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1. Whole blood transcriptomics identifies subclasses of pediatric septic shock.

Author

Yang, Jamie, Zinter, Matt, Pellegrini, Matteo, Wong, Man, Gala, Kinisha, Markovic, Daniela, Nadel, Brian, Peng, Kerui, Do, Nguyen, Mangul, Serghei, Nadkarni, Vinay, Karlsberg, Aaron, Deshpande, Dhrithi, Butte, Manish, Asaro, Lisa, Agus, Michael, and Sapru, Anil

Subjects
Adaptive immunity, Gene expression, RNA-Seq, Sepsis, Subclassification, Child, Humans, Shock, Septic, Prospective Studies, Gene Expression Profiling, Sepsis, Transcriptome
Abstract

BACKGROUND: Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically homogenous subgroups of patients with septic shock and critical illnesses. Transcriptomic analysis can identify subclasses derived from differences in underlying pathophysiological processes that may provide the basis for new targeted therapies. The goal of this study was to elucidate pathophysiological pathways and identify pediatric septic shock subclasses based on whole blood RNA expression profiles. METHODS: The subjects were critically ill children with cardiopulmonary failure who were a part of a prospective randomized insulin titration trial to treat hyperglycemia. Genome-wide expression profiling was conducted using RNA sequencing from whole blood samples obtained from 46 children with septic shock and 52 mechanically ventilated noninfected controls without shock. Patients with septic shock were allocated to subclasses based on hierarchical clustering of gene expression profiles, and we then compared clinical characteristics, plasma inflammatory markers, cell compositions using GEDIT, and immune repertoires using Imrep between the two subclasses. RESULTS: Patients with septic shock depicted alterations in innate and adaptive immune pathways. Among patients with septic shock, we identified two subtypes based on gene expression patterns. Compared with Subclass 2, Subclass 1 was characterized by upregulation of innate immunity pathways and downregulation of adaptive immunity pathways. Subclass 1 had significantly worse clinical outcomes despite the two classes having similar illness severity on initial clinical presentation. Subclass 1 had elevated levels of plasma inflammatory cytokines and endothelial injury biomarkers and demonstrated decreased percentages of CD4 T cells and B cells and less diverse T cell receptor repertoires. CONCLUSIONS: Two subclasses of pediatric septic shock patients were discovered through genome-wide expression profiling based on whole blood RNA sequencing with major biological and clinical differences. Trial Registration This is a secondary analysis of data generated as part of the observational CAF-PINT ancillary of the HALF-PINT study (NCT01565941). Registered March 29, 2012.

Published
2023

2. Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study.

Author

Gardner, Monique, Hehir, David, Reeder, Ron, Ahmed, Tageldin, Bell, Michael, Berg, Robert, Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph, Carpenter, Todd, Dean, J, Diddle, J, Federman, Myke, Fernandez, Richard, Fink, Ericka, Franzon, Deborah, Frazier, Aisha, Friess, Stuart, Graham, Kathryn, Hall, Mark, Harding, Monica, Horvat, Christopher, Huard, Leanna, Maa, Tensing, Manga, Arushi, McQuillen, Patrick, Meert, Kathleen, Morgan, Ryan, Mourani, Peter, Nadkarni, Vinay, Naim, Maryam, Notterman, Daniel, Pollack, Murray, Sapru, Anil, Schneiter, Carleen, Sharron, Matthew, Srivastava, Neeraj, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather, Yates, Andrew, Zuppa, Athena, Sutton, Robert, and Topjian, Alexis

Subjects
Blood pressure, Cardiopulmonary resuscitation, Hypotension, Infant, Neonatal, Outcomes, Pediatric, Post-cardiac arrest, Child, Humans, Blood Pressure, Heart Arrest, Cardiopulmonary Resuscitation, Hypotension, Hospital Mortality, Intensive Care Units
Abstract

INTRODUCTION: Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage prospectively collected BP data to explore the association of post-arrest BP thresholds with outcomes. We hypothesized that post-arrest systolic and diastolic BP thresholds would be higher than the currently recommended post-cardiopulmonary resuscitation BP targets and would be associated with higher rates of survival to hospital discharge. METHODS: We performed a secondary analysis of prospectively collected BP data from the first 24 h following return of circulation from index IHCA events enrolled in the ICU-RESUScitation trial (NCT02837497). The lowest documented systolic BP (SBP) and diastolic BP (DBP) were percentile-adjusted for age, height and sex. Receiver operator characteristic curves and cubic spline analyses controlling for illness category and presence of pre-arrest hypotension were generated exploring the association of lowest post-arrest SBP and DBP with survival to hospital discharge and survival to hospital discharge with favorable neurologic outcome (Pediatric Cerebral Performance Category of 1-3 or no change from baseline). Optimal cutoffs for post-arrest BP thresholds were based on analysis of receiver operator characteristic curves and spline curves. Logistic regression models accounting for illness category and pre-arrest hypotension examined the associations of these thresholds with outcomes. RESULTS: Among 693 index events with 0-6 h post-arrest BP data, identified thresholds were: SBP > 10th percentile and DBP > 50th percentile for age, sex and height. Fifty-one percent (n = 352) of subjects had lowest SBP above threshold and 50% (n = 346) had lowest DBP above threshold. SBP and DBP above thresholds were each associated with survival to hospital discharge (SBP: aRR 1.21 [95% CI 1.10, 1.33]; DBP: aRR 1.23 [1.12, 1.34]) and survival to hospital discharge with favorable neurologic outcome (SBP: aRR 1.22 [1.10, 1.35]; DBP: aRR 1.27 [1.15, 1.40]) (all p  10th percentile for age and DBP > 50th percentile for age during the first 6 h post-arrest.

