, and diabetes. There is substantial evidence that accumulation of ectopic fat and associated metabolic traits are markers for and pathogenic components of high-risk atherosclerosis. Conceptually, the subset of advanced lesions in high-risk atherosclerosis that triggers vascular complications is closely related to a set of coordinated high-risk traits clustering around a distinct metabolic phenotype. A key feature of this phenotype is accumulation of ectopic fat, which, coupled with age-related muscle loss, creates a milieu conducive for the development of ASCVD: atherogenic dyslipidemia, nonresolving inflammation, endothelial dysfunction, hyperinsulinemia, and impaired fibrinolysis. Sustained vascular inflammation, a hallmark of high-risk atherosclerosis, impairs plaque stabilization in this phenotype. This review describes how metabolic and inflammatory processes that are promoted in large measure by ectopic adiposity, as opposed to subcutaneous adipose tissue, relate to the pathogenesis of high-risk atherosclerosis. Clinical biomarkers indicative of these processes provide incremental information to standard risk factor algorithms and advanced lipid testing identifies atherogenic lipoprotein patterns that are below the discrimination level of standard lipid testing. This has the potential to enable improved identification of high-risk patients who are candidates for therapeutic interventions aimed at prevention of ASCVD.

Published
2020

2. Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors

Author

Lechner, Katharina, von Schacky, Clemens, McKenzie, Amy L, Worm, Nicolai, Nixdorff, Uwe, Lechner, Benjamin, Kränkel, Nicolle, Halle, Martin, Krauss, Ronald M, and Scherr, Johannes

Subjects
Nutrition, Cardiovascular, Patient Safety, Aging, Prevention, Atherosclerosis, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Healthy Lifestyle, Heart Disease Risk Factors, Humans, Life Style, Protective Factors, Risk Assessment, Risk Reduction Behavior, Atherosclerotic cardiovascular disease, adipose tissue phenotype, ketone body ß-hydroxybutyrate, n-3 fatty acids, novel lifestyle risk factors, plaque phenotype, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract

Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with conventional risk factor control, significant residual risk remains. Recent evidence on non-traditional determinants of cardiometabolic health has advanced our understanding of lifestyle-disease interactions. Chronic exposure to environmental stressors like poor diet quality, sedentarism, ambient air pollution and noise, sleep deprivation and psychosocial stress affect numerous traditional and non-traditional intermediary pathways related to ASCVD. These include body composition, cardiorespiratory fitness, muscle strength and functionality and the intestinal microbiome, which are increasingly recognized as major determinants of cardiovascular health. Evidence points to partially overlapping mechanisms, including effects on inflammatory and nutrient sensing pathways, endocrine signalling, autonomic function and autophagy. Of particular relevance is the potential of low-risk lifestyle factors to impact on plaque vulnerability through altered adipose tissue and skeletal muscle phenotype and secretome. Collectively, low-risk lifestyle factors cause a set of phenotypic adaptations shifting tissue cross-talk from a proinflammatory milieu conducive for high-risk atherosclerosis to an anti-atherogenic milieu. The ketone body ß-hydroxybutyrate, through inhibition of the NLRP-3 inflammasome, is likely to be an intermediary for many of these observed benefits. Adhering to low-risk lifestyle factors adds to the prognostic value of optimal risk factor management, and benefit occurs even when the impact on conventional risk markers is discouragingly minimal or not present. The aims of this review are (a) to discuss novel lifestyle risk factors and their underlying biochemical principles and (b) to provide new perspectives on potentially more feasible recommendations to improve long-term adherence to low-risk lifestyle factors.

Published
2020

10. Imaging in cardiovascular prevention

Author

Nixdorff, Uwe, primary, Achenbach, Stephan, additional, Bengel, Frank, additional, Faggiano, Pompillio, additional, Fernández, Sara, additional, Heiss, Christian, additional, Mengden, Thomas, additional, Mureddu, Gian Francesco, additional, Nagel, Eike, additional, Puntmann, Valentina, additional, and Zamorano, Jose, additional

Published
2015
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11. Cardiac Rehabilitation in German Speaking Countries of Europe-Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 1

