Search

Your search keyword '"Musella, Alessandra"' showing total 194 results
Start Over Author "Musella, Alessandra" Publication Year Range Last 10 years
194 results on '"Musella, Alessandra"'

1. Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis

Author

Guadalupi, Livia, Mandolesi, Georgia, Vanni, Valentina, Balletta, Sara, Caioli, Silvia, Pavlovic, Anto, De Vito, Francesca, Fresegna, Diego, Sanna, Krizia, Vitiello, Laura, Nencini, Monica, Tartacca, Alice, Mariani, Fabrizio, Rovella, Valentina, Schippling, Sven, Ruf, Iris, Collin, Ludovic, Centonze, Diego, and Musella, Alessandra

Published
2024
Full Text
View/download PDF

4. Re-emergence of T lymphocyte-mediated synaptopathy in progressive multiple sclerosis

Author

Sanna, Krizia, primary, Bruno, Antonio, additional, Balletta, Sara, additional, Caioli, Silvia, additional, Nencini, Monica, additional, Fresegna, Diego, additional, Guadalupi, Livia, additional, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Buttari, Fabio, additional, Fantozzi, Roberta, additional, Borrelli, Angela, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Lauritano, Gianluca, additional, Vanni, Valentina, additional, De Vito, Francesca, additional, Tartacca, Alice, additional, Mariani, Fabrizio, additional, Rovella, Valentina, additional, Musella, Alessandra, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2024
Full Text
View/download PDF

5. Interleukin-9 protects from microglia- and TNF-mediated synaptotoxicity in experimental multiple sclerosis

Author

Guadalupi, Livia, primary, Vanni, Valentina, additional, Balletta, Sara, additional, Caioli, Silvia, additional, De Vito, Francesca, additional, Fresegna, Diego, additional, Sanna, Krizia, additional, Nencini, Monica, additional, Donninelli, Gloria, additional, Volpe, Elisabetta, additional, Mariani, Fabrizio, additional, Battistini, Luca, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Buttari, Fabio, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Musella, Alessandra, additional

Published
2024
Full Text
View/download PDF

6. Interaction between miR-142-3p and BDNF Val/Met Polymorphism Regulates Multiple Sclerosis Severity

Author

Dolcetti, Ettore, primary, Musella, Alessandra, additional, Balletta, Sara, additional, Gilio, Luana, additional, Bruno, Antonio, additional, Stampanoni Bassi, Mario, additional, Lauritano, Gianluca, additional, Buttari, Fabio, additional, Fresegna, Diego, additional, Tartacca, Alice, additional, Mariani, Fabrizio, additional, Palmerio, Federica, additional, Rovella, Valentina, additional, Ferese, Rosangela, additional, Gambardella, Stefano, additional, Giardina, Emiliano, additional, Finardi, Annamaria, additional, Furlan, Roberto, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and De Vito, Francesca, additional

Published
2024
Full Text
View/download PDF

8. Inflammatory signature in amyotrophic lateral sclerosis predicting disease progression.

Author

Femiano, Cinzia, Bruno, Antonio, Gilio, Luana, Buttari, Fabio, Dolcetti, Ettore, Galifi, Giovanni, Azzolini, Federica, Borrelli, Angela, Furlan, Roberto, Finardi, Annamaria, Musella, Alessandra, Mandolesi, Georgia, Storto, Marianna, Centonze, Diego, and Stampanoni Bassi, Mario

Subjects
TUMOR necrosis factors, MOTOR neuron diseases, GRANULOCYTE-colony stimulating factor, AMYOTROPHIC lateral sclerosis, CEREBROSPINAL fluid examination, DISEASE progression, MACROPHAGE inflammatory proteins, PROGNOSIS
Abstract

Experimental studies identified a role of neuroinflammation in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, the role of inflammatory molecules as diagnostic and prognostic biomarkers in patients with ALS is unclear. In this cross-sectional study, the cerebrospinal fluid (CSF) levels of a set of inflammatory cytokines and chemokines were analyzed in 56 newly diagnosed ALS patients and in 47 age- and sex-matched control patients without inflammatory or degenerative neurological disorders. The molecules analyzed included: interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12, IL-13, IL-17, granulocyte colony stimulating factor (GCSF), macrophage inflammatory protein (MIP)-1a, MIP-1b, tumor necrosis factors (TNF), eotaxin. Principal component analysis (PCA) was used to explore possible associations between CSF molecules and ALS diagnosis. In addition, we analyzed the association between CSF cytokine profiles and clinical characteristics, including the disease progression rate score, and peripheral inflammation assessed using the Neutrophil-to-lymphocyte ratio (NLR). PCA identified six principal components (PCs) explaining 70.67% of the total variance in the CSF cytokine set. The principal component (PC1) explained 26.8% of variance and showed a positive load with CSF levels of IL-9, IL-4, GCSF, IL-7, IL-17, IL-13, IL-6, IL-1β, TNF, and IL-2. Logistic regression showed a significant association between PC1 and ALS diagnosis. In addition, in ALS patients, the same component was significantly associated with higher disease progression rate score and positively correlated with NLR. CSF inflammatory activation in present in ALS at the time of diagnosis and may characterize patients at higher risk for disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Interleukin-10 contrasts inflammatory synaptopathy and central neurodegenerative damage in multiple sclerosis.

