35 results on '"Mutlu, Levent Cem"'
Search Results
2. Predictive value of NLRC3 levels for pulmonary hypertension in patients with chronic obstructive pulmonary disease.
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Yılmaz, Meltem, Mutlu, Levent Cem, Alpsoy, Şeref, Akyüz, Aydın, Çelikkol, Aliye, and Kaymaz, Özlem
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CHRONIC obstructive pulmonary disease , *PULMONARY hypertension , *OBSTRUCTIVE lung diseases , *PULMONARY artery , *AIRWAY (Anatomy) - Abstract
Objectives: Chronic obstructive pulmonary disease (COPD) is a medical condition defined by persistent airflow limitation and respiratory symptoms caused by airway and/or alveolar abnormalities. Pulmonary hypertension (PH) is one of the cardiovascular comorbidities associated with COPD. We investigated the correlation of NLRC3 levels in patients with COPD with prognostic and surrogate parameters of PH on echocardiography and examined whether it could be used to predict PH in this patient population. Methods: A total of 80 patients diagnosed with COPD and 40 healthy volunteers as the control group were included in the study. The COPD group was further divided into two subgroups according to the systolic pulmonary artery pressure (sPAP) as follows: sPAP<35 mmHg and sPAP≥35 mmHg. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the levels of NLRC3 in peripheral blood. Results: Patients with sPAP≥35 mmHg had a lower mean NLRC3 level than those with sPAP<35 mmHg (P=0.006). The NLRC3 levels showed a significant negative correlation with sPAP, tricuspid regurgitation velocity, right atrium, and pulmonary artery diameter. For NLRC3, the cut-off value was found to be 271,486 ng/L, with a sensitivity of 74%, and specificity of 63% in distinguishing patients with sPAP≥35 mmHg from all patients with sPAP<35 mmHg. Conclusion: Our study results suggest that NLRC3 levels measured from peripheral blood are predictive of PH in patients with COPD. Although the exact function of NLRC3 in the lungs, COPD, and PH have not been completely understood, we believe these findings will serve as a model for future studies. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea.
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Altintas, Nejat, Mutlu, Levent Cem, Akkoyun, Dursun Cayan, Aydin, Murat, Bilir, Bulent, Yilmaz, Ahsen, and Malhotra, Atul
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Humans ,Sleep Apnea ,Obstructive ,Vascular Diseases ,Proteoglycans ,Neoplasm Proteins ,Polysomnography ,Continuous Positive Airway Pressure ,Risk Factors ,Adult ,Aged ,Middle Aged ,Female ,Male ,Carotid Intima-Media Thickness ,Biomarkers ,biomarkers ,carotid intima media thickness ,endocan ,flow-mediated dilatation ,obstructive sleep apnea ,Cardiovascular System & Hematology ,Clinical Sciences - Abstract
Obstructive sleep apnea (OSA) is associated with increased cardiovascular (CV) morbidity and mortality. Endocan is a surrogate endothelial dysfunction marker that may be associated with CV risk factors. In this study, we tested whether serum endocan is a biomarker for OSA. Serum endocan levels were measured at baseline in 40 patients with OSA and 40 healthy controls and after 3 months of continuous positive airway pressure (CPAP) treatment in the patients with OSA. All participants were evaluated by full polysomnography. Flow-mediated dilatation (FMD) and carotid intima media thickness (cIMT) were measured in all participants. Endocan levels were significantly higher in patients with OSA than in healthy controls. After adjusting confounders, endocan was a good predictor of OSA. Endocan levels correlated with OSA severity (measured by the apnea-hypopnea index [AHI]). After 3 months of CPAP treatment, endocan levels significantly decreased. Endocan levels were significantly and independently correlated with cIMT and FMD after multiple adjustments. The cIMT and FMD also had significant and independent correlation with AHI. Endocan might be a useful marker for the predisposition of patients with OSA to premature vascular disease.
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- 2016
4. Methemoglobinemia after local anesthesia with prilocaine in adults: four case reports.
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Yılmaz, Meltem, İşcan, Arif, and Mutlu, Levent Cem
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METHEMOGLOBINEMIA ,LOCAL anesthesia ,PRILOCAINE ,PHYSIOLOGICAL transport of oxygen ,CYANOSIS - Abstract
Methemoglobinemia is a serious hematological disease characterized by the incapability of sufficient oxygen delivery to tissues and cyanosis when iron within hemoglobin in ferrous form (Fe+2) is oxidized to ferric form (Fe+3). Methemoglobinemia may be congenital or acquired. While prilocaine-induced methemoglobinemia can be seen in newborns and early pediatric ages, it is a rare condition in adults. We aimed to investigate prilocaine-induced adult methemoglobinemia with four cases. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Cystic fibrosis diagnosed in a nineteen-year-old case.
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Yılmaz, Meltem and Mutlu, Levent Cem
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CYSTIC fibrosis diagnosis , *ASTHMA diagnosis , *BRONCHIECTASIS , *ASTHMA in children , *GENETIC disorders - Abstract
Cystic fibrosis is the most common autosomal recessive hereditary disease in white populations. It is characterized by the formation of abnormal secretions in the exocrine glands located in the sweat and salivary glands, tracheobronchial tree, large intestine, and pancreas. The severity of the clinic depends on the type of "cystic fibrosis transmembrane regulatory protein" gene mutation. Although most cases are diagnosed in infancy or childhood, some patients are also diagnosed during adolescence and adulthood. We report a case a 19-yearold patient who was followed up with a diagnosis of asthma and bronchiectasis since childhood and diagnosed with cystic fibrosis. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Effect of CPAP on Hemocyte Profile C-reactive Protein and Fibrinogen Levels in People with Obstructive Sleep Apnea
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YILMAZ, Meltem, primary and MUTLU, Levent Cem, additional
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- 2023
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7. Expert Opinion on Practice Patterns in Mild Asthma After the GINA 2019 Updates: A Major Shift in Treatment Paradigms from a Long-Standing SABA-Only Approach to a Risk Reduction-Based Strategy with the Use of Symptom-Driven (As-Needed) Low-Dose ICS/LABA
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MUTLU, PINAR, ÖZŞEKER, ZEYNEP FERHAN, MUTLU, LEVENT CEM, ÖZTÜRK, CAN, and Aksu, Kurtulus
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Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Abstract
Purpose of Review This expert opinion, prepared by a panel of chest disease specialists, aims to review the current knowledge on practice patterns in real-life management of mild asthma and to address the relevant updates in asthma treatment by The Global Initiative for Asthma (GINA) to guide clinicians for the best clinical practice in applying these new treatment paradigms. Recent Findings On the basis of the emerging body of evidence suggesting the non-safety of short-acting beta 2-agonists (SABA)-only therapy and comparable efficacy of the as-needed inhaled corticosteroids (ICS)-formoterol combinations with maintenance ICS regimens, GINA recently released their updated Global Strategy for Asthma Management and Prevention Guide (2019). The new GINA 2019 recommendations no longer support the SABA-only therapy in mild asthma but instead includes new off-label recommendations such as symptom-driven (as-needed) low-dose ICS-formoterol and "low dose ICS taken whenever SABA is taken." The GINA 2019 asthma treatment recommendations include a major shift from long-standing approach of clinical practice regarding the use of symptom-driven SABA treatment alone in the management of mild asthma. This expert opinion supports the transition from a long-standing SABA-only approach to a risk reduction-based strategy, with the use of symptom-driven (as-needed) low-dose ICS/LABA in mild asthma patients, particularly in those with poor adherence to controller medications. The thoughtful and comprehensive approach of clinicians to these strategies is important, given that the exact far-reaching impact of this major change in management of mild asthma in the real-world settings will only be clarified over time.
