5 results on '"Murnane C"'
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2. P166 Measures of overnight sleep stability in patients with hypersomnolence
- Author
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Woods, S, Frenkel, S, Lopez, C, Murnane, C, Southcott, A, Woods, S, Frenkel, S, Lopez, C, Murnane, C, and Southcott, A
- Abstract
Introduction Hypersomnolence causes significant impairment of daytime functioning. The multiple sleep latency test (MSLT) measures objective hypersomnolence (OH). Patients with hypersomnolence with a normal MSLT are said to have subjective hypersomnolence (SH). The mechanisms of hypersomnolence in such patients is uncertain. This study describes differences in measures of sleep stability derived from the overnight polysomnography (PSG) in patients with OH and SH. Methods A retrospective analysis of 100 patients undergoing PSG/MSLT for investigation of hypersomnolence was performed. Patients were classified as OH (MSLT≤8 min) or SH (MSLT>8min). Sleep stage distribution and PSG-derived markers of sleep stability including cardiopulmonary coupling (CPC), cyclic alternating pattern (CAP) and sleep stage shifts were compared between the two groups. Results When compared to OH patients (N=50), SH patients (N=50) had significantly more sleep stage shifts, more shifts to stage N1 and longer PSG sleep latency. Small but significantly lower sleep efficiency, higher stage N1 and N3 proportions were also observed in SH patients. OH patients had a small but significantly higher CAP rate and CAP index compared to SH patients. There were no significant differences in CPC metrics between the two groups. Conclusion Several PSG-derived markers of sleep stability indicated that patients with SH experienced more unstable sleep than OH patients. This may provide insight into the underlying pathophysiological mechanisms which differentiate these patient groups and may serve as a future therapeutic target.
- Published
- 2021
3. Blood and immune development in human fetal bone marrow and Down syndrome
- Author
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Jardine, L, Webb, S, Goh, I, Londono, MQ, Reynolds, G, Mather, M, Olabi, B, Stephenson, E, Botting, RA, Horsfall, D, Engelbert, J, Maunder, D, Mende, N, Murnane, C, Dann, E, McGrath, J, King, H, Kucinski, I, Queen, R, Carey, CD, Shrubsole, C, Poyner, E, Acres, M, Jones, C, Ness, T, Coulthard, R, Elliott, N, O'Byrne, S, Haltalli, MLR, Lawrence, JE, Lisgo, S, Balogh, P, Meyer, KB, Prigmore, E, Ambridge, K, Jain, MS, Efremova, M, Pickard, K, Creasey, T, Bacardit, J, Henderson, D, Coxhead, J, Filby, A, Hussain, R, Dixon, D, McDonald, D, Popescu, D-M, Kowalczyk, MS, Li, B, Ashenberg, O, Tabaka, M, Dionne, D, Tickle, TL, Slyper, M, Rozenblatt-Rosen, O, Regev, A, Behjati, S, Laurenti, E, Wilson, NK, Roy, A, Goettgens, B, Roberts, I, Teichmann, SA, Haniffa, M, Jardine, L, Webb, S, Goh, I, Londono, MQ, Reynolds, G, Mather, M, Olabi, B, Stephenson, E, Botting, RA, Horsfall, D, Engelbert, J, Maunder, D, Mende, N, Murnane, C, Dann, E, McGrath, J, King, H, Kucinski, I, Queen, R, Carey, CD, Shrubsole, C, Poyner, E, Acres, M, Jones, C, Ness, T, Coulthard, R, Elliott, N, O'Byrne, S, Haltalli, MLR, Lawrence, JE, Lisgo, S, Balogh, P, Meyer, KB, Prigmore, E, Ambridge, K, Jain, MS, Efremova, M, Pickard, K, Creasey, T, Bacardit, J, Henderson, D, Coxhead, J, Filby, A, Hussain, R, Dixon, D, McDonald, D, Popescu, D-M, Kowalczyk, MS, Li, B, Ashenberg, O, Tabaka, M, Dionne, D, Tickle, TL, Slyper, M, Rozenblatt-Rosen, O, Regev, A, Behjati, S, Laurenti, E, Wilson, NK, Roy, A, Goettgens, B, Roberts, I, Teichmann, SA, and Haniffa, M
- Abstract
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11-12 weeks after conception1,2, yet almost nothing is known about how fetal BM (FBM) evolves to meet the highly specialized needs of the fetus and newborn. Here we detail the development of FBM, including stroma, using multi-omic assessment of mRNA and multiplexed protein epitope expression. We find that the full blood and immune cell repertoire is established in FBM in a short time window of 6-7 weeks early in the second trimester. FBM promotes rapid and extensive diversification of myeloid cells, with granulocytes, eosinophils and dendritic cell subsets emerging for the first time. The substantial expansion of B lymphocytes in FBM contrasts with fetal liver at the same gestational age. Haematopoietic progenitors from fetal liver, FBM and cord blood exhibit transcriptional and functional differences that contribute to tissue-specific identity and cellular diversification. Endothelial cell types form distinct vascular structures that we show are regionally compartmentalized within FBM. Finally, we reveal selective disruption of B lymphocyte, erythroid and myeloid development owing to a cell-intrinsic differentiation bias as well as extrinsic regulation through an altered microenvironment in Down syndrome (trisomy 21).