Author

Gilio, Luana, Fresegna, Diego, Bassi, Mario Stampanoni, Musella, Alessandra, De Vito, Francesca, Balletta, Sara, Sanna, Krizia, Caioli, Silvia, Pavone, Luigi, Galifi, Giovanni, Simonelli, Ilaria, Guadalupi, Livia, Vanni, Valentina, Buttari, Fabio, Dolcetti, Ettore, Bruno, Antonio, Azzolini, Federica, Borrelli, Angela, Fantozzi, Roberta, and Finardi, Annamaria

Subjects
MEDIUM spiny neurons, INTERLEUKIN-10, BRAIN anatomy, LABORATORY mice, MULTIPLE sclerosis, NEURAL transmission
Abstract

Proinflammatory cytokines are implicated in promoting neurodegeneration in multiple sclerosis (MS) by affecting excitatory and inhibitory transmission at central synapses. Conversely, the synaptic effects of anti-inflammatory molecules remain underexplored, despite their potential neuroprotective properties and their presence in the cerebrospinal fluid (CSF) of patients. In a study involving 184 newly diagnosed relapsing-remitting (RR)-MS patients, we investigated whether CSF levels of the anti-inflammatory interleukin (IL)-10 were linked to disease severity and neurodegeneration measures. Additionally, we examined IL-10 impact on synaptic transmission in striatal medium spiny neurons and its role in counteracting inflammatory synaptopathy induced by IL-1β in female C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Our findings revealed a significant positive correlation between IL-10 CSF levels and changes in EDSS (Expanded Disability Status Scale) scores one year after MS diagnosis. Moreover, IL-10 levels in the CSF were positively correlated with volumes of specific subcortical brain structures, such as the nucleus caudate. In both MS patients' CSF and EAE mice striatum, IL-10 and IL-1β expressions were upregulated, suggesting possible antagonistic effects of these cytokines. Notably, IL-10 exhibited the ability to decrease glutamate transmission, increase GABA transmission in the striatum, and reverse IL-1β-induced abnormal synaptic transmission in EAE. In conclusion, our data suggest that IL-10 exerts direct neuroprotective effects in MS patients by modulating both excitatory and inhibitory transmission and attenuating IL-1β-induced inflammatory synaptopathy. These findings underscore the potential therapeutic significance of IL-10 in mitigating neurodegeneration in MS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. An IL-5 Single-Nucleotide Polymorphism Influences Neuroinflammation and Prospective Disease Activity in Multiple Sclerosis.

Author

Dolcetti, Ettore, Buttari, Fabio, Bruno, Antonio, Azzolini, Federica, Gilio, Luana, Borrelli, Angela, Di Caprio, Veronica, Lauritano, Gianluca, Galifi, Giovanni, Gambardella, Stefano, Ferese, Rosangela, Giardina, Emiliano, Rovella, Valentina, Furlan, Roberto, Finardi, Annamaria, Musella, Alessandra, Balletta, Sara, Mandolesi, Georgia, Centonze, Diego, and Stampanoni Bassi, Mario

Subjects
SINGLE nucleotide polymorphisms, INFLAMMATORY mediators, GENETIC variation, CEREBROSPINAL fluid, SYMPTOMS, VOXEL-based morphometry
Abstract

