23 results on '"NANNINI, ESTEBAN C."'
Search Results
2. CHARACTERISTICS OF ENDEMIC HUMAN CORONAVIRUS INFECTIONS DURING TIMES OF COVID-19 PANDEMIC.
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CROCCI, ERIC E., SCHREINER, DELFINA, GARCIA, EMILIA A., NANNINI, ESTEBAN C., COBOS, MANUELA, DOUBIK, PAULA, BALBUENA, JUAN P., ROMANDETTA, AGUSTIN, COOKE, BETTINA, ALZOGARAY, MARÍA F., BAUMEISTER, ELSA, and MYKIETIUK, ANALIA
- Abstract
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
3. Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections
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Ortiz-Covarrubias, Alejandro, Fang, Edward, Prokocimer, Philippe G., Flanagan, Shawn D., Zhu, Xu, Cabré-Márquez, Jose Francisco, Tanaka, Toshiaki, Passarell, Julie, Fiedler-Kelly, Jill, and Nannini, Esteban C.
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- 2016
- Full Text
- View/download PDF
4. IMPACTO DE LA MOVILIDAD POBLACIONAL EN EL COMPORTAMIENTO DE VIRUS RESPIRATORIOS DURANTE LA PANDEMIA COVID-19.
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COBOS, MANUELA, NANNINI, ESTEBAN C., BALBUENA, JUAN P., CROCCI, ERIC E., SCHREINER, DELFINA, GARCIA, EMILIA A., CHAPARTEGUI, SEBASTIÁN, DOUBIK, PAULA, ROMANDETTA, AGUSTÍN, COOKE, BETTINA, ALZOGARAY, MARIA F., BAUMEISTER, ELSA, and MYKIETIUK, ANALÍA
- Abstract
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
5. Abatacept for Treatment of Adults Hospitalized with Moderate or Severe Covid-19
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Ko, Emily R., Anstrom, Kevin J., Panettieri, Reynold A., Lachiewicz, Anne M., Maillo, Martin, O’Halloran, Jane A., Boucher, Cynthia, Smith, P. Brian, McCarthy, Matthew W., Segura Nunez, Patricia, Mendivil Tuchia de Tai, Sabina, Khan, Akram, Mena Lora, Alfredo J., Salathe, Matthias, Kedar, Eyal, Capo, Gerardo, Rodríguez Gonzalez, Daniel, Patterson, Thomas F., Palma, Christopher, Ariza, Horacio, Patelli Lima, Maria, Blamoun, John, Nannini, Esteban C., Sprinz, Eduardo, Mykietiuk, Analia, Wang, Jennifer P., Parra-Rodriguez, Luis, Der, Tatyana, Willsey, Kate, Benjamin, Daniel K., Wen, Jun, Zakroysky, Pearl, Halabi, Susan, Silverstein, Adam, McNulty, Steven E., O’Brien, Sean M., Al-Khalidi, Hussein R., Butler, Sandra, Atkinson, Jane, Adam, Stacey J., Chang, Soju, Maldonado, Michael A., Proscham, Michael, LaVange, Lisa, Bozzette, Samuel A., and Powderly, William G.
- Subjects
Article - Abstract
BackgroundWe investigated whether abatacept, a selective costimulation modulator, provides additional benefit when added to standard-of-care for patients hospitalized with Covid-19.MethodsWe conducted a master protocol to investigate immunomodulators for potential benefit treating patients hospitalized with Covid-19 and report results for abatacept. Intravenous abatacept (one-time dose 10 mg/kg, maximum dose 1000 mg) plus standard of care (SOC) was compared with shared placebo plus SOC. Primary outcome was time-to-recovery by day 28. Key secondary endpoints included 28-day mortality.ResultsBetween October 16, 2020 and December 31, 2021, a total of 1019 participants received study treatment (509 abatacept; 510 shared placebo), constituting the modified intention-to-treat cohort. Participants had a mean age 54.8 (SD 14.6) years, 60.5% were male, 44.2% Hispanic/Latino and 13.7% Black. No statistically significant difference for the primary endpoint of time-to-recovery was found with a recovery-rate-ratio of 1.14 (95% CI 1.00–1.29; p=0.057) compared with placebo. We observed a substantial improvement in 28-day all-cause mortality with abatacept versus placebo (11.0% vs. 15.1%; odds ratio [OR] 0.62 [95% CI 0.41– 0.94]), leading to 38% lower odds of dying. Improvement in mortality occurred for participants requiring oxygen/noninvasive ventilation at randomization. Subgroup analysis identified the strongest effect in those with baseline C-reactive protein >75mg/L. We found no statistically significant differences in adverse events, with safety composite index slightly favoring abatacept. Rates of secondary infections were similar (16.1% for abatacept; 14.3% for placebo).ConclusionsAddition of single-dose intravenous abatacept to standard-of-care demonstrated no statistically significant change in time-to-recovery, but improved 28-day mortality.Trial registrationClinicalTrials.gov(NCT04593940).