Published
2023

3. Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial.

Author

Morgan, Ryan, Reeder, Ron, Ahmed, Tageldin, Bell, Michael, Berger, John, Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph, Carpenter, Todd, Dean, J, Diddle, J, Federman, Myke, Fernandez, Richard, Fink, Ericka, Franzon, Deborah, Frazier, Aisha, Friess, Stuart, Graham, Kathryn, Hall, Mark, Hehir, David, Himebauch, Adam, Horvat, Christopher, Huard, Leanna, Maa, Tensing, Manga, Arushi, McQuillen, Patrick, Meert, Kathleen, Mourani, Peter, Nadkarni, Vinay, Naim, Maryam, Notterman, Daniel, Page, Kent, Pollack, Murray, Sapru, Anil, Schneiter, Carleen, Sharron, Matthew, Srivastava, Neeraj, Tabbutt, Sarah, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather, Yates, Andrew, Zuppa, Athena, Berg, Robert, and Sutton, Robert

Subjects
Blood pressure, Cardiac arrest, Cardiopulmonary resuscitation, Pediatrics, Pulmonary hypertension, Child, Humans, Cardiopulmonary Resuscitation, Heart Arrest, Hypertension, Pulmonary, Intensive Care Units, Prospective Studies
Abstract

BACKGROUND: Previous studies have identified pulmonary hypertension (PH) as a relatively common diagnosis in children with in-hospital cardiac arrest (IHCA), and preclinical laboratory studies have found poor outcomes and low systemic blood pressures during CPR for PH-associated cardiac arrest. The objective of this study was to determine the prevalence of PH among children with IHCA and the association between PH diagnosis and intra-arrest physiology and survival outcomes. METHODS: This was a prospectively designed secondary analysis of patients enrolled in the ICU-RESUS clinical trial (NCT02837497). The primary exposure was a pre-arrest diagnosis of PH. The primary survival outcome was survival to hospital discharge with favorable neurologic outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged from baseline). The primary physiologic outcome was event-level average diastolic blood pressure (DBP) during CPR. RESULTS: Of 1276 patients with IHCAs during the study period, 1129 index IHCAs were enrolled; 184 (16.3%) had PH and 101/184 (54.9%) were receiving inhaled nitric oxide at the time of IHCA. Survival with favorable neurologic outcome was similar between patients with and without PH on univariate (48.9% vs. 54.4%; p = 0.17) and multivariate analyses (aOR 0.82 [95%CI: 0.56, 1.20]; p = 0.32). There were no significant differences in CPR event outcome or survival to hospital discharge. Average DBP, systolic BP, and end-tidal carbon dioxide during CPR were similar between groups. CONCLUSIONS: In this prospective study of pediatric IHCA, pre-existing PH was present in 16% of children. Pre-arrest PH diagnosis was not associated with statistically significant differences in survival outcomes or intra-arrest physiologic measures.

Published
2023

4. Ketamine Use in the Intubation of Critically Ill Children with Neurological Indications: A Multicenter Retrospective Analysis

Author

Loi, Mervin V., Lee, Jan Hau, Huh, Jimmy W., Mallory, Palen, Napolitano, Natalie, Shults, Justine, Krawiec, Conrad, Shenoi, Asha, Polikoff, Lee, Al-Subu, Awni, Sanders, Jr, Ronald, Toal, Megan, Branca, Aline, Glater-Welt, Lily, Ducharme-Crevier, Laurence, Breuer, Ryan, Parsons, Simon, Harwayne-Gidansky, Ilana, Kelly, Serena, Motomura, Makoto, Gladen, Kelsey, Pinto, Matthew, Giuliano, Jr, John, Bysani, Gokul, Berkenbosch, John, Biagas, Katherine, Rehder, Kyle, Kasagi, Mioko, Lee, Anthony, Jung, Philipp, Shetty, Rakshay, Nadkarni, Vinay, and Nishisaki, Akira

Published
2024
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5. Calcium use during paediatric in-hospital cardiac arrest is associated with worse outcomes.

Author

Cashen, Katherine, Sutton, Robert, Reeder, Ron, Ahmed, Tageldin, Bell, Michael, Berg, Robert, Burns, Candice, Carcillo, Joseph, Carpenter, Todd, Michael Dean, J, Wesley Diddle, J, Federman, Myke, Fink, Ericka, Franzon, Deborah, Frazier, Aisha, Friess, Stuart, Graham, Kathryn, Hall, Mark, Hehir, David, Horvat, Christopher, Huard, Leanna, KirkpatrickN, Theresa, Maa, Tensing, Manga, Arushi, Morgan, Ryan, Mourani, Peter, Nadkarni, Vinay, Naim, Maryam, Notterman, Daniel, Page, Kent, Pollack, Murray, Qunibi, Danna, Sapru, Anil, Schneiter, Carleen, Sharron, Matthew, Srivastava, Neeraj, Viteri, Shirley, Wessel, David, Wolfe, Heather, Yates, Andrew, Zuppa, Athena, Meert, Kathleen, and Mcquillen, Patrick

