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103 results on '"Mullan, Brendan"'

1. Star Clusters in Tidal Debris

Author

Rodruck, Michael, Charlton, Jane, Borthakur, Sanchayeeta, Chitre, Aparna, Durrell, Patrick R., Elmegreen, Debra, English, Jayanne, Gallagher, Sarah C., Gronwall, Caryl, Knierman, Karen, Konstantopoulos, Iraklis, Li, Yuexing, Maji, Moupiya, Mullan, Brendan, Trancho, Gelys, and Vacca, William

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present results of a Hubble Space Telescope (HST) UBVI-band study of star clusters in tidal tails, using new WFC3 and ACS imaging to complement existing WFPC2 data. We survey 12 tidal tails across seven merging systems, deriving ages and masses for 425 star cluster candidates (SCCs). The stacked mass distribution across all systems follows a power law of the form $dN/dM \propto M^{\beta}$, with $\beta = -2.02 \pm 0.15$, consistent with what is seen in other star forming environments. GALEX and Swift UV imaging provide star formation rates (SFRs) for our tidal tails, which when compared with ages and masses of our SCCs, allows for a determination of the cluster formation efficiency (CFE). We find the CFE increases with increasing SFR surface density, matching the theoretical model. We confirm this fit down at SFR densities lower than previously measured (log $\Sigma_\text{SFR} \: (\text{M}_\odot \: \text{yr}^{-1} \: \text{kpc}^{-2}) \approx -4.2$), as related to the CFE. We determine the half-light radii for a refined sample of 57 SCCs with our HST WFC3 and ACS imaging, and calculate their dynamical age, finding the majority of them to be gravitationally bound. We also provide evidence of only low-mass ($< 10^4 \: \text{M}_\odot$) cluster formation in our nearest galaxy, NGC 1487, consistent with the theory that this system is a dwarf merger., Comment: 26 pages, 27 figures. Accepted at MNRAS

Published
2023

2. Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.

Author

Messinger, Dana, Harris, Micah, Cummings, Jessica, Thomas, Chase, Yang, Tao, Sweha, Stefan, Woo, Rinette, Siddaway, Robert, Burkert, Martin, Stallard, Stefanie, Qin, Tingting, Mullan, Brendan, Siada, Ruby, Ravindran, Ramya, Niculcea, Michael, Dowling, Abigail, Bradin, Joshua, Ginn, Kevin, Gener, Melissa, Dorris, Kathleen, Vitanza, Nicholas, Schmidt, Susanne, Spitzer, Jasper, Li, Jiang, Filbin, Mariella, Cao, Xuhong, Castro, Maria, Lowenstein, Pedro, Mody, Rajen, Chinnaiyan, Arul, Desprez, Pierre-Yves, McAllister, Sean, Dun, Matthew, Hawkins, Cynthia, Waszak, Sebastian, Venneti, Sriram, Koschmann, Carl, and Yadav, Viveka

Subjects
CBD, DMG, ID1, ROS, invasion/migration, Animals, Humans, Mice, Brain, Brain Neoplasms, Calcium-Binding Proteins, Extracellular Matrix Proteins, Glioma, Histones, Inhibitor of Differentiation Protein 1, Mutation, Signal Transduction
Abstract

BACKGROUND: Diffuse midline gliomas (DMG) are highly invasive brain tumors with rare survival beyond two years past diagnosis and limited understanding of the mechanism behind tumor invasion. Previous reports demonstrate upregulation of the protein ID1 with H3K27M and ACVR1 mutations in DMG, but this has not been confirmed in human tumors or therapeutically targeted. METHODS: Whole exome, RNA, and ChIP-sequencing was performed on the ID1 locus in DMG tissue. Scratch-assay migration and transwell invasion assays of cultured cells were performed following shRNA-mediated ID1-knockdown. In vitro and in vivo genetic and pharmacologic [cannabidiol (CBD)] inhibition of ID1 on DMG tumor growth was assessed. Patient-reported CBD dosing information was collected. RESULTS: Increased ID1 expression in human DMG and in utero electroporation (IUE) murine tumors is associated with H3K27M mutation and brainstem location. ChIP-sequencing indicates ID1 regulatory regions are epigenetically active in human H3K27M-DMG tumors and prenatal pontine cells. Higher ID1-expressing astrocyte-like DMG cells share a transcriptional program with oligo/astrocyte-precursor cells (OAPCs) from the developing human brain and demonstrate upregulation of the migration regulatory protein SPARCL1. Genetic and pharmacologic (CBD) suppression of ID1 decreases tumor cell invasion/migration and tumor growth in H3.3/H3.1K27M PPK-IUE and human DIPGXIIIP* in vivo models of pHGG. The effect of CBD on cell proliferation appears to be non-ID1 mediated. Finally, we collected patient-reported CBD treatment data, finding that a clinical trial to standardize dosing may be beneficial. CONCLUSIONS: H3K27M-mediated re-activation of ID1 in DMG results in a SPARCL1+ migratory transcriptional program that is therapeutically targetable with CBD.

Published
2023

3. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

Author

Panwalkar, Pooja, Tamrazi, Benita, Dang, Derek, Chung, Chan, Sweha, Stefan, Natarajan, Siva Kumar, Pun, Matthew, Bayliss, Jill, Ogrodzinski, Martin P, Pratt, Drew, Mullan, Brendan, Hawes, Debra, Yang, Fusheng, Lu, Chao, Sabari, Benjamin R, Achreja, Abhinav, Heon, Jin, Animasahun, Olamide, Cieslik, Marcin, Dunham, Christopher, Yip, Stephen, Hukin, Juliette, Phillips, Joanna J, Bornhorst, Miriam, Griesinger, Andrea M, Donson, Andrew M, Foreman, Nicholas K, Garton, Hugh JL, Heth, Jason, Muraszko, Karin, Nazarian, Javad, Koschmann, Carl, Jiang, Li, Filbin, Mariella G, Nagrath, Deepak, Kool, Marcel, Korshunov, Andrey, Pfister, Stefan M, Gilbertson, Richard J, Allis, C David, Chinnaiyan, Arul M, Lunt, Sophia Y, Blüml, Stefan, Judkins, Alexander R, and Venneti, Sriram

Subjects
Cancer, Biotechnology, Genetics, Rare Diseases, Orphan Drug, Neurosciences, Brain Disorders, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Child, Ependymoma, Epigenesis, Genetic, Epigenomics, Histones, Humans, Metabolic Networks and Pathways, Mice, Biological Sciences, Medical and Health Sciences
Abstract