Author

Rauch, Bernhard, Salzwedel, Annett, Bjarnason-Wehrens, Birna, Albus, Christian, Meng, Karin, Schmid, Jean-Paul, Benzer, Werner, Hackbusch, Matthes, Jensen, Katrin, Schwaab, Bernhard, Altenberger, Johann, Benjamin, Nicola, Bestehorn, Kurt, Bongarth, Christa, Doerr, Gesine, Eichler, Sarah, Einwang, Hans-Peter, Falk, Johannes, Glatz, Johannes, Gielen, Stephan, Grilli, Maurizio, Grunig, Ekkehard, Guha, Manju, Hermann, Matthias, Hoberg, Eike, Hoefer, Stefan, Kaemmerer, Harald, Ladwig, Karl-Heinz, Mayer-Berger, Wolfgang, Metzendorf, Maria-Inti, Nebel, Roland, Neidenbach, Rhoia Clara, Niebauer, Josef, Nixdorff, Uwe, Oberhoffer, Renate, Reibis, Rona, Reiss, Nils, Saure, Daniel, Schlitt, Axel, Voeler, Heinz, von Kaenel, Roland, Weinbrenner, Susanne, Westphal, Ronja, Rauch, Bernhard, Salzwedel, Annett, Bjarnason-Wehrens, Birna, Albus, Christian, Meng, Karin, Schmid, Jean-Paul, Benzer, Werner, Hackbusch, Matthes, Jensen, Katrin, Schwaab, Bernhard, Altenberger, Johann, Benjamin, Nicola, Bestehorn, Kurt, Bongarth, Christa, Doerr, Gesine, Eichler, Sarah, Einwang, Hans-Peter, Falk, Johannes, Glatz, Johannes, Gielen, Stephan, Grilli, Maurizio, Grunig, Ekkehard, Guha, Manju, Hermann, Matthias, Hoberg, Eike, Hoefer, Stefan, Kaemmerer, Harald, Ladwig, Karl-Heinz, Mayer-Berger, Wolfgang, Metzendorf, Maria-Inti, Nebel, Roland, Neidenbach, Rhoia Clara, Niebauer, Josef, Nixdorff, Uwe, Oberhoffer, Renate, Reibis, Rona, Reiss, Nils, Saure, Daniel, Schlitt, Axel, Voeler, Heinz, von Kaenel, Roland, Weinbrenner, Susanne, and Westphal, Ronja

Abstract

Background: Although cardiovascular rehabilitation (CR) is well accepted in general, CR-attendance and delivery still considerably vary between the European countries. Moreover, clinical and prognostic effects of CR are not well established for a variety of cardiovascular diseases. Methods: The guidelines address all aspects of CR including indications, contents and delivery. By processing the guidelines, every step was externally supervised and moderated by independent members of the Association of the Scientific Medical Societies in Germany (AWMF). Four meta-analyses were performed to evaluate the prognostic effect of CR after acute coronary syndrome (ACS), after coronary bypass grafting (CABG), in patients with severe chronic systolic heart failure (HFrEF), and to define the effect of psychological interventions during CR. All other indications for CR-delivery were based on a predefined semi-structured literature search and recommendations were established by a formal consenting process including all medical societies involved in guideline generation. Results: Multidisciplinary CR is associated with a significant reduction in all-cause mortality in patients after ACS and after CABG, whereas HFrEF-patients (left ventricular ejection fraction <40%) especially benefit in terms of exercise capacity and health-related quality of life. Patients with other cardiovascular diseases also benefit from CR-participation, but the scientific evidence is less clear. There is increasing evidence that the beneficial effect of CR strongly depends on treatment intensity including medical supervision, treatment of cardiovascular risk factors, information and education, and a minimum of individually adapted exercise volume. Additional psychologic interventions should be performed on the basis of individual needs. Conclusions: These guidelines reinforce the substantial benefit of CR in specific clinical indications, but also describe remaining deficits in CR-delivery in clinical practi

Published
2021

12. EAPC Core Curriculum for Preventive Cardiology

Author

Wilhelm, Matthias, primary, Abreu, Ana, additional, Adami, Paolo Emilio, additional, Ambrosetti, Marco, additional, Antonopoulou, Maria, additional, Biffi, Alessandro, additional, Cavarretta, Elena, additional, D'Ascenzi, Flavio, additional, Gibson, Irene, additional, Grobbee, Diederick E, additional, Iliou, Marie-Christine, additional, Koskinas, Konstantinos, additional, Marques-Vidal, Pedro, additional, Nixdorff, Uwe, additional, Papadakis, Michael, additional, Piepoli, Massimo F, additional, Vassiliou, Vass, additional, Wood, David, additional, Dendale, Paul, additional, and Halle, Martin, additional