Subjects
Calcium, Cardiac arrest, Cardiopulmonary resuscitation, Child, Infant, Neonate, Child, Infant, Newborn, Humans, Infant, Cardiopulmonary Resuscitation, Calcium, Heart Arrest, Patient Discharge, Hospitals, Pediatric, Retrospective Studies
Abstract

AIM: To evaluate associations between calcium administration and outcomes among children with in-hospital cardiac arrest and among specific subgroups in which calcium use is hypothesized to provide clinical benefit. METHODS: This is a secondary analysis of observational data collected prospectively as part of the ICU-RESUScitation project. Children 37 weeks post-conceptual age to 18 years who received chest compressions in one of 18 intensive care units from October 2016-March 2021 were eligible. Data included child and event characteristics, pre-arrest laboratory values, pre- and intra-arrest haemodynamics, and outcomes. Outcomes included sustained return of spontaneous circulation (ROSC), survival to hospital discharge, and survival to hospital discharge with favourable neurologic outcome. A propensity score weighted cohort was used to evaluate associations between calcium use and outcomes. Subgroups included neonates, and children with hyperkalaemia, sepsis, renal insufficiency, cardiac surgery with cardiopulmonary bypass, and calcium-avid cardiac diagnoses. RESULTS: Of 1,100 in-hospital cardiac arrests, median age was 0.63 years (IQR 0.19, 3.81); 450 (41%) received calcium. Among the weighted cohort, calcium use was not associated with sustained ROSC (aOR, 0.87; CI95 0.61-1.24; p = 0.445), but was associated with lower rates of both survival to hospital discharge (aOR, 0.68; CI95 0.52-0.89; p = 0.005) and survival with favourable neurologic outcome at hospital discharge (aOR, 0.75; CI95 0.57-0.98; p = 0.038). Among subgroups, calcium use was associated with lower rates of survival to hospital discharge in children with sepsis and renal insufficiency. CONCLUSIONS: Calcium use was common during paediatric in-hospital cardiac arrest and associated with worse outcomes at hospital discharge.

Published
2023

6. Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).

Author

Emeriaud, Guillaume, López-Fernández, Yolanda, Iyer, Narayan, Bembea, Melania, Agulnik, Asya, Barbaro, Ryan, Baudin, Florent, Bhalla, Anoopindar, Brunow de Carvalho, Werther, Carroll, Christopher, Cheifetz, Ira, Chisti, Mohammod, Cruces, Pablo, Curley, Martha, Dahmer, Mary, Dalton, Heidi, Erickson, Simon, Essouri, Sandrine, Fernández, Analía, Flori, Heidi, Grunwell, Jocelyn, Jouvet, Philippe, Killien, Elizabeth, Kneyber, Martin, Kudchadkar, Sapna, Korang, Steven, Lee, Jan, Macrae, Duncan, Maddux, Aline, Modesto I Alapont, Vicent, Morrow, Brenda, Nadkarni, Vinay, Napolitano, Natalie, Newth, Christopher, Pons-Odena, Martí, Quasney, Michael, Rajapreyar, Prakadeshwari, Rambaud, Jerome, Randolph, Adrienne, Rimensberger, Peter, Rowan, Courtney, Sanchez-Pinto, L, Sapru, Anil, Sauthier, Michael, Shein, Steve, Smith, Lincoln, Steffen, Katerine, Takeuchi, Muneyuki, Thomas, Neal, Tse, Sze, Valentine, Stacey, Ward, Shan, Watson, R, Yehya, Nadir, Zimmerman, Jerry, and Khemani, Robinder

Subjects
Child, Humans, Respiratory Distress Syndrome, Respiration, Artificial, Acute Lung Injury, Consensus
Abstract

OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science. SETTING: Not applicable. PATIENTS: Patients with or at risk for PARDS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%. CONCLUSIONS: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.

Published
2023

7. Epinephrine Dosing Intervals Are Associated With Pediatric In-Hospital Cardiac Arrest Outcomes: A Multicenter Study

Author

Kienzle, Martha F., Morgan, Ryan W., Reeder, Ron W., Ahmed, Tageldin, Berg, Robert A., Bishop, Robert, Bochkoris, Matthew, Carcillo, Joseph A., Carpenter, Todd C., Cooper, Kellimarie K., Diddle, J. Wesley, Federman, Myke, Fernandez, Richard, Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Frizzola, Meg, Graham, Kathryn, Hall, Mark, Horvat, Christopher, Huard, Leanna L., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Meert, Kathleen L., Mourani, Peter M., Nadkarni, Vinay M., Naim, Maryam Y., Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Tabbutt, Sarah, Viteri, Shirley, Wolfe, Heather A., Sutton, Robert M., Bell, Michael J., Burns, Candice, Dean, J. Michael, Fink, Ericka L., Hehir, David, Landis, William P., Notterman, Daniel, Palmer, Chella A., Siems, Ashley, Srivastava, Neeraj, Tilford, Bradley, Wessel, David, Yates, Andrew R., and Zuppa, Athena F.

Published
2024
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9. Diastolic Blood Pressure Threshold During Pediatric Cardiopulmonary Resuscitation and Survival Outcomes: A Multicenter Validation Study.