Childhood posterior fossa group A ependymomas (PFAs) have limited treatment options and bear dismal prognoses compared to group B ependymomas (PFBs). PFAs overexpress the oncohistone-like protein EZHIP (enhancer of Zeste homologs inhibitory protein), causing global reduction of repressive histone H3 lysine 27 trimethylation (H3K27me3), similar to the oncohistone H3K27M. Integrated metabolic analyses in patient-derived cells and tumors, single-cell RNA sequencing of tumors, and noninvasive metabolic imaging in patients demonstrated enhanced glycolysis and tricarboxylic acid (TCA) cycle metabolism in PFAs. Furthermore, high glycolytic gene expression in PFAs was associated with a poor outcome. PFAs demonstrated high EZHIP expression associated with poor prognosis and elevated activating mark histone H3 lysine 27 acetylation (H3K27ac). Genomic H3K27ac was enriched in PFAs at key glycolytic and TCA cycle–related genes including hexokinase-2 and pyruvate dehydrogenase. Similarly, mouse neuronal stem cells (NSCs) expressing wild-type EZHIP (EZHIP-WT) versus catalytically attenuated EZHIP-M406K demonstrated H3K27ac enrichment at hexokinase-2 and pyruvate dehydrogenase, accompanied by enhanced glycolysis and TCA cycle metabolism. AMPKα-2, a key component of the metabolic regulator AMP-activated protein kinase (AMPK), also showed H3K27ac enrichment in PFAs and EZHIP-WT NSCs. The AMPK activator metformin lowered EZHIP protein concentrations, increased H3K27me3, suppressed TCA cycle metabolism, and showed therapeutic efficacy in vitro and in vivo in patient-derived PFA xenografts in mice. Our data indicate that PFAs and EZHIP-WT–expressing NSCs are characterized by enhanced glycolysis and TCA cycle metabolism. Repurposing the antidiabetic drug metformin lowered pathogenic EZHIP, increased H3K27me3, and suppressed tumor growth, suggesting that targeting integrated metabolic/epigenetic pathways is a potential therapeutic strategy for treating childhood ependymomas.

Published
2021

4. Population Growth, Energy Use, and the Implications for the Search for Extraterrestrial Intelligence

Author

Mullan, Brendan and Haqq-Misra, Jacob

Subjects
Physics - Popular Physics
Abstract

Von Hoerner (1975) examined the effects of human population growth and predicted agricultural, environmental, and other problems from observed growth rate trends. Using straightforward calculations, VH75 predicted the "doomsday" years for these scenarios (2020-2050), when we as a species should run out of space or food, or induce catastrophic anthropogenic climate change through thermodynamically unavoidable direct heating of the planet. Now that over four decades have passed, in this paper we update VH75. We perform similar calculations as that work, with improved data and trends in population growth, food production, energy use, and climate change. For many of the impacts noted in VH75 our work amounts to pushing the "doomsday" horizon back to the 2300s-2400s (or much further for population-driven interstellar colonization). This is largely attributable to using worldwide data that exhibit smaller growth rates of population and energy use in the last few decades. While population-related catastrophes appear less likely than in VH75, our continued growth in energy use provides insight into possible future issues. We find that, if historic trends continue, direct heating of the Earth will be a substantial contributor to climate change by about 2260, regardless of the energy source used, coincident with our transition to a Kardashev type-I civilization. We also determine that either an increase of Earth's global mean temperature of 12K will occur or an unreasonably high fraction of the planet will need to be covered by solar collectors by about 2400 to keep pace with our growth in energy use. We further discuss the implications in terms of interstellar expansion, the transition to type II and III civilizations, SETI, and the Fermi Paradox. We conclude that the "sustainability solution" to the Fermi Paradox is a compelling possibility., Comment: Accepted for publication in Futures, special issue: Detectability of Future Earth; 30 pages, 3 figures

Published
2018
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5. The Astrobiology of the Anthropocene

Author

Haqq-Misra, Jacob, Som, Sanjoy, Mullan, Brendan, Loureiro, Rafael, Schwieterman, Edward, Seyler, Lauren, Mogosanu, Haritina, Frank, Adam, Wolf, Eric, Forgan, Duncan, Cockell, Charles, and Sullivan, Woodruff

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Popular Physics, Physics - Physics and Society
Abstract

Human influence on the biosphere has been evident at least since the development of widespread agriculture, and some stratigraphers have suggested that the activities of modern civilization indicate a geological epoch transition. The study of the anthropocene as a geological epoch, and its implication for the future of energy-intensive civilizations, is an emerging transdisciplinary field in which astrobiology can play a leading role. Habitability research of Earth, Mars, and exoplanets examines extreme cases relevant for understanding climate change as a planetary process. Energy-intensive civilizations will also face thermodynamic limits to growth, which provides an important constraint for estimating the longevity of human civilization and guiding the search for extraterrestrial intelligence. We recommend that missions concepts such as LUVOIR, HabEx, and OST be pursued in order to make significant progress toward understanding the future evolution of life on our planet and the possible evolution of technological, energy-intensive life elsewhere in the universe., Comment: A white paper on "Astrobiology Science Strategy" submitted to the NAS

Published
2017

7. A Tale of Two Tails: Exploring Stellar Populations in the Tidal Tails of NGC 3256

Author

Rodruck, Michael, Konstantopoulos, Iraklis, Knierman, Karen, Fedotov, Konstantin, Mullan, Brendan, Gallagher, Sarah, Durrell, Patrick, Ciardullo, Robin, Gronwall, Caryl, and Charlton, Jane

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We have developed an observing program using deep, multiband imaging to probe the chaotic regions of tidal tails in search of an underlying stellar population, using NGC 3256's 400 Myr twin tidal tails as a case study. These tails have different colours of $u - g = 1.05 \pm 0.07$ and $r - i = 0.13 \pm 0.07$ for NGC 3256W, and $u - g = 1.26 \pm 0.07$ and $r - i = 0.26 \pm 0.07$ for NGC 3256E, indicating different stellar populations. These colours correspond to simple stellar population ages of $288^{+11}_{-54}$ Myr and $841^{+125}_{-157}$ Myr for NGC 3256W and NGC 3256E, respectively, suggesting NGC 3256W's diffuse light is dominated by stars formed after the interaction, while light in NGC 3256E is primarily from stars that originated in the host galaxy. Using a mixed stellar population model, we break our diffuse light into two populations: one at 10 Gyr, representing stars pulled from the host galaxies, and a younger component, whose age is determined by fitting the model to the data. We find similar ages for the young populations of both tails, ($195^{-13}_{+0}$ and $170^{-70}_{+44}$ Myr for NGC 3256W and NGC 3256E, respectively), but a larger percentage of mass in the 10 Gyr population for NGC 3256E ($98^{+1}_{-3}\%$ vs $90^{+5}_{-6}\%$). Additionally, we detect 31 star cluster candidates in NGC 3256W and 19 in NGC 2356E, with median ages of 141 Myr and 91 Myr, respectively. NGC 3256E contains several young (< 10 Myr), low mass objects with strong nebular emission, indicating a small, recent burst of star formation., Comment: Accepted for publication in MNRAS. 16 pages, 19 figures