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- 2022
8. Characteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors
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Şengül, Aysun, primary, Mutlu, Pınar, additional, Özdemir, Özer, additional, Satıcı, Celal, additional, Turan, Muzaffer Onur, additional, Arslan, Sertaç, additional, Ogan, Nalan, additional, Ekici Ünsal, Zuhal, additional, Bozkuş, Fulsen, additional, Çapraz, Aylin, additional, Demirkol, Mustafa Asım, additional, Mutlu, Levent Cem, additional, Yıldız Gülhan, Pınar, additional, Alkılınç, Ersin, additional, Fazlıoğlu, Nevin, additional, Söyler, Yasemin, additional, Kabalak, Pınar Akın, additional, Kızılgöz, Derya, additional, Turan, Pakize Ayşe, additional, Yıldırım, Fatma, additional, Aydemir, Yusuf, additional, Şen, Nazan, additional, and Mirici, Arzu, additional
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- 2022
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9. Growth Differentiation Factor-15 Is a Novel Biomarker Predicting Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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Mutlu, Levent Cem, Altintas, Nejat, Aydin, Murat, Tulubas, Feti, Oran, Mustafa, Kucukyalin, Volkan, Kaplan, Gizem, and Gurel, Ahmet
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- 2015
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10. Reduction Mammaplasty Effect on Pulmonary Function and Arterial Blood Gas in the Overweight Female
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Ceber, Mehmet, Yuksek, Adnan, Mutlu, Levent Cem, Bali, Ilhan, and Topcu, Birol
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- 2015
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11. The incidence of acute kidney injury and its association with mortality in patients diagnosed withCOVID‐19 followed up in intensive care unit
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Bayrakci, Nergiz, primary, Özkan, Gülsüm, additional, Şakaci, Murat, additional, Sedef, Samet, additional, Erdem, İlknur, additional, Tuna, Nazan, additional, Mutlu, Levent Cem, additional, Yildirim, İlker, additional, Kiraz, Nuri, additional, Erdal, Berna, additional, Gelgeç, Ebru, additional, Erer, Ayşen, additional, Saraç, Ömürhan, additional, Yavuz, Ahmet, additional, Dolap, Uysal, additional, Hayri, Uluğ Bey, additional, Kocadelioğlu, İnci, additional, and Batmaz, Emrah, additional
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- 2022
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12. A Correlation Between Quantitative Measurement Parameters of Thorax Computed Tomography and Pulmonary Function Test: A Retrospective Study
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SASANI, Hadi, primary and MUTLU, Levent Cem, additional
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- 2021
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13. The incidence of acute kidney injury and its association with mortality in patients diagnosed with COVID‐19 followed up in intensive care unit.
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Bayrakci, Nergiz, Özkan, Gülsüm, Şakaci, Murat, Sedef, Samet, Erdem, İlknur, Tuna, Nazan, Mutlu, Levent Cem, Yildirim, İlker, Kiraz, Nuri, Erdal, Berna, Gelgeç, Ebru, Erer, Ayşen, Saraç, Ömürhan, Yavuz, Ahmet, Dolap, Uysal, Hayri, Uluğ Bey, Kocadelioğlu, İnci, and Batmaz, Emrah
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COVID-19 ,ACUTE kidney failure ,INTENSIVE care units ,CHRONIC obstructive pulmonary disease - Abstract
Introduction: The kidneys are some of the most frequently affected organs during coronavirus disease 2019 (COVID‐19). This multicenter study evaluated the incidence of and risk factors for acute kidney injury (AKI) in COVID‐19 patients followed up in intensive care unit (ICU) and its association with mortality. Methods: Three hundred twenty‐eight patients diagnosed with COVID‐19 and hospitalized in ICU were included. Risk factors associated with AKI and mortality were evaluated. Results: Eighty‐eight patients (27.9%) were diagnosed with AKI. AKI was significantly associated with older age, higher baseline creatinine level, lower albumin level, and coexistence of cardiovascular disease and chronic obstructive pulmonary disease. Mortality in the entire study group was significantly associated with AKI, older age, requirement of invasive mechanical ventilation, higher neutrophil level, lower lymphocyte, and albumin levels. Conclusion: AKI is frequently seen during the course of COVID‐19 and is associated with high mortality. Identifying AKI‐related risk factors appears essential in the management of COVID‐19 patients. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings
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Bayrakci, Nergiz, primary, Ozkan, Gulsum, additional, Mutlu, Levent Cem, additional, Erdem, lknur, additional, Yildirim, Ilker, additional, Gulen, Dumrul, additional, and Celikkol, Aliye, additional
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- 2021
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15. Nitrofurantoin Kullanımına Bağlı Gelişen Akut Akciğer Toksisitesi: Bir Olgu Eşliğinde
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Yılmaz, Meltem, İşcan, Arif, and Mutlu, Levent Cem
- Abstract
5-nitrofuran türevi olan nitrofurantoin, kadın hastalarda komplikasyonsuz idrar yolu infeksiyonlarının tedavisinde ilk seçenektir. Kullanımında önemli yan etkiler bildirilmiştir ve bunlar arasında dozdan bağımsız olarak akciğer tutulumu da mevcuttur. Akut pulmoner reaksiyonlar genellikle nitrofurantoinin başlangıcından sonraki 3-8 gün içinde gelişir, ancak ilk dozdan birkaç saat ila 4 hafta sonra da ortaya çıkabilir. Bu olgu sunumunda, nitrofurantoin kullanımına bağlı, akut akciğer toksisitesi gelişen bir hasta sunulmuştur. Nitrofurantoin, a 5-nitrofuran derivative, is the first choice in the treatment of uncomplicated urinary tract infections in female patients. Significant side effects have been reported in its use, including lung involvement independent of dose. Acute pulmonary reactions usually develop within 3-8 days after start using nitrofurantoin. However, it can also occur a few hours to 4 weeks after the first dose. In this case report, a patient with acute lung toxicity due to nitrofurantoin use will be presented.
