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Objective: Prosopis juliflora, commonly known as algaroba or mesquite, was introduced and has since proliferated throughout the semi-arid region of the Caatinga biome. Various studies have documented its properties, including antimicrobial, antioxidant, and antitumor activities, attributed to the presence of diverse secondary metabolites such as alkaloids, terpenoids, tannins, and flavonoids. The objective of this study was to evaluate the antioxidant and antityrosinase activities of P. juliflora fruit extract as a multifunctional active ingredient, and to develop cosmetic formulations containing this vegetal extract for potential applications in skincare products targeting pro-ageing and skin colour homogenization properties., Methods: The extraction process followed established protocols. Chemical characterization of the extract involved quantification of total flavonoids and phenolic compounds, along with Liquid Chromatography-Mass Spectrometry (LC-MS) analysis. In vitro antioxidant activity was assessed using different methods. Antityrosinase activity was determined by employing enzymatic assays. Cosmetic formulations containing Disodium EDTA, Phenoxyethanol (and) Ethylhexyl Glycerin, Distilled Water, Sodium Acrylates Copolymer Lecithin, Polyacrylamide (and) C13-14 Isoparaffin (and) Laureth-7, and 3.0% of the investigated plant extract were subjected to preliminary and accelerated stability tests., Results: The extract demonstrated a concentration of total flavonoids (1.71 ± 0.26 μg EQ/mg) and exhibited concentrations of phenolic compounds at 0.21 ± 0.01 mg EAG/g. Metabolites such as flavonoids and saponins were annotated, as well as some of their respective glycosidic derivatives. The extract showed antioxidant potential and the ability to inhibit the oxidation cascade in both the initiation and propagation phases. Moreover, the extract exhibited noteworthy inhibition of antityrosinase activity, presenting 62.48 ± 2.09 at a concentration of 30.00 mg/mL. The formulations were stable in accelerated stability tests over a 60-day period., Conclusion: This research not only demonstrates scientifically by demonstrating the potential of a plant from the Caatinga biome with antioxidant and antityrosinase properties in the development of cosmetic products aimed at pro-ageing effects and skin colour harmonization, but also adds value to the P. juliflora production chain. This valorization encompasses various aspects which include environmental, social, and biodiversity responsibilities., (© 2024 Society of Cosmetic Scientists and Societe Francaise de Cosmetologie.)

Background: Brain death (BD) is defined as the total and irreversible cessation of brain functions including the brain stem. The team that assists the patient in this situation is made up of higher-level and technical health professionals. Our objective was to analyze the understanding of nursing assistants and technicians of BD., Methods: Descriptive and exploratory research with a qualitative approach was carried out with nursing assistants and technicians who were members of the Regional Nursing Council of São Paulo, Brazil. After collection, the data were submitted to the thematic-category content analysis technique., Results: From the analysis, the following categories emerged: an understanding of BD; religiosity and hope in the reversal of BD; and "brain death associated with the possibility of organ donation.", Conclusions: This study reinforces the need to train professionals at a technical nursing level on the subject in order to improve nursing care and avoid mistaken beliefs that can negatively influence the process of donating organs and tissues for transplantation., (Copyright © 2022 Elsevier Inc. All rights reserved.)

Rehabilitation with implant-supported prostheses has reached high success rates. However, mechanical failures are still reported, mainly in retention screws of abutments in single implant-supported crowns; which is designed to be the weakest structure and the first component to fail under overloading. In this sense, the aim of this in vitro study was to evaluate the influence of different joint designs (square or hexagonal) on resistance to deformation of driver-retention screw assembly of 3 commercial brands (Neodent, Singular, and Sin). A total of 42 retention screws from 3 commercial brands were used. The samples were divided into 2 joint groups, square (SQU) and hexagonal (HEX), and separated by commercial brands. Several components (implants and abutments) with standard platform (4.1 mm in diameter) were used. The resistance to deformation of the driver-retention screw assembly was measured using an accurate digital torque wrench for all commercial brands (Neodent [NEO], Singular [SGL], and Sin [SIN]) and joint designs (square or hexagonal). It was found no statistically significant difference (P <0.05) among the brands evaluated. On the other hand, square screws showed higher resistance to torsion than hexagonal screws; regardless the commercial brand.