Published
2016
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8. The \^G Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. III. The Reddest Extended Sources in WISE

Author

Griffith, Roger L., Wright, Jason T., Maldonado, Jessica, Povich, Matthew S., Sigurdsson, Steinn, and Mullan, Brendan

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Nearby Type III (galaxy-spanning) Kardashev supercivilizations would have high mid-infrared (MIR) luminosities. We have used the Wide-field Infrared Survey Explorer (WISE) to survey ~$1 \times 10^5$ galaxies for extreme MIR emission, $10^3$ times more galaxies than the only previous such search. We have calibrated the WISE All-sky Catalog pipeline products to improve its photometry for extended sources. We present 563 extended sources with $|b| \ge 10$ and red MIR colors, having visually vetted them to remove artifacts. No galaxies in our sample host an alien civilization reprocessing more than 85% of its starlight into the MIR, and only 50 galaxies, including Arp 220, have MIR luminosities consistent with >50% reprocessing. Ninety of these (likely) extragalactic sources have little literature presence; in most cases they are likely barely resolved galaxies or pairs of galaxies undergoing large amounts of star formation. Five are new to science and deserve further study. The Be star 48 Librae sits within a MIR nebula, and we suggest that it may be creating dust. WISE, 2MASS, and Spitzer imagery shows that IRAS 04287+6444 is consistent with a previously unnoticed, heavily extinguished cluster of young stellar objects. We identify five "passive" (i.e. red) spiral galaxies with unusually high MIR and low NUV luminosity. We search a set of optically "dark" HI galaxies for MIR emission, and find none. These 90 poorly understood sources and five anomalous passive spirals deserve follow-up via both SETI and conventional astrophysics., Comment: ApJS 217 25. 44pp, 9 tables, 25 figures. Due to limitations of arXiv LaTeX compilation, figures are sub-optimally placed and tables are not landscape. See http://astro.psu.edu/~jtwright/Dyson/GHAT3.pdf for version with full resolution figures and fully legible tables

Published
2015
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9. Everolimus improves the efficacy of dasatinib in PDGFR[alpha]-driven glioma

Author

Miklja, Zachary, Yadav, Viveka Nand, Cartaxo, Rodrigo T., Siada, Ruby, Thomas, Chase C., Cummings, Jessica R., Mullan, Brendan, Stallard, Stefanie, Paul, Alyssa, Bruzek, Amy K., Wierzbicki, Kyle, Yang, Tao, Garcia, Taylor, Wolfe, Ian, Leonard, Marcia, Robertson, Patricia L., Garton, Hugh J.L., Wahl, Daniel R., Parmar, Hemant, Sarkaria, Jann N., Kline, Cassie, Mueller, Sabine, Nicolaides, Theodore, Glasser, Chana, Leary, Sarah E.S., Venneti, Sriram, Kumar-Sinha, Chandan, Chinnaiyan, Arul M., Mody, Rajen, Pai, Manjunath P., Phoenix, Timothy N., Marini, Bernard L., and Koschmann, Carl

Subjects
Gliomas -- Drug therapy, Tumor proteins -- Drug therapy, Child health, Lenvatinib, Antineoplastic agents, Health care industry
Abstract

Pediatric and adult high-grade gliomas (HGGs) frequently harbor PDGFR[alpha] alterations. We hypothesized that cotreatment with everolimus may improve the efficacy of dasatinib in PDGFR[alpha]-driven glioma through combinatorial synergism and increased tumor accumulation of dasatinib. We performed dose-response, synergism, P-glycoprotein inhibition, and pharmacokinetic studies in in vitro and in vivo human and mouse models of HGG. Six patients with recurrent PDGFR[alpha]-driven glioma were treated with dasatinib and everolimus. We found that dasatinib effectively inhibited the proliferation of mouse and human primary HGG cells with a variety of PDGFR[alpha] alterations. Dasatinib exhibited synergy with everolimus in the treatment of HGG cells at low nanomolar concentrations of both agents, with a reduction in mTOR signaling that persisted after dasatinib treatment alone. Prolonged exposure to everolimus significantly improved the CNS retention of dasatinib and extended the survival of PPK tumor-bearing mice (mutant TP53, mutant PDGFR[alpha], H3K27M). Six pediatric patients with glioma tolerated this combination without significant adverse events, and 4 patients with recurrent disease (n = 4) had a median overall survival of 8.5 months. Our results show that the efficacy of dasatinib treatment of PDGFR[alpha]-driven HGG was enhanced with everolimus and suggest a promising route for improving targeted therapy for this patient population., Introduction High-grade gliomas (HGGs) are common and aggressive pediatric and adult brain tumors. The median overall survival (OS) of adult patients diagnosed with glioblastoma (GBM), grade IV glioma, is 12.6 [...]

Published
2020
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10. Star clusters in tidal debris

Author

Rodruck, Michael, primary, Charlton, Jane, additional, Borthakur, Sanchayeeta, additional, Chitre, Aparna, additional, Durrell, Patrick R, additional, Elmegreen, Debra, additional, English, Jayanne, additional, Gallagher, Sarah C, additional, Gronwall, Caryl, additional, Knierman, Karen, additional, Konstantopoulos, Iraklis, additional, Li, Yuexing, additional, Maji, Moupiya, additional, Mullan, Brendan, additional, Trancho, Gelys, additional, and Vacca, William, additional

Published
2023
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15. CSIG-09. THERAPEUTIC TARGETING OF PRENATAL PONTINE ID1 SIGNALING IN DIFFUSE MIDLINE GLIOMA

Author

Messinger, Dana, primary, Harris, Micah, additional, Cummings, Jessica, additional, Thomas, Chase, additional, Yang, Tao, additional, Sweha, Stefan, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Burkert, Martin, additional, Stallard, Stefanie, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Dowling, Abigail, additional, Bradin, Joshua, additional, Ginn, Kevin, additional, Gener, Melissa, additional, Dorris, Kathleen, additional, Vitanza, Nicholas, additional, Schmidt, Susanne, additional, Spitzer, Jasper, additional, Li, Jiang, additional, Filbin, Mariella, additional, Cao, Xuhong, additional, Castro, Maria, additional, Lowenstein, Pedro, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Desprez, Pierre-Yves, additional, McAllister, Sean, additional, Dun, Matthew, additional, Hawkins, Cynthia, additional, Waszak, Sebastian, additional, Venneti, Sriram, additional, Koschmann, Carl, additional, and Yadav, Viveka, additional

