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6. Carbohydrate-Mediated Purification of Petrochemicals

Author

Holcroft, James M, Hartlieb, Karel J, Moghadam, Peyman Z, Bell, Jon G, Barin, Gokhan, Ferris, Daniel P, Bloch, Eric D, Algaradah, Mohammed M, Nassar, Majed S, Botros, Youssry Y, Thomas, K Mark, Long, Jeffrey R, Snurr, Randall Q, and Stoddart, J Fraser

Subjects
Chemical Sciences, General Chemistry
Abstract

Metal-organic frameworks (MOFs) are known to facilitate energy-efficient separations of important industrial chemical feedstocks. Here, we report how a class of green MOFs-namely CD-MOFs-exhibits high shape selectivity toward aromatic hydrocarbons. CD-MOFs, which consist of an extended porous network of γ-cyclodextrins (γ-CDs) and alkali metal cations, can separate a wide range of benzenoid compounds as a result of their relative orientation and packing within the transverse channels formed from linking (γ-CD)6 body-centered cuboids in three dimensions. Adsorption isotherms and liquid-phase chromatographic measurements indicate a retention order of ortho- > meta- > para-xylene. The persistence of this regioselectivity is also observed during the liquid-phase chromatography of the ethyltoluene and cymene regioisomers. In addition, molecular shape-sorting within CD-MOFs facilitates the separation of the industrially relevant BTEX (benzene, toluene, ethylbenzene, and xylene isomers) mixture. The high resolution and large separation factors exhibited by CD-MOFs for benzene and these alkylaromatics provide an efficient, reliable, and green alternative to current isolation protocols. Furthermore, the isolation of the regioisomers of (i) ethyltoluene and (ii) cymene, together with the purification of (iii) cumene from its major impurities (benzene, n-propylbenzene, and diisopropylbenzene) highlight the specificity of the shape selectivity exhibited by CD-MOFs. Grand canonical Monte Carlo simulations and single component static vapor adsorption isotherms and kinetics reveal the origin of the shape selectivity and provide insight into the capability of CD-MOFs to serve as versatile separation platforms derived from renewable sources.

Published
2015

9. Assessment of Proinflammatory Cytokines Among Patients with Middle East Respiratory Syndrome Coronavirus Infection

Author

Alhetheel, Abdulkarim F., primary, Albarrag, Ahmed M., additional, Shakoor, Zahid A., additional, Somily, Ali M., additional, Barry, Mazin A., additional, Altalhi, Haifa, additional, Bakhrebah, Muhammed A., additional, Nassar, Majed S., additional, Alfageeh, Mohamed B., additional, Assiri, Ayed, additional, Alfaraj, Sarah H., additional, and Memish, Ziad A., additional

Published
2023
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10. Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Author

Rabaan, Ali A., primary, AlSaihati, Hajir, additional, Bukhamsin, Rehab, additional, Bakhrebah, Muhammed A., additional, Nassar, Majed S., additional, Alsaleh, Abdulmonem A., additional, Alhashem, Yousef N., additional, Bukhamseen, Ammar Y., additional, Al-Ruhimy, Khalil, additional, Alotaibi, Mohammed, additional, Alsubki, Roua A., additional, Alahmed, Hejji E., additional, Al-Abdulhadi, Saleh, additional, Alhashem, Fatemah A., additional, Alqatari, Ahlam A., additional, Alsayyah, Ahmed, additional, Farahat, Ramadan Abdelmoez, additional, Abdulal, Rwaa H., additional, Al-Ahmed, Ali H., additional, Imran, Mohd., additional, and Mohapatra, Ranjan K., additional

Published
2023
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11. Developing Wolbachia-based disease interventions for an extreme environment

Author

Ross, Perran A., primary, Elfekih, Samia, additional, Collier, Sophie, additional, Klein, Melissa J., additional, Lee, Su Shyan, additional, Dunn, Michael, additional, Jackson, Sarah, additional, Zhang, Yexin, additional, Axford, Jason K., additional, Gu, Xinyue, additional, Home, Jessica L., additional, Nassar, Majed S., additional, Paradkar, Prasad N., additional, Tawfik, Essam A., additional, Jiggins, Francis M., additional, Almalik, Abdulaziz M., additional, Al-Fageeh, Mohamed B., additional, and Hoffmann, Ary A., additional

Published
2023
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12. Omics Approaches in Drug Development against Leishmaniasis: Current Scenario and Future Prospects