Published
2021
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13. Cardiac Rehabilitation in German Speaking Countries of Europe—Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH—Part 1

Author

Rauch, Bernhard;Salzwedel, Annett;Bjarnason-Wehrens, Birna;Albus, Christian;Meng, Karin;Schmid, Jean-Paul;Benzer, Werner;Hackbusch, Matthes;Jensen, Katrin;Schwaab, Bernhard;Altenberger, Johann;Benjamin, Nicola;Bestehorn, Kurt;Bongarth, Christa;Dörr, Gesine;Eichler, Sarah;Einwang, Hans-Peter;Falk, Johannes;Glatz, Johannes;Gielen, Stephan;Grilli, Maurizio;Grünig, Ekkehard;Guha, Manju;Hermann, Matthias;Hoberg, Eike;Höfer, Stefan;Kaemmerer, Harald;Ladwig, Karl-Heinz;Mayer-Berger, Wolfgang;Metzendorf, Maria-Inti;Nebel, Roland;Neidenbach, Rhoia;Niebauer, Josef;Nixdorff, Uwe;Oberhoffer, Renate;Reibis, Rona;Reiss, Nils;Saure, Daniel;Schlitt, Axel;Völler, Heinz;von Känel, Roland;Weinbrenner, Susanne;Westphal, Ronja and Rauch, Bernhard;Salzwedel, Annett;Bjarnason-Wehrens, Birna;Albus, Christian;Meng, Karin;Schmid, Jean-Paul;Benzer, Werner;Hackbusch, Matthes;Jensen, Katrin;Schwaab, Bernhard;Altenberger, Johann;Benjamin, Nicola;Bestehorn, Kurt;Bongarth, Christa;Dörr, Gesine;Eichler, Sarah;Einwang, Hans-Peter;Falk, Johannes;Glatz, Johannes;Gielen, Stephan;Grilli, Maurizio;Grünig, Ekkehard;Guha, Manju;Hermann, Matthias;Hoberg, Eike;Höfer, Stefan;Kaemmerer, Harald;Ladwig, Karl-Heinz;Mayer-Berger, Wolfgang;Metzendorf, Maria-Inti;Nebel, Roland;Neidenbach, Rhoia;Niebauer, Josef;Nixdorff, Uwe;Oberhoffer, Renate;Reibis, Rona;Reiss, Nils;Saure, Daniel;Schlitt, Axel;Völler, Heinz;von Känel, Roland;Weinbrenner, Susanne;Westphal, Ronja