Author

Berg, Robert, Morgan, Ryan, Reeder, Ron, Ahmed, Tageldin, Bell, Michael, Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph, Carpenter, Todd, Dean, J, Diddle, J, Federman, Myke, Fernandez, Richard, Fink, Ericka, Franzon, Deborah, Frazier, Aisha, Friess, Stuart, Graham, Kathryn, Hall, Mark, Hehir, David, Horvat, Christopher, Maa, Tensing, Manga, Arushi, McQuillen, Patrick, Meert, Kathleen, Mourani, Peter, Nadkarni, Vinay, Naim, Maryam, Notterman, Daniel, Palmer, Chella, Pollack, Murray, Sapru, Anil, Schneiter, Carleen, Sharron, Matthew, Srivastava, Neeraj, Tabbutt, Sarah, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather, Yates, Andrew, Zuppa, Athena, Sutton, Robert, and Huard, Leanna

Subjects
Infant, Child, Humans, Adolescent, Prospective Studies, Blood Pressure, Cardiopulmonary Resuscitation, Heart Arrest, Patient Discharge
Abstract

OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and greater than 30 mm Hg in children greater than 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge in one prospective study. We sought to validate these potential hemodynamic targets in a larger multicenter cohort. DESIGN: Prospective observational study. SETTING: Eighteen PICUs in the ICU-RESUScitation prospective trial from October 2016 to March 2020. PATIENTS: Children less than or equal to 18 years old with CPR greater than 30 seconds and invasive blood pressure (BP) monitoring during CPR. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Invasive BP waveform data and Utstein-style CPR data were collected, including prearrest patient characteristics, intra-arrest interventions, and outcomes. Primary outcome was survival to hospital discharge, and secondary outcomes were return of spontaneous circulation (ROSC) and survival to hospital discharge with favorable neurologic outcome. Multivariable Poisson regression models with robust error estimates evaluated the association of DBP greater than 25 mm Hg in infants and greater than 30 mm Hg in older children with these outcomes. Among 1,129 children with inhospital cardiac arrests, 413 had evaluable DBP data. Overall, 85.5% of the patients attained thresholds of mean DBP greater than or equal to 25 mm Hg in infants and greater than or equal to 30 mm Hg in older children. Initial return of circulation occurred in 91.5% and 25% by placement on extracorporeal membrane oxygenator. Survival to hospital discharge occurred in 58.6%, and survival with favorable neurologic outcome in 55.4% (i.e. 94.6% of survivors had favorable neurologic outcomes). Mean DBP greater than 25 mm Hg for infants and greater than 30 mm Hg for older children was significantly associated with survival to discharge (adjusted relative risk [aRR], 1.32; 1.01-1.74; p = 0.03) and ROSC (aRR, 1.49; 1.12-1.97; p = 0.002) but did not reach significance for survival to hospital discharge with favorable neurologic outcome (aRR, 1.30; 0.98-1.72; p = 0.051). CONCLUSIONS: These validation data demonstrate that achieving mean DBP during CPR greater than 25 mm Hg for infants and greater than 30 mm Hg for older children is associated with higher rates of survival to hospital discharge, providing potential targets for DBP during CPR.

Published
2023

10. The Temporal Association of the COVID-19 Pandemic and Pediatric Cardiopulmonary Resuscitation Quality and Outcomes.

Author

Morgan, Ryan W, Wolfe, Heather A, Reeder, Ron W, Alvey, Jessica S, Frazier, Aisha H, Friess, Stuart H, Maa, Tensing, McQuillen, Patrick S, Meert, Kathleen L, Nadkarni, Vinay M, Sharron, Matthew P, Siems, Ashley, Yates, Andrew R, Ahmed, Tageldin, Bell, Michael J, Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A, Carpenter, Todd C, Dean, J Michael, Diddle, J Wesley, Federman, Myke, Fernandez, Richard, Fink, Ericka L, Franzon, Deborah, Hall, Mark, Hehir, David, Horvat, Christopher M, Huard, Leanna L, Manga, Arushi, Mourani, Peter M, Naim, Maryam Y, Notterman, Daniel, Pollack, Murray M, Sapru, Anil, Schneiter, Carleen, Srivastava, Nerraj, Tabbutt, Sarah, Tilford, Bradley, Viteri, Shirley, Wessel, David, Zuppa, Athena F, Berg, Robert A, and Sutton, Robert M

Subjects
Humans, Heart Arrest, Cardiopulmonary Resuscitation, Retrospective Studies, Prospective Studies, Child, Pandemics, COVID-19, Cardiovascular, Clinical Research, Pediatric, Rehabilitation, Good Health and Well Being, cardiac arrest, cardiopulmonary resuscitation, pediatrics, Nursing, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectivesThe COVID-19 pandemic resulted in adaptations to pediatric resuscitation systems of care. The objective of this study was to determine the temporal association between the pandemic and pediatric in-hospital cardiac arrest (IHCA) process of care metrics, cardiopulmonary resuscitation (cardiopulmonary resuscitation) quality, and patient outcomes.DesignMulticenter retrospective analysis of a dataset comprising observations of IHCA outcomes pre pandemic (March 1, 2019 to February 29, 2020) versus pandemic (March 1, 2020 to February 28, 2021).SettingData source was the ICU-RESUScitation Project ("ICU-RESUS;" NCT028374497), a prospective, multicenter, cluster randomized interventional trial.PatientsChildren (≤ 18 yr) who received cardiopulmonary resuscitation while admitted to the ICU and were enrolled in ICU-RESUS.InterventionsNone.Measurements and main resultsAmong 429 IHCAs meeting inclusion criteria, occurrence during the pandemic period was associated with higher frequency of hypotension as the immediate cause of arrest. Cardiac arrest physiology, cardiopulmonary resuscitation quality metrics, and postarrest physiologic and quality of care metrics were similar between the two periods. Survival with favorable neurologic outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged from baseline) occurred in 102 of 195 subjects (52%) during the pandemic compared with 140 of 234 (60%) pre pandemic ( p = 0.12). Among survivors, occurrence of IHCA during the pandemic period was associated with a greater increase in Functional Status Scale (FSS) (i.e., worsening) from baseline (1 [0-3] vs 0 [0-2]; p = 0.01). After adjustment for confounders, IHCA survival during the pandemic period was associated with a greater increase in FSS from baseline (+1.19 [95% CI, 0.35-2.04] FSS points; p = 0.006) and higher odds of a new FSS-defined morbidity (adjusted odds ratio, 1.88 [95% CI, 1.03-3.46]; p = 0.04).ConclusionsUsing the ICU-RESUS dataset, we found that relative to the year prior, pediatric IHCA during the first year of the COVID-19 pandemic was associated with greater worsening of functional status and higher odds of new functional morbidity among survivors.