Author

Rabaan, Ali A., primary, Bakhrebah, Muhammed A., additional, Mohapatra, Ranjan K., additional, Farahat, Ramadan Abdelmoez, additional, Dhawan, Manish, additional, Alwarthan, Sara, additional, Aljeldah, Mohammed, additional, Al Shammari, Basim R., additional, Al-Najjar, Amal H., additional, Alhusayyen, Mona A., additional, Al-Absi, Ghadeer H., additional, Aldawood, Yahya, additional, Alsaleh, Abdulmonem A., additional, Alshamrani, Saleh A., additional, Almuthree, Souad A., additional, Alawfi, Abdulsalam, additional, Alshengeti, Amer, additional, Alwashmi, Ameen S. S., additional, Hajissa, Khalid, additional, and Nassar, Majed S., additional

Published
2022
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13. Mitochondrial DNA variation in Aedes aegypti(Diptera: Culicidae) mosquitoes from Jeddah, Saudi Arabia

Author

Thia, Joshua A, Endersby-Harshman, Nancy, Collier, Sophie, Nassar, Majed S, Tawfik, Essam A, Alfageeh, Mohamed B, Elfekih, Samia, and Hoffmann, Ary A

Abstract

Wolbachia(Hertig 1936) (Rickettsiales: Ehrlichiaceae) has emerged as a valuable biocontrol tool in the fight against dengue by suppressing the transmission of the virus through mosquitoes. Monitoring the dynamics of Wolbachiais crucial for evaluating the effectiveness of release programs. Mitochondrial (mtDNA) markers serve as important tools for molecular tracking of infected mitochondrial backgrounds over time but require an understanding of the variation in release sites. In this study, we investigated the mitochondrial lineages of Aedes aegypti(Linnaeus 1762) in Jeddah, Saudi Arabia, which is a prospective release site for the “wAlbBQ” Wolbachia-infected strain of this mosquito species. We employed a combination of comprehensive mitogenomic analysis (including all protein-coding genes) and mtDNA marker analysis (cox1and nad5) using data collected from Jeddah. We combined our mitogenome and mtDNA marker data with those from previous studies to place mitochondrial variation in Saudi Arabia into a broader global context. Our findings revealed the presence of 4 subclades that can be broadly categorized into 2 major mitochondrial lineages. Ae. aegyptimosquitoes from Jeddah belonged to both major lineages. Whilst mitogenomic data offered a higher resolution for distinguishing Jeddah mosquitoes from the wAlbBQstrain, the combination of cox1and nad5mtDNA markers alone proved to be sufficient. This study provides the first important characterization of Ae. aegyptimitochondrial lineages in Saudi Arabia and offers essential baseline information for planning future molecular monitoring efforts during the release of Wolbachia-infected mosquitoes.

Published
2024
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15. Reply to Zandi, M.; Soltani, S. Comment on “Alfassam et al. Development of a Colorimetric Tool for SARS-CoV-2 and Other Respiratory Viruses Detection Using Sialic Acid Fabricated Gold Nanoparticles. Pharmaceutics 2021, 13, 502”

Author

Alfassam, Haya A., primary, Nassar, Majed S., additional, Almusaynid, Manal M., additional, Khalifah, Bashayer A., additional, Alshahrani, Abdullah S., additional, Almughem, Fahad A., additional, Alshehri, Abdullah A., additional, Alawad, Majed O., additional, Massadeh, Salam, additional, Alaamery, Manal, additional, Aldeailej, Ibrahim M., additional, Alamri, Aref A., additional, Binjomah, Abdulwahab Z., additional, and Tawfik, Essam A., additional

Published
2022
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16. Developing Wolbachia-based disease interventions for an extreme environment

Author

Ross, Perran A., primary, Elfekih, Samia, additional, Collier, Sophie, additional, Klein, Melissa J., additional, Lee, Su Shyan, additional, Dunn, Michael, additional, Jackson, Sarah, additional, Zhang, Yexin, additional, Axford, Jason K., additional, Gu, Xinyue, additional, Nassar, Majed S., additional, Paradkar, Prasad N., additional, Tawfik, Essam A., additional, Jiggins, Francis M., additional, Almalik, Abdulaziz M., additional, Al-Fageeh, Mohamed B., additional, and Hoffmann, Ary A., additional

Published
2022
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17. Suspected Adenovirus Causing an Emerging HEPATITIS among Children below 10 Years: A Review

Author

Rabaan, Ali A., primary, Bakhrebah, Muhammed A., additional, Nassar, Majed S., additional, Natto, Zuhair S., additional, Al Mutair, Abbas, additional, Alhumaid, Saad, additional, Aljeldah, Mohammed, additional, Garout, Mohammed, additional, Alfouzan, Wadha A., additional, Alshahrani, Fatimah S., additional, Sulaiman, Tarek, additional, AlFonaisan, Meshal K., additional, Alfaresi, Mubarak, additional, Alshamrani, Saleh A., additional, Nainu, Firzan, additional, Yong, Shin Jie, additional, Choudhary, Om Prakash, additional, and Ahmed, Naveed, additional

Published
2022
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18. Omics Approaches in Drug Development against Leishmaniasis: Current Scenario and Future Prospects.