(1) Multiple sclerosis (MS) is identified by a complex interaction between central inflammation and neurodegeneration. Genetic individual variability could play a significative role in clinical presentation. The interleukin-5 (IL-5) rs2069812 single-nucleotide polymorphism (SNP) seems to define the clinical course of Th2 autoimmune diseases, while its role in MS has never been investigated. (2) In a group of 230 patients diagnosed with relapsing–remitting MS (RR-MS) or progressive MS (P-MS) and controls (IC), rs2069812 polymorphism, cerebrospinal fluid (CSF) levels of inflammatory mediators, and clinical and demographic characteristics were determined. In RR-MS patients, No Evidence of Disease Activity (NEDA-3) at three years of follow-up was detected. (3) We identified higher levels of proinflammatory cytokines, particularly IL-2 (median [IQR], RR-MS = 0.2 [0–0.7]; P-MS = 0.1 [0–1.6]; IC = 0.1 [0.0–0.1]; p < 0.005), IL-6 (RR-MS = 0.9 [0.3–2.3]; P-MS = 0.8 [0.1–2.7]; IC = 0.1 [0.0–0.5]; p < 0.005), IL-12 (RR-MS = 0.5 [0–1.1]; P-MS = 0.5 [0–1.1]; IC = 0.0 [0.0–0.3]; p < 0.005), and GM-CSF (RR-MS = 15.6 [4.8–26.4]; P-MS = 14 [3.3–29.7]; IC = 8.9 [4.7–11.7]; p < 0.005) in MS patients compared with IC. Conversely, anti-inflammatory cytokines, specifically IL-5 (RR-MS = 0.65 [0–2.4]; P-MS = 0.1 [0–0.8]; IC = 1.7 [0.6–2.8]; p < 0.005) and IL-1ra (RR-MS = 14.7 [4.9–26.4]; P-MS = 13.1 [4.7–22.2]; IC = 27.8 [17.7–37.6]; p < 0.005) were higher in controls. According to rs2069812, in MS patients, the T-allele was associated with higher concentrations of proinflammatory mediators (IL-2, CT/TT = 0.2 [0.0–2.0]; CC = 0.1 [0.0–0.4], p = 0.015; IL-6, CT/TT = 1.2 [0.4–3.2] vs. CC = 0.7 [0.1–1.7], p = 0.007; IL-15, CT/TT = 0.1 [0.0–9.5] vs. CC = 0.0 [0.0–0.1], p = 0.019; and GM-CSF, CT/TT = 0.1 [0.0–0.6] vs. CC = 0.05 [0.0–0.1], p < 0.001), and CC was associated with anti-inflammatory mediators (IL-5, CT/TT = 0.03 [0.0–1.9] vs. CC = 1.28 [0.0–2.7], p = 0.001; IL-1ra, CT/TT = 12.1 [4.1–25.9] vs. CC = 18.1 [12.1–26.9], p = 0.006). We found the same differences in RR-MS patients (IL-2, T-allele median [IQR] = 0.3 [0.0–2.0] vs. C-allele, median [IQR] = 0.04 [0.0–0.3]; p = 0.005; IL-6, T-allele, median [IQR] = 1.3 [0.4–3.3] vs. C-allele, median [IQR] = 0.6 [0.03–1.5]; p = 0.001; IL-15, T-allele, median [IQR] = 0.1 [0.0–9.5] vs. C-allele, median [IQR] = 0.0 [0.0–0.1]; p = 0.008; GM-CSF, T-allele, median [IQR] = 0.1 [0.0–97.9] vs. C-allele, median [IQR] = 0.0 [0.0–0.001]; p < 0.001; IL-5, T-allele, median [IQR] = 0.02 [0.0–2.2] vs. C-allele, median [IQR] = 1.5 [0.0–2.9]; p = 0.016; and IL-1ra, T-allele, median [IQR] = 12.1 [4.3–26.4] vs. C-allele, median [IQR] = 18.5 [12.7–28.3]; p = 0.006) but not in P-MS, except for IL-5 (T-allele, median [IQR] = 0.1 [0–0.23] vs. C-allele, median [IQR] = 0.6 [0.0–2.5]; p = 0.022). Finally, we identified an association between CC in RR-MS patients and NEDA-3 after three years of follow-up (p = 0.007). (4) We describe, for the first time, the role of an SNP of the IL-5 gene in regulating central neuroinflammation and influencing clinical course in MS patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Author

Rizzo, Francesca Romana, Guadalupi, Livia, Sanna, Krizia, Vanni, Valentina, Fresegna, Diego, De Vito, Francesca, Musella, Alessandra, Caioli, Silvia, Balletta, Sara, Bullitta, Silvia, Bruno, Antonio, Dolcetti, Ettore, Stampanoni Bassi, Mario, Buttari, Fabio, Gilio, Luana, Mandolesi, Georgia, Centonze, Diego, and Gentile, Antonietta

Published
2021
Full Text
View/download PDF

12. MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis

Author

De Vito, Francesca, primary, Balletta, Sara, additional, Caioli, Silvia, additional, Musella, Alessandra, additional, Guadalupi, Livia, additional, Vanni, Valentina, additional, Fresegna, Diego, additional, Bassi, Mario Stampanoni, additional, Gilio, Luana, additional, Sanna, Krizia, additional, Gentile, Antonietta, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Buttari, Fabio, additional, Pavone, Luigi, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Perlas, Emerald, additional, Hornstein, Eran, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2023
Full Text
View/download PDF

13. Low-contrast visual acuity test is associated with central inflammation and predicts disability development in newly diagnosed multiple sclerosis patients.