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- 2021
16. Quantitative evaluation of computed tomography findings in patients with pulmonary embolism: the link between D-Dimer level and thrombus volume
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Sasani, Hadi, primary and Mutlu, Levent Cem, additional
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- 2021
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17. Acute Lung Toxicity Due to Nitrofurantoin Use: With A Case
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Yılmaz, Meltem, primary, İşcan, Arif, additional, and Mutlu, Levent Cem, additional
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- 2021
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18. Trakeobronkopatia Osteokondroplastika; Bir Olgu Eşliğinde.
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YILMAZ, Meltem, İŞCAN, Arif, and MUTLU, Levent Cem
- Abstract
Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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19. Carotid intima‐media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
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Gulbas, Gazi, primary, Turan, Onur, additional, Sarioglu, Nurhan, additional, Diken, Ozlem Ercen, additional, Ogan, Nalan, additional, Ekbic Kadioglu, Esra, additional, Kurtipek, Ercan, additional, Bozkus, Fulsen, additional, Yilmaz Demirci, Nilgün, additional, Coskun Beyan, Ayşe, additional, Mutlu, Levent Cem, additional, Sahin Duyar, Sezgi, additional, Deniz, Sami, additional, Fazlioglu, Nevin, additional, Sengul, Aysun, additional, Tanriverdi, Hakan, additional, Okutan, Oğuzhan, additional, Turan, Pakize Ayse, additional, İnonu, Handan, additional, Ortakoylu, Mediha Gonenc, additional, Lakadamyali, Huseyin, additional, Kivanc, Tulay, additional, Atli̇, Ozgur, additional, Özdemir, Ozer, additional, Filiz Koşar, A., additional, Mirici, Arzu, additional, and Suerdem, Mecit, additional
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- 2019
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20. KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞINDA KAROTİS İNTİMA-MEDİA KALINLIĞI VE SAĞ KALIM ÜZERİNE ETKİSİ
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BOZKUŞ, FULSEN, TURAN, ONUR, EKBİÇ KADIOĞLU, ESRA, OGAN, NALAN, GÜLBAŞ, GAZİ, ERÇEN DİKEN, ÖZLEM, COŞKUN BEYAN, AYŞE, SÜERDEM, MECİT, MİRİCİ, NİHAL ARZU, ÖZDEMİR, ÖZER, ATLI, ÖZGÜR, KIVANÇ, TÜLAY, LAKADAMYALI, HÜSEYİN, ORTAKÖYLÜ, GÖNENÇ, İNÖNÜ KÖSEOĞLU, HANDAN, TURAN, AYŞE, OKUTAN, OĞUZHAN, TANRIVERDİ, HAKAN, ŞENGÜL, AYSUN, FAZLIOĞLU, NEVİN, DENİZ, SAMİ, SARIOĞLU, NURHAN, YILMAZ DEMİRCİ, NİLGÜN, KURTİPEK, ERCAN, ŞAHİN DUYAR, SEZGİ, and MUTLU, LEVENT CEM
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- 2017
21. Obstructive sleep apnea syndrome frequency in obese patients
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Elbuken, Gulsah, primary, Yildiz, Ismail, additional, Mutlu, Levent Cem, additional, Altintas, Nejat, additional, and Zuhur, Sayid Shafi, additional
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- 2018
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22. Kot Kumlamaya Bağlı Olarak Gelişen İki Silikozis Olgusu
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Ermiş, Hilal, Gülbaş, Gazi, Yumrutepe, Tuncay, İn, Erdal, Mutlu, Levent Cem, Günen, Hakan, and Aydın, N. Engin
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Denim Sandblasting ,Silicosis ,Kot Kumlama ,Silikozis - Abstract
Silicosis which is one of the oldest known occupational diseases is characterized by an irreversible and progressive fibrotic reaction occuring in the lungs caused by inhaling crystalline silica dust. Effective treatment for silicosis is not available. Recently, denim sandblasting especially being made in uncontrolled small-scale workplace in primitive conditions has been a striking occupation leading to silicosis . Twenty and 28 years old male patients who work in denim sandblasting for 3 years were admitted to our clinics with complaints of dyspnea and loss of weight. Chest X ray and thorax computerized tomography revealed bilateral diffuse reticulonodular and nodular opacities which were prominent in the upper and middle zones and peripheric area of pulmonary parenchyma. Restrictive disorder was observed at their pulmonary function tests. Silicosis was diagnosed by performing transbronchial biopsy in one case. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was performed and the other patient was also diagnosed as silicosis. In developing countries in which the labor force is very cheap, silicosis becomes a public health problem in denim sandblasters and can be prevented with improvement of working conditions. We believe that further precaution must be taken to stop darkened lives while jeans is bleaching. Key words: Denim Sandblasting; Silicosis., Bilinen en eski meslek hastalıklarından biri olan silikozis, solunabilir büyüklükteki silika kristallerinin akciğer dokusunda geri dönüşümsüz ve ilerleyici bir fibrotik reaksiyon oluşturması ile karakterize tedavisi olmayan bir hastalıktır. Son yıllarda özellikle küçük ve denetimsiz atölyelerde uygunsuz koşullarda yapılan kot kumlama işi hastalığın gelişiminde farklı bir işkolu haline gelmiştir. 3 yıldır kot kumlama işinde çalışan 20 ve 28 yaşlarında iki erkek hasta, nefes darlığı ve kilo kaybı şikayetleri ile kliniğimize başvurdu. Posteroanterior akciğer grafilerinde ve toraks bilgisayarlı tomografilerinde özellikle her iki üst ve orta zonlarda ve periferik bölgelerde yoğun yerleşimli, yaygın retikülonodüler ve nodüler opasiteler izlendi. Solunum fonksiyon testlerinde restriktif tipte ventilasyon bozukluğu saptandı. Birinci olgumuza transbronşiyal biyopsi ile silikozis tanısı kondu. İkinci olgu ise ilki ile benzer yakınmaları, radyolojik bulguları ve mesleksel maruziyet öyküsü nedeniyle ileri girişimsel inceleme yapılmadan tanı aldı. İş gücünün ucuz olduğu gelişmekte olan ülkelerde kot kumlama işinde çalışanlarda bir toplum sağlığı sorunu haline gelen silikozis çalışma şartlarının düzeltilmesi ile önlenebilir. Kotlar beyazlarken kararan hayatlara son vermek için daha fazla önlem alınması gerektiği inancındayız. Anahtar kelimeler: Kot Kumlama; Silikozis.