Author

Rabaan, Ali A., Bakhrebah, Muhammed A., Mohapatra, Ranjan K., Farahat, Ramadan Abdelmoez, Dhawan, Manish, Alwarthan, Sara, Aljeldah, Mohammed, Al Shammari, Basim R., Al-Najjar, Amal H., Alhusayyen, Mona A., Al-Absi, Ghadeer H., Aldawood, Yahya, Alsaleh, Abdulmonem A., Alshamrani, Saleh A., Almuthree, Souad A., Alawfi, Abdulsalam, Alshengeti, Amer, Alwashmi, Ameen S. S., Hajissa, Khalid, and Nassar, Majed S.

Subjects
LEISHMANIASIS, DRUG development, DRUG discovery, ZOONOSES, DRUG target, PHARMACOGENOMICS
Abstract

Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis are diagnosed across the globe, with a mortality rate of nearly seven percent. There are over 20 parasitic strains of Leishmania which are known to cause distinct types of leishmaniasis and pose an endemic threat to humans worldwide. Therefore, it is crucial to develop potential medications and vaccines to combat leishmaniasis. However, the task of developing therapeutic solutions is challenging due to Leishmania's digenetic lifecycle. The challenge is further intensified by cases of resistance against the available drugs. Owing to these challenges, the conventional drug development regimen is further limited by target discovery and ligand suitability for the targets. On the other hand, as an added advantage, the emergence of omics-based tools, such as high-end proteomics, transcriptomics and genomics, has hastened the pace of target discovery and target-based drug development. It is now becoming apparent that multi-omics convergence and an inter-connected systems approach is less time-consuming and more cost-effective for any drug-development process. This comprehensive review is an attempt to summarize the current knowledge on the muti-omics approach in drug development against leishmaniasis. In particular, it elaborates the potential target identification from secreted proteins in various stages of Leishmania infection and also illustrates the convergence of transcriptomic and genomic data towards the collective goal of drug discovery. This review also provides an understanding of the potential parasite's drug targets and drug resistance characteristics of the parasite, which can be used in designing effective and specific therapeutics. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Development of a Colorimetric Tool for SARS-CoV-2 and Other Respiratory Viruses Detection Using Sialic Acid Fabricated Gold Nanoparticles

Author

Alfassam, Haya A., primary, Nassar, Majed S., additional, Almusaynid, Manal M., additional, Khalifah, Bashayer A., additional, Alshahrani, Abdullah S., additional, Almughem, Fahad A., additional, Alshehri, Abdullah A., additional, Alawad, Majed O., additional, Massadeh, Salam, additional, Alaamery, Manal, additional, Aldeailej, Ibrahim M., additional, Alamri, Aref A., additional, Binjomah, Abdulwahab Z., additional, and Tawfik, Essam A., additional

Published
2021
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21. Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis

Author

Hosny, Khaled M., primary, Sindi, Amal M., additional, Alkhalidi, Hala M., additional, Kurakula, Mallesh, additional, Alruwaili, Nabil K., additional, Alhakamy, Nabil A., additional, Abualsunun, Walaa A., additional, Bakhaidar, Rana B., additional, Bahmdan, Rahaf H., additional, Rizg, Waleed Y., additional, Ali, Sarah A., additional, Abdulaal, Wesam H., additional, Nassar, Majed S., additional, Alsuabeyl, Mohammed S., additional, Alghaith, Adel F., additional, and Alshehri, Sultan, additional

Published
2021
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22. Promising Antibiofilm Agents: Recent Breakthrough against Biofilm Producing Methicillin-Resistant Staphylococcus aureus

Author

Abd El-Hamid, Marwa I., primary, Y. El-Naenaeey, El-sayed, additional, M kandeel, Toka, additional, Hegazy, Wael A. H., additional, Mosbah, Rasha A., additional, Nassar, Majed S., additional, Bakhrebah, Muhammed A., additional, Abdulaal, Wesam H., additional, Alhakamy, Nabil A., additional, and Bendary, Mahmoud M., additional

