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A 50-year-old woman was admitted to our institute because of a large tumour in her neck. This patient had been diagnosed with thyroid goitre for 5 years, but no treatment was administered. No specific medical history was noted. A large mass in the neck region was found during clinical examination, which restricted neck movement. Computed tomography revealed a diffuse, large, multinodular goitre with tracheal compression. Results from the fine-needle aspiration procedure showed benign cytology. Laboratory tests revealed normal results, including serum thyroid-stimulating hormone, free triiodothyronine, and free thyroxine levels. The patient underwent surgery for the removal of the entire thyroid tumour. The patient's postoperative period was uneventful. The patient was discharged on the 5th postoperative day. In conclusion, surgical management remains the standard treatment for giant thyroid tumours with compressive symptoms. Careful dissection and awareness of the high risk of postoperative complications in these cases are crucial for achieving good outcomes.

Organic thermally activated delayed fluorescence (TADF) materials have been widely investigated due to their impressive electronic properties and applied potential for the third generation of organic light-emitting diodes (OLED). We present organic TADF material (4BGIPN) based on the strained benzoguanidine donor and compare it with the benchmark carbazole-based material (4CzIPN). Extended π-conjugation in 4BGIPN material results in yellow-green luminescence at 512 nm with a fast radiative rate of 5.5 × 10−5 s−1 and a photoluminescence quantum yield of 46% in methylcyclohexane solution. Such a nitrogen-rich 4BGIPN material has a significantly stabilized highest occupied molecular orbital (HOMO) at −6.4 eV while the lowest unoccupied molecular orbital (LUMO) at −4.0 eV, indicating potential suitability for application as the electron transport layer or TADF class III emitter in OLEDs.

The molecular design of metal-free organic phosphors is essential for realizing persistent room-temperature phosphorescence (pRTP) despite its spin-forbidden nature. A series of halobenzonitrile–carbazoles has been prepared following a one-pot nucleophilic substitution protocol involving commercially available and laboratory-synthesized carbazoles. We demonstrate how halo- and cyano-substituents affect the molecular geometry in the crystal lattice, resulting in tilt and/or twist of the carbazole with respect to the phenyl moiety. Compounds obtained from the commercially available carbazole result in efficient pRTP of organic phosphors with a high quantum yield of up to 22% and a long excited state lifetime of up to 0.22 s. Compounds obtained from the laboratory-synthesized carbazole exhibit thermally activated delayed fluorescence with an excited state lifetime in the millisecond range. In-depth photophysical studies reveal that luminescence originates from the mixed locally excited state (3LE, nπ*)/charge transfer state.

Sternal cleft is a rare congenital chest wall deformity, with a reported incidence of 1 in 100,000 live births, accounting for less than 1% of all chest wall deformities. Patients with sternal clefts can be asymptomatic; however, most cases have recurrent respiratory infections and cosmetic disfigurement. Therefore, surgical correction of this deformity is still necessary to address cosmetic issues, assuage parental concerns, and prevent repeated respiratory infections caused by paradoxical breathing patterns. Here, we report a case of complete sternal cleft associated with pectus excavatum that was successfully treated with sternal reconstruction and pectus bar insertion.

Gold-centered carbene–metal–amides (CMAs) containing cyclic (alkyl)(amino)carbenes (CAACs) are promising emitters for thermally activated delayed fluorescence (TADF). Aiming at the design and optimization of new TADF emitters, we report a density functional theory study of over 60 CMAs with various CAAC ligands, systematically evaluating computed parameters in relation to photoluminescence properties. The CMA structures were primarily selected based on experimental synthesis prospects. We demonstrate that TADF efficiency of the CMA materials originates from a compromise between oscillator strength coefficients and exchange energy (ΔEST). The latter is governed by the overlap of HOMO and LUMO orbitals, where HOMO is localized on the amide and LUMO over the Au–carbene bond. The S0 ground and excited T1 states of the CMAs adopt approximately coplanar geometry of carbene and amide ligands, but rotate perpendicular in the excited S1 states, resulting in degeneracy or near-degeneracy of S1 and T1, accompanied by a decrease in the S1-S0 oscillator strength from its maximum at coplanar geometries to near zero at rotated geometries. Based on the computations, promising new TADF emitters are proposed and synthesized. Bright CMA complex (Et2CAAC)Au(carbazolide) is obtained and fully characterized in order to demonstrate that excellent stability and high radiative rates up to 106 s−1 can be obtained for the gold–CMA complexes with small CAAC–carbene ligands.