Published
2020

14. Wytyczne ESC/ESH dotyczące postępowania w nadciśnieniu tętniczym (2018)

Author

Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Agabiti Rosei, Enrico, Azizi, Michel, Burnier, Michel, Clement, Denis L, Coca, Antonio, de Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E, Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y H, McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E, Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, De Backer, Guy, Heagerty, Anthony M, Agewall, Stefan, Bochud, Murielle, Borghi, Claudio, Boutouyrie, Pierre, Brguljan, Jana, Bueno, Héctor, Caiani, Enrico G, Carlberg, Bo, Chapman, Neil, Cífková, Renata, Cleland, John G F, Collet, Jean-Philippe, Coman, Ioan Mircea, de Leeuw, Peter W, Delgado, Victoria, Dendale, Paul, Diener, Hans-Christoph, Dorobantu, Maria, Fagard, Robert, Farsang, Csaba, Ferrini, Marc, Graham, Ian M, Grassi, Guido, Haller, Hermann, Hobbs, F D Richard, Jelakovic, Bojan, Jennings, Catriona, Katus, Hugo A, Kroon, Abraham A, Leclercq, Christophe, Lovic, Dragan, Lurbe, Empar, Manolis, Athanasios J, McDonagh, Theresa A, Messerli, Franz, Muiesan, Maria Lorenza, Nixdorff, Uwe, Olsen, Michael Hecht, Parati, Gianfranco, Perk, Joep, Piepoli, Massimo Francesco, Polonia, Jorge, Ponikowski, Piotr, Richter, Dimitrios J, Rimoldi, Stefano F, Roffi, Marco, Sattar, Naveed, Seferovic, Petar M, Simpson, Iain A, Sousa-Uva, Miguel, Stanton, Alice V, van de Borne, Philippe, Vardas, Panos, Volpe, Massimo, Wassmann, Sven, Windecker, Stephan, Zamorano, Jose Luis, Barbato, Emanuele, Dean, Veronica, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Knuuti, Juhani, Lancellotti, Patrizio, Rosei, Enrico Agabiti, Januszewics, Andrzej, Manolis, Athanasios, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Linhart, Aleš, Shaker, Amin Fouad, Viigimaa, Margus, Metsärinne, Kaj, Vavlukis, Marija, Halimi, Jean-Michel, Pagava, Zurab, Schunkert, Heribert, Thomopoulos, Costas, Páll, Dénes, Andersen, Karl, Shechter, Michael, Mercuro, Giuseppe, Bajraktari, Gani, Romanova, Tatiana, Trušinskis, Kārlis, Saade, Georges A, Sakalyte, Gintare, Noppe, Stéphanie, DeMarco, Daniela Cassar, Caraus, Alexandru, Wittekoek, Janneke, Aksnes, Tonje Amb, Jankowski, Piotr, Vinereanu, Dragos, Baranova, Elena I, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Bertomeu-Martínez, Vicente, Burkard, Thilo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Brady, Adrian, Weber, Thomas, Lazareva, Irina, Backer, Tine De, Sokolovic, Sekib, Widimsky, Jiri, Pörsti, Ilkka, Denolle, Thierry, Krämer, Bernhard K, Stergiou, George S, Miglinas, Marius, Gerdts, Eva, Tykarski, Andrzej, de Carvalho Rodrigues, Manuel, Chazova, Irina, Segura, Julian, Gottsäter, Anders, Pechère-Bertschi, Antoinette, Erdine, Serap, Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thoma, Mahfoud, Felix, Redon, Josep, Ruilope, Lui, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y. H., Mcmanus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costa, Aboyans, Victor, Desormais, Ileana, De Backer, Guy, Heagerty, Anthony M., Agewall, Stefan, Bochud, Murielle, Borghi, Claudio, Boutouyrie, Pierre, Brguljan, Jana, Bueno, Héctor, Caiani, Enrico G., Carlberg, Bo, Chapman, Neil, Cífková, Renata, Cleland, John G. F., Collet, Jean-Philippe, Coman, Ioan Mircea, De Leeuw, Peter W., Delgado, Victoria, Dendale, Paul, Diener, Hans-Christoph, Dorobantu, Maria, Fagard, Robert, Farsang, Csaba, Ferrini, Marc, Graham, Ian M., Grassi, Guido, Haller, Hermann, Hobbs, F. D. Richard, Jelakovic, Bojan, Jennings, Catriona, Katus, Hugo A., Kroon, Abraham A., Leclercq, Christophe, Lovic, Dragan, Lurbe, Empar, Manolis, Athanasios J., Mcdonagh, Theresa A., Messerli, Franz, Muiesan, Maria Lorenza, Nixdorff, Uwe, Olsen, Michael Hecht, Parati, Gianfranco, Perk, Joep, Piepoli, Massimo Francesco, Polonia, Jorge, Ponikowski, Piotr, Richter, Dimitrios J., Rimoldi, Stefano F., Roffi, Marco, Sattar, Naveed, Seferovic, Petar M., Simpson, Iain A., Sousa-Uva, Miguel, Stanton, Alice V., Van De Borne, Philippe, Vardas, Pano, Volpe, Massimo, Wassmann, Sven, Windecker, Stephan, Zamorano, Jose Luis, University College of London [London] (UCL), University College London Hospitals (UCLH), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université de Lausanne = University of Lausanne (UNIL), Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Danderyds sjukhus = Danderyd University Hospital, Universitätsklinikum des Saarlandes, Universitat de València (UV), Hospital 12 de Octubre, Oslo University Hospital [Oslo], Clinical Pharmacology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Liverpool, Aalborg University [Denmark] (AAU), Nuffield Department of Primary Care Health Sciences, University of Oxford, University of Oxford, Medical University of Gdańsk, University Heart Centre Freiburg - Bad Krozingen, Med Klinik IV, Univ.-Klinik Erlangen-Nürnberg, Almazov National Medical Research Centre (St. Petersburg), National and Kapodistrian University of Athens (NKUA), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de cardiologie [CHU Limoges], CHU Limoges, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], Agabiti Rosei, Enrico, Clement, Denis L, de Simone, Giovanni, Kjeldsen, Sverre E, Lip, Gregory Y H, McManus, Richard, Schmieder, Roland E, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet [Stockholm], Chercheur indépendant, Department of Cardiology, Birmingham City Hospital, Department of Public Health, University of Gent, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano [Milan] (POLIMI), 2nd Department of Internal Medicine, Hasselt University (UHasselt), Universität Duisburg-Essen [Essen], Australian Museum, Australian Museum [Sydney], Division of Nephrology and Hypertension, Department of Medicine, Hanover Medical School, Department of Earth Science, Durham University, School of Health and Caring Sciences, Linnaeus University, Department of Pathological Biochemistry, Royal Infirmary, Karolinska Institute, karolinska institute, 'Federico II' University of Naples Medical School, Hospital General Universitario 'Gregorio Marañón' [Madrid], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU de Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), St. Michael's Hospital, Heidelberg University Hospital [Heidelberg], Turku PET Centre, University of Turku, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Wroclaw Medical University, Servicio de Pediatría, Consorcio Hospital General Universitario de Valencia, Institute of Social and Preventive Medicine, Lausanne university hospital, Department of Internal Medicine, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Aging and Clinical Nephrology, Food Science and Technology, Université Francois Rabelais [Tours], Medizinische Klinik II, Universität zu Lübeck [Lübeck], Warsaw University of Technology [Warsaw], Cardiology, University and Emergency Hospital, IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Sheffield [Sheffield], Faculty of metals engineering and industrial computer science, Centre of Cardiology, North Estonia Medical Centre, Medical School, University of Tampere [Finland], Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], IRCCS Istituto Auxologico Italiano, University of Zurich, Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hasselt University, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Università di Bologna [Bologna] (UNIBO)-Aging and Clinical Nephrology, Universität zu Lübeck [Lübeck] - University of Lübeck [Lübeck], IRCELYON-Caractérisation et remédiation des polluants dans l'air et l'eau (CARE), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie et maladies vasculaires [CHU de Rennes], Diener, Hans Christoph (Beitragende*r), Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, de Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, and Grassi, G