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- 2015
23. Swyer-James (Macleod) Sendromu: Bir Olgu Nedeniyle
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Gülbaş, Gazi, Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Yumrutepe, Tuncay, and Günen, Hakan
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Akciğer,Hiperlüsent,Swyer-James (Macleod) Sendromu - Abstract
Fourty two-year old male patient applied wih complaints of cough and dispnea. As there was evident hyperinflation in left lung on Posterior-Anterior (PA) chest roentgenogram, the patients was diagnosed to have Swyer-James (MacLeod) syndrome using the findings on ventilation/ perfusion scintigraphy, computerised thorax tomography and magnetic resonans (MR) angiography of thorax. We presented the case with the latest literature update as it is a rarely encountered syndrome. Key words: Lung, Hyperlucenct, Swyer-James ( Macleod ) Syndrome, 42 yaşında erkek hasta nefes darlığı ve öksürük şikayetleri ile başvurdu. Posterior Anterior (PA) akciğer grafisinde sol akciğerde belirgin havalanma artışı mevcut olan hastaya, ventilasyon- perfüzyon sintigrafisi, bilgisayarlı toraks tomografisi, toraks manyetik rezonans (MR) anjiyografi bulguları ile ‘Swyer-James (MacLeod) sendromu' tanısı konuldu. Nadir görülen bir sendrom olması nedeniyle son literatür bilgileri ışığında sunmayı uygun gördük. Anahtar Kelime:Akciğer, Hiperlüsent, Swyer-James (Macleod) Sendromu
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- 2015
24. Akut Solunum Yetmezliği Olan KOAH Hastalarında İlave Oksijen Tedavisinin Hipoksi Ve Hiperkapniye Etkisi
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Mutlu, Levent Cem, Hacıevliyagil, Süleyman Savaş, Günen, Hakan, and Kızkın, Özkan
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COPD,Supplemental oxygen therapy,Hypoxemia,Hypercapnia ,KOAH,İlave oksijen tedavisi,Hipoksi,Hiperkapni - Abstract
Background: Hypoxemia and hypercapnia are frequently encountered in chronic obstructive pulmonary disease (COPD) patients with acute attack. Objectives: To investigate the effect of 2 L/min oxygen given with nasal cannula on hypoxemia and hypercapnia in COPD patients with respiratory failure. Methods: Twenty-six type I (Group I) and 36 type II (Group II) respiratory failure patients were included in the study. The patients' initial clinical and laboratory findings were obtained. Spirometric examination and arterial blood gas (ABG) analysis were repeated after the administration of optimal medical therapy including 2 L/min oxygen given with nasal cannula. The patients whose PaCO2 values increased more than 10 mmHg with the treatment were also grouped as Group III, and their comparison was made with the rest of the patients (Group IV). Results: Among the initial laboratory parameters; PaO2 was lower in Group II (p0.05). In Group III, longer disease duration and higher rate of cor pulmonale were found to be statistically significant when compared with Group IV (p, Giriş: Kronik obstruktif akciğer hastalığı (KOAH) akut atağında; hipoksemi ve hiperkapniye sıklıkla rastlanılmaktadır. Amaç: Solunum yetmezliği olan KOAH hastalarında, nazal kanül ile verilen 2 L/dk oksijenin, hipoksemi ve hiperkapniye etkisini araştırmaktır. Gereç ve Yöntem: Yirmi altı tip I (Grup I) ve 36 tip II (Grup II) solunum yetmezlikli hasta çalışmaya alındı. Hastaların başvuru klinik ve laboratuar bulguları kaydedildi. Hastalar tam tıbbi tedavi yanısıra nazal kanülle 2 L/dk ilave oksijen aldıktan sonra, solunum fonksiyon testleri ve arter kan gazı (AKG) ölçümleri tekrar edildi. Tedavi ile PaCO2 değerleri 10 mmHg'dan daha fazla yükselenler Grup III'ü oluşturdu ve geri kalan hastalarla (Grup 4) karşılaştırılmaları yapıldı. Bulgular: Başlangıç laboratuvar parametrelerinden; PaO2 Grup II'de daha düşüktü. Her iki grupta tedavi sonrası saptanan PaO2 değerlerindeki artış istatistiksel olarak anlamlıydı (p0.05). Grup 3'de Grup 4'e göre hastalık süresinin daha uzun olması ve kor pulmonale'nin daha fazla olması istatistiksel olarak anlamlı saptandı (p
- Published
- 2015
25. Pulmoner Tromboembolide Genetik Risk Faktörleri (Beş Olgu Nedeniyle)
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KIZKIN, Özkan, HACIEVLİYAGİL, S. Savaş, MUTLU, Levent Cem, GÜNEN, Hakan, and YILDIRIM, Zeki
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Pulmonary thromboembolus is a disease with high mortality and morbidity. In addition to well known and frequent risk factors, there are some rare congenital predisposing factors. In five of 43 patients (11.6%) diagnosed as pulmonary embolus between 1998 and 2001 in our clinic we detected a genetic risk factor for venous thromboemboli. Except one patient, there were no formerly known genetic risk factor. Due to our results, it can be proposed that the genetical predisposition should be searched in patients who developed venous thromboemboli without any known risk factor. We discussed 3 patients with antiphospholipid syndrome, one patient with protein C deficiency and one patient with protein S deficiency and activated protein C resistance (APC-R), in total 5 cases, with regard to current literature. Keywords: Antiphospholipid Syndrome, Protein C Deficency, Protein S Deficency, Activated C Resistance, Pulmonary Thromboemboli, Pulmoner tromboemboli mortalite ve morbiditesi yüksek bir hastalıktır. Hastalık için bilinen ve sık görülen risk faktörlerinin yanı sıra, kongenital predispozisyon yaratan nadir durumlar da vardır. Kliniğimizde 1998-2001 yıllarında takip edilen pulmoner tromboembolili 43 hastanın beşinde (%11.6) venöz tromboemboli için genetik risk faktörü saptadık. Hastaların biri dışında hiçbirisinde daha önceden bilinen bir genetik risk faktörü yoktu. Bu yüzden; bilinen bir risk faktörü olmadığı halde, venöz tromboemboli gelişen hastalarda genetik yatkınlık sebepleri araştırılmalıdır. Biz antifosfolipid sendromlu üç, protein C eksikliği olan bir ve protein S eksikliği- aktive protein C rezistanslı (APC-R) bir olguda gelişen pulmoner tromboembolili toplam beş olguyu, ilgili literatür eşliğinde tartıştık. Anahtar kelimeler: Antifosfolipid Sendromu, Protein C Eksikliği, Protein S Eksikliği, Aktive Protein C Rezistansı, Pulmoner Tromboemboli.