- Published
- 2021
4. The One Health aspect of climate events with impact on foodborne pathogens transmission.
- Author
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Balta I, Lemon J, Murnane C, Pet I, Vintila T, McCleery D, Callaway T, Douglas A, Stef L, and Corcionivoschi N
- Abstract
The ongoing effects of climate change have exacerbated two significant challenges to global populations: the transmission of foodborne pathogens and antimicrobial resistance (AMR) through the food chain. Using the latest available scientific information this review explores how climate-related factors such as rainfall, floods, storms, hurricanes, cyclones, dust, temperature and humidity impact the spread of the foodborne pathogens Salmonella , E. coli , Campylobacter , Vibrio , Listeria , and Staphylococcus aureus . We explore the complex dynamics between environmental changes and the heightened risk of foodborne diseases, analysing the contribution of wildlife, insects and contaminated environments in the proliferation of AMR and climate change. This review paper combines a thorough analysis of current literature with a discussion on findings from a wide variety of studies to provide a comprehensive overview of how climatic factors contribute to the survival, persistence and transmission of bacterial pathogens in the food chain. In addition, we discuss the necessity for effective mitigation strategies and policies. By providing insights into the interrelationships between climate change and food safety, this review hopes to inform future research and policy development to promote safer and more sustainable food systems and further integration within the One Health approach., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier B.V.)
- Published
- 2024
- Full Text
- View/download PDF
5. Blood and immune development in human fetal bone marrow and Down syndrome.
- Author
-
Jardine L, Webb S, Goh I, Quiroga Londoño M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O'Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu DM, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Göttgens B, Roberts I, Teichmann SA, and Haniffa M
- Subjects
- B-Lymphocytes cytology, Dendritic Cells cytology, Down Syndrome metabolism, Down Syndrome pathology, Endothelial Cells pathology, Eosinophils cytology, Erythroid Cells cytology, Granulocytes cytology, Humans, Immunity, Myeloid Cells cytology, Stromal Cells cytology, Bone Marrow, Bone Marrow Cells cytology, Down Syndrome blood, Down Syndrome immunology, Fetus cytology, Hematopoiesis, Immune System cytology
- Abstract
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11-12 weeks after conception
1,2 , yet almost nothing is known about how fetal BM (FBM) evolves to meet the highly specialized needs of the fetus and newborn. Here we detail the development of FBM, including stroma, using multi-omic assessment of mRNA and multiplexed protein epitope expression. We find that the full blood and immune cell repertoire is established in FBM in a short time window of 6-7 weeks early in the second trimester. FBM promotes rapid and extensive diversification of myeloid cells, with granulocytes, eosinophils and dendritic cell subsets emerging for the first time. The substantial expansion of B lymphocytes in FBM contrasts with fetal liver at the same gestational age. Haematopoietic progenitors from fetal liver, FBM and cord blood exhibit transcriptional and functional differences that contribute to tissue-specific identity and cellular diversification. Endothelial cell types form distinct vascular structures that we show are regionally compartmentalized within FBM. Finally, we reveal selective disruption of B lymphocyte, erythroid and myeloid development owing to a cell-intrinsic differentiation bias as well as extrinsic regulation through an altered microenvironment in Down syndrome (trisomy 21)., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2021
- Full Text
- View/download PDF
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