Published
2022
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16. Blood-brain barrier–adapted precision medicine therapy for pediatric brain tumors

Author

Marini, Bernard L., Benitez, Lydia L., Zureick, Andrew H., Salloum, Ralph, Gauthier, Angela C., Brown, Julia, Wu, Yi-Mi, Robinson, Dan R., Kumar, Chandan, Lonigro, Robert, Vats, Pankaj, Cao, Xuhong, Kasaian, Katayoon, Anderson, Bailey, Mullan, Brendan, Chandler, Benjamin, Linzey, Joseph R., Camelo-Piragua, Sandra I., Venneti, Sriram, McKeever, Paul E., McFadden, Kathryn A., Lieberman, Andrew P., Brown, Noah, Shao, Lina, Leonard, Marcia A.S., Junck, Larry, McKean, Erin, Maher, Cormac O., Garton, Hugh J.L., Muraszko, Karin M., Hervey-Jumper, Shawn, Mulcahy-Levy, Jean M., Green, Adam, Hoffman, Lindsey M., Dorris, Katie, Vitanza, Nicholas A., Wang, Joanne, Schwartz, Jonathan, Lulla, Rishi, Smiley, Natasha Pillay, Bornhorst, Miriam, Haas-Kogan, Daphne A., Robertson, Patricia L., Chinnaiyan, Arul M., Mody, Rajen, and Koschmann, Carl

Published
2017
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17. CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response

Author

Stallard, Stefanie, Savelieff, Masha G., Wierzbicki, Kyle, Mullan, Brendan, Miklja, Zachary, Bruzek, Amy, Garcia, Taylor, Siada, Ruby, Anderson, Bailey, Singer, Benjamin H., Hashizume, Rintaro, Carcaboso, Angel M., McMurray, Kaitlin Q., Heth, Jason, Muraszko, Karin, Robertson, Patricia L., Mody, Rajen, Venneti, Sriram, Garton, Hugh, and Koschmann, Carl

Published
2018
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18. Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma

Author

Messinger, Dana, primary, Harris, Micah K, additional, Cummings, Jessica R, additional, Thomas, Chase, additional, Yang, Tao, additional, Sweha, Stefan R, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Burkert, Martin, additional, Stallard, Stefanie, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Dowling, Abigail R, additional, Bradin, Joshua, additional, Ginn, Kevin F, additional, Gener, Melissa A H, additional, Dorris, Kathleen, additional, Vitanza, Nicholas A, additional, Schmidt, Susanne V, additional, Spitzer, Jasper, additional, Li, Jiang, additional, Filbin, Mariella G, additional, Cao, Xuhong, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Desprez, Pierre-Yves, additional, McAllister, Sean, additional, Dun, Matthew D, additional, Hawkins, Cynthia, additional, Waszak, Sebastian M, additional, Venneti, Sriram, additional, Koschmann, Carl, additional, and Yadav, Viveka Nand, additional

Published
2022
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19. ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

Author

Qin, Tingting, primary, Mullan, Brendan, additional, Ravindran, Ramya, additional, Messinger, Dana, additional, Siada, Ruby, additional, Cummings, Jessica R., additional, Harris, Micah, additional, Muruganand, Ashwath, additional, Pyaram, Kalyani, additional, Miklja, Zachary, additional, Reiber, Mary, additional, Garcia, Taylor, additional, Tran, Dustin, additional, Danussi, Carla, additional, Brosnan-Cashman, Jacqueline, additional, Pratt, Drew, additional, Zhao, Xinyi, additional, Rehemtulla, Alnawaz, additional, Sartor, Maureen A., additional, Venneti, Sriram, additional, Meeker, Alan K., additional, Huse, Jason T., additional, Morgan, Meredith A., additional, Lowenstein, Pedro R., additional, Castro, Maria G., additional, Yadav, Viveka Nand, additional, and Koschmann, Carl, additional

Published
2022
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20. TAMI-79. THERAPEUTIC REVERSAL OF PRENATAL PONTINE ID1 SIGNALING IN DIPG

Author

Yadav, Viveka Nand, primary, Harris, Micah K, additional, Messinger, Dana, additional, Thomas, Chase, additional, Cummings, Jessica R, additional, Yang, Tao, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Burkert, Martin, additional, Stallard, Stefanie, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Ginn, Kevin F, additional, Gener, Melissa A H, additional, Dorris, Kathleen, additional, Vitanza, Nicholas A, additional, Schmidt, Susanne V, additional, Spitzer, Jasper, additional, Li, Jiang, additional, Filbin, Mariella G, additional, Cao, Xuhong, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Desprez, Pierre, additional, McAllister, Sean, additional, Hawkins, Cynthia, additional, Waszak, Sebastian M, additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2021
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21. EPCT-07. ID1 IS A KEY TRANSCRIPTIONAL REGULATOR OF DIPG INVASION AND IS TARGETABLE WITH CANNABIDIOL

Author

Nand Yadav, Viveka, primary, Harris, Micah K, additional, Thomas, Chase, additional, Stallard, Stefanie, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Qin, Tingting, additional, Cummings, Jessica R, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Cao, Xuhong, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Hawkins, Cynthia, additional, Desprez, Pierre, additional, McAllister, Sean, additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2021
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22. Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

Author

Yadav, Viveka Nand, primary, Harris, Micah K., additional, Messinger, Dana, additional, Thomas, Chase, additional, Cummings, Jessica R., additional, Yang, Tao, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Burkert, Martin, additional, Stallard, Stefanie, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Niculcea, Michael, additional, Ginn, Kevin F., additional, Gener, Melissa A.H., additional, Dorris, Kathleen, additional, Vitanza, Nicholas A., additional, Schmidt, Susanne V., additional, Spitzer, Jasper, additional, Li, Jiang, additional, Filbin, Mariella G., additional, Cao, Xuhong, additional, Castro, Maria G., additional, Lowenstein, Pedro R., additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Desprez, Pierre-Yves, additional, McAllister, Sean, additional, Hawkins, Cynthia, additional, Waszak, Sebastian M., additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2021
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23. Everolimus improves the efficacy of dasatinib in the treatment of PDGFRA-driven glioma