Published
2020
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27. Concurrent Covalent and Supramolecular Polymerization

Author

Hou, Xisen, primary, Ke, Chenfeng, additional, Zhou, Yu, additional, Xie, Zhuang, additional, Alngadh, Ahmed, additional, Keane, Denis T., additional, Nassar, Majed S., additional, Botros, Youssry Y., additional, Mirkin, Chad A., additional, and Stoddart, J. Fraser, additional

Published
2016
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28. CD-MOF: A Versatile Separation Medium

Author

Hartlieb, Karel J., primary, Holcroft, James M., additional, Moghadam, Peyman Z., additional, Vermeulen, Nicolaas A., additional, Algaradah, Mohammed M., additional, Nassar, Majed S., additional, Botros, Youssry Y., additional, Snurr, Randall Q., additional, and Stoddart, J. Fraser, additional

Published
2016
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29. Oligorotaxane Radicals under Orders

Author

Wang, Yuping, primary, Frasconi, Marco, additional, Liu, Wei-Guang, additional, Sun, Junling, additional, Wu, Yilei, additional, Nassar, Majed S., additional, Botros, Youssry Y., additional, Goddard, William A., additional, Wasielewski, Michael R., additional, and Stoddart, J. Fraser, additional

Published
2016
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31. Lithium-Ion Batteries: A Rigid Naphthalenediimide Triangle for Organic Rechargeable Lithium-Ion Batteries (Adv. Mater. 18/2015)

Author

Chen, Dongyang, primary, Avestro, Alyssa-Jennifer, additional, Chen, Zonghai, additional, Sun, Junling, additional, Wang, Shuanjin, additional, Xiao, Min, additional, Erno, Zach, additional, Algaradah, Mohammed M., additional, Nassar, Majed S., additional, Amine, Khalil, additional, Meng, Yuezhong, additional, and Stoddart, J. Fraser, additional

Published
2015
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36. Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Author

Fernando, Isurika R., primary, Ferris, Daniel P., additional, Frasconi, Marco, additional, Malin, Dmitry, additional, Strekalova, Elena, additional, Yilmaz, M. Deniz, additional, Ambrogio, Michael W., additional, Algaradah, Mohammed M., additional, Hong, Michael P., additional, Chen, Xinqi, additional, Nassar, Majed S., additional, Botros, Youssry Y., additional, Cryns, Vincent L., additional, and Stoddart, J. Fraser, additional

Published
2015
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39. Genomic Sequencing and Analysis of Eight Camel-Derived Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Isolates in Saudi Arabia.

Author

Al-Shomrani, Badr M., Manee, Manee M., Alharbi, Sultan N., Altammami, Mussad A., Alshehri, Manal A., Nassar, Majed S., Bakhrebah, Muhammed A., and Al-Fageeh, Mohamed B.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia. The dromedary camel is considered a possible host of the virus and also to act as a reservoir, transmitting the virus to humans. Here, we studied evolutionary relationships for 31 complete genomes of betacoronaviruses, including eight newly sequenced MERS-CoV genomes isolated from dromedary camels in Saudi Arabia. Through bioinformatics tools, we also used available sequences and 3D structure of MERS-CoV spike glycoprotein to predict MERS-CoV epitopes and assess antibody binding affinity. Phylogenetic analysis showed the eight new sequences have close relationships with existing strains detected in camels and humans in Arabian Gulf countries. The 2019-nCov strain appears to have higher homology to both bat coronavirus and SARS-CoV than to MERS-CoV strains. The spike protein tree exhibited clustering of MERS-CoV sequences similar to the complete genome tree, except for one sequence from Qatar (KF961222). B cell epitope analysis determined that the MERS-CoV spike protein has 24 total discontinuous regions from which just six epitopes were selected with score values of >80%. Our results suggest that the virus circulates by way of camels crossing the borders of Arabian Gulf countries. This study contributes to finding more effective vaccines in order to provide long-term protection against MERS-CoV and identifying neutralizing antibodies. [ABSTRACT FROM AUTHOR]

Published
2020
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40. Mitochondrial DNA variation in Aedes aegypti (Diptera: Culicidae) mosquitoes from Jeddah, Saudi Arabia.

