Meat pork is a food rich in proteins and lipids that are highly susceptible to oxidation, which can compromise your nutritional and sensory characteristics. The recent advances in research point to an alternative to attenuate these undesirable effects with the use of dietary antioxidants. Among the natural antioxidants, lycopene is known to protect cells against damage caused by reactive oxygen species and prevents lipid peroxidation, in addition to exerting actions on the lipid components of the blood and the immune system. The objective of this work was to evaluate the levels of lycopene supplementation for barrows and gilts pigs, from 75 to 100 kg, on performance, carcass quantitative characteristics, meat quality, plasma biochemical parameters, gene expression of antioxidant enzymes and Immune responses. Eighty pigs were used, 40 barrows and 40 gilts, with a means initial weight of 75.04 ± 1.6 kg. In a 2 x 5 factorial scheme, two sexes (male and female) and five levels of lycopene (0, 12.5, 25.0, 37.5 and 50.0 mg/kg of diet) were additionally included in the model, the effect of the meat storage period (0, 24, 48 and 72 hours) for analyzes of the radical DPPH and TBARS of the longissimus lumborum muscle and, for the determination of IgG, the collection periods (0, 12 and 24 days). Data were submitted to analysis of variance at 5%, using the SAS computer program. No interactions (P>0.05) were observed between sex and levels lycopene to the performance variables. Sex influenced daily feed intake (P=0.001) and feed:gain ratio (P=0.001), being lower for gilts. The unfolding of the interaction between levels of lycopene and sex revealed a linear reduction in the gene expression of superoxide dismutase (SOD) enzymes (P=0.018) and catalase (P=0.001) in the liver for the gilts pigs. Gilts showed lower SOD gene expression (P=0.001) with 50.0 mg of lycopene supplementation and for catalase (P=0.001) and glutathione peroxidase (P=0.001) at levels of 0; 12.5 and 50.0mg of lycopene, in relation to barrows. Lipoprotein supplementation in the diet provided improvements in the lipid profile of the blood plasma, as the levels of dietary supplementation of lycopene increased, total cholesterol (P=0.001), LDL (P=0.001) and LDL:HDL ratio (P=0.001) reduced, and increased levels of HDL (P=0.001). Gilts presented higher plasma concentrations of urea (P=0.001) and triglycerides (P=0.001) and lower concentrations of HDL (P=0.001), LDL (P=0.001) and besides lower LDL:HDL ratio (P=0.001) in to relation barrows. There was a difference in sex for the quantitative characteristics of the carcass, in which the barrows had higher hot carcass yield (P=0.049), cold carcass yield (P=0.023), backfat thickness (P=0.001) and abdominal fat (P=0.001) higher Lean meat yield (P=0.001). Thawing loss reduced linearly (P=0.024) as a function levels of lycopene, reducing by up to 17.46% in relation to treatment without lycopene. The barrows had higher staining intensities for the variables a* (P=0.001) and b* (P=0.045), having a tendency to red and yellow. Interaction (P=0.006) was observed between storage periods and levels of lycopene in the diet for the longissimus lumborum muscle. Interaction (P=0.006) was observed between storage periods and levels of lycopene in the diet for lipid oxidation of the longissimus lumborum muscle. The unfolding revealed in a reduction of lipid oxidation as the dietary lycopene supplementation was increased in all evaluated periods (0, 24, 48 and 72 hours). Linear increase of the lipid oxidation was obtained with the increase the days of storage days for all lycopene levels evaluated (0, 12.5, 25.0, 37.5 and 50.0 mg/kg of diet). No interactions (P>0.05) were observed for the inhibition of the DPPH radical in the meat, however, the DPPH radical was influenced by the storage period and levels of lycopene supplementation in the diet. Inhibition of the DPPH radical in meat was reduced up until at 72h. Regarding the level of lycopene supplementation in the diet, there was an increase (P=0.001) in the capture of the DPPH radical by antioxidants in the meat. The lipid oxidation of the liver was reduced by the supplementation of lycopene in the diet of pigs, where at the level of 34.47 mg of lycopene/kg of diet, there was the lowest oxidation. The