Author

Miklja, Zachary, Yadav, Vivek Nand, Cartaxo, Rodrigo, Siada, Ruby, Mullan, Brendan, Stallard, Stefanie, Paul, Alyssa, Bruzek, Amy K., Wierzbicki, Kyle, Yang, Tao, Garcia, Taylor, Wolfe, Ian, Parmar, Hemant, Leonard, Marcia, Robertson, Patricia L., Garton, Hugh, Venneti, Sriram, Kumar-Sinha, Chandan, Chinnaiyan, Arul, Mody, Rajen, Manjunath, Pai P., Phoenix, Timothy N., Marini, Bernard L., and Koschmann, Carl

Subjects
hemic and lymphatic diseases, digestive system diseases
Abstract

Background: Pediatric and adult high-grade glioma (HGG) frequently harbor PDGFRA alterations. Treatment of PDGFRA-driven HGG with targeted agents, such as the tyrosine kinase inhibitor dasatinib, has failed in the clinic. We hypothesized that co-treatment with everolimus may improve the efficacy of dasatinib in PDGFRA-driven glioma through combinatorial synergism and increased tumor accumulation of dasatinib. Methods: Dose response, synergism studies, P-gp inhibition and pharmacokinetic studies were performed on in vitro and in vivo human and mouse models of HGG. De novo tumors were generated in mice using intra-uterine electroporation (IUE) by injecting PB plasmids of TP53 mutation, PDGFRA mutation and H3K27M mutation (PPK) in the lateral vertical of mice embryos. Two children with recurrent PDGFRA-driven HGG were treated with dasatinib and everolimus with correlate CSF analysis. Results: Dasatinib effectively inhibited the proliferation of mouse and human primary HGG cells with a dose-dependent reduction of PDGFRA and pPDGFRA. Dasatinib exhibited synergy with everolimus in the treatment of HGG cells at low nanomolar concentrations of both agents. Prolonged exposure to everolimus significantly improved the CNS retention of dasatinib and extended survival of PPK tumor bearing mice. Two children with recurrent PDGFRA-driven HGG treated with dasatinib and everolimus survived six months and nine months after progression. A paired CSF sample from the patient with PDGFRA-amplified HGG showed 50% increase in CSF dasatinib levels after the addition of everolimus. Conclusion: Efficacy of dasatinib treatment of PDGFRA-driven HGG is improved with everolimus and suggests a promising route for improving targeted therapy for this patient population. Clinical Trial Registration ID # NCT03352427 .

Published
2020
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24. EXCESS, SURPLUS LINES, AND REINSURANCE.

Author

Palazzolo, Hilary Loynes, Carolan, Michael, Mullan, Brendan, Greenbaum, Aaron, and Sackett, Elizabeth

Subjects
Reinsurance -- Surveys, Surplus lines (Insurance) -- Surveys
Abstract

I. Reinsurance A. Liability Beyond the "Reinsurance Accepted" Amount in Facultative Certificates B. Power of Arbitration Panels C. Discovery of Reinsurance and Claim Information in Reinsurance Disputes II. Excess Insurance [...]

Published
2018

25. ATRX Loss in Glioma Results in Epigenetic Dysregulation of Cell Cycle Phase Transition

Author

Qin, Tingting, primary, Mullan, Brendan, additional, Ravindran, Ramya, additional, Siada, Ruby, additional, Cummings, Jessica R., additional, Harris, Micah, additional, Muruganand, Ashwath, additional, Pyaram, Kalyani, additional, Miklja, Zachary, additional, Reiber, Mary, additional, Garcia, Taylor, additional, Tran, Dustin, additional, Danussi, Carla, additional, Brosnan-Cashman, Jacqueline, additional, Pratt, Drew, additional, Zhao, Xinyi, additional, Rehemtulla, Alnawaz, additional, Sartor, Maureen A., additional, Venneti, Sriram, additional, Meeker, Alan K., additional, Huse, Jason, additional, Morgan, Meredith A., additional, Lowenstein, Pedro R., additional, Castro, Maria G., additional, Yadav, Viveka Nand, additional, and Koschmann, Carl, additional

Published
2021
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26. DIPG-59. UPREGULATION OF PRENATAL PONTINE ID1 SIGNALING IN DIPG

Author

Harris, Micah K, primary, Yadav, Viveka Nand, additional, Stallard, Stefanie, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Miklja, Zachary, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Cao, Xuhong, additional, Pasternak, Amy, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Hawkins, Cynthia, additional, Desprez, Pierre, additional, McAllister, Sean, additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2020
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27. CTNI-17. CLINICAL EFFICACY AND PREDICTIVE BIOMARKERS OF ONC201 IN H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA

Author

Rahman Kawakibi, Abed, primary, Tarapore, Rohinton S, additional, Gardner, Sharon, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka Nand, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, de Groot, John, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Umemura, Yoshie, additional, Garton, Hugh, additional, Franson, Andrea, additional, Robertson, Patricia, additional, Schwartz, Jonathan, additional, Cantor, Evan, additional, Miklja, Zachary, additional, Mullan, Brendan, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Cummings, Jessica, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Jiang, Li, additional, Filbin, Mariella, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Venneti, Sriram, additional, Lu, Guangrong, additional, Mueller, Sabine, additional, Martinez, Daniel, additional, Resnick, Adam, additional, Nazarian, Javad, additional, Waszak, Sebastian, additional, Allen, Joshua, additional, and Koschmann, Carl, additional

Published
2020
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28. TAMI-29. MULTIFACTORIAL UPREGULATION OF ID1 DRIVES DIPG INVASIVENESS AND IS THERAPEUTICALLY TARGETABLE

Author

Nand Yadav, Viveka, primary, Harris, Micah K, additional, Stallard, Stefanie, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Qin, Tingting, additional, Cummings, Jessica, additional, Mullan, Brendan, additional, Miklja, Zachary, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Cao, Xuhong, additional, Pasternak, Amy, additional, Castro, Maria G, additional, Lowenstein, Pedro, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Hawkins, Cynthia, additional, Desprez, Pierre, additional, McAllister, Sean, additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2020
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29. CBIO-03. ATRX LOSS IN GLIOMA RESULTS IN EPIGENETIC DYSREGULATION OF CELL CYCLE PHASE TRANSITION

Author

Mullan, Brendan, primary, Qin, Tingting, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Thomas, Chase, additional, Harris, Micah, additional, Muruganand, Ashwat, additional, Pyaram, Kalyani, additional, Miklja, Zachary, additional, Reiber, Mary, additional, Garcia, Taylor, additional, Tran, Dustin, additional, Danussi, Carla, additional, Brosnan-Cashman, Jackie, additional, Pratt, Drew, additional, Zhao, Xinyi, additional, Rehemtulla, Alnawaz, additional, Sartor, Maureen, additional, Venneti, Sriram, additional, Meeker, Alan, additional, Huse, Jason, additional, Morgan, Meredith, additional, Lowenstein, Pedro, additional, Castro, Maria, additional, Yadav, Viveka Nand, additional, and Koschmann, Carl, additional