Author

Dolcetti, Ettore, Buttari, Fabio, Bruno, Antonio, Azzolini, Federica, Gilio, Luana, Di Caprio, Veronica, Lauritano, Gianluca, Borrelli, Angela, Galifi, Giovanni, Furlan, Roberto, Finardi, Annamaria, Musella, Alessandra, Guadalupi, Livia, Mandolesi, Georgia, Rovella, Valentina, Centonze, Diego, and Bassi, Mario Stampanoni

Subjects
VISUAL acuity, MULTIPLE sclerosis, VISUAL evoked potentials, VISION disorders, DISABILITIES, LOW vision
Abstract

Introduction: The visual system is a prominent site of damage in MS since the earliest phases of the disease. Altered low-contrast visual acuity (LCVA) test has been associated with visual impairment and retinal degeneration, predicting medium- and long-term disability. However, it is unclear whether LCVA may also represent a reliable measure of neuroinflammation and a predictor of disease evolution in the very early stages of MS. Methods: We explored in a group of 76 consecutive newly diagnosed relapsing-- remitting MS (RR-MS) patients without visual impairment or altered visual evoked potentials, the association between LCVA scores at 2.5% and 1.25% and clinical characteristics, including prospective disability evaluated after 1- and 2 years of follow-up. Associations between LCVA and the CSF levels of IL-10 at diagnosis were also analyzed. Results: A negative correlation was found between LCVA at 2.5% and Expanded Disability Status Scale (EDSS) evaluated at first (Spearman's Rho= -0.349, p =0.005, n =62) and second year (Spearman's Rho= -0.418, p <0.001, n =62) of follow-up, and negative correlations were found with Multiple Sclerosis Severity Score (MSSS) at first (Spearman's Rho= -0.359, p =0.004, n =62) and second year (Spearman's Rho= -0.472, p <0.001, n=62). All the data were confirmed by a mixed effect model, considering other clinical variables. A positive correlation was found between the CSF concentrations of IL-10 and LCVA at 2.5% (Spearman's Rho=0.272, p =0.020, n =76), and 1.25% (Spearman's Rho, = 0.276, p =0.018, n=76), also evidenced in a linear regression. Discussion: In MS patients at diagnosis, altered LCVA may be associated with CSF inflammation and represent a useful parameter to identify patients with worse disease course. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Preventive exercise and physical rehabilitation promote long‐term potentiation‐like plasticity expression in patients with multiple sclerosis.

Author

Stampanoni Bassi, Mario, Gilio, Luana, Buttari, Fabio, Dolcetti, Ettore, Bruno, Antonio, Galifi, Giovanni, Azzolini, Federica, Borrelli, Angela, Mandolesi, Georgia, Gentile, Antonietta, De Vito, Francesca, Musella, Alessandra, Simonelli, Ilaria, Centonze, Diego, and Iezzi, Ennio

Subjects
PREMENSTRUAL syndrome, MEDICAL rehabilitation, MULTIPLE sclerosis, LONG-term potentiation, NEUROPLASTICITY, TRANSCRANIAL magnetic stimulation
Abstract

Background and purpose: Loss of long‐term potentiation (LTP) expression has been associated with a worse disease course in relapsing–remitting multiple sclerosis (RR‐MS) and represents a pathophysiological hallmark of progressive multiple sclerosis (PMS). Exercise and physical rehabilitation are the most prominent therapeutic approaches to promote synaptic plasticity. We aimed to explore whether physical exercise is able to improve the expression of LTP‐like plasticity in patients with multiple sclerosis (MS). Methods: In 46 newly diagnosed RR‐MS patients, we explored the impact of preventive exercise on LTP‐like plasticity as assessed by intermittent theta‐burst stimulation. Patients were divided into sedentary or active, based on physical activity performed during the 6 months prior to diagnosis. Furthermore, in 18 patients with PMS, we evaluated the impact of an 8‐week inpatient neurorehabilitation program on clinical scores and LTP‐like plasticity explored using paired associative stimulation (PAS). Synaptic plasticity expression was compared in patients and healthy subjects. Results: Reduced LTP expression was found in RR‐MS patients compared with controls. Exercising RR‐MS patients showed a greater amount of LTP expression compared with sedentary patients. In PMS patients, LTP expression was reduced compared with controls and increased after 8 weeks of rehabilitation. In this group of patients, LTP magnitude at baseline predicted the improvement in hand dexterity. Conclusions: Both preventive exercise and physical rehabilitation may enhance the expression of LTP‐like synaptic plasticity in MS, with potential beneficial effects on disability accumulation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Preventive exercise and physical rehabilitation promote long‐term potentiation‐like plasticity expression in patients with multiple sclerosis

Author

Stampanoni Bassi, Mario, primary, Gilio, Luana, additional, Buttari, Fabio, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Galifi, Giovanni, additional, Azzolini, Federica, additional, Borrelli, Angela, additional, Mandolesi, Georgia, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Musella, Alessandra, additional, Simonelli, Ilaria, additional, Centonze, Diego, additional, and Iezzi, Ennio, additional

Published
2023
Full Text
View/download PDF

16. Pharmacological blockade of 2-AG degradation ameliorates clinical, neuroinflammatory and synaptic alterations in experimental autoimmune encephalomyelitis