- Published
- 2015
26. Bir Olgu Nedeniyle Poland Sendromu
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Hacıevliyagil, Süleyman Savaş, Gülbaş, Gazi, Mutlu, Levent Cem, Yetkin, Özkan, Ulutaş, Hakkı, and Günen, Hakan
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Poland sendromu,Pektoralis major kası,Tek taraflı saydam akciğer. Poland Syndrome ,Poland syndrome,Absence of pectoralis major,Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital - Abstract
Poland syndrome is a rarely encountered genetical disorder that is characterized with unilateral absence of pectoralis major muscle. Upper extremity deformities and anomalies in the breast, nipple and hand may accompany the syndrome. It is generally right sided and is more frequent in males. A 36 year-old male patient's PA chest X-ray who was admitted with the complaint of haemoptysis, showed rightsided hyperlucency. His chest computed tomography demonstrated Poland syndrome. This patient was presented as case report because of rarity of Poland syndrome. Key words: Poland syndrome, Absence of pectoralis major, Unilateral hyperlusensy. Poland sendromu tek taraflı pektoralis major kasının yokluğu ile karakterize konjenital, Poland sendromu pektoralis major kasının tek taraflı yokluğu ile karakterize konjenital bir sendromdur. Bu sendroma meme, el ve diğer organ anomalileri de eşlik edebilir. Genellikle sağ tarafı tutar ve erkeklerde daha sıktır. Otuzaltı yaşında hemoptizi ile başvuran erkek hastanın çekilen akciğer grafisinde sağ hemitoraksta saydamlık artışı saptandı. Bu nedenle çekilen toraks bilgisayarlı tomografisinde Poland sendromu saptandı. Bu olgu az görüldüğü ve radyolojik özellikleri nedeniyle sunulmuştur. Anahtar kelimeler: Poland sendromu, Pektoralis major kası, Tek taraflı saydam akciğer. Poland Syndrome
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- 2015
27. Tekirdağ’da Tüberkülozun Yıllar İçindeki Değişimi
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Güneş, Hayati, Altın, Remzi, Mutlu, Levent Cem, Doğan, Mustafa, Oran, Mustafa, Işık, Salman, Salt, Gürdal, Kaya, Ayşe Demet, and Topçu, Birol
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antitüberküloz ajanlar ,Tüberküloz ,antibiyotik direnci ,antibiotic resistance ,multidrug resistance ,Incidence ,Tuberculosis ,insidans ,çoklu ilaç direnci ,antitubercular agents - Abstract
Amaç Dünya Sağlık Örgütü tarafından tüm dünyada hesaplanan tüberküloz (TB) insidansı 100.000'de 128'dir. TB kontrolünün ana prensipleri erken tanı ve tedavi, bunu takiben de hastaların direkt gözlemsel tedavisidir. Bu çalışmanın amacı, 2007-2011 yılları arasında Tekirdağ’da tüberküloz verilerindeki değişimin analizini yapmaktı. Materyal ve Metod Tekirdağ il sınırları içinde bulunan Tekirdağ ve Çorlu Verem savaş dispanserlerinden elde edilen veriler birer yıllık kategorilere ayrıldı. Hastalar, yaş gruplarına göre 0-14, 15-24, 25-44, 45-64, 65 ve Üzeri olmak Üzere 5 gruba ayrıldı ve vaka bildirim oranları tüm gruplarda analiz edildi. Hastalar, tutulan organa göre 2 gruba ayrıldı: Pulmoner (smear/kültür pozitif =PSP ve smear/kültür negatif/bilinmeyen =PSB/N) ve ekstrapulmoner. Kültürde üremiş ve dirençli olduğundan şüphelenilen M. Tuberculosis suşlarına major ilaçlar olan izoniazid (INH), rifampisin, etambutol ve streptomisine karşı duyarlılık testi uygulandı. INH ve rifampisine dirençli suşlar çoklu ilaca dirençli tüberküloz olarak kabul edildi (ÇİD-TB). Bulgular Toplam 162.291 hasta muayene edildi ve bunlardan 1311 (%0,8)’i TB hastası olarak değerlendirildi. Vaka bildirim oranlarının yıllara gore dağılımı 2007 ile 2011 arasında sırasıyla %44,6, %34,6, %33,4 ve %28,6 idi. Pulmoner ve ekstrapulmoner TB oranları sırasıyla %74,5 (%46 PSP ve %28,5 PSN/B) ve %25,5 idi. Ekstrapulmoner tüberküloz oranları erkekler ve kadınlarda sırasıyla %42,3 ve %17,6 idi. INH, rifampisin, etambutol ve streptomisine direnöoranları sırasıyla %21,6, %8,8, %1,6 ve %6,4 idi. ÇİD-TB oranı %6,4 olarak tespit edildi. Sonuç Doğrudan gözetimli tedavinin sistematik uygulanması tüberküloz insidansının düşmesinde önemli rol oynar. Bölgemizde tüberküloz oranları türkiye ortalamasının üzerinde olduğundan tarama ve takip prosedürleri daha sıkı ve düzenli olarak uygulanmalıdır. Aim The incidence rate of tuberculosis (TB) is estimated by the World Health Organization as 128/100.000 worldwide. The main principles of TB control are early case detection and diagnosis, followed by directly observed treatment of patients. The aim of this study was to analyse the dynamics of TB between 2007 and 2011 in Tekirdağ. Material and Methods Data were obtained from TB dispensaries and separated into oneyear categories. Case notification rates were analysed by different age groups (0–14, 15–24, 25–44, 45–64, 65 and above). The patients were divided into two groups according to involved organs: pulmonary (smear/culture positive=PSP and smear/culture negative/unknown=PSN/U) and extrapulmonary. Antibiotic susceptibility tests to major antituberculosis drugs were performed on M. tuberculosis strains that were grown in culture and suspected of being resistant. Resistance to both INH and rifampicin were accepted as multiple drug resistance tuberculosis (MDR-TB). Results A total of 162.291 patients were examined, and out of this population, 1311 (0.8%) tuberculosis patients were evaluated. The distribution of case notification rates by year were 44.6%, 34.6%, 33.4%, 28.6%, and 27.6%from 2007 to 2011, respectively. Pulmonary and extrapulmonary TB rates were 74.5%(46.0%PSP and 28.5%PSN/U) and 25.5%, respectively. Extrapulmonary TB rates were 42.3% and 17.6% in men and women, respectively. Resistance rates against INH, rifampicin, ethambutol, and streptomycin were 21.6%, 8.8%, 1.6%, and 6.4%, respectively. The MDR-TB rate was 6.4%. Conclusion Systematic implementation of directly observed treatment programs plays an important role in decreasing TB incidence. Because the TB rates in our region are above the average for Turkey, screening and follow-up procedures must be conducted more stringently and regularly.