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- 2022
6. Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), Lipopeptides (Daptomycin), and Lipoglycopeptides (Telavancin)
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Murray, Barbara E., primary, Arias, Cesar A., additional, and Nannini, Esteban C., additional
- Published
- 2015
- Full Text
- View/download PDF
7. Contributors
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Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional
- Published
- 2015
- Full Text
- View/download PDF
8. CEFTAROLINE AS SALVAGE THERAPY FOR METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS COMPLICATED BACTEREMIA.
- Author
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OBED, MORA N., TORESANI, INÉS, MYKIETUK, ANALÍA, and NANNINI, ESTEBAN C.
- Abstract
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
9. Polyclonal outbreak of bacteremia caused by Burkholderia cepacia complex and the presumptive role of ultrasound gel
- Author
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Nannini, Esteban C., Ponessa, Adriana, Muratori, Rosa, Marchiaro, Patricia, Ballerini, Viviana, Flynn, Luis, and Limansky, Adriana S.
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- 2015
- Full Text
- View/download PDF
10. 30 - Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
- Author
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Murray, Barbara E., Arias, Cesar A., and Nannini, Esteban C.
- Published
- 2020
- Full Text
- View/download PDF
11. A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
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Simonovich, Ventura A., primary, Burgos Pratx, Leandro D., additional, Scibona, Paula, additional, Beruto, María V., additional, Vallone, Marcelo G., additional, Vázquez, Carolina, additional, Savoy, Nadia, additional, Giunta, Diego H., additional, Pérez, Lucía G., additional, Sánchez, Marisa del L., additional, Gamarnik, Andrea Vanesa, additional, Ojeda, Diego S., additional, Santoro, Diego M., additional, Camino, Pablo J., additional, Antelo, Sebastian, additional, Rainero, Karina, additional, Vidiella, Gabriela P., additional, Miyazaki, Erica A., additional, Cornistein, Wanda, additional, Trabadelo, Omar A., additional, Ross, Fernando M., additional, Spotti, Mariano, additional, Funtowicz, Gabriel, additional, Scordo, Walter E., additional, Losso, Marcelo H., additional, Ferniot, Inés, additional, Pardo, Pablo E., additional, Rodriguez, Eulalia, additional, Rucci, Pablo, additional, Pasquali, Julieta, additional, Fuentes, Nora A., additional, Esperatti, Mariano, additional, Speroni, Gerardo A., additional, Nannini, Esteban C., additional, Matteaccio, Alejandra, additional, Michelangelo, Hernán G., additional, Follmann, Dean, additional, Lane, H. Clifford, additional, and Belloso, Waldo H., additional
- Published
- 2021
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12. Colaboradores
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Aagaard, Kjersti, Abdallah, Marie, Abrahamian, Fredrick M., Agnihotri, Shruti, Ahmed, Sana S., Allos, Ban Mishu, Alqahtani, Saleh A., Anderson, Jeffrey L., Andes, David R., Andrews, Jason R., Aoki, Fred Y., Apicella, Michael A., Araos, Rafael, Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Aronson, Naomi E., Augenbraun, Michael H., Auwaerter, Paul G., Averhoff, Francisco, Azar, Dimitri T., Babu, Tara M., Bachmann, Laura Hinkle, Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Sarah-Blythe, Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Bartelt, Luther A., Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Beigi, Richard H., Bennett, John E., Berbari, Elie F., Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birch, Torrey Boland, Birdsall, Holly H., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Blazes, David L., Bleck, Thomas P., Blijlevens, Nicole M.A., Blyth, Dana M., Boggild, Andrea K., Bogoch, Isaac I., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Braden, Christopher R., Branche, Angela R., Britt, William J., Brook, Itzhak, Brouwer, Matthijs C., Brown, Kevin E., Brown, Patricia, Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Casadevall, Arturo, Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chapman, Stephen J., Chappell, Catherine A., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chiang, Augusto Dulanto, Chopra, Sanjiv, Chow, Anthony W., Clancy, Cornelius J., Clark, Richard B., Cohen, Jeffrey I., Cohen, Myron S., Cohen, Yehuda Z., Cohen-Poradosu, Ronit, Cohn, Susan E., Colton, Benjamin, Connors, Mark, Copeland, Nathanial K., Corey, Lawrence, Cosgrove, Sara E., Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Crass, Ryan L., Cunha, Cheston B., Curran, James W., Currie, Bart J., D’Agata, Erika, Daly, Jennifer S., Damon, Inger K., Darouiche, Rabih O., Dawid, Suzanne, Deepe, George S., Jr., Dekker, John P., del Rio, Carlos, DeLeo, Frank R., DeMuri, Gregory P., Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donowitz, Gerald R., Donskey, Curtis J., Dormitzer, Philip R., Dumler, J. Stephen, Dupnik, Kathryn, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Duval, Xavier, Edelstein, Paul H., Edwards, John E., Jr., Edwards, Morven