Author

Guadalupi, Livia, primary, Mandolesi, Georgia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Caioli, Silvia, additional, De Vito, Francesca, additional, Fresegna, Diego, additional, Sanna, Krizia, additional, Vitiello, Laura, additional, Nencini, Monica, additional, Tartacca, Alice, additional, Rovella, Valentina, additional, Schippling, Sven, additional, Pavlovic, Anto, additional, Ruf, Iris, additional, Collin, Ludovic, additional, Centonze, Diego, additional, and Musella, Alessandra, additional

Published
2023
Full Text
View/download PDF

17. Distinct intrathecal inflammatory signatures following relapse and anti-COVID-19 mRNA vaccination in multiple sclerosis

Author

Bruno, Antonio, primary, Buttari, Fabio, additional, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Borrelli, Angela, additional, Lauritano, Gianluca, additional, Di Caprio, Veronica, additional, Rizzo, Francesca Romana, additional, Gilio, Luana, additional, Galifi, Giovanni, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Guadalupi, Livia, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2023
Full Text
View/download PDF

20. Distinct intrathecal inflammatory signatures following relapse and anti- COVID-19 mRNA vaccination in Multiple Sclerosis. A cross-sectional study.

Author

Bruno, Antonio, primary, Buttari, Fabio, additional, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Borrelli, Angela, additional, Lauritano, Gianluca, additional, Caprio, Veronica, additional, Rizzo, Francesca Romana, additional, Gilio, Luana, additional, Galifi, Giovanni, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Guadalupi, Livia, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Bassi, Mario Stampanoni, additional

Published
2023
Full Text
View/download PDF

21. Genetic regulation of IL-8 influences disease presentation of multiple sclerosis

Author

Dolcetti, Ettore, primary, Bruno, Antonio, additional, Azzolini, Federica, additional, Gilio, Luana, additional, Pavone, Luigi, additional, Iezzi, Ennio, additional, Galifi, Giovanni, additional, Gambardella, Stefano, additional, Ferese, Rosangela, additional, Buttari, Fabio, additional, De Vito, Francesca, additional, Colantuono, Paola, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2023
Full Text
View/download PDF

22. Preventive exercise attenuates IL-2-driven mood disorders in multiple sclerosis

Author

Gilio, Luana, primary, Fresegna, Diego, additional, Gentile, Antonietta, additional, Guadalupi, Livia, additional, Sanna, Krizia, additional, De Vito, Francesca, additional, Balletta, Sara, additional, Caioli, Silvia, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Iezzi, Ennio, additional, Moscatelli, Alessandro, additional, Galifi, Giovanni, additional, Fantozzi, Roberta, additional, Bellantonio, Paolo, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Vanni, Valentina, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

24. Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Azzolini, Federica, additional, Moscatelli, Alessandro, additional, Gambardella, Stefano, additional, Ferese, Rosangela, additional, Rizzo, Francesca Romana, additional, Gilio, Luana, additional, Iezzi, Ennio, additional, Galifi, Giovanni, additional, Borrelli, Angela, additional, Buttari, Fabio, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, De Vito, Francesca, additional, Musella, Alessandra, additional, Guadalupi, Livia, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

26. The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis

Author

Dolcetti, Ettore, primary, Bruno, Antonio, additional, Azzolini, Federica, additional, Gilio, Luana, additional, Moscatelli, Alessandro, additional, De Vito, Francesca, additional, Pavone, Luigi, additional, Iezzi, Ennio, additional, Gambardella, Stefano, additional, Giardina, Emiliano, additional, Ferese, Rosangela, additional, Buttari, Fabio, additional, Rizzo, Francesca Romana, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Guadalupi, Livia, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

27. Neuroinflammation Is Associated with GFAP and sTREM2 Levels in Multiple Sclerosis

Author

Azzolini, Federica, primary, Gilio, Luana, additional, Pavone, Luigi, additional, Iezzi, Ennio, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Guadalupi, Livia, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Micillo, Teresa, additional, Carbone, Fortunata, additional, Matarese, Giuseppe, additional, Centonze, Diego, additional, and Stampanoni Bassi, Mario, additional

Published
2022
Full Text
View/download PDF

29. MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis

Author

De Vito, Francesca, primary, Musella, Alessandra, additional, Fresegna, Diego, additional, Rizzo, Francesca Romana, additional, Gentile, Antonietta, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Buttari, Fabio, additional, Procaccini, Claudio, additional, Colamatteo, Alessandra, additional, Bullitta, Silvia, additional, Guadalupi, Livia, additional, Caioli, Silvia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Licursi, Valerio, additional, Drulovic, Jelena, additional, Pekmezovic, Tatjana, additional, Fusco, Clorinda, additional, Bruzzaniti, Sara, additional, Hornstein, Eran, additional, Uccelli, Antonio, additional, Salvetti, Marco, additional, Matarese, Giuseppe, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2021
Full Text
View/download PDF

