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Abstract Background Patients with Type 2 diabetes mellitus (T2DM) have decreased bone health. We aimed to investigate serum levels of bone turnover markers (BTMs) (markers of bone formation and bone resorption) and bone mineral density (BMD) at three sites (lumber, neck femur, and total femur) in middle-aged men with type 2 diabetes and to analyze the relationship between them. Also to evaluate serum osteoglycin as a novel marker and its relation to BTMs, BMD, and diabetic status. Methods We recruited seventy-eight patients with T2DM and thirteen non-diabetic, male volunteers as a control group. BMD was measured using a DEXA scan. BTMs (carboxy-terminal crosslinking telopeptide of type 1 collagen [CTX] and procollagen type 1 N propeptide [P1NP]), osteoglycin, PTH, and vitamin D were estimated. Data was compared among subjects and statistical analysis was performed. Results Most of the patients were having normal BMD with no significant difference between patients and the controls. BTMs and osteoglycin were significantly higher and vitamin D was significantly lower in the diabetic patients. Serum osteoglycin was positively correlated with DEXA Neck Femur (r = 0.233; p-value

Detection of recurrence of breast cancer after conserving breast surgery and radiotherapy still represents a challenge because of changes in breast tissue after treatment. The aim was to assess the value of Multislice CT mammography in the detection of recurrent breast cancer in patients with previous conservative surgery and radiotherapy. Subject and Methods: The study included 126 consecutive patients with breast cancer treated with conservative surgery and radiotherapy. CTM scans were evaluated by morphological and dynamic characteristics. CTM diagnosis was compared with histology results. Results: MD-CTM findings were compared with histology in 126 patients. CT mammography (CTM) showed 80% sensitivity, 99% specificity, 97% positive predictive value and 92% negative predictive value for detection of recurrence on the surgical.