S., Ellison, Richard T., III, Embry, Alan C., Endy, Timothy P., Engleberg, N. Cary, Englund, Janet A., Erdem, Hakan, Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Monica, Garrett, Wendy S., Gauthier, Gregory M., Gaydos, Charlotte A., Gea-Banacloche, Juan C., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Giri, Pushpanjali, Gold, Howard S., Goldstein, Ellie J.C., González-Marín, Ángel, Graman, Paul S., Grayson, M. Lindsay, Greenberg, David, Greene, Matthew H., Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, Hanefi C., Haake, David A., Haas, David W., Haidar, Ghady, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hartzell, Joshua D., Hasbun, Rodrigo, Hawkins, Claudia, Hay, Roderick J., Henderson, David K., High, Kevin P., Hill, Adrian V.S., Hinman, Alan R., Hirsch, Martin S., Hochman, Sarah, Hoen, Bruno, Hohl, Tobias M., Holland, Steven M., Holland, Thomas L., Holzman, Robert S., Hooper, David C., Hooton, Thomas M., Hoover, Susan E., Horowitz, Harold W., Horton, James M., Hospenthal, Duane R., Hotez, Peter J., Hynes, Noreen A., Iovine, Nicole M., Ison, Michael G., Jaggi, Preeti, Janda, J. Michael, Janoff, Edward N., Jernigan, Daniel, Johannsen, Eric C., Johnson, Jennie E., Juliano, Jonathan J., Kamboj, Mini, Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima F., Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Kirkpatrick, Beth D., Kiyono, Hiroshi, Klein, Bruce S., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., LaSalvia, Mary T., Leaf, Howard L., Leggett, James E., Lepak, Alexander J., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lionakis, Michail S., Lipkin, W. Ian, Litman, Nathan, Luna, Ruth Ann, Lutgring, Joseph D., MacDougall, Conan, Maddocks, Susan, Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McCarthy, James S., McCormack, William, McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mejia, Rojelio, Mekala, Vijayashree, Messonnier, Nancy, Mikulska, Małgorzata, Miller, Robert F., Miller, Samuel I., Miller, William R., Moffa, Matthew, Moir, Susan, Montoya, José G., Moonah, Shannon N., Moore, Thomas A., Moreillon, Philippe, Morgan, Janet, Morris, J. Glenn, Jr., Munita, Jose M., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Mylonakis, Eleftherios, Nagel, Jerod L., Naggie, Susanna, Nannini, Esteban C., Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., Nelson, George E., Nelson, Joanna K., Nesbitt, Whitney J., Nguyen, M. Hong, O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Paris, Daniel H., Parks, Tom, Parsonnet, Julie, Parta, Mark, Pasternack, Mark S., Pastula, Daniel M., Patel, Robin, Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Pelton, Stephen I., Penn, Robert L., Perfect, John R., Perkins, Ryan, Perlman, Stanley, Petersen, Brett W., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Polsky, Bruce, Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Ramakrishnan, Lalita, Raoult, Didier, Ravdin, Jonathan I., Reboli, Annette C., Redel, Henry, Reitz, Marvin S., Jr., Relman, David A., Reno, Hilary E.L., Restrepo-Moreno, Ángela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romanovsky, Andrej A., Romero, José R., Rose, Stacey R., Rosenberg, Ronald, Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Sajadi, Mohammad M., Salazar, Juan C., Saleeb, Paul G., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco, Singh, Nina, Singh, Upinder, Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Sorrell, Tania C., Spellberg, Brad, Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Stephenson, Kathryn E., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Stoner, Bradley P., Strahilevitz, Jacob, IV, Charles W. Stratton, Strnad, Luke C., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talati, Naasha J., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Tande, Aaron J., Tesini, Brenda L., Thio, Chloe Lynne, Thomas, Stephen J., Thompson, George R., III, Thorner, Anna R., Tobón-Orozco, Ángela Ma., Tramont, Edmund C., Trautner, Barbara W., Treanor, John J., Trivedi, Hirsh D., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Tyler, Kenneth L., Uluer, Ahmet Z., Urban, Marguerite A., Ustun, Celalettin, Uyeki, Timothy M., van de Beek, Diederik, van der Poll, Tom, van der Velden, Walter J.F.M., Van Schooneveld, Trevor C., Vannier, Edouard, Vellozzi, Claudia, Versalovic, James, Vijayan, Vini, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Ward, Honorine D., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Watkins, Richard R., Watts, Matthew R., Weatherhead, Jill, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weiss, Louis M., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wiersinga, Willem Joost, Williams, Brett, Wilson, Walter R., Winslow, Dean L., Winthrop, Kevin L., Wong, Karen K., Wortmann, Glenn W., Wright, William F., Wyles, David L., Young, Jo-Anne H., Young, Vincent Bensan, Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
- Published
- 2021
- Full Text
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13. 30 - Glucopéptidos (vancomicina y teicoplanina) y lipoglucopéptidos (telavancina, oritavancina y dalbavancina)
- Author
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Murray, Barbara E., Arias, Cesar A., and Nannini, Esteban C.