30. Age at Disease Onset Associates With Oxidative Stress, Neuroinflammation, and Impaired Synaptic Plasticity in Relapsing-Remitting Multiple Sclerosis

Author

Stampanoni Bassi, Mario, primary, Gilio, Luana, additional, Iezzi, Ennio, additional, Moscatelli, Alessandro, additional, Pekmezovic, Tatjana, additional, Drulovic, Jelena, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Mandolesi, Georgia, additional, Musella, Alessandra, additional, Galifi, Giovanni, additional, Fantozzi, Roberta, additional, Bellantonio, Paolo, additional, Storto, Marianna, additional, Centonze, Diego, additional, and Buttari, Fabio, additional

Published
2021
Full Text
View/download PDF

32. The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis

Author

Mandolesi, Georgia, primary, Rizzo, Francesca Romana, additional, Balletta, Sara, additional, Stampanoni Bassi, Mario, additional, Gilio, Luana, additional, Guadalupi, Livia, additional, Nencini, Monica, additional, Moscatelli, Alessandro, additional, Ryan, Colleen Patricia, additional, Licursi, Valerio, additional, Dolcetti, Ettore, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, Fresegna, Diego, additional, Bullitta, Silvia, additional, Caioli, Silvia, additional, Vanni, Valentina, additional, Sanna, Krizia, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Castelli, Chiara, additional, Presutti, Carlo, additional, De Santa, Francesca, additional, Finardi, Annamaria, additional, Furlan, Roberto, additional, Centonze, Diego, additional, and De Vito, Francesca, additional

Published
2021
Full Text
View/download PDF

33. sj-pdf-1-tan-10.1177_1756286420970833 – Supplemental material for Cerebrospinal fluid inflammatory biomarkers predicting interferon-beta response in MS patients

Author

Bassi, Mario Stampanoni, Drulovic, Jelena, Pekmezovic, Tatjana, Iezzi, Ennio, Sica, Francesco, Gilio, Luana, Gentile, Antonietta, Musella, Alessandra, Mandolesi, Georgia, Furlan, Roberto, Finardi, Annamaria, Marfia, Girolama Alessandra, Bellantonio, Paolo, Fantozzi, Roberta, Centonze, Diego, and Buttari, Fabio

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-tan-10.1177_1756286420970833 for Cerebrospinal fluid inflammatory biomarkers predicting interferon-beta response in MS patients by Mario Stampanoni Bassi, Jelena Drulovic, Tatjana Pekmezovic, Ennio Iezzi, Francesco Sica, Luana Gilio, Antonietta Gentile, Alessandra Musella, Georgia Mandolesi, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Paolo Bellantonio, Roberta Fantozzi, Diego Centonze and Fabio Buttari in Therapeutic Advances in Neurological Disorders

Published
2020
Full Text
View/download PDF

34. Corrigendum: Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2021
Full Text
View/download PDF

35. MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis.

Author

De Vito, Francesca, Musella, Alessandra, Fresegna, Diego, Rizzo, Francesca Romana, Gentile, Antonietta, Stampanoni Bassi, Mario, Gilio, Luana, Buttari, Fabio, Procaccini, Claudio, Colamatteo, Alessandra, Bullitta, Silvia, Guadalupi, Livia, Caioli, Silvia, Vanni, Valentina, Balletta, Sara, Sanna, Krizia, Bruno, Antonio, Dolcetti, Ettore, Furlan, Roberto, and Finardi, Annamaria

Subjects
*MULTIPLE sclerosis, *TRANSCRANIAL magnetic stimulation, *DISEASE progression, *DIMETHYL fumarate, *CEREBROSPINAL fluid, *PROGNOSIS, *CEREBROSPINAL fluid examination
Abstract

Aim: We recently proposed miR‐142‐3p as a molecular player in inflammatory synaptopathy, a new pathogenic hallmark of multiple sclerosis (MS) and of its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently of demyelination. MiR‐142‐3p seems to be unique among potential biomarker candidates in MS, since it is an inflammatory miRNA playing a dual role in the immune and central nervous systems. Here, we aimed to verify the impact of miR‐142‐3p circulating in the cerebrospinal fluid (CSF) of MS patients on clinical parameters, neuronal excitability and its potential interaction with disease modifying therapies (DMTs). Methods and Results: In a cohort of 151 MS patients, we found positive correlations between CSF miR‐142‐3p levels and clinical progression, IL‐1β signalling as well as synaptic excitability measured by transcranial magnetic stimulation. Furthermore, therapy response of patients with 'low miR‐142‐3p' to dimethyl fumarate (DMF), an established disease‐modifying treatment (DMT), was superior to that of patients with 'high miR‐142‐3p' levels. Accordingly, the EAE clinical course of heterozygous miR‐142 mice was ameliorated by peripheral DMF treatment with a greater impact relative to their wild type littermates. In addition, a central protective effect of this drug was observed following intracerebroventricular and ex vivo acute treatments of EAE wild type mice, showing a rescue of miR‐142‐3p‐dependent glutamatergic alterations. By means of electrophysiology, molecular and biochemical analysis, we suggest miR‐142‐3p as a molecular target of DMF. Conclusion: MiR‐142‐3p is a novel and potential negative prognostic CSF marker of MS and a promising tool for identifying personalised therapies. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