Subjects
Male, Lifestyle intervention, [SDV]Life Sciences [q-bio], Medizin, Secondary hypertension, 030204 cardiovascular system & hematology, Guideline, Hypertension-mediated organ damage, Blood pressure treatment thresholds and targets, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Disease management (health), 610 Medicine & health, Lifestyle interventions, Societies, Medical, ComputingMilieux_MISCELLANEOUS, Disease Management, Blood pressure, Blood pressure measurement, Combination therapy, Device therapy, Drug therapy, Guidelines, Hypertension, Cardiology and Cardiovascular Medicine, Europe, Arterial hypertension, blood pressure control, guidelines, 10209 Clinic for Cardiology, Female, medicine.medical_specialty, Blood pressure treatment thresholds and target, MEDLINE, Cardiology, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, Pharmacotherapy, Blood pressure treatmentthresholds and targets, Journal Article, Humans, Hypertension diagnosis, Intensive care medicine, Antihypertensive Agents, business.industry, medicine.disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

International audience; : Document reviewers: Guy De Backer (ESC Review Co-ordinator) (Belgium), Anthony M. Heagerty (ESH Review Co-ordinator) (UK), Stefan Agewall (Norway), Murielle Bochud (Switzerland), Claudio Borghi (Italy), Pierre Boutouyrie (France), Jana Brguljan (Slovenia), Héctor Bueno (Spain), Enrico G. Caiani (Italy), Bo Carlberg (Sweden), Neil Chapman (UK), Renata Cifkova (Czech Republic), John G. F. Cleland (UK), Jean-Philippe Collet (France), Ioan Mircea Coman (Romania), Peter W. de Leeuw (The Netherlands), Victoria Delgado (The Netherlands), Paul Dendale (Belgium), Hans-Christoph Diener (Germany), Maria Dorobantu (Romania), Robert Fagard (Belgium), Csaba Farsang (Hungary), Marc Ferrini (France), Ian M. Graham (Ireland), Guido Grassi (Italy), Hermann Haller (Germany), F. D. Richard Hobbs (UK), Bojan Jelakovic (Croatia), Catriona Jennings (UK), Hugo A. Katus (Germany), Abraham A. Kroon (The Netherlands), Christophe Leclercq (France), Dragan Lovic (Serbia), Empar Lurbe (Spain), Athanasios J. Manolis (Greece), Theresa A. McDonagh (UK), Franz Messerli (Switzerland), Maria Lorenza Muiesan (Italy), Uwe Nixdorff (Germany), Michael Hecht Olsen (Denmark), Gianfranco Parati (Italy), Joep Perk (Sweden), Massimo Francesco Piepoli (Italy), Jorge Polonia (Portugal), Piotr Ponikowski (Poland), Dimitrios J. Richter (Greece), Stefano F. Rimoldi (Switzerland), Marco Roffi (Switzerland), Naveed Sattar (UK), Petar M. Seferovic (Serbia), Iain A. Simpson (UK), Miguel Sousa-Uva (Portugal), Alice V. Stanton (Ireland), Philippe van de Borne (Belgium), Panos Vardas (Greece), Massimo Volpe (Italy), Sven Wassmann (Germany), Stephan Windecker (Switzerland), Jose Luis Zamorano (Spain).The disclosure forms of all experts involved in the development of these Guidelines are available on the ESC website www.escardio.org/guidelines.