- Published
- 2021
- Full Text
- View/download PDF
14. Contributors
- Author
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Aagaard, Kjersti, Abdallah, Marie, Abrahamian, Fredrick M., Agnihotri, Shruti, Ahmed, Sana S., Allos, Ban Mishu, Alqahtani, Saleh A., Anderson, Jeffrey L., Andes, David R., Andrews, Jason R., Aoki, Fred Y., Apicella, Michael A., Araos, Rafael, Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Aronson, Naomi E., Augenbraun, Michael H., Auwaerter, Paul G., Averhoff, Francisco, Azar, Dimitri T., Babu, Tara M., Bachmann, Laura Hinkle, Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Sarah-Blythe, Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Bartelt, Luther A., Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Beigi, Richard H., Bennett, John E., Berbari, Elie F., Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birch, Torrey Boland, Birdsall, Holly H., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Blazes, David L., Bleck, Thomas P., Blijlevens, Nicole M.A., Blyth, Dana M., Boggild, Andrea K., Bogoch, Isaac I., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Braden, Christopher R., Branche, Angela R., Britt, William J., Brook, Itzhak, Brouwer, Matthijs C., Brown, Kevin E., Brown, Patricia, Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Casadevall, Arturo, Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chapman, Stephen J., Chappell, Catherine A., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chiang, Augusto Dulanto, Chopra, Sanjiv, Chow, Anthony W., Clancy, Cornelius J., Clark, Richard B., Cohen, Jeffrey I., Cohen, Myron S., Cohen, Yehuda Z., Cohen-Poradosu, Ronit, Cohn, Susan E., Colton, Benjamin, Connors, Mark, Copeland, Nathanial K., Corey, Lawrence, Cosgrove, Sara E., Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Crass, Ryan L., Cunha, Cheston B., Curran, James W., Currie, Bart J., D'Agata, Erika, Daly, Jennifer S., Damon, Inger K., Darouiche, Rabih O., Dawid, Suzanne, Deepe, George S., Jr., Dekker, John P., del Rio, Carlos, DeLeo, Frank R., DeMuri, Gregory P., Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donowitz, Gerald R., Donskey, Curtis J., Dormitzer, Philip R., Dumler, J. Stephen, Dupnik, Kathryn, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Duval, Xavier, Edelstein, Paul H., Edwards, John E., Jr., Edwards, Morven S., Ellison, Richard T., III, Embry, Alan C., Endy, Timothy P., Engleberg, N. Cary, Englund, Janet A., Erdem, Hakan, Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Monica, Garrett, Wendy S., Gauthier, Gregory M., Gaydos, Charlotte A., Gea-Banacloche, Juan C., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Giri, Pushpanjali, Gold, Howard S., Goldstein, Ellie J.C., González-Marín, Ángel, Graman, Paul S., Grayson, M. Lindsay, Greenberg, David, Greene, Matthew H., Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, Hanefi C., Haake, David A., Haas, David W., Haidar, Ghady, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hartzell, Joshua D., Hasbun, Rodrigo, Hawkins, Claudia, Hay, Roderick J., Henderson, David K., High, Kevin P., Hill, Adrian V.S., Hinman, Alan R., Hirsch, Martin S., Hochman, Sarah, Hoen, Bruno, Hohl, Tobias M., Holland, Steven M., Holland, Thomas L., Holzman, Robert S., Hooper, David C., Hooton, Thomas M., Hoover, Susan E., Horowitz, Harold W., Horton, James M., Hospenthal, Duane R., Hotez, Peter J., Hynes, Noreen A., Iovine, Nicole M., Ison, Michael G., Jaggi, Preeti, Janda, J. Michael, Janoff, Edward N., Jernigan, Daniel, Johannsen, Eric C., Johnson, Jennie E., Juliano, Jonathan J., Kamboj, Mini, Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima F., Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Kirkpatrick, Beth D., Kiyono, Hiroshi, Klein, Bruce S., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., LaSalvia, Mary T., Leaf, Howard L., Leggett, James E., Lepak, Alexander J., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lionakis, Michail S., Lipkin, W. Ian, Litman, Nathan, Luna, Ruth Ann, Lutgring, Joseph D., MacDougall, Conan, Maddocks, Susan, Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McCarthy, James S., McCormack, William, McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mejia, Rojelio, Mekala, Vijayashree, Messonnier, Nancy, Mikulska, Małgorzata, Miller, Robert F., Miller, Samuel I., Miller, William R., Moffa, Matthew, Moir, Susan, Montoya, José G., Moonah, Shannon N., Moore, Thomas A., Moreillon, Philippe, Morgan, Janet, Morris, J. Glenn, Jr., Munita, Jose M., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Mylonakis, Eleftherios, Nagel, Jerod L., Naggie, Susanna, Nannini, Esteban C., Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., Nelson, George E., Nelson, Joanna K., Nesbitt, Whitney J., Nguyen, M. Hong, O'Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Paris, Daniel H., Parks, Tom, Parsonnet, Julie, Parta, Mark, Pasternack, Mark S., Pastula, Daniel M., Patel, Robin, Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Pelton, Stephen I., Penn, Robert L., Perfect, John R., Perkins, Ryan, Perlman, Stanley, Petersen, Brett W., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Polsky, Bruce, Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Ramakrishnan, Lalita, Raoult, Didier, Ravdin, Jonathan I., Reboli, Annette C., Redel, Henry, Reitz, Marvin S., Jr., Relman, David A., Reno, Hilary E.L., Restrepo-Moreno, Ángela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romanovsky, Andrej A., Romero, José R., Rose, Stacey R., Rosenberg, Ronald, Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Sajadi, Mohammad