36. Re-Examining the Role of TNF in MS Pathogenesis and Therapy

Author

Fresegna, Diego, primary, Bullitta, Silvia, additional, Musella, Alessandra, additional, Rizzo, Francesca Romana, additional, De Vito, Francesca, additional, Guadalupi, Livia, additional, Caioli, Silvia, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Dolcetti, Ettore, additional, Vanni, Valentina, additional, Bruno, Antonio, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Gentile, Antonietta, additional

Published
2020
Full Text
View/download PDF

37. Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis

Author

Dolcetti, Ettore, primary, Bruno, Antonio, additional, Guadalupi, Livia, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Bullitta, Silvia, additional, Fresegna, Diego, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

38. Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Author

Bruno, Antonio, primary, Dolcetti, Ettore, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Musella, Alessandra, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Balletta, Sara, additional, Sanna, Krizia, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

39. A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum

Author

Farini, Donatella, primary, Cesari, Eleonora, additional, Weatheritt, Robert J., additional, La Sala, Gina, additional, Naro, Chiara, additional, Pagliarini, Vittoria, additional, Bonvissuto, Davide, additional, Medici, Vanessa, additional, Guerra, Marika, additional, Di Pietro, Chiara, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Carola, Valeria, additional, Centonze, Diego, additional, Blencowe, Benjamin J., additional, Marazziti, Daniela, additional, and Sette, Claudio, additional

Published
2020
Full Text
View/download PDF

40. Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis

Author

Musella, Alessandra, primary, Gentile, Antonietta, additional, Guadalupi, Livia, additional, Rizzo, Francesca Romana, additional, De Vito, Francesca, additional, Fresegna, Diego, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Vanni, Valentina, additional, Vitiello, Laura, additional, Bullitta, Silvia, additional, Sanna, Krizia, additional, Caioli, Silvia, additional, Balletta, Sara, additional, Nencini, Monica, additional, Buttari, Fabio, additional, Stampanoni Bassi, Mario, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

41. ‘Prototypical’ proinflammatory cytokine (IL-1) in multiple sclerosis: role in pathogenesis and therapeutic targeting

Author

Musella, Alessandra, primary, Fresegna, Diego, additional, Rizzo, Francesca Romana, additional, Gentile, Antonietta, additional, De Vito, Francesca, additional, Caioli, Silvia, additional, Guadalupi, Livia, additional, Bruno, Antonio, additional, Dolcetti, Ettore, additional, Buttari, Fabio, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2020
Full Text
View/download PDF

42. Cerebrospinal fluid inflammatory biomarkers predicting interferon-beta response in MS patients

Author

Stampanoni Bassi, Mario, primary, Drulovic, Jelena, additional, Pekmezovic, Tatjana, additional, Iezzi, Ennio, additional, Sica, Francesco, additional, Gilio, Luana, additional, Gentile, Antonietta, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Marfia, Girolama Alessandra, additional, Bellantonio, Paolo, additional, Fantozzi, Roberta, additional, Centonze, Diego, additional, and Buttari, Fabio, additional

Published
2020
Full Text
View/download PDF

44. Spplementary_figure – Supplemental material for Interleukin-6 Disrupts Synaptic Plasticity and Impairs Tissue Damage Compensation in Multiple Sclerosis

Author

Bassi, Mario Stampanoni, Iezzi, Ennio, Mori, Francesco, Simonelli, Ilaria, Gilio, Luana, Buttari, Fabio, Sica, Francesco, Paolis, Nicla De, Mandolesi, Georgia, Musella, Alessandra, Vito, Francesca De, Dolcetti, Ettore, Bruno, Antonio, Furlan, Roberto, Finardi, Annamaria, Marfia, Girolama A., Centonze, Diego, and Rizzo, Francesca Romana

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, Spplementary_figure for Interleukin-6 Disrupts Synaptic Plasticity and Impairs Tissue Damage Compensation in Multiple Sclerosis by Mario Stampanoni Bassi, Ennio Iezzi, Francesco Mori, Ilaria Simonelli, Luana Gilio, Fabio Buttari, Francesco Sica, Nicla De Paolis, Georgia Mandolesi, Alessandra Musella, Francesca De Vito, Ettore Dolcetti, Antonio Bruno, Roberto Furlan, Annamaria Finardi, Girolama A. Marfia, Diego Centonze and Francesca Romana Rizzo in Neurorehabilitation and Neural Repair