Published
2022

11. Sodium Bicarbonate Use During Pediatric Cardiopulmonary Resuscitation: A Secondary Analysis of the ICU-RESUScitation Project Trial.

Author

Cashen, Katherine, Reeder, Ron, Ahmed, Tageldin, Bell, Michael, Berg, Robert, Burns, Candice, Carcillo, Joseph, Carpenter, Todd, Dean, J, Diddle, J, Maa, Tensing, Manga, Arushi, McQuillen, Patrick, Morgan, Ryan, Mourani, Peter, Nadkarni, Vinay, Naim, Maryam, Notterman, Daniel, Palmer, Chella, Pollack, Murray, Schneiter, Carleen, Sharron, Matthew, Srivastava, Neeraj, Wessel, David, Wolfe, Heather, Yates, Andrew, Zuppa, Athena, Sutton, Robert, Meert, Kathleen, Fink, Ericka, Frazier, Aisha, Friess, Stuart, Graham, Kathryn, Hall, Mark, Hehir, David, Horvat, Christopher, Huard, Leanna, and Federman, Myke

Subjects
Cardiopulmonary Resuscitation, Child, Cohort Studies, Heart Arrest, Humans, Infant, Intensive Care Units, Prospective Studies, Sodium Bicarbonate
Abstract

OBJECTIVES: To evaluate associations between sodium bicarbonate use and outcomes during pediatric in-hospital cardiac arrest (p-IHCA). DESIGN: Prespecified secondary analysis of a prospective, multicenter cluster randomized interventional trial. SETTING: Eighteen participating ICUs of the ICU-RESUScitation Project (NCT02837497). PATIENTS: Children less than or equal to 18 years old and greater than or equal to 37 weeks post conceptual age who received chest compressions of any duration from October 2016 to March 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Child and event characteristics, prearrest laboratory values (2-6 hr prior to p-IHCA), pre- and intraarrest hemodynamics, and outcomes were collected. In a propensity score weighted cohort, the relationships between sodium bicarbonate use and outcomes were assessed. The primary outcome was survival to hospital discharge. Secondary outcomes included return of spontaneous circulation (ROSC) and survival to hospital discharge with favorable neurologic outcome. Of 1,100 index cardiopulmonary resuscitation events, median age was 0.63 years (interquartile range, 0.19-3.81 yr); 528 (48.0%) received sodium bicarbonate; 773 (70.3%) achieved ROSC; 642 (58.4%) survived to hospital discharge; and 596 (54.2%) survived to hospital discharge with favorable neurologic outcome. Among the weighted cohort, sodium bicarbonate use was associated with lower survival to hospital discharge rate (adjusted odds ratio [aOR], 0.7; 95% CI, 0.54-0.92; p = 0.01) and lower survival to hospital discharge with favorable neurologic outcome rate (aOR, 0.69; 95% CI, 0.53-0.91; p = 0.007). Sodium bicarbonate use was not associated with ROSC (aOR, 0.91; 95% CI, 0.62-1.34; p = 0.621). CONCLUSIONS: In this propensity weighted multicenter cohort study of p-IHCA, sodium bicarbonate use was common and associated with lower rates of survival to hospital discharge.

Published
2022

12. The impact of pediatric post-cardiac arrest care on survival: A multicenter review from the AHA get with the Guidelines®-resuscitation post-cardiac arrest care registry

Author

Fowler, Jessica C., Morgan, Ryan W., O’Halloran, Amanda, Gardner, Monique M., Appel, Scott, Wolfe, Heather, Kienzle, Martha F., Raymond, Tia T., Scholefield, Barnaby R, Guerguerian, Anne-Marie, Bembea, Melania M., Nadkarni, Vinay, Berg, Robert A., Sutton, Robert, and Topjian, Alexis A.

Published
2024
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23. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Barcala-Furelos, Roberto, Beerman, Stephen B., Bruckner, Marlies, Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Finan, Emer, Fukuda, Tatsuma, Lalgudi Ganesan, Saptharishi, Gately, Callum, Gois, Aecio, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Hurst, Cameron, Josephsen, Justin, Kollander, Louise, Omar Kamlin, C., Kool, Mirjam, Li, Lei, Mecrow, Thomas S., Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Lee Solevåg, Anne, Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thom, Ogilvie, Tobin, Joshua M., Trang, Jacinta, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., Fernanda de Almeida, Maria, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Daripa Kawakami, Mandira, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., John Madar, R., Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Gene Ong, Yong-Kwang, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., and Nolan, Jerry P.