M., Salazar, Juan C., Saleeb, Paul G., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco, Singh, Nina, Singh, Upinder, Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Sorrell, Tania C., Spellberg, Brad, MD, Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Stephenson, Kathryn E., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Stoner, Bradley P., Strahilevitz, Jacob, Stratton, Charles W., IV, Strnad, Luke C., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talati, Naasha J., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Tande, Aaron J., Tesini, Brenda L., Thio, Chloe Lynne, Thomas, Stephen J., Thompson, George R., III, Thorner, Anna R., Tobón-Orozco, Ángela Ma., Tramont, Edmund C., Trautner, Barbara W., Treanor, John J., Trivedi, Hirsh D., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Tyler, Kenneth L., Uluer, Ahmet Z., Urban, Marguerite A., Ustun, Celalettin, Uyeki, Timothy M., van de Beek, Diederik, van der Poll, Tom, van der Velden, Walter J.F.M., Van, Trevor C., Vannier, Edouard, Vellozzi, Claudia, Versalovic, James, Vijayan, Vini, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Ward, Honorine D., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Watkins, Richard R., Watts, Matthew R., Weatherhead, Jill, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weiss, Louis M., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wiersinga, Willem Joost, Williams, Brett, Wilson, Walter R., Winslow, Dean L., Winthrop, Kevin L., Wong, Karen K., Wortmann, Glenn W., Wright, William F., Wyles, David L., Young, Jo-Anne H., Young, Vincent Bensan, Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
- Published
- 2020
- Full Text
- View/download PDF
15. 30 - Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), Lipopeptides (Daptomycin), and Lipoglycopeptides (Telavancin)
- Author
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Murray, Barbara E., Arias, Cesar A., and Nannini, Esteban C.
- Published
- 2015
- Full Text
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16. Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis
- Author
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Singh, Kavindra V., primary, Tran, Truc T., additional, Nannini, Esteban C., additional, Tam, Vincent H., additional, Arias, Cesar A., additional, and Murray, Barbara E., additional
- Published
- 2017
- Full Text
- View/download PDF
17. Colaboradores
- Author
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Aagaard, Kjersti, Abrahamian, Fredrick M., Allos, Ban Mishu, Andes, David R., Aoki, Fred Y., Apicella, Michael A., Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Augenbraun, Michael H., Averhoff, Francisco, Azar, Dimitri T., Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Ronald C., Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Bell, Beth P., Bennett, John E., Bente, Dennis A., Berbari, Elie F., Berman, Jonathan, Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birdsall, Holly H., Bisno, Alan L., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Bleck, Thomas P., Blijlevens, Nicole M.A., Bobak, David A., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Bower, John, Bradsher, Robert W., Jr., Brook, Itzhak, Brown, Kevin E., Brown, Patricia D., Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Calderwood, Stephen B., Cano, Luz Elena, Carpenter, Charles C.J., Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chambers, Henry F., Chapman, Stephen J., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chow, Anthony W., Clark, Rebecca A., Cohen, Jeffrey I., Cohen, Myron S., Cohen-Poradosu, Ronit, Cohn, Susan E., Connors, Mark, Corey, Lawrence, Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Craig, William A., Crossley, Kent B., Crumpacker, Clyde S., II, Curran, James W., Currie, Bart J., D’Agata, Erika, Damon, Inger K., Darouiche, Rabih O., DeBiasi, Roberta L., Deepe, George S., Jr., del Rio, Carlos, Delemos, Andrew S., DeLeo, Frank R., DeMuri, Gregory P., Densen, Peter, Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donnelly, J. Peter, Donnenberg, Michael S., Donowitz, Gerald R., Dormitzer, Philip R., Drake, James M., Dumler, J. Stephen, Dummer, J. Stephen, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Edelstein, Paul H., Edmond, Michael B., Edwards, John E., Jr., Edwards, Morven S., Eliopoulos, George M., Ellison, Richard T., III, Endy, Timothy P., Engleberg, N. Cary, Erdem, Hakan, Ernst, Joel D., Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Forster, Derek, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Tejal N., Garrett, Wendy S., Gaydos, Charlotte A., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Goldstein, Ellie J.C., Gordin, Fred M., Graman, Paul S., Grayson, M. Lindsay, Greene, Jeffrey Bruce, Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, H. Cem, Haake, David A., Haas, David W., Haines, Charles, Hall, Caroline Breese, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hawkins, Claudia, Hay, Roderick J., Hedberg, Craig W., Henderson, David K., Henderson, Donald A., High, Kevin P., Hill, Adrian V.S., Hill, David R., Hinman, Alan R., Hirsch, Martin S., Hodowanec, Aimee, Hohl, Tobias M., Holland, Steven M., Holzman, Robert S., Hook, Edward W., III, Hooper, David C., Hooton, Thomas M., Horowitz, Harold W., Horsburgh, C. Robert, Jr., Horton, James M., Hospenthal, Duane R., Hsueh, Kevin, Hughes, James M., Hynes, Noreen A., Iovine, Nicole M., Iredell, Jonathan R., Ison, Michael G., Janda, J. Michael, Janoff, Edward N., Johannsen, Eric