Published
2019
Full Text
View/download PDF

45. Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

Author

Rizzo, Francesca Romana, Musella, Alessandra, De Vito, Francesca, Fresegna, Diego, Bullitta, Silvia, Vanni, Valentina, Guadalupi, Livia, Stampanoni Bassi, Mario, Buttari, Fabio, Mandolesi, Georgia, Centonze, Diego, and Gentile, Antonietta

Subjects
Article Subject
Abstract

Cytokines are constitutively released in the healthy brain by resident myeloid cells to keep proper synaptic plasticity, either in the form of Hebbian synaptic plasticity or of homeostatic plasticity. However, when cytokines dramatically increase, establishing a status of neuroinflammation, the synaptic action of such molecules remarkably interferes with brain circuits of learning and cognition and contributes to excitotoxicity and neurodegeneration. Among others, interleukin-1β (IL-1β) and tumor necrosis factor (TNF) are the best studied proinflammatory cytokines in both physiological and pathological conditions and have been invariably associated with long-term potentiation (LTP) (Hebbian synaptic plasticity) and synaptic scaling (homeostatic plasticity), respectively. Multiple sclerosis (MS) is the prototypical neuroinflammatory disease, in which inflammation triggers excitotoxic mechanisms contributing to neurodegeneration. IL-β and TNF are increased in the brain of MS patients and contribute to induce the changes in synaptic plasticity occurring in MS patients and its animal model, the experimental autoimmune encephalomyelitis (EAE). This review will introduce and discuss current evidence of the role of IL-1β and TNF in the regulation of synaptic strength at both physiological and pathological levels, in particular speculating on their involvement in the synaptic plasticity changes observed in the EAE brain.

Published
2018
Full Text
View/download PDF

46. Immunomodulatory Effects of Exercise in Experimental Multiple Sclerosis

Author

Gentile, Antonietta, primary, Musella, Alessandra, additional, De Vito, Francesca, additional, Rizzo, Francesca Romana, additional, Fresegna, Diego, additional, Bullitta, Silvia, additional, Vanni, Valentina, additional, Guadalupi, Livia, additional, Stampanoni Bassi, Mario, additional, Buttari, Fabio, additional, Centonze, Diego, additional, and Mandolesi, Georgia, additional

Published
2019
Full Text
View/download PDF

47. Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination

Author

Mandolesi, Georgia, primary, Bullitta, Silvia, additional, Fresegna, Diego, additional, De Vito, Francesca, additional, Rizzo, Francesca Romana, additional, Musella, Alessandra, additional, Guadalupi, Livia, additional, Vanni, Valentina, additional, Stampanoni Bassi, Mario, additional, Buttari, Fabio, additional, Viscomi, Maria Teresa, additional, Centonze, Diego, additional, and Gentile, Antonietta, additional

Published
2019
Full Text
View/download PDF

48. Interleukin-6 Disrupts Synaptic Plasticity and Impairs Tissue Damage Compensation in Multiple Sclerosis

Author

Stampanoni Bassi, Mario, primary, Iezzi, Ennio, additional, Mori, Francesco, additional, Simonelli, Ilaria, additional, Gilio, Luana, additional, Buttari, Fabio, additional, Sica, Francesco, additional, De Paolis, Nicla, additional, Mandolesi, Georgia, additional, Musella, Alessandra, additional, De Vito, Francesca, additional, Dolcetti, Ettore, additional, Bruno, Antonio, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Marfia, Girolama A., additional, Centonze, Diego, additional, and Rizzo, Francesca Romana, additional

Published
2019
Full Text
View/download PDF

49. Obesity worsens central inflammation and disability in multiple sclerosis

Author

Stampanoni Bassi, Mario, primary, Iezzi, Ennio, additional, Buttari, Fabio, additional, Gilio, Luana, additional, Simonelli, Ilaria, additional, Carbone, Fortunata, additional, Micillo, Teresa, additional, De Rosa, Veronica, additional, Sica, Francesco, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Fantozzi, Roberta, additional, Storto, Marianna, additional, Bellantonio, Paolo, additional, Pirollo, Pamela, additional, Di Lemme, Sonia, additional, Musella, Alessandra, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Matarese, Giuseppe, additional

Published
2019
Full Text
View/download PDF

50. Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis

Author

Stampanoni Bassi, Mario, primary, Gentile, Antonietta, additional, Iezzi, Ennio, additional, Zagaglia, Sara, additional, Musella, Alessandra, additional, Simonelli, Ilaria, additional, Gilio, Luana, additional, Furlan, Roberto, additional, Finardi, Annamaria, additional, Marfia, Girolama A., additional, Guadalupi, Livia, additional, Bullitta, Silvia, additional, Mandolesi, Georgia, additional, Centonze, Diego, additional, and Buttari, Fabio, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results