Published
2020
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30. Clinical efficacy and predictive biomarkers of ONC201 in H3 K27M-mutant diffuse midline glioma

Author

Koschmann, Carl, primary, Kawakibi, Abed Rahman, additional, Tarapore, Rohinton, additional, Gardner, Sharon, additional, Thomas, Chase, additional, Cartaxo, Rodrigo, additional, Yadav, Viveka, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, Groot, John De, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Kim, Michelle, additional, Umemura, Yoshie, additional, Garton, Hugh, additional, Franson, Andrea, additional, Robertson, Patricia, additional, Schwartz, Jonathan, additional, Marini, Bernard, additional, Pai, Manjunath, additional, Phoenix, Timothy, additional, Ji, Sunjong, additional, Cantor, Evan, additional, Miklja, Zachary, additional, Mullan, Brendan, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Cummings, Jessica, additional, Stallard, Stefanie, additional, Wierzbicki, Kyle, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Dun, Matthew, additional, Cain, Jason, additional, Jiang, Li, additional, Filbin, Mariella, additional, Vats, Pankaj, additional, Kumar-Sinha, Chandan, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Pratt, Drew, additional, Venneti, Sriram, additional, Lu, Guangrong, additional, Mueller, Sabine, additional, Resnick, Adam, additional, Nazarian, Javad, additional, Waszak, Sebastian, additional, and Allen, Joshua, additional

Published
2020
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31. Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma

Author

Miklja, Zachary, primary, Yadav, Viveka Nand, additional, Cartaxo, Rodrigo T., additional, Siada, Ruby, additional, Thomas, Chase C., additional, Cummings, Jessica R., additional, Mullan, Brendan, additional, Stallard, Stefanie, additional, Paul, Alyssa, additional, Bruzek, Amy K., additional, Wierzbicki, Kyle, additional, Yang, Tao, additional, Garcia, Taylor, additional, Wolfe, Ian, additional, Leonard, Marcia, additional, Robertson, Patricia L., additional, Garton, Hugh J.L., additional, Wahl, Daniel R., additional, Parmar, Hemant, additional, Sarkaria, Jann N., additional, Kline, Cassie, additional, Mueller, Sabine, additional, Nicolaides, Theodore, additional, Glasser, Chana, additional, Leary, Sarah E.S., additional, Venneti, Sriram, additional, Kumar-Sinha, Chandan, additional, Chinnaiyan, Arul M., additional, Mody, Rajen, additional, Pai, Manjunath P., additional, Phoenix, Timothy N., additional, Marini, Bernard L., additional, and Koschmann, Carl, additional

Published
2020
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32. Searches for Technosignatures: The State of the Profession

Author

Wright, Jason, Allen, Veronica, Alvarado-Gómez, Julián D., Angerhausen, Daniel, Apai, Daniel, Atri, Dimitra, Balbi, Amedeo, Barclay, Thomas, Barentsen, Geert, Beasley, Tony, Beatty, Thomas, Behmard, Aida, Berea, Anamaria, Boyajian, Tabetha, Bridge, Joanna S., Bryson, Steve, Bytof, Jeff, Cleaves, Henderson, Colon, Knicole, Cordes, James, Cowing, Keith, Curtis, Jason, Davenport, James, Davies, Paul, DeMarines, Julia, Denning, Kathryn, Dick, Steven, Dong, Chuanfei, Dutil, Yvan, Edmonds, Peter, Enriquez, Emilio, Eubanks, Marshall, Fernandez, Yan, Frank, Adam, De la Torre, Gabriel G., Gajjar, Vishal, Garrett, Michael, Gelino, Dawn, Geller, Harold, Giles, Daniel, Gillum, Eliot, Gomez, Jose L., Graham, R. J., Grimaldi, Claudio, Grinspoon, David, Haqq-Misra, Jacob, Hellbourg, Greg, Helman, Daniel, Horowitz, Paul, Howard, Andrew, Isaacson, Howard, Jackson, Albert, Jia, Tony Z., Kainu, Morgan, Kanodia, Shubham, Kawaler, Steven, Kendall, Shana, Khan, Afshin, Kipping, David, Kite, Edwin, Knuth, Kevin H., Kopparapu, Ravi, Korpela, Eric, Laine, Pauli, Lau, Graham, Lesyna, Larry, Loureiro, Rafael, MacDonald, Mariah, Margot, Jean-Luc, Mendez, Abel, Mishra, Amit, Morrison, Ian, Mullally, Susan, Mullan, Brendan, Nita, Gelu, O'Neil, Karen, Pass, Jim, Paulino-Lima, Ivan Glaucio, Piotelat, Elisabeth, Pope, Benjamin, Raymond, Sean N., Ricker, George, Riley, Crystal S., Robertson, Paul, Rocha, Graça, Rodriguez, Joseph, Rosenthal, Lee, Roy, Arpita, Rybarczyk, Daniel, de Souza, Rafael S., Sallmen, Shauna, Santander, Marcos, Scharf, Caleb, Schwieterman, Edward, Seiler, Douglas, Shabram, Megan, Sheikh, Sofia, Shostak, Seth, Shrestha, Pradipta, Siemion, Andrew, Sigurdsson, Steinn, Sneed, Evan, Socas-Navarro, Hector, Soderblom, David, Solmaz, Arif, Subramaniam, Sadasivan, Suresh, Akshay, Tan, Joshua, Tanner, Angelle, Tarter, Jill, Taylor, Stuart F., Terrien, Ryan, Turner, Jake D., Vakoch, Douglas, Villa, Ciro, Walkowicz, Lucianne, Wang, Sharon Xuesong, Weiss, Lauren, Werthimer, Dan, Williams, David, Winn, Joshua, Wishnow, Ed, Worden, Simon (Pete), Wright, Shelley, Zackrisson, Erik, Zanis, Michael, Zarka, Philippe, Center for Space and Habitability (CSH), University of Bern, Space Telescope Science Institute (STSci), NYUAD Center for Space Science, New York University [Abu Dhabi], NYU System (NYU)-NYU System (NYU), Dipartimento di Fisica, Università di Roma 'Tor Vergata', Università degli Studi di Roma Tor Vergata [Roma], NASA Ames Research Center Cooperative for Research in Earth Science in Technology (ARC-CREST), NASA Ames Research Center (ARC), Department of Geological Sciences [Gainesville] (UF|Geological), University of Florida [Gainesville] (UF), Department of Computer Science [Bath], University of Bath [Bath], Denver Museum of Nature and Science, Princeton University, Department of Physics and Astronomy [Rochester], University of Rochester [USA], Safran Aircraft Engines, Caltech Department of Astronomy [Pasadena], California Institute of Technology (CALTECH), Department of Earth and Planetary Science [UC Berkeley] (EPS), University of California [Berkeley], University of California-University of California, Department of Physics and Astronomy [Iowa City], University of Iowa [Iowa City], Space Sciences Laboratory [Berkeley] (SSL), Department of Biological Sciences (DBS), Central Campus, University of Essex, Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris Saclay (COmUE)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11), ECLIPSE 2019, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Center for Space Research [Cambridge] (CSR), Massachusetts Institute of Technology (MIT), Department of Astronomy [Berkeley], SETI Institute, Université de Montréal (UdeM), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP]
Abstract