C., Kashuba, Angela D.M., Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima, Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Klein, Jerome O., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kozarsky, Phyllis, Krieger, John, Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., Leggett, James E., Legido-Quigley, Helena, Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lipkin, W. Ian, Litman, Nathan, Lorber, Bennett, Luna, Ruth Ann, MacDougall, Conan, MacGregor, Rob Roy, Mackowiak, Philip A., Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McBride, John T., McCarthy, James S., McCormack, William M., McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mikulska, Malgorzata, Miller, Robert F., Miller, Samuel I., Mitchell, David H., Modlin, John F., Mody, Rajal K., Moellering, Robert C., Jr., Moffa, Matthew, Moir, Susan, Montoya, José G., Moore, Thomas A., Moreillon, Philippe, Morris, J. Glenn, Jr., Morse, Caryn Gee, Moseley, Robin, Munford, Robert S., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Murray, Patrick R., Musher, Daniel M., Nagel, Jerod L., Nannini, Esteban C., Narezkina, Anna, Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Osterholm, Michael T., Ostroff, Stephen M., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Pasternack, Mark S., Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Penn, Robert L., Perfect, John R., Perlman, Stanley, Petersen, Brett W., Peterson, Phillip K., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Raoult, Didier, Ravdin, Jonathan I., Ray, Stuart C., Reboli, Annette C., Reitz, Marvin S., Jr., Relman, David A., Renault, Cybèle A., Restrepo, Angela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romero, José R., Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Safdar, Amar, Sajadi, Mohammad M., Salazar, Juan C., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Scheld, W. Michael, Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schuchat, Anne, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Septimus, Edward J., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco R., Singh, Kamaljit, Singh, Nina, Singh, Upinder, Sinner, Scott W., Sivapalasingam, Sumathi, Slater, Leonard N., Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Soper, David E., Sorrell, Tania C., Steckelberg, James M., Steere, Allen C., Steigbigel, Neal H., Steinberg, James P., Stephens, David S., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Strahilevitz, Jacob, Stratton, Charles W., IV, Suffredini, Anthony F., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Thio, Chloe Lynne, Thomas, David L., Thomas, Lora D., Thomas, Stephen J., Thorner, Anna R., Tobón, Angela María, Tramont, Edmund C., Treanor, John J., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Turner, Ronald B., Tyler, Kenneth L., Uluer, Ahmet, van de Beek, Diederik, van der Velden, Walter J.F. M., Vannier, Edouard G., Van Schooneveld, Trevor C., Versalovic, James, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weisdorf, Daniel J., Weiss, Louis M., Welch, David F., Wellems, Thomas E., Wenzel, Richard P., Wharton, Melinda, White, A. Clinton, Jr., Whitley, Richard J., Wilson, Walter R., Wortmann, Glenn W., Wright, William F., Young, Jo-Anne H., Young, Vincent B., Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
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- 2016
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18. 30 - Glucopéptidos (vancomicina y teicoplanina), estreptograminas (quinupristina-dalfopristina), lipopéptidos (daptomicina) y lipoglucopéptidos (telavancina)
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Murray, Barbara E., Arias, Cesar A., and Nannini, Esteban C.
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- 2016
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19. Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureusExhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis
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Singh, Kavindra V., Tran, Truc T., Nannini, Esteban C., Tam, Vincent H., Arias, Cesar A., and Murray, Barbara E.
- Abstract
ABSTRACTCertain Staphylococcus aureusstrains exhibit an inoculum effect (InE) with cefazolin (CFZ) that has been associated with therapeutic failures in high-inoculum infections. We assessed the in vitroactivities of ceftaroline (CPT), CFZ, and nafcillin (NAF) against 17 type A β-lactamase (βla)-producing, methicillin-susceptible S. aureus(MSSA) strains, including the previously reported TX0117, which exhibits the CFZ InE, and its βla-cured derivative, TX0117c. Additionally, we determined the pharmacokinetics of CPT in rats after single intramuscular doses of 20 and 40 mg/kg of body weight and evaluated the activities of CPT (40 mg/kg every 8 h [q8h]), CFZ, and NAF against TX0117 and TX0117c in a rat model of infective endocarditis. No InE was observed for CPT or NAF, whereas a marked InE was detected for CFZ (MIC, 8 to ≥128 μg/ml). CPT and NAF treatment against TX0117 resulted in mean bacterial counts of 2.3 and 2.1 log10CFU/g in vegetations, respectively, compared to a mean of 5.9 log10CFU/g in the CFZ-treated group (CPT and NAF versus CFZ, P= 0.001; CPT versus NAF, P= 0.9830). Both CFZ and CPT were efficacious against the βla-cured derivative, TX0117c, compared to time zero (t0) (P= <0.0001 and 0.0015, respectively). Our data reiterate the in vivoconsequences of the CFZ InE and show that CPT is not affected by this phenomenon. CPT might be considered for high-inoculum infections caused by MSSA exhibiting the CFZ InE.
