1. Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- Author
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Kwang Ho Kim, Nara Moon, Ryung-Ah Lee, Kyung Sook Hong, Hee Jung Yi, and Soon Sup Chung
- Subjects
medicine.medical_specialty ,Colorectal cancer ,5-Fluorouracil ,medicine.medical_treatment ,Encephalopathy ,Case Report ,Neutropenia ,Gastroenterology ,03 medical and health sciences ,Folinic acid ,0302 clinical medicine ,Internal medicine ,medicine ,Hyperammonemia ,Colorectal neoplasma ,Chemotherapy ,Metabolic brain diseases ,business.industry ,medicine.disease ,Surgery ,Oxaliplatin ,Fluorouracil ,030220 oncology & carcinogenesis ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
- Published
- 2016
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