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Your search keyword '"Muller, Mareike"' showing total 5 results
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5 results on '"Muller, Mareike"'

1. The role of the dopamine D1 receptor in social cognition : Studies using a novel genetic rat model

Author

Homberg, Judith R., Olivier, Jocelien D A, VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K., Karel, Peter, Shan, Ling, Van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R., Cuppen, Edwin, Ellenbroek, Bart A., Homberg, Judith R., Olivier, Jocelien D A, VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K., Karel, Peter, Shan, Ling, Van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R., Cuppen, Edwin, and Ellenbroek, Bart A.

Published
2016

2. The role of the dopamine D1 receptor in social cognition: Studies using a novel genetic rat model

Author

Hubrecht Institute with UMC, CMM Groep Cuppen, CMM, Circulatory Health, Cancer, Child Health, Brain, Homberg, Judith R., Olivier, Jocelien D A, VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K., Karel, Peter, Shan, Ling, Van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R., Cuppen, Edwin, Ellenbroek, Bart A., Hubrecht Institute with UMC, CMM Groep Cuppen, CMM, Circulatory Health, Cancer, Child Health, Brain, Homberg, Judith R., Olivier, Jocelien D A, VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K., Karel, Peter, Shan, Ling, Van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R., Cuppen, Edwin, and Ellenbroek, Bart A.

Published
2016

4. Targeting non-apoptotic cell death in cancer treatment by nanomaterials: Recent advances and future outlook

Author

Mohammad Raoufi, Mostafa Akbariani, Mohammad Reza Sepand, Mareike Müller, Mohammad Hossein Ghahremani, Sheyda Ranjbar, Ivan M. Kempson, Willis Collins Akeyo Muganda, Sepand, Mohammad Reza, Ranjbar, Sheyda, Kempson, Ivan M, Akbariani, Mostafa, Muganda, Willis Collins Akeyo, Muller, Mareike, Ghahremani, Mohammad Hossein, and Raoufi, Mohammad

Subjects
autophagy, Programmed cell death, Necroptosis, medicine.medical_treatment, Biomedical Engineering, necroptosis, Pharmaceutical Science, Medicine (miscellaneous), Apoptosis, Bioengineering, 02 engineering and technology, 03 medical and health sciences, Neoplasms, Autophagy, medicine, Ferroptosis, Humans, cancer, General Materials Science, 030304 developmental biology, 0303 health sciences, Cell Death, business.industry, nanoparticle, Cancer, Immunotherapy, Photothermal therapy, 021001 nanoscience & nanotechnology, medicine.disease, ferroptosis, Nanostructures, cell death, Cancer cell, Drug delivery, Cancer research, Molecular Medicine, 0210 nano-technology, business
Abstract

Many tumors develop resistance to most of the apoptosis-based cancer therapies. In this sense targeting non-apoptotic forms of cell death including necroptosis, autophagy and ferroptosis may have therapeutic benefits in apoptosis-defective cancer cells. Nanomaterials have shown great advantages in cancer treatment owing to their unique characteristics. Besides, the capability of nanomaterials to induce different forms of cell death has gained widespread attention in cancer treatment. Reports in this field reflect the therapeutic potential of necroptotic cell death induced by nanomaterials in cancer. Also, autophagic cell death induced by nanomaterials alone and as a part of chemo-, radio- and photothermal therapy holds great promise as anticancer therapeutic option. Besides, ferroptosis induction by iron-based nanomaterials in drug delivery, immunotherapy, hyperthermia and imaging systems shows promising results in malignancies. Hence, this review is devoted to the latest efforts and the challenges in this field of research and its clinical merits. Refereed/Peer-reviewed

Published
2020
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5. The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model.

Author

Homberg JR, Olivier JD, VandenBroeke M, Youn J, Ellenbroek AK, Karel P, Shan L, van Boxtel R, Ooms S, Balemans M, Langedijk J, Muller M, Vriend G, Cools AR, Cuppen E, and Ellenbroek BA

Subjects
Animals, Cell Membrane metabolism, Disease Models, Animal, Exploratory Behavior, Grooming, Ligands, Male, Maze Learning, Models, Molecular, Mutation genetics, Rats, Wistar, Receptors, Dopamine D1 chemistry, Ultrasonics, Vocalization, Animal, Cognition, Models, Genetic, Receptors, Dopamine D1 genetics, Social Behavior
Abstract

Social cognition is an endophenotype that is impaired in schizophrenia and several other (comorbid) psychiatric disorders. One of the modulators of social cognition is dopamine, but its role is not clear. The effects of dopamine are mediated through dopamine receptors, including the dopamine D1 receptor (Drd1). Because current Drd1 receptor agonists are not Drd1 selective, pharmacological tools are not sufficient to delineate the role of the Drd1. Here, we describe a novel rat model with a genetic mutation in Drd1 in which we measured basic behavioural phenotypes and social cognition. The I116S mutation was predicted to render the receptor less stable. In line with this computational prediction, this Drd1 mutation led to a decreased transmembrane insertion of Drd1, whereas Drd1 expression, as measured by Drd1 mRNA levels, remained unaffected. Owing to decreased transmembrane Drd1 insertion, the mutant rats displayed normal basic motoric and neurological parameters, as well as locomotor activity and anxiety-like behaviour. However, measures of social cognition like social interaction, scent marking, pup ultrasonic vocalizations and sociability, were strongly reduced in the mutant rats. This profile of the Drd1 mutant rat offers the field of neuroscience a novel genetic rat model to study a series of psychiatric disorders including schizophrenia, autism, depression, bipolar disorder and drug addiction., Competing Interests: The authors declare no competing or financial interests., (© 2016. Published by The Company of Biologists Ltd.)

Published
2016
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