Published
2024
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24. A research definition and framework for acute paediatric critical illness across resource-variable settings: a modified Delphi consensus

Author

Arias, Anita V, Lintner-Rivera, Michael, Shafi, Nadeem I, Abbas, Qalab, Abdelhafeez, Abdelhafeez H, Ali, Muhammad, Ammar, Halaashuor, Anwar, Ali I, Adabie Appiah, John, Attebery, Jonah E, Diaz Villalobos, Willmer E, Ferreira, Daiane, González-Dambrauskas, Sebastián, Irfan Habib, Muhammad, Lee, Jan Hau, Kissoon, Niranjan, Tekleab, Atnafu M, Molyneux, Elizabeth M, Morrow, Brenda M, Nadkarni, Vinay M, Rivera, Jocelyn, Silvers, Rebecca, Steere, Mardi, Tatay, Daniel, Bhutta, Adnan T, Kortz, Teresa B, and Agulnik, Asya

Published
2024
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26. Early Cardiac Arrest Hemodynamics, End-Tidal CO2, and Outcome in Pediatric Extracorporeal Cardiopulmonary Resuscitation: Secondary Analysis of the ICU-RESUScitation Project Dataset (2016–2021)*

Author

Yates, Andrew R., Naim, Maryam Y., Reeder, Ron W., Ahmed, Tageldin, Banks, Russell K., Bell, Michael J., Berg, Robert A., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A., Carpenter, Todd C., Dean, J. Michael, Diddle, J. Wesley, Federman, Myke, Fernandez, Richard, Fink, Ericka L., Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Graham, Kathryn, Hall, Mark, Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Morgan, Ryan W., Mourani, Peter M., Nadkarni, Vinay M., Notterman, Daniel, Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Srivastava, Neeraj, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather A., Yeh, Justin, Zuppa, Athena F., Sutton, Robert M., and Meert, Kathleen L.

Published
2024
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27. Adverse Tracheal Intubation Events in Critically Ill Underweight and Obese Children: Retrospective Study of the National Emergency Airway for Children Registry (2013–2020)

Author

Gladen, Kelsey M., Tellez, David, Napolitano, Natalie, Edwards, Lauren R., Sanders, Ronald C., Jr, Kojima, Taiki, Malone, Matthew P., Shults, Justine, Krawiec, Conrad, Ambati, Shashikanth, McCarthy, Riley, Branca, Aline, Polikoff, Lee A., Jung, Philipp, Parsons, Simon J., Mallory, Palen, Komeswaran, Kavipriya, Page-Goertz, Christopher, Toal, Megan C., Bysani, G. Kris, Meyer, Keith, Chiusolo, Fabrizio, Glater-Welt, Lily B., Al-Subu, Awni, Biagas, Katherine, Hau Lee, Jan, Miksa, Michael, Giuliano, John S., Jr, Kierys, Krista L., Talukdar, Andrea M., DeRusso, Michelle, Cucharme-Crevier, Laurence, Adu-Arko, Michelle, Shenoi, Asha, Kimura, Dai, Flottman, Molly, Gangu, Shantaveer, Freeman, Ashley D., Piehl, Mark D., Nuthall, G. A., Tarquinio, Keiko M., Harwayne-Gidansky, Ilana, Hasegawa, Tatsuya, Rescoe, Erin S., Breuer, Ryan K., Kasagi, Mioko, Nadkarni, Vinay M., Nishisaki, Akira, Flori, Heidi, Thomas, Neal, Agus, Michael, Dahmer, Mary, Goertzen, Lexie, Khemani, Robinder, Pinto, Neethi, Faustino, Vincent, Brown, Ann-Marie, Prieto, Monica, Wing, Robyn, and Buffman, Hayley

Published
2023
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28. Chest compressions for pediatric organized rhythms: A hemodynamic and outcomes analysis

Author

Zinna, Shairbanu S., Morgan, Ryan W., Reeder, Ron W., Ahmed, Tageldin, Bell, Michael J., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A., Carpenter, Todd C., Cooper, Kellimarie K., Michael Dean, J., Wesley Diddle, J., Federman, Myke, Fernandez, Richard, Fink, Ericka L., Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Graham, Kathryn, Hall, Mark, Harding, Monica L., Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Landis, William P., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Meert, Kathleen L., Mourani, Peter M, Nadkarni, Vinay M., Naim, Maryam Y., Notterman, Daniel, Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Srivastava, Neeraj, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather A., Yates, Andrew R., Zuppa, Athena F., Berg, Robert A., and Sutton, Robert M.

Published
2024
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29. Mehr als 500 Kinder pro Jahr könnten gerettet werden! Zehn Thesen zur Verbesserung der Qualität pädiatrischer Reanimationen im deutschsprachigen Raum: Positionspapier der Austrian, German and Swiss Resuscitation Councils

Author

Jung, Philipp, Brenner, Sebastian, Bachmann, Iris, Both, Christian, Cardona, Francesco, Dohna-Schwake, Christian, Eich, Christoph, Eifinger, Frank, Huth, Ralf, Heimberg, Ellen, Landsleitner, Bernd, Olivieri, Martin, Sasse, Michael, Weisner, Thomas, Wagner, Michael, Warnke, Gert, Ziegler, Bernhard, Boettiger, Bernd W., Nadkarni, Vinay, and Hoffmann, Florian

Published
2023
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31. Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes

Author

Chan, Paul S., Greif, Robert, Anderson, Theresa, Atiq, Huba, Bittencourt Couto, Thomaz, Considine, Julie, De Caen, Allan R., Djärv, Therese, Doll, Ann, Douma, Matthew J., Edelson, Dana P., Xu, Feng, Finn, Judith C., Firestone, Grace, Girotra, Saket, Lauridsen, Kasper G., Kah-Lai Leong, Carrie, Lim, Swee Han, Morley, Peter T., Morrison, Laurie J., Moskowitz, Ari, Mullasari Sankardas, Ajit, Mustafa Mohamed, Mahmoud Tageldin, Myburgh, Michelle Christy, Nadkarni, Vinay M., Neumar, Robert W., Nolan, Jerry P., Odakha, Justine Athieno, Olasveengen, Theresa M., Orosz, Judit, Perkins, Gavin D., Previdi, Jeanette K., Vaillancourt, Christian, Montgomery, William H., Sasson, Comilla, and Nallamothu, Brahmajee K.

Published
2023
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32. Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest

Author

Gray, James M., Raymond, Tia T., Atkins, Dianne L., Tegtmeyer, Ken, Niles, Dana E., Nadkarni, Vinay M., Pandit, Sandeep V., Dewan, Maya, Abulebda, Kamal, Atkins, Dianne, Balikai, Shilpa, Berg, Marc, Berg, Robert, Bhalala, Utpal, Braga, Matthew S., Buysse, Corinne, Cheng, Adam, Christoff, Andrea, Corbett, Kelly, DeCaen, Allan, deJong, Gabry, Castillo, Jimena del, Dewan, Maya, Donoghue, Aaron, Duval-Arnould, Jordan, Esangbedo, Ivie, Flaherty, Michael, Frazier, Maria, Friess, Stuart, Gangadharan, Sandeep, Gawronski, Orsola, Gilleland, Jonathan, Griffis, Heather, Gray, James, Harvey, Helen, Harwayne-Gidansky, Ilana, Haskell, Sarah, Hayes, Jennifer, Heber, Kiran, Hunt, Betsy, Ikeyama, Takanari, Jani, Priti, Daniels, Katherine, Kleinman, Monica, Knight, Lynda, Kurosawa, Hiroshi, Lasa, Javier, Lauridsen, Kasper Glerup, Lemoine, Tara, Maa, Tensing, Masse, Elizabeth, Mejia, Luz Marina, Meyer, Michael, Mok, Yee Hui, Morgan, Ryan, Nadkarni, Vinay, Nett, Sholeen, Niles, Dana, O’Halloran, Amanda, Olson, Michelle, Ong, Gene, Rajapreyar, Prakad, Raymond, Tia, Roberts, Joan, Sen, Anita, Skellet, Sophie, Stromberg, Daniel, Su, Felice, Sutton, Robert, Sweberg, Todd, Tegg, Oscar, Tegtmeyer, Ken, Topjian, Alexis, Van Ittersum, Wendy, Villaescusa, Javier Urbano, Watanabe, Ichiro, Welsby, Denise, Wenger, Jesse, Wolfe, Heather, Yeo, Andrea, and Yu, Pricilla

Published
2023
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33. Associations Between End-Tidal Carbon Dioxide During Pediatric Cardiopulmonary Resuscitation, Cardiopulmonary Resuscitation Quality, and Survival

Author

Morgan, Ryan W., Reeder, Ron W., Bender, Dieter, Cooper, Kellimarie K., Friess, Stuart H., Graham, Kathryn, Meert, Kathleen L., Mourani, Peter M., Murray, Robert, Nadkarni, Vinay M., Nataraj, Chandrasekhar, Palmer, Chella A., Srivastava, Neeraj, Tilford, Bradley, Wolfe, Heather A., Yates, Andrew R., Berg, Robert A., Sutton, Robert M., Ahmed, Tageldin, Bell, Michael J., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carpenter, Todd C., Carcillo, Joseph A., Dean, J. Michael, Diddle, J. Wesley, Federman, Myke, Fernandez, Richard, Fink, Ericka L, Franzon, Deborah, Frazier, Aisha H., Hall, Mark, Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Maa, Tensing, Manga, Arushi, McQuillen, Patrick S., Naim, Maryam Y., Notterman, Daniel, Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Tabbutt, Sarah, Viteri, Shirley, Wessel, David, and Zuppa, Athena F.

Published
2024
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34. Survival With Favorable Neurologic Outcome and Quality of Cardiopulmonary Resuscitation Following In-Hospital Cardiac Arrest in Children With Cardiac Disease Compared With Noncardiac Disease*

Author

Federman, Myke, Sutton, Robert M., Reeder, Ron W., Ahmed, Tageldin, Bell, Michael J., Berg, Robert A., Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A., Carpenter, Todd C., Dean, J. Michael, Diddle, J. Wesley, Fernandez, Richard, Fink, Ericka L., Franzon, Deborah, Frazier, Aisha H., Friess, Stuart H., Graham, Kathryn, Hall, Mark, Hehir, David A., Horvat, Christopher M., Huard, Leanna L., Kirkpatrick, Theresa, Maa, Tensing, Maitoza, Laura A., Manga, Arushi, McQuillen, Patrick S., Meert, Kathleen L., Morgan, Ryan W., Mourani, Peter M., Nadkarni, Vinay M., Notterman, Daniel, Palmer, Chella A., Pollack, Murray M., Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P., Srivastava, Neeraj, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather A., Yates, Andrew R., Zuppa, Athena F., and Naim, Maryam Y.