Published
2018

15. EAPC Core Curriculum for Preventive Cardiology.

Author

Wilhelm, Matthias, Abreu, Ana, Adami, Paolo Emilio, Ambrosetti, Marco, Antonopoulou, Maria, Biffi, Alessandro, Cavarretta, Elena, D'Ascenzi, Flavio, Gibson, Irene, Grobbee, Diederick E, Iliou, Marie-Christine, Koskinas, Konstantinos, Marques-Vidal, Pedro, Nixdorff, Uwe, Papadakis, Michael, Piepoli, Massimo F, Vassiliou, Vass, Wood, David, Dendale, Paul, and Halle, Martin

Published
2022
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16. Cardiovascular risk algorithms in primary care: Results from the DETECT study

Author

Grammer, Tanja B., Dressel, Alexander, Gergei, Ingrid, Kleber, Marcus E., Laufs, Ulrich, Scharnagl, Hubert, Nixdorff, Uwe, Klotsche, Jens, Pieper, Lars, Pittrow, David, Silber, Sigmund, Wittchen, Hans-Ulrich, and März, Winfried

Subjects
Adult, Male, Primary Health Care, lcsh:R, lcsh:Medicine, Middle Aged, Atherosclerosis, Risk Assessment, Article, Germany, Humans, lcsh:Q, Female, Prospective Studies, lcsh:Science, Author Correction, Algorithms, Aged
Abstract

Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. The risk equations correlate well with each other. All risk equations have a similar discriminatory power. Absolute risks differ widely, in part due to the components of clinical endpoints predicted: The risk equations produced median risks between 8.4% and 2.0%. With three out of 10 risk scores calculated and observed risks well coincided. At a risk threshold of 10 percent in 10 years, the ACC/AHA atherosclerotic cardiovascular disease (ASCVD) equation has a sensitivity to identify future CVD events of approximately 80%, with the highest specificity (69%) and positive predictive value (17%) among all the equations. Due to the most precise calibration over a wide range of risks, the large age range covered and the combined endpoint including non-fatal and fatal events, the ASCVD equation provides valid risk prediction for primary prevention in Germany.

Published
2018

17. Linee guida ESC/ESH 2018 per la diagnosi e il trattamento dell'ipertensione arteriosa: Task Force per la Diagnosi e il Trattamento dell'Ipertensione Arteriosa della Società Europea di Cardiologia (ESC) e della Società Europea dell'Ipertensione Arteriosa (ESH)

Author

Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y. H., Mcmanus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, De Backer, Guy, Heagerty, Anthony M., Agewall, Stefan, Bochud, Murielle, Borghi, Claudio, Boutouyrie, Pierre, Brguljan, Jana, Bueno, Héctor, Caiani, Enrico G., Carlberg, Bo, Chapman, Neil, Cífková, Renata, Cleland, John G. F., Collet, Jean-Philippe, Coman, Ioan Mircea, De Leeuw, Peter W., Delgado, Victoria, Dendale, Paul, Diener, Hans-Christoph, Dorobantu, Maria, Fagard, Robert, Farsang, Csaba, Ferrini, Marc, Graham, Ian M., Grassi, Guido, Haller, Hermann, Richard Hobbs, F. D., Jelakovic, Bojan, Jennings, Catriona, Katus, Hugo A., Kroon, Abraham A., Leclercq, Christophe, Lovic, Dragan, Lurbe, Empar, Manolis, Athanasios J., Mcdonagh, Theresa A., Messerli, Franz, Muiesan, Maria Lorenza, Nixdorff, Uwe, Olsen, Michael Hecht, Parati, Gianfranco, Perk, Joep, Piepoli, Massimo Francesco, Polonia, Jorge, Ponikowski, Piotr, Richter, Dimitrios J., Rimoldi, Stefano F., Roffi, Marco, Sattar, Naveed, Seferovic, Petar M., Simpson, Iain A., Sousa-Uva, Miguel, Stanton, Alice V., Van De Borne, Philippe, Vardas, Panos, Volpe, Massimo, Wassmann, Sven, Windecker, Stephan, and Zamorano, Jose Luis