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- 2015
28. Desquamative interstitial pneumonia: Risk factors, laboratory and bronchoalveolar lavage findings, radiological and histopathological examination, clinical features, treatment and prognosis.
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Diken, Özlem Erçen, Şengül, Aysun, Beyan, Ayşe Coşkun, Ayten, Ömer, Mutlu, Levent Cem, and Okutan, Oğuzhan
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IDIOPATHIC pulmonary fibrosis ,PULMONARY fibrosis ,IDIOPATHIC interstitial pneumonias ,BRONCHOALVEOLAR lavage ,PULMONARY alveolar proteinosis ,PNEUMONIA ,PULMONARY function tests - Abstract
Desquamative interstitial pneumonia is a type of smoking-associated major idiopathic interstitial pneumonia, which is characterized by accumulation of alveolar macrophages in alveolar lumens and septa and develops secondary to mainly active or passive exposure to cigarette smoke. Desquamative interstitial pneumonia mostly occurs in male smokers in association with non-specific symptoms responsive to steroid therapy and has a better prognosis than usual interstitial pneumonia. To date, no large-scale clinical studies have been performed on desquamative interstitial pneumonia patients. Factors responsible for the scarcity of data on the clinical course of this condition include the retrospective nature of the available information as well as its rare occurrence. Despite this, a general consensus exists as to the nature of its symptoms, association with smoking, age and gender distribution, findings of respiratory function tests, steroid responsivity and mortality. The objective of the present review article was to report on desquamative interstitial pneumonia and to describe its etiology, risk factors and clinical features, as well as the laboratory, bronchoalveolar lavage, radiological and histopathological findings, and the treatment and prognosis of affected patients. [ABSTRACT FROM AUTHOR]
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- 2019
29. Assesment of palliative care in lung cancer in Turkey (ASPECT study)
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Bulbul, Yilmaz, primary, Ozlu, Tevfik, additional, Arinc, Sibel, additional, Ozyurek, Berna A., additional, Gunbatar, Hulya, additional, Senturk, Aysegul, additional, Bahadir, Ayse, additional, Ozcelik, Melike, additional, Yilmaz, Ufuk, additional, Akbay, Makbule Ozlem, additional, Saglam, Leyla, additional, Kilic, Talat, additional, Kirkil, Gamze, additional, Ozcelik, Neslihan, additional, Tatar, Dursun, additional, Baris, Serap Argun, additional, Yavsan, Mehmet, additional, Sen, Hatice Selimoglu, additional, Berk, Serdar, additional, Acat, Murat, additional, Cakmak, Gulfidan, additional, Yumuk, Perran Fulden, additional, Intepe, Yavuz Selim, additional, Toru, Umran, additional, Ayik, Sibel O., additional, Basyigit, Ilknur, additional, Ozkurt, Sibel, additional, Mutlu, Levent Cem, additional, Yasar, Zehra Asuk, additional, Esme, Hidir, additional, Erol, Muharrem, additional, Oruc, Ozlem, additional, Erdogan, Yurdanur, additional, Asker, Selvi, additional, Ulas, Arife, additional, Erol, Serhat, additional, Kerget, Bugra, additional, Erbaycu, Ahmet Emin, additional, Teke, Turgut, additional, Besiroglu, Mehmet, additional, Can, Huseyin, additional, and Talay, Fahrettin, additional
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- 2015
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30. General characteristics and therapeutic options in lung cancer in Turkey
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Ozlu, Tevfik, primary, Bulbul, Yilmaz, additional, Arinc, Sibel, additional, Ozyurek, Berna A., additional, Gunbatar, Hulya, additional, Senturk, Aysegul, additional, Bahadir, Ayse, additional, Ozcelik, Melike, additional, Yilmaz, Ufuk, additional, Akbay, Makbule Ozlem, additional, Saglam, Leyla, additional, Kilic, Talat, additional, Kirkil, Gamze, additional, Ozcelik, Neslihan, additional, Tatar, Dursun, additional, Baris, Serap Argun, additional, Yavsan, Mehmet, additional, Sen, Hatice Selimoglu, additional, Berk, Serdar, additional, Acat, Murat, additional, Cakmak, Gulfidan, additional, Yumuk, Perran Fulden, additional, Intepe, Yavuz Selim, additional, Toru, Umran, additional, Ayik, Sibel O., additional, Basyigit, Ilknur, additional, Ozkurt, Sibel, additional, Mutlu, Levent Cem, additional, Yasar, Zehra Asuk, additional, Esme, Hidir, additional, Erol, Muharrem, additional, Oruc, Ozlem, additional, Erdogan, Yurdanur, additional, Asker, Selvi, additional, Ulas, Arife, additional, Erol, Serhat, additional, Kerget, Bugra, additional, Erbaycu, Ahmet Emin, additional, Teke, Turgut, additional, Besiroglu, Mehmet, additional, Can, Huseyin, additional, and Talay, Fahrettin, additional
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- 2015
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31. Effect of CPAP on New Endothelial Dysfunction Marker, Endocan, in People With Obstructive Sleep Apnea
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Altintas, Nejat, primary, Mutlu, Levent Cem, additional, Akkoyun, Dursun Cayan, additional, Aydin, Murat, additional, Bilir, Bulent, additional, Yilmaz, Ahsen, additional, and Malhotra, Atul, additional
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- 2015