Published
2024
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41. Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial

Author

Morgan, Ryan W, Reeder, Ron W, Ahmed, Tageldin, Bell, Michael J, Berger, John T, Bishop, Robert, Bochkoris, Matthew, Burns, Candice, Carcillo, Joseph A, Carpenter, Todd C, Dean, J Michael, Diddle, J Wesley, Federman, Myke, Fernandez, Richard, Fink, Ericka L, Franzon, Deborah, Frazier, Aisha H, Friess, Stuart H, Graham, Kathryn, Hall, Mark, Hehir, David A, Himebauch, Adam S, Horvat, Christopher M, Huard, Leanna L, Maa, Tensing, Manga, Arushi, McQuillen, Patrick S, Meert, Kathleen L, Mourani, Peter M, Nadkarni, Vinay M, Naim, Maryam Y, Notterman, Daniel, Page, Kent, Pollack, Murray M, Sapru, Anil, Schneiter, Carleen, Sharron, Matthew P, Srivastava, Neeraj, Tabbutt, Sarah, Tilford, Bradley, Viteri, Shirley, Wessel, David, Wolfe, Heather A, Yates, Andrew R, Zuppa, Athena F, Berg, Robert A, and Sutton, Robert M

Published
2023
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42. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, Katherine M., Bray, Janet E., Ng, Kee-Chong, Liley, Helen G., Greif, Robert, Carlson, Jestin N., Morley, Peter T., Drennan, Ian R., Smyth, Michael, Scholefield, Barnaby R., Weiner, Gary M., Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W., Atkins, Dianne L., Berry, David C., Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W., Bradley, Richard N., Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Dassanayake, Vihara, Davis, Peter G., Dawson, Jennifer A., de Almeida, Maria Fernanda, De Caen, Allan R., Deakin, Charles D., Dicker, Bridget, Douma, Matthew J., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Fijacko, Nino, Finn, Judith C., Flores, Gustavo E., Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica E., Kloeck, David A., Ko, Ying-Chih, Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun, Lockey, Andrew S., Macneil, Finlay, Maconochie, Ian K., Madar, R. John, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J.D., Meyran, Daniel, Monnelly, Vix, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., Ohshimo, Shinchiro, Olasveengen, Theresa M., Ong, Yong-Kwang Gene, Orkin, Aaron M., Parr, Michael J., Patocka, Catherine, Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V., Raymond, Tia T., Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmölzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M., Skrifvars, Markus B., Smith, Christopher M., Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A., Topjian, Alexis A., Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M., Zideman, David A., Nolan, Jerry P., Barcala-Furelos, Roberto, Beerman, Stephen B., Castrén, Maaret, Chong, ShuLing, Claesson, Andreas, Dunne, Cody L., Ersdal, Hege L., Finan, Emer, Fuerch, Janene, Fukuda, Tatsuma, Ganesan, Saptharishi Lalgudi, Gately, Callum, Gray, Seth, Halamek, Louis P., Hoover, Amber V., Kollander, Louise, Kamlin, C. Omar, Koo, Mirjam, Li, Lei, Leone, Tina A., Mecrow, s, Montgomery, William, Ristau, Patrick, Jayashree, Muralidharan, Quek, Bin Huey, Schmidt, Andrew, Scquizzato, Tommaso, Seesink, Jeroen, Sempsrott, Justin, Shah, Birju A., Strand, Marya L., Szpilman, David, Szyld, Edgardo, Thio, Marta, Thom, Ogilvie, Tobin, Joshua M., Udaeta, Enrique, Webber, Jonathon, Webster, Hannah K., Wellsford, Michelle, and Yamada, Nicole K.

Published
2023
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49. Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes

Author

Nallamothu, Brahmajee K., Greif, Robert, Anderson, Theresa, Atiq, Huba, Couto, Thomaz Bittencourt, Considine, Julie, De Caen, Allan R., Djärv, Therese, Doll, Ann, Douma, Matthew J., Edelson, Dana P., Xu, Feng, Finn, Judith C., Firestone, Grace, Girotra, Saket, Lauridsen, Kasper G., Leong, Carrie Kah-Lai, Lim, Swee Han, Morley, Peter T., Morrison, Laurie J., Moskowitz, Ari, Mullasari Sankardas, Ajit, Mohamed, Mahmoud Tageldin Mustafa, Myburgh, Michelle Christy, Nadkarni, Vinay M., Neumar, Robert W., Nolan, Jerry P., Athieno Odakha, Justine, Olasveengen, Theresa M., Orosz, Judit, Perkins, Gavin D., Previdi, Jeanette K., Vaillancourt, Christian, Montgomery, William H., Sasson, Comilla, and Chan, Paul S.

Published
2023
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50. Multiple Electrolytes Solution Versus Saline as Bolus Fluid for Resuscitation in Pediatric Septic Shock: A Multicenter Randomized Clinical Trial*

Author

Sankar, Jhuma, Muralidharan, Jayashree, Lalitha, A. V., Rameshkumar, Ramachandran, Pathak, Mona, Das, Rashmi Ranjan, Nadkarni, Vinay M., Ismail, Javed, Subramanian, Mahadevan, Nallasamy, Karthi, Dev, Nishanth, Kumar, U. Vijay, Kumar, Kiran, Sharma, Taniya, Jaravta, Kanika, Thakur, Neha, Aggarwal, Praveen, Jat, Kana Ram, Kabra, S. K., and Lodha, Rakesh

Published
2023
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