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- 2017
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20. Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial.
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O'Halloran JA, Ko ER, Anstrom KJ, Kedar E, McCarthy MW, Panettieri RA Jr, Maillo M, Nunez PS, Lachiewicz AM, Gonzalez C, Smith PB, de Tai SM, Khan A, Lora AJM, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Wen J, Silverstein A, O'Brien SM, Al-Khalidi HR, Maldonado MA, Melsheimer R, Ferguson WG, McNulty SE, Zakroysky P, Halabi S, Benjamin DK Jr, Butler S, Atkinson JC, Adam SJ, Chang S, LaVange L, Proschan M, Bozzette SA, and Powderly WG
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- Male, Humans, Adult, Middle Aged, Female, Abatacept, Infliximab, SARS-CoV-2, Pandemics, COVID-19
- Abstract
Importance: Immune dysregulation contributes to poorer outcomes in COVID-19., Objective: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia., Design, Setting, and Participants: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and December 2021., Interventions: Single infusion of abatacept (10 mg/kg; maximum dose, 1000 mg) or infliximab (5 mg/kg) or a 28-day oral course of cenicriviroc (300-mg loading dose followed by 150 mg twice per day)., Main Outcomes and Measures: The primary outcome was time to recovery by day 28 evaluated using an 8-point ordinal scale (higher scores indicate better health). Recovery was defined as the first day the participant scored at least 6 on the ordinal scale., Results: Of the 1971 participants randomized across the 3 substudies, the mean (SD) age was 54.8 (14.6) years and 1218 (61.8%) were men. The primary end point of time to recovery from COVID-19 pneumonia was not significantly different for abatacept (recovery rate ratio [RRR], 1.12 [95% CI, 0.98-1.28]; P = .09), cenicriviroc (RRR, 1.01 [95% CI, 0.86-1.18]; P = .94), or infliximab (RRR, 1.12 [95% CI, 0.99-1.28]; P = .08) compared with placebo. All-cause 28-day mortality was 11.0% for abatacept vs 15.1% for placebo (odds ratio [OR], 0.62 [95% CI, 0.41-0.94]), 13.8% for cenicriviroc vs 11.9% for placebo (OR, 1.18 [95% CI 0.72-1.94]), and 10.1% for infliximab vs 14.5% for placebo (OR, 0.59 [95% CI, 0.39-0.90]). Safety outcomes were comparable between active treatment and placebo, including secondary infections, in all 3 substudies., Conclusions and Relevance: Time to recovery from COVID-19 pneumonia among hospitalized participants was not significantly different for abatacept, cenicriviroc, or infliximab vs placebo., Trial Registration: ClinicalTrials.gov Identifier: NCT04593940.
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- 2023
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21. [Impact of population mobility on the behavior of respiratory viruses during the COVID-19 pandemic].
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Cobos M, Nannini EC, Balbuena JP, Crocci EE, Schreiner D, Garcia EA, Chapartegui S, Doubik P, Romandetta A, Cooke B, Alzogaray MF, Baumeister E, and Mykietiuk A
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- Humans, SARS-CoV-2, Pandemics, Retrospective Studies, Argentina epidemiology, COVID-19
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Introduction: During the SARS-CoV-2 pandemic, Argentina population suffered from significant changes in population mobility due to non-pharmaceutical interventions. The aim of this study was to describe the impact of the mobility restrictions to the rates of positivity and diversity among different respiratory viruses., Methods: Retrospective analytical study performed at Instituto Médico Platense in La Plata that included 458 patients with nasopharyngeal swab to search for respiratory pathogens by multiplex PCR. Changes in mobility were studied using "Community Mobility Reports", data set developed by Google and publicly available., Results: Community mobility had significant correlation with the percentages of viral test positivity (p = < 0.01; R2=0.89) and viral diversity (p = 0.04; R2 = 0.78)., Discussion: Non-pharmaceutical interventions established to contain SARS-CoV-2 spread had a significant impact in the circulation patterns of other respiratory viruses.