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32. Assesment of palliative care in lung cancer in Turkey (ASPECT study)
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Makbule Ozlem Akbay, Serdar Berk, Hüseyin Can, Zehra Yasar, Melike Ozcelik, Aysegul Senturk, Serap Argun Baris, Hidir Esme, Fahrettin Talay, Hatice Selimoglu Sen, Talat Kilic, Mehmet Yavsan, Serhat Erol, Arife Ulas, Perran Fulden Yumuk, Hulya Gunbatar, Yavuz Selim Intepe, Ayse Bahadir, Ufuk Yilmaz, Ozlem Oruc, Mehmet Besiroglu, Gamze Kirkil, Tevfik Özlü, Sibel Ayik, Levent Cem Mutlu, Yurdanur Erdogan, Ümran Toru, Murat Acat, Ilknur Basyigit, Dursun Tatar, Buğra Kerget, Sibel Arinc, Leyla Saglam, Yılmaz Bülbül, Neslihan Özçelik, Gulfidan Cakmak, Ahmet Emin Erbaycu, Muharrem Erol, Berna Akıncı Özyürek, Selvi Asker, Turgut Teke, Sibel Özkurt, [Bulbul, Yilmaz -- Ozlu, Tevfik -- Ozcelik, Neslihan] Karadeniz Tech Univ, Sch Med, Chest Dis, Trabzon, Turkey -- [Arinc, Sibel -- Akbay, Makbule Ozlem -- Oruc, Ozlem] Sureyyapasa Pulm Dis & Thorac Surg Educ & Res Hos, Chest Dis, Istanbul, Turkey -- [Ozyurek, Berna A. -- Erdogan, Yurdanur] Ataturk Pulm Dis & Thorac Surg Educ & Res Hosp, Chest Dis, Ankara, Turkey -- [Gunbatar, Hulya -- Asker, Selvi] Yuzuncu Yil Univ, Sch Med, Chest Dis, Van, Turkey -- [Senturk, Aysegul -- Ulas, Arife] Ataturk Educ & Res Hosp, Chest Dis, Ankara, Turkey -- [Bahadir, Ayse] Yedikule Pulm Dis & Thorac Surg Educ & Res Hosp, Chest Dis, Istanbul, Turkey -- [Ozcelik, Melike] Kartal Educ & Res Hosp, Med Oncol, Istanbul, Turkey -- [Yilmaz, Ufuk -- Tatar, Dursun -- Erol, Serhat -- Erbaycu, Ahmet Emin] Dr Suat Seren Pulm Dis & Thorac Surg Educ & Res H, Chest Dis, Izmir, Turkey -- [Saglam, Leyla -- Kerget, Bugra] Ataturk Univ, Sch Med, Chest Dis, Erzurum, Turkey -- [Kilic, Talat] Inonu Univ, Sch Med, Chest Dis, Malatya, Turkey -- [Kirkil, Gamze] Firat Univ, Sch Med, Chest Dis, Elazig, Turkey -- [Baris, Serap Argun -- Basyigit, Ilknur] Kocaeli Univ, Sch Med, Chest Dis, Kocaeli, Turkey -- [Yavsan, Mehmet -- Teke, Turgut] Necmettin Erbakan Univ, Meram Sch Med, Chest Dis, Konya, Turkey -- [Sen, Hatice Selimoglu] Dicle Univ, Sch Med, Chest Dis, Diyarbakir, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Sch Med, Chest Dis, Sivas, Turkey -- [Acat, Murat] Karabuk Univ, Sch Med, Chest Dis, Zonguldak, Turkey -- [Cakmak, Gulfidan] Haseki Educ & Res Hosp, Chest Dis, Istanbul, Turkey -- [Yumuk, Perran Fulden -- Besiroglu, Mehmet] Marmara Univ, Sch Med, Med Oncol, Istanbul, Turkey -- [Intepe, Yavuz Selim] Bozok Univ, Sch Med, Chest Dis, Yozgat, Turkey -- [Toru, Umran] Dumlupinar Univ, Sch Med, Chest Dis, Kutahya, Turkey -- [Ayik, Sibel O. -- Can, Huseyin] Katip Celebi Univ, Sch Med, Chest Dis, Izmir, Turkey -- [Ozkurt, Sibel] Pamukkale Univ, Sch Med, Chest Dis, Denizli, Turkey -- [Mutlu, Levent Cem] Namik Kemal Univ, Sch Med, Chest Dis, Tekirdag, Turkey -- [Yasar, Zehra Asuk -- Talay, Fahrettin] Abant Izzet Baysal Univ, Sch Med, Chest Dis, Bolu, Turkey -- [Esme, Hidir] Konya Educ & Res Hosp, Thorac Surg, Konya, Turkey -- [Erol, Muharrem] Uludag Univ, Sch Med, Thorac Surg, Bursa, Turkey, Bulbul, Yilmaz -- 0000-0002-8488-3650, and Zonguldak Bülent Ecevit Üniversitesi
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medicine.medical_specialty ,Lung cancer / Oncology ,Palliative care ,Neoplastic diseases ,Nausea ,business.industry ,Analgesic ,macromolecular substances ,Disease ,medicine.disease ,Enteral administration ,Internal medicine ,Anesthesia ,medicine ,Anxiety ,medicine.symptom ,business ,Lung cancer ,Depression (differential diagnoses) - Abstract
WOS: 000451979407036, …
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- 2015
33. General characteristics and therapeutic options in lung cancer in Turkey
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Turgut Teke, Muharrem Erol, Berna Akıncı Özyürek, Ilknur Basyigit, Dursun Tatar, Melike Ozcelik, Hatice Selimoglu Sen, Hidir Esme, Mehmet Yavsan, Perran Fulden Yumuk, Serhat Erol, Leyla Saglam, Neslihan Özçelik, Gulfidan Cakmak, Serap Argun Baris, Ahmet Emin Erbaycu, Sibel Arinc, Arife Ulas, Tevfik Özlü, Gamze Kirkil, Mehmet Besiroglu, Yurdanur Erdogan, Ufuk Yilmaz, Buğra Kerget, Sibel Özkurt, Zehra Yasar, Makbule Ozlem Akbay, Serdar Berk, Talat Kilic, Hulya Gunbatar, Hüseyin Can, Aysegul Senturk, Ozlem Oruc, Fahrettin Talay, Levent Cem Mutlu, Yılmaz Bülbül, Ümran Toru, Ayse Bahadir, Selvi Asker, Yavuz Selim Intepe, Sibel Ayik, Murat Acat, Zonguldak Bülent Ecevit Üniversitesi, [Ozlu, Tevfik -- Bulbul, Yilmaz -- Ozcelik, Neslihan] Karadeniz Tech Univ, Chest Dis, Sch Med, Trabzon, Turkey -- [Arinc, Sibel -- Akbay, Makbule Ozlem -- Oruc, Ozlem] Sureyyapasa Pulm Dis & Thorac Surg Educ & Res Hos, Chest Dis, Istanbul, Turkey -- [Ozyurek, Berna A. -- Erdogan, Yurdanur] Ataturk Pulm Dis & Thorac Surg Educ & Res Hosp, Chest Dis, Ankara, Turkey -- [Gunbatar, Hulya -- Asker, Selvi] Yuzuncu Yil Univ, Chest Dis, Sch Med, Van, Turkey -- [Senturk, Aysegul -- Ulas, Arife] Ataturk Educ & Res Hosp, Chest Dis, Ankara, Turkey -- [Bahadir, Ayse] Yedikule Pulm Dis & Thorac Surg Educ & Res Hosp, Chest Dis, Istanbul, Turkey -- [Ozcelik, Melike] Kartal Educ & Res Hosp, Med Oncol, Istanbul, Turkey -- [Yilmaz, Ufuk -- Tatar, Dursun -- Erol, Serhat -- Erbaycu, Ahmet Emin] Dr Suat Seren Pulm Dis & Thorac Surg