capture of the DPPH radical by antioxidants in the liver was increased (P=0.001), resulting in an increase of the antioxidant power exerted by the lycopene in the liver, due to the increase of the dietary supplementation of lycopene. The gilts showed lower concentration of malonaldehyde (P=0.001) and higher DPPH (P=0.001) radical capture by antioxidants, compared to barrows. The increase in the inclusion of lycopene in the diet of pigs increased (P = 0.012) the albumin in the plasma. As levels of lycopene increased in the diet, the lymphocyte concentration increased (P=0.045) in linear fashion. The neutrophil concentration and the neutrophil:lymphocyte ratio were influenced (P0,05) entre o sexo e os níveis de licopeno para as variáveis de desempenho. O sexo influenciou o consumo diário de ração (P=0,001) e a conversão alimentar (P=0,001), sendo inferior para as fêmeas. O desdobramento da interação entre os níveis de licopeno e o sexo, revelou uma redução linear na expressão gênica das enzimas superóxido dismutase (SOD) (P=0,018) e catalase (P=0,001), no fígado, para as fêmeas suínas. As fêmeas apresentaram menor expressão gênica da SOD (P=0,001) com 50,0 mg de suplementação de licopeno e para a catalase (P=0,001) e glutattiona peroxidase (P=0,001), nos níveis de 0; 12,5 e 50,0 mg de licopeno, em relação aos machos castrados. A suplementação de licopeno na dieta proporcionou melhorias no perfl lipídico do plasma sanguíneo, pois à medida que os níveis de suplementação dietética de licopeno aumentaram, o colesterol total (P=0,001), LDL (P=0,001) e a relação LDL:HDL (P=0,001) reduziram, e aumentaram os níveis de HDL (P=0,001). As fêmeas apresentaram maiores concentrações plasmáticas de ureia (P=0,001) e triglicerídeos (P=0,001) e menores concentrações de HDL (P=0,001), LDL (P=0,001), além de menor relação LDL:HDL (P=0,001) em relação aos machos castrados. Houve diferença quanto ao sexo para as características quantitativas da carcaça, em que os machos castrados apresentaram maior rendimento da carcaça quente (P=0,049), rendimento da carcaça refrigerada (P=0,023), espessura de toucinho (P=0,001) e gordura abdominal (P=0,001) e as fêmeas um maior rendimento de carne magra (P=0,001). A perda de líquido no descongelamento reduziu linearmente (P=0,024) em função dos níveis de licopeno, reduzindo em até 17,46% em relação ao tratamento sem licopeno. Os machos apresentaram maiores intensidades de coloração para as variáveis a* (P=0,001) e b* (P=0,045), tendo tendência ao vermelho e amarelo. Foi observada interação (P=0,006) entre os períodos de armazenamento e os níveis de licopeno na dieta para a oxidação lipídica do músculo longissimus lumborum. O desdobramento revelou em uma redução da oxidação lipídica à medida que aumentou-se a suplementação de licopeno na dieta, em todos os períodos avaliados (0, 24, 48 e 72 horas). Obteve-se um aumento linear da oxidação lipídica com o aumento dos dias de armazenamento, para todos os níveis de licopeno avaliados (0; 12,5; 25,0; 37,5 e 50,0 mg/kg de ração). Não foram observadas interações (P>0,05) para a inibição do radical DPPH na carne, no entanto, o radical DPPH foi influenciado pelo período de armazenamento e pelos níveis de suplementação de licopeno na dieta. A inibição do radical DPPH na carne foi reduzida até as 72 h. Com relação ao nível de suplementação de licopeno na dieta, houve um aumento (P=0,001) na captura do radical DPPH por antioxidantes na carne. A oxidação lipídica do fígado foi reduzida pela suplementação de licopeno na dieta de suínos, em que ao nível de 34,47 mg de licopeno/kg de ração houve a menor oxidação. A captura do radical DPPH por antioxidantes no fígado foi aumentada (P=0,001), resultando em um aumento do poder antioxidante exercido pelo licopeno no fígado, devido ao aumento da suplementação dietética de licopeno. As fêmeas apresentaram menor concentração de malonaldeído (P=0,001) e maior captura do radical DPPH (P=0,001) por antioxidantes, em relação aos machos castrados. O aumento da inclusão do licopeno na dieta de suínos aumentou a albumina no plasma (P=0,012). À medida que os níveis de licopeno aumentaram na dieta, a concentração de linfócitos aumentou (P=0,045) de forma linear. A concentração de neutrófilos e a relação neutrófilos:linfócitos foram influenciadas (P