1. Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans
- Author
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Tatiana Karla dos Santos Borges, Dragan Milenkovic, Artur J.M. Rosa, Ana Maria Costa, Lívia de Lacerda de Oliveira, Christine Morand, Isabella de Araújo Esteves Duarte, Universidade de Brasilia [Brasília] (UnB), Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California [Davis] (UC Davis), University of California (UC), EMBRAPA Cerrados (EMBRAPA CERRADOS), EMBRAPA Cerrados, National Council for Scientific and Technological Development (CNPq)CAPES 001, and University of California
- Subjects
0301 basic medicine ,Male ,medicine.medical_treatment ,Gene Expression ,phenolic compounds ,0302 clinical medicine ,Risk Factors ,Receptors ,2. Zero hunger ,Nutrition and Dietetics ,Passiflora ,Interleukin-17 ,Diabetes ,Interleukin ,Middle Aged ,3. Good health ,Fruit and Vegetable Juices ,Cholesterol ,Homeostatic model assessment ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,Adult ,medicine.medical_specialty ,insulin ,HDL ,lcsh:TX341-641 ,Inflammation ,Peripheral blood mononuclear cell ,Article ,03 medical and health sciences ,Immune system ,Insulin resistance ,Food Sciences ,nutrigenomics ,Clinical Research ,Internal medicine ,Passiflora setacea ,medicine ,Cell Adhesion ,Genetics ,Humans ,Receptors, Cytokine ,Cytokine ,Metabolic and endocrine ,Nutrition ,bioactive compounds ,business.industry ,Insulin ,Prevention ,Cholesterol, HDL ,Overweight ,medicine.disease ,cytokines ,cardiovascular diseases ,immune system ,030104 developmental biology ,Endocrinology ,Dietary Supplements ,gene expression ,Insulin Resistance ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,030217 neurology & neurosurgery ,Food Science ,Lipoprotein - Abstract
Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine&ndash, cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases.
- Published
- 2020
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