International audience; The small size of the SETI workforce is a major problem for NASA and the search for life elsewhere in the universe. The Astro2020 Decadal should address this issue by making nurturing the field an explicit priority for the next decade.

Published
2019

33. GENE-17. ATRX LOSS IN GLIOMA RESULTS IN EPIGENETIC DYSREGULATION OF THE G2/M CHECKPOINT AND SENSITIVITY TO ATM INHIBITION

Author

Mullan, Brendan, primary, Qin, Tingting, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Garcia, Taylor, additional, Muruganand, Ashwath, additional, Harris, Micah, additional, Danussi, Carla, additional, Brosnan-Cashman, Jacqueline, additional, Pratt, Drew, additional, Zhao, Xinyi, additional, Rehemtulla, Alnawaz, additional, Sartor, Maureen, additional, Venneti, Sriram, additional, Meeker, Alan, additional, Huse, Jason, additional, Morgan, Meredith, additional, Lowenstein, Pedro, additional, Castro, Maria, additional, Yadav, Vivekanand, additional, and Koschmann, Carl, additional

Published
2019
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34. PDCT-12. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA

Author

Rahman Kawakibi, Abed, primary, Gardner, Sharon, additional, Chi, Andrew, additional, Kurz, Sylvia, additional, Wen, Patrick, additional, Arrillaga-Romany, Isabel, additional, Batchelor, Tracy, additional, Butowski, Nicholas, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Harrison, Rebecca, additional, DeGroot, John, additional, Mehta, Minesh, additional, Odia, Yazmin, additional, Hall, Matthew, additional, Daghistani, Doured, additional, Cloughesy, Timothy, additional, Ellingson, Benjamin, additional, Umemura, Yoshie, additional, Schwartz, Jonathan, additional, Yadav, Vivekanand, additional, Cartaxo, Rodrigo, additional, Miklja, Zachary, additional, Bruzek, Amy, additional, Siada, Ruby, additional, Mullan, Brendan, additional, Stallard, Stefanie, additional, Muruganand, Ashwath, additional, Wierzbicki, Kyle, additional, Paul, Alyssa, additional, Wolfe, Ian, additional, Kumar-Sinha, Chandan, additional, Marini, Bernard, additional, Leonard, Marcia, additional, Garton, Hugh, additional, Mody, Rajen, additional, Robertson, Patricia, additional, Merdinger, Krystal, additional, Tarapore, Rohinton, additional, Oster, Wolfgang, additional, Allen, Joshua, additional, and Koschmann, Carl, additional

Published
2019
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35. EXTH-47. THERAPEUTIC REVERSAL OF PRENATAL PONTINE ID1 SIGNALING IN DIPG

Author

Harris, Micah, primary, Yadav, Vivekanand, additional, Stallard, Stefanie, additional, Woo, Rinette, additional, Siddaway, Robert, additional, Qin, Tingting, additional, Mullan, Brendan, additional, Miklja, Zachary, additional, Siada, Ruby, additional, Ravindran, Ramya, additional, Cao, Xuhong, additional, Pasternak, Amy, additional, Castro, Maria, additional, Lowenstein, Pedro, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Hawkins, Cynthia, additional, McAllister, Sean, additional, Desprez, Pierre, additional, Venneti, Sriram, additional, and Koschmann, Carl, additional

Published
2019
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36. The effect of everolimus on CNS penetration and efficacy of dasatinib in the treatment of PDGFRA-driven glioma.

Author

Miklja, Zachary, primary, Mullan, Brendan, additional, Siada, Ruby, additional, Stallard, Stefanie, additional, Yadav, Viveka Nand, additional, Bruzek, Amy, additional, Garcia, Taylor, additional, Leonard, Marcia, additional, Robertson, Patricia, additional, Paul, Alyssa, additional, Pai, Manjunath, additional, Phoenix, Timothy, additional, Marini, Bernard, additional, and Koschmann, Carl Johannes, additional

Published
2019
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37. HGG-08. ATRX LOSS IN PEDIATRIC GBM RESULTS IN EPIGENETIC DYSREGULATION OF G2/M CHECKPOINT MAINTENANCE AND SENSITIVITY TO ATM INHIBITION

Author

Mullan, Brendan, primary, Qin, Tingting, additional, Siada, Ruby, additional, Danussi, Carla, additional, Brosnan-Cashman, Jacqueline, additional, Pratt, Drew, additional, Garcia, Taylor, additional, Yadav, Viveka Nand, additional, Zhao, Xinyi, additional, Morgan, Meredith, additional, Venneti, Sriram, additional, Meeker, Alan, additional, Huse, Jason, additional, Rehemtulla, Alnawaz, additional, Lowenstein, Pedro, additional, Castro, Maria, additional, and Koschmann, Carl, additional

Published
2019
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38. HGG-03. EVEROLIMUS TREATMENT IMPROVES THE CNS PENETRATION AND EFFICACY OF DASATINIB IN THE TREATMENT OF PDGFRA-DRIVEN PEDIATRIC HIGH-GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA

Author

Miklja, Zachary, primary, Mullan, Brendan, additional, Stallard, Stefanie, additional, Yadav, Viveka Nand, additional, Bruzek, Amy K, additional, Garcia, Taylor, additional, Leonard, Marcia, additional, Robertson, Patricia L, additional, Paul, Alyssa, additional, Pai, Manjunath P, additional, Phoenix, Timothy, additional, Marini, Bernard, additional, and Koschmann, Carl, additional

Published
2019
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39. Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations

Author

Miklja, Zachary, primary, Pasternak, Amy, additional, Stallard, Stefanie, additional, Nicolaides, Theodore, additional, Kline-Nunnally, Cassie, additional, Cole, Bonnie, additional, Beroukhim, Rameen, additional, Bandopadhayay, Pratiti, additional, Chi, Susan, additional, Ramkissoon, Shakti H, additional, Mullan, Brendan, additional, Bruzek, Amy K, additional, Gauthier, Angela, additional, Garcia, Taylor, additional, Atchison, Christie, additional, Marini, Bernard, additional, Fouladi, Maryam, additional, Parsons, D William, additional, Leary, Sarah, additional, Mueller, Sabine, additional, Ligon, Keith L, additional, and Koschmann, Carl, additional

Published
2019
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40. Clinically Integrated Sequencing Alters Therapy in Children and Young Adults With High-Risk Glial Brain Tumors

Author

Koschmann, Carl, primary, Wu, Yi-Mi, additional, Kumar-Sinha, Chandan, additional, Lonigro, Robert, additional, Vats, Pankaj, additional, Kasaian, Katayoon, additional, Cieslik, Marcin, additional, Cao, Xuhong, additional, Anderson, Bailey, additional, Frank, Kevin, additional, Zhao, Lili, additional, Prensner, John R., additional, Zureick, Andrew H., additional, Everett, Jessica, additional, Mullan, Brendan, additional, Marini, Bernard, additional, Camelo-Piragua, Sandra, additional, Venneti, Sriram, additional, McKeever, Paul, additional, McFadden, Kathryn, additional, Lieberman, Andrew P., additional, Leonard, Marcia, additional, Maher, Cormac O., additional, Garton, Hugh, additional, Muraszko, Karin, additional, Robertson, Patricia, additional, Robinson, Dan, additional, Chinnaiyan, Arul M., additional, and Mody, Rajen, additional

Published
2018
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41. PDTM-29. CSF H3F3A K27M CIRCULATING TUMOR DNA COPY NUMBER QUANTIFIES TUMOR GROWTH AND TREATMENT RESPONSE

Author

Stallard, Stefanie, primary, G. Savelieff, Masha, additional, Mullan, Brendan, additional, Miklja, Zachary, additional, Bruzek, Amy, additional, Garcia, Taylor, additional, Wierzbicki, Kyle, additional, Singer, Benjamin, additional, Hashizume, Rintaro, additional, Montero Carcaboso, Angel, additional, Q. McMurray, Kaitlin, additional, Heth, Jason, additional, Muraszko, Karin, additional, L. Robertson, Patricia, additional, Mody, Rajen, additional, Venneti, Sriram, additional, Garton, Hugh, additional, and Koschmann, Carl, additional

Published
2018
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42. DIPG-38. ID1 EXPRESSION CORRELATES WITH H3F3A K27M MUTATION AND EXTRA-PONTINE INVASION IN DIPG

Author

Stallard, Stefanie, primary, Siddaway, Robert, additional, Miklja, Zachary, additional, Mullan, Brendan, additional, Garcia, Taylor, additional, Zamler, Daniel, additional, Kasaian, Katayoon, additional, Cao, Xuhong, additional, Anderson, Bailey, additional, Hervey-Jumper, Shawn, additional, Castro, Maria G, additional, Lowenstein, Pedro R, additional, Mody, Rajen, additional, Chinnaiyan, Arul, additional, Venneti, Sriram, additional, Hawkins, Cynthia, additional, and Koschmann, Carl, additional

Published
2018
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43. PDCT-14. CLINICALLY INTEGRATED SEQUENCING SIGNIFICANTLY ALTERS THERAPY IN CHILDREN AND YOUNG ADULTS WITH HIGH-RISK GLIAL BRAIN TUMORS

Author

Koschmann, Carl, primary, Wu, Yi-Mi, additional, Kumar, Chandan, additional, Lonigro, Robert, additional, Vats, Pankaj, additional, Kasaian, Katayoon, additional, Cieslik, Marcin, additional, Cao, Xuhong, additional, Frank, Kevin, additional, Prensner, John R, additional, Zureick, Andrew, additional, Everett, Jessica, additional, Anderson, Bailey, additional, Mullan, Brendan, additional, Marini, Bernard, additional, Camelo-Piragua, Sandra, additional, Vennneti, Sriram, additional, Keever, Paul Mc, additional, McFadden, Kathryn A, additional, Lieberman, Andrew, additional, Leonard, Marcia, additional, Maher, Cormac O, additional, Garton, Hugh J L, additional, Muraszko, Karin, additional, Robertson, Patricia, additional, Robinson, Dan, additional, Chinnaiyan, Arul, additional, and Mody, Rajen, additional

Published
2017
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46. The �� Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. III. The Reddest Extended Sources in WISE

Author

Griffith, Roger L., Wright, Jason T., Maldonado, Jessica, Povich, Matthew S., Sigurdsson, Steinn, and Mullan, Brendan

Subjects
Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences
Abstract

Nearby Type III (galaxy-spanning) Kardashev supercivilizations would have high mid-infrared (MIR) luminosities. We have used the Wide-field Infrared Survey Explorer (WISE) to survey ~$1 \times 10^5$ galaxies for extreme MIR emission, $10^3$ times more galaxies than the only previous such search. We have calibrated the WISE All-sky Catalog pipeline products to improve its photometry for extended sources. We present 563 extended sources with $|b| \ge 10$ and red MIR colors, having visually vetted them to remove artifacts. No galaxies in our sample host an alien civilization reprocessing more than 85% of its starlight into the MIR, and only 50 galaxies, including Arp 220, have MIR luminosities consistent with >50% reprocessing. Ninety of these (likely) extragalactic sources have little literature presence; in most cases they are likely barely resolved galaxies or pairs of galaxies undergoing large amounts of star formation. Five are new to science and deserve further study. The Be star 48 Librae sits within a MIR nebula, and we suggest that it may be creating dust. WISE, 2MASS, and Spitzer imagery shows that IRAS 04287+6444 is consistent with a previously unnoticed, heavily extinguished cluster of young stellar objects. We identify five "passive" (i.e. red) spiral galaxies with unusually high MIR and low NUV luminosity. We search a set of optically "dark" HI galaxies for MIR emission, and find none. These 90 poorly understood sources and five anomalous passive spirals deserve follow-up via both SETI and conventional astrophysics., ApJS 217 25. 44pp, 9 tables, 25 figures. Due to limitations of arXiv LaTeX compilation, figures are sub-optimally placed and tables are not landscape. See http://astro.psu.edu/~jtwright/Dyson/GHAT3.pdf for version with full resolution figures and fully legible tables

Published
2015
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