Educ & Res H, Chest Dis, Izmir, Turkey -- [Saglam, Leyla -- Kerget, Bugra] Ataturk Univ, Chest Dis, Sch Med, Erzurum, Turkey -- [Kilic, Talat] Inonu Univ, Chest Dis, Sch Med, Malatya, Turkey -- [Kirkil, Gamze] Firat Univ, Chest Dis, Sch Med, Elazig, Turkey -- [Baris, Serap Argun -- Basyigit, Ilknur] Kocaeli Univ, Chest Dis, Sch Med, Kocaeli, Turkey -- [Yavsan, Mehmet -- Teke, Turgut] Necmettin Erbakan Univ, Chest Dis, Meram Sch Med, Konya, Turkey -- [Sen, Hatice Selimoglu] Dicle Univ, Chest Dis, Sch Med, Diyarbakir, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Chest Dis, Sch Med, Sivas, Turkey -- [Acat, Murat] Karabuk Univ, Chest Dis, Sch Med, Zonguldak, Turkey -- [Cakmak, Gulfidan] Haseki Educ & Res Hosp, Chest Dis, Istanbul, Turkey -- [Yumuk, Perran Fulden -- Besiroglu, Mehmet] Marmara Univ, Med Oncol, Sch Med, Istanbul, Turkey -- [Intepe, Yavuz Selim] Bozok Univ, Chest Dis, Sch Med, Yozgat, Turkey -- [Toru, Umran] Dumlupinar Univ, Chest Dis, Sch Med, Kutahya, Turkey -- [Ayik, Sibel O. -- Can, Huseyin] Katip Celebi Univ, Chest Dis, Sch Med, Izmir, Turkey -- [Ozkurt, Sibel] Pamukkale Univ, Chest Dis, Sch Med, Denizli, Turkey -- [Mutlu, Levent Cem] Namik Kemal Univ, Chest Dis, Sch Med, Tekirdag, Turkey -- [Yasar, Zehra Asuk -- Talay, Fahrettin] Abant Izzet Baysal Univ, Chest Dis, Sch Med, Bolu, Turkey -- [Esme, Hidir] Konya Educ & Res Hosp, Thorac Surg, Konya, Turkey -- [Erol, Muharrem] Uludag Univ, Thorac Surg, Sch Med, Bursa, Turkey, and Bulbul, Yilmaz -- 0000-0002-8488-3650
- Subjects
Oncology ,medicine.medical_specialty ,Chemotherapy ,Lung cancer / Oncology ,Neoplastic diseases ,business.industry ,medicine.medical_treatment ,Cancer ,medicine.disease ,Gemcitabine ,Metastasis ,Radiation therapy ,Mediastinal tumour ,Pemetrexed ,Internal medicine ,medicine ,Lung cancer ,business ,Etoposide ,medicine.drug - Abstract
WOS: 000451979406201, …
- Published
- 2015
34. Demographic and Asthma-Related Characteristics of Asthmatics Using Pressurized Metered Dose Inhalers and Dry Powder Inhalers.
- Author
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Aksu K, Vural Solak GT, Mutlu LC, Mutlu P, Vayısoğlu Şahin G, Erdem Türe E, Yormaz B, Çapraz A, Coşkun Beyan A, Solak Y, and Aksu F
- Abstract
Background: Asthma controller medications can be delivered via pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI) devices. Objective: This study aimed to evaluate the frequency of exacerbations and satisfaction rate with device use in asthmatics using pMDIs or DPIs. Methods: A multicenter, cross-sectional study was conducted in adults who used pMDIs or DPIs with correct inhaler technique and good adherence for asthma treatment. Demographic and asthma-related characteristics of the subjects and data regarding device satisfaction were collected through a face-to-face interview in the outpatient clinic. Rates of pMDI and DPI users and the data were compared between the two groups. Results: The study included 338 patients (mean age: 48.6 ± 14.5 years, 253 [74.9%] women). Among participants, 96 (28.4%) were using pMDI and 242 (71.6%) were using DPI. The age of patients using pMDI were significantly lower compared with DPI users. No significant difference was observed in terms of device satisfaction and clinical outcomes of asthma between pMDI and DPI users with good inhaler technique and good adherence. Conclusion: More asthmatics use DPIs, however, pMDIs are used in younger asthmatic patients. No significant difference in terms of device satisfaction and clinical outcomes of asthma was observed between pMDI and DPI users.
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- 2024
- Full Text
- View/download PDF
35. Is Mean Platelet Volume a Predictive Marker for the Development of Thrombosis in Patients with COVID-19 Infection?
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Erdem I, Ardic E, Yildirim I, Kavak C, Mutlu LC, Erdal B, and Ozkan G
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- Humans, Male, Female, Middle Aged, Aged, Platelet Count, Adult, Predictive Value of Tests, Biomarkers blood, Blood Platelets metabolism, Platelet Activation, Prognosis, Aged, 80 and over, SARS-CoV-2, COVID-19 complications, COVID-19 blood, COVID-19 diagnosis, Mean Platelet Volume, Thrombosis blood, Thrombosis etiology, Thrombosis diagnosis
- Abstract
Mean platelet volume (MPV) can provide important information about the course and prognosis of many diseases. MPV is an early indicator of platelet activation, which has an important role in the pathogenesis of thrombosis. In this study, we aimed to investigate whether MPV was a predictive marker for the development of thrombosis in hospitalized patients with COVID-19 infection. Fifty-seven patients whose courses were followed after the diagnosis of COVID-19 infection using a polymerase chain reaction test during the pandemic were included in the study. Our results demonstrated that there was a negative correlation between platelet count and MPV (r=0.470, p≤ 0.01), and there was a positive correlation between Platelet Distribution Width (PDW) and MPV (r=0,933, p≤ 0.01), but no significant correlation was found between the other variables and MPV.
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- 2024
- Full Text
- View/download PDF
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