Author

Thia JA, Endersby-Harshman N, Collier S, Nassar MS, Tawfik EA, Alfageeh MB, Elfekih S, and Hoffmann AA

Subjects
Animals, Saudi Arabia, Prospective Studies, Mutation, DNA, Mitochondrial, Mosquito Vectors genetics, Aedes, Wolbachia genetics
Abstract

Wolbachia (Hertig 1936) (Rickettsiales: Ehrlichiaceae) has emerged as a valuable biocontrol tool in the fight against dengue by suppressing the transmission of the virus through mosquitoes. Monitoring the dynamics of Wolbachia is crucial for evaluating the effectiveness of release programs. Mitochondrial (mtDNA) markers serve as important tools for molecular tracking of infected mitochondrial backgrounds over time but require an understanding of the variation in release sites. In this study, we investigated the mitochondrial lineages of Aedes aegypti (Linnaeus 1762) in Jeddah, Saudi Arabia, which is a prospective release site for the "wAlbBQ" Wolbachia-infected strain of this mosquito species. We employed a combination of comprehensive mitogenomic analysis (including all protein-coding genes) and mtDNA marker analysis (cox1 and nad5) using data collected from Jeddah. We combined our mitogenome and mtDNA marker data with those from previous studies to place mitochondrial variation in Saudi Arabia into a broader global context. Our findings revealed the presence of 4 subclades that can be broadly categorized into 2 major mitochondrial lineages. Ae. aegypti mosquitoes from Jeddah belonged to both major lineages. Whilst mitogenomic data offered a higher resolution for distinguishing Jeddah mosquitoes from the wAlbBQ strain, the combination of cox1 and nad5 mtDNA markers alone proved to be sufficient. This study provides the first important characterization of Ae. aegypti mitochondrial lineages in Saudi Arabia and offers essential baseline information for planning future molecular monitoring efforts during the release of Wolbachia-infected mosquitoes., (© The Author(s) 2023. Published by Oxford University Press on behalf of Entomological Society of America.)

Published
2024
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41. Insights from the molecular docking analysis of SGLT2 and FIMH to combat uropathogenicity.

Author

Abdulaal WH, Bakhrebah MA, Nassar MS, Almazni IA, Almutairi WA, Natto ZS, and Khattab AK

Abstract

SGLT2 inhibitors are a novel class of FDA approved anti-diabetes drugs. They act by blocking the SGLT2 protein, which prevents glucose reabsorption, leading in enhance glucose excretion and lower blood glucose levels. In diabetic patients, SGLT2 inhibitors have been linked to urinary tract infections (UTIs). Therefore, the development of novel SGLT2 inhibitors with no adverse effects is a need of time. With this purpose, in this study, 48164natural compounds from ZINC database were screened targeting both the SGLT2 and FimH protein using insilico approaches. FimH has been discovered as a promising target for preventing and treating UTIs. The hit compounds ZINC69481892, ZINC1612996, and ZINC4039265 exhibited strong binding with both SGLT2 and FimH with binding energies values of -9.88, -8.96, and -10.57 kcal/mol for SGLT2, and -7.86, -7.01, and -8.92 kcal/mol for FimH, which is higher than that of controls (-6.78 kcal/mol (Empaglifozolin for SGLT2) and -5.14 kcal/mol (Heptyl α-d-mannopyranoside for FimH)). Hits were found to bind with key residues of both SGLT2 and FimH protein. In addition, physiochemical properties showed that these compounds have good drug-likeness properties. Therefore, we anticipate that if these compounds are investigated further, might be potential SGLT2 inhibitors with less uropathogenic adverse effects., Competing Interests: There are no conflicts of interest., (© 2022 Biomedical Informatics.)

Published
2022
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42. Concurrent Covalent and Supramolecular Polymerization.

Author

Hou X, Ke C, Zhou Y, Xie Z, Alngadh A, Keane DT, Nassar MS, Botros YY, Mirkin CA, and Stoddart JF

Abstract

Covalent and supramolecular polymerizations, both of which offer their own unique advantages, have emerged as popular strategies for making artificial materials. Herein, we describe a concurrent covalent and supramolecular polymerization strategy-namely, one which utilizes 1) a bis-azide-functionalized diazaperopyrenium dication that undergoes polymeriation covalently with a bis-alkyne-functionalized biphenyl derivative in one dimension as a result of a rapid and efficient β-cyclodextrin(CD)-accelerated, cucurbit[6]uril(CB)-templated azide-alkyne cycloaddition, while 2) the aromatic core of the dication is able to dimerize in a criss-cross fashion by dint of π-π interactions, enabling simultaneous supramolecular assembly, resulting in an extended polymer network in an orthogonal dimension., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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