Subjects
Cardiology and Cardiovascular Medicine
Published
2018

23. EAPC core curriculum for preventive cardiology

Author

Marco Ambrosetti, David R. Wood, Vass Vassiliou, Pedro Marques-Vidal, Paolo Emilio Adami, Marie-Christine Iliou, Michael Papadakis, Massimo F Piepoli, Paul Dendale, Ana Abreu, Elena Cavarretta, Flavio D'Ascenzi, Maria Antonopoulou, Alessandro Biffi, Matthias Wilhelm, Irene Gibson, Martin Halle, Diederick E. Grobbee, Uwe Nixdorff, Konstantinos C. Koskinas, Repositório da Universidade de Lisboa, Wilhelm, Matthias/0000-0003-4541-3995, Vassiliou, Vassilios/0000-0002-4005-7752, Marques-Vidal, Pedro/0000-0002-4548-8500, Wood , David, Ambrosetti, Marco, Gibson, Irene, Marques-Vidal, Pedro, Piepoli, Massimo F., Halle, Martin, Antonopoulou, Maria, DENDALE, Paul, Biffi, Alessandro, D'Ascenzi, Flavio, Iliou, Marie-Christine, Nixdorff, Uwe, Vassiliou, Vass, Koskinas, Konstantinos, Grobbee, Diederick E., Wilhelm, Matthias, Adami, Paolo Emilio, Abreu, Ana, Papadakis, Michael, and Cavarretta, Elena

Subjects
Cardiac & Cardiovascular Systems, certification, Epidemiology, medicine.medical_treatment, curriculum, Disease, Certification, DISEASE, population science, Weight management, cardiovascular rehabilitation, Prevention of CVD, Medicine, CARDIOVASCULAR PREVENTION, 610 Medicine & health, humans, exercise, ASSOCIATION, EUROPEAN-SOCIETY, Cardiovascular rehabilitation, cardiology, Population science, LIFE-STYLE, sports, Cardiology and Cardiovascular Medicine, prevention of CVD, Psychosocial, Life Sciences & Biomedicine, sports cardiology, POSITION PAPER, COUNTRIES, REHABILITATION, medicine.medical_specialty, Exercise testing, Context (language use), AMERICAN-COLLEGE, Subspecialty, Social determinants of health, Sports cardiology, exercise testing, Science & Technology, business.industry, cardiovascular diseases, Family medicine, Cardiovascular System & Cardiology, RISK-FACTORS, Smoking cessation, business
Abstract

© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited., Preventive cardiology encompasses the whole spectrum of cardiovascular disease (CVD) prevention, at individual and population level, through all stages of life. This includes promotion of cardiovascular (CV) health, management of individuals at risk of developing CVD, and management of patients with established CVD, through interdisciplinary care in different settings. Preventive cardiology addresses all aspects of CV health in the context of the social determinants of health, including physical activity, exercise, sports, nutrition, weight management, smoking cessation, psychosocial factors and behavioural change, environmental, genetic and biological risk factors, and CV protective medications. This is the first European Core Curriculum for Preventive Cardiology, which will help to standardize, structure, deliver, and evaluate training in preventive cardiology across Europe. It will be the basis for dedicated fellowship programmes and a European Society of Preventive Cardiology (EAPC) subspecialty certification for cardiologists, with the intention to improve quality and outcome in CVD prevention.