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- 2023
22. Infliximab for Treatment of Adults Hospitalized with Moderate or Severe Covid-19.
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O'Halloran JA, Kedar E, Anstrom KJ, McCarthy MW, Ko ER, Nunez PS, Boucher C, Smith PB, Panettieri RA, de Tai SMT, Maillo M, Khan A, Mena Lora AJ, Salathe M, Capo G, Gonzalez DR, Patterson TF, Palma C, Ariza H, Lima MP, Lachiewicz AM, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Alicic R, Rauseo AM, Wolfe CR, Witting B, Benjamin DK, McNulty SE, Zakroysky P, Halabi S, Butler S, Atkinson J, Adam SJ, Melsheimer R, Chang S, LaVange L, Proschan M, Bozzette SA, and Powderly WG
- Abstract
Background: Immune dysregulation contributes to poorer outcomes in severe Covid-19. Immunomodulators targeting various pathways have improved outcomes. We investigated whether infliximab provides benefit over standard of care., Methods: We conducted a master protocol investigating immunomodulators for potential benefit in treatment of participants hospitalized with Covid-19 pneumonia. We report results for infliximab (single dose infusion) versus shared placebo both with standard of care. Primary outcome was time to recovery by day 29 (28 days after randomization). Key secondary endpoints included 14-day clinical status and 28-day mortality., Results: A total of 1033 participants received study drug (517 infliximab, 516 placebo). Mean age was 54.8 years, 60.3% were male, 48.6% Hispanic or Latino, and 14% Black. No statistically significant difference in the primary endpoint was seen with infliximab compared with placebo (recovery rate ratio 1.13, 95% CI 0.99-1.29; p=0.063). Median (IQR) time to recovery was 8 days (7, 9) for infliximab and 9 days (8, 10) for placebo. Participants assigned to infliximab were more likely to have an improved clinical status at day 14 (OR 1.32, 95% CI 1.05-1.66). Twenty-eight-day mortality was 10.1% with infliximab versus 14.5% with placebo, with 41% lower odds of dying in those receiving infliximab (OR 0.59, 95% CI 0.39-0.90). No differences in risk of serious adverse events including secondary infections., Conclusions: Infliximab did not demonstrate statistically significant improvement in time to recovery. It was associated with improved 14-day clinical status and substantial reduction in 28- day mortality compared with standard of care., Trial Registration: ClinicalTrials.gov ( NCT04593940 ).
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- 2022
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23. Abatacept for Treatment of Adults Hospitalized with Moderate or Severe Covid-19.
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Ko ER, Anstrom KJ, Panettieri RA, Lachiewicz AM, Maillo M, O'Halloran JA, Boucher C, Smith PB, McCarthy MW, Segura Nunez P, Mendivil Tuchia de Tai S, Khan A, Mena Lora AJ, Salathe M, Kedar E, Capo G, Rodríguez Gonzalez D, Patterson TF, Palma C, Ariza H, Patelli Lima M, Blamoun J, Nannini EC, Sprinz E, Mykietiuk A, Wang JP, Parra-Rodriguez L, Der T, Willsey K, Benjamin DK, Wen J, Zakroysky P, Halabi S, Silverstein A, McNulty SE, O'Brien SM, Al-Khalidi HR, Butler S, Atkinson J, Adam SJ, Chang S, Maldonado MA, Proscham M, LaVange L, Bozzette SA, and Powderly WG
- Abstract
Background: We investigated whether abatacept, a selective costimulation modulator, provides additional benefit when added to standard-of-care for patients hospitalized with Covid-19., Methods: We conducted a master protocol to investigate immunomodulators for potential benefit treating patients hospitalized with Covid-19 and report results for abatacept. Intravenous abatacept (one-time dose 10 mg/kg, maximum dose 1000 mg) plus standard of care (SOC) was compared with shared placebo plus SOC. Primary outcome was time-to-recovery by day 28. Key secondary endpoints included 28-day mortality., Results: Between October 16, 2020 and December 31, 2021, a total of 1019 participants received study treatment (509 abatacept; 510 shared placebo), constituting the modified intention-to-treat cohort. Participants had a mean age 54.8 (SD 14.6) years, 60.5% were male, 44.2% Hispanic/Latino and 13.7% Black. No statistically significant difference for the primary endpoint of time-to-recovery was found with a recovery-rate-ratio of 1.14 (95% CI 1.00-1.29; p=0.057) compared with placebo. We observed a substantial improvement in 28-day all-cause mortality with abatacept versus placebo (11.0% vs. 15.1%; odds ratio [OR] 0.62 [95% CI 0.41- 0.94]), leading to 38% lower odds of dying. Improvement in mortality occurred for participants requiring oxygen/noninvasive ventilation at randomization. Subgroup analysis identified the strongest effect in those with baseline C-reactive protein >75mg/L. We found no statistically significant differences in adverse events, with safety composite index slightly favoring abatacept. Rates of secondary infections were similar (16.1% for abatacept; 14.3% for placebo)., Conclusions: Addition of single-dose intravenous abatacept to standard-of-care demonstrated no statistically significant change in time-to-recovery, but improved 28-day mortality., Trial Registration: ClinicalTrials.gov ( NCT04593940 ).
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- 2022
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