Published
2022

24. A Case Report of Genetic Cascade Screening in Dilated Cardiomyopathy: A Perspective for Preventive Cardiology.

Author

Barati Z, Farhoud D, Nixdorff U, Mohammadhasani M, Eslami M, and Nayernia K

Abstract

Cardiomyopathies are heterogeneous and critical disorders of cardiovascular diseases. One of the most common inherited cardiomyopathies is DCM (dilated cardiomyopathy). Genetic disorders are found in approximately 50% of DCM cases. We aimed to describe a case of DCM in a 42-year-old woman in 2018 at Farhud Genetic Clinic, Tehran, Iran. To detect genetic involvement, Next-generation sequencing (NGS) was performed and the data were evaluated carefully. Variations in different genes coding crucial proteins in cardiac muscle structure (i.e. Titin, Obscurin, MYH6, and LAMA4) and proteins involved in channels (i.e. CAVNA1C, SCN1B and SCN5A) were detected by whole-exome sequencing (WES). In agreement with the clinical manifestations and molecular analysis, DCM was confirmed. This study provides further evidence on the diagnostic role of NGS in borderline DCM cases. It also shows the recently developed high throughput sequencing can provide clinicians with this approach to diagnosis, treatment, and prevention of such hard-to-diagnose disorders. Furthermore, this study highlights the basis of personalized medicine, namely detection of high-risk individuals by revealing some genetic variants as predictive risk factors, and initial prevention of DCM., Competing Interests: Conflict of interest The authors declare that there is no conflict of interests., (Copyright © 2021 Barati et al. Published by Tehran University of Medical Sciences.)

Published
2021
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25. Cardiac Rehabilitation in German Speaking Countries of Europe-Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 1.

Author

Rauch B, Salzwedel A, Bjarnason-Wehrens B, Albus C, Meng K, Schmid JP, Benzer W, Hackbusch M, Jensen K, Schwaab B, Altenberger J, Benjamin N, Bestehorn K, Bongarth C, Dörr G, Eichler S, Einwang HP, Falk J, Glatz J, Gielen S, Grilli M, Grünig E, Guha M, Hermann M, Hoberg E, Höfer S, Kaemmerer H, Ladwig KH, Mayer-Berger W, Metzendorf MI, Nebel R, Neidenbach RC, Niebauer J, Nixdorff U, Oberhoffer R, Reibis R, Reiss N, Saure D, Schlitt A, Völler H, von Känel R, Weinbrenner S, Westphal R, and On Behalf Of The Cardiac Rehabilitation Guideline Group

Abstract

Background: Although cardiovascular rehabilitation (CR) is well accepted in general, CR-attendance and delivery still considerably vary between the European countries. Moreover, clinical and prognostic effects of CR are not well established for a variety of cardiovascular diseases., Methods: The guidelines address all aspects of CR including indications, contents and delivery. By processing the guidelines, every step was externally supervised and moderated by independent members of the " Association of the Scientific Medical Societies in Germany" (AWMF). Four meta-analyses were performed to evaluate the prognostic effect of CR after acute coronary syndrome (ACS), after coronary bypass grafting (CABG), in patients with severe chronic systolic heart failure (HFrEF), and to define the effect of psychological interventions during CR. All other indications for CR-delivery were based on a predefined semi-structured literature search and recommendations were established by a formal consenting process including all medical societies involved in guideline generation., Results: Multidisciplinary CR is associated with a significant reduction in all-cause mortality in patients after ACS and after CABG, whereas HFrEF-patients (left ventricular ejection fraction <40%) especially benefit in terms of exercise capacity and health-related quality of life. Patients with other cardiovascular diseases also benefit from CR-participation, but the scientific evidence is less clear. There is increasing evidence that the beneficial effect of CR strongly depends on "treatment intensity" including medical supervision, treatment of cardiovascular risk factors, information and education, and a minimum of individually adapted exercise volume. Additional psychologic interventions should be performed on the basis of individual needs., Conclusions: These guidelines reinforce the substantial benefit of CR in specific clinical indications, but also describe remaining deficits in CR-delivery in clinical practice as well as in CR-science with respect to methodology and presentation.

Published
2021
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26. [Meaningful diagnostics: imaging].

Author

Nixdorff U

Subjects
Bayes Theorem, Humans, Risk Assessment, Risk Factors, Atherosclerosis diagnostic imaging, Coronary Artery Disease diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging
Abstract

Imaging of subclinical atherosclerosis is an integrated component of a preventive medicine algorithm; i.e. on the basis of a cardiovascular risk stratification patients with a low and intermediate risk qualify for further imaging (cave: Bayes' theorem). Imaging procedures for subclinical atherosclerosis have one thing in common: atherosclerosis is detected and localized directly, for which cardiac multidetector computed tomography (MDCT; coronary calcium scoring, CACS) and vascular ultrasound (carotid and/or femoral arteries) are used to measure the plaque burden. The result is viewed as a risk modifier. The risk assessment is not related to symptoms. In addition to the detection and localization of atherosclerosis this also enables assessment of the "risk age" according to the tables of the European Society of Cardiology (ESC) and even the biological age, which can be estimated based on nomograms. This knowledge can be used to promote patient compliance and adherence to medication.

Published
2020
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