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1. Risk factors for discontinuation of exclusive breast feeding within 1month: a retrospective cohort study in Japan

Author

Yasuda, Shun, Fukuda, Toma, Toba, Naoya, Kamo, Norihito, Imaizumi, Karin, Yokochi, Midori, Okawara, Tomoko, Takano, Seiko, Yoshida, Hideko, Kobayashi, Nobuko, Kudo, Shingo, Miyazaki, Kyohei, Hosoya, Mamiko, Sato, Kenichi, Takano, Kei, Kanno, Aya, Murata, Tsuyoshi, Kyozuka, Hyo, Yamaguchi, Akiko, Ito, Fumihiro, Oda, Shinichiro, Momoi, Nobuo, Hosoya, Mitsuaki, and Fujimori, Keiya

Published
2022
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4. Calmodulinopathy in Japanese Children ― Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy ―

Author

Fukuyama, Megumi, primary, Horie, Minoru, additional, Kato, Koichi, additional, Aoki, Hisaaki, additional, Fujita, Shuhei, additional, Yoshida, Yoko, additional, Sakazaki, Hisanori, additional, Toda, Takako, additional, Ueno, Michihiko, additional, Izumi, Gaku, additional, Momoi, Nobuo, additional, Muneuchi, Jun, additional, Makiyama, Takeru, additional, Nakagawa, Yoshihisa, additional, and Ohno, Seiko, additional

Published
2023
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6. Sterilization efficacy of a new water‐free breast milk pasteurizer.

Author

Chishiki, Mina, Nishiyama, Kyoko, Suzutani, Tatsuo, Hiruta, Shun, Ichikawa, Hirotaka, Haneda, Kentaro, Maeda, Hajime, Shimizu, Hiromi, Kanai, Yuji, Ogasawara, Kei, Go, Hayato, Sato, Maki, Momoi, Nobuo, Nollet, Kenneth E., Ohto, Hitoshi, and Hosoya, Mitsuaki

Subjects
PREVENTION of infectious disease transmission, CYTOMEGALOVIRUSES, NEONATAL intensive care, BREAST milk, NEONATAL intensive care units, FOOD pasteurization, BACTERIAL growth, MICROBIOLOGICAL techniques, RESEARCH funding, STERILIZATION (Disinfection)
Abstract

Background: Breast milk, nature's optimum source of nutrition for infants, can contain undesirable microorganisms that cause severe morbidity. After an outbreak of multidrug‐resistant Escherichia coli among neonates receiving breast milk donated by another mother in our neonatal intensive care unit (NICU), we were motivated to develop a high‐grade breast milk pasteurizer (BMP) designed to thaw and pasteurize breast milk at 63°C for 30 min in a sealed bag without having to open the bag or immerse it in water. Methods: Pre‐existing bacteria and spiked cytomegalovirus (CMV) were measured pre‐ and post‐pasteurization in frozen breast milk donated by mothers of children admitted to the NICU. Results: Among 48 breast milk samples (mean ± standard deviation [SD]), pre‐existing bacterial counts of 5.1±1.1 × 104 colony forming units (cfu)/mL decreased to less than 10 cfu/mL (below detection level) in 45 samples after pasteurization for 30 min. In three samples, 10–110 cfu/mL persisted. As no CMV was detected in any of the 48 samples, CMV at ≥5 × 104 pfu/mL was spiked into 11 breast milk samples. After just 10 min of pasteurization, infectious CMV was not detected (threshold <50 pfu/mL) in any sample. Conclusion: A new BMP was shown to pasteurize milk effectively with more than a 3‐log reduction of microorganisms. Compared to conventional pasteurizers, this device reduces the effort involved in pasteurizing breast milk, avoids various contamination risks, and may reduce the risk of infectious disease transmission via breast milk. [ABSTRACT FROM AUTHOR]

Published
2023
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9. A burden of sarcomere gene variants in fetal-onset patients with left ventricular noncompaction

Author

Hirono, Keiichi, primary, Hata, Yukiko, additional, Ozawa, Sayaka Watanabe, additional, Toda, Takako, additional, Momoi, Nobuo, additional, Fukuda, Yutaka, additional, Inuzuka, Ryo, additional, Nagamine, Hiroki, additional, Sakaguchi, Heima, additional, Kurosaki, Kenichi, additional, Okabe, Mako, additional, Takarada, Shinya, additional, Miyao, Nariaki, additional, Nakaoka, Hideyuki, additional, Ibuki, Keijiro, additional, Origasa, Hideki, additional, Bowles, Neil E., additional, Nishida, Naoki, additional, and Ichida, Fukiko, additional

Published
2021
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10. Towards the development of a human in vitro model of the blood–brain barrier for virus-associated acute encephalopathy: assessment of the time- and concentration-dependent effects of TNF-α on paracellular tightness

Author

Maeda, Hajime, primary, Hashimoto, Koichi, additional, Go, Hayato, additional, Miyazaki, Kyohei, additional, Sato, Masatoki, additional, Kawasaki, Yukihiko, additional, Momoi, Nobuo, additional, and Hosoya, Mitsuaki, additional

Published
2020
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12. Risk factors for discontinuation of exclusive breast feeding within 1-month: A retrospective cohort study

Author

Yasuda, Shun, primary, Fukuda, Toma, additional, Toba, Naoya, additional, Kamo, Norihito, additional, Imaizumi, Karin, additional, Yokochi, Midori, additional, Okawara, Tomoko, additional, Takano, Seiko, additional, Yoshida, Hideko, additional, Kobayashi, Nobuko, additional, Kudo, Shingo, additional, Miyazaki, Kyohei, additional, Hosoya, Mamiko, additional, Sato, Kenichi, additional, Takano, Kei, additional, Kanno, Aya, additional, Murata, Tsuyoshi, additional, Kyozuka, Hyo, additional, Yamaguchi, Akiko, additional, Ito, Fumihiro, additional, Oda, Shinichiro, additional, Momoi, Nobuo, additional, Hosoya, Mitsuaki, additional, and Fujimori, Keiya, additional

Published
2020
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14. Increased Burden of Ion Channel Gene Variants Is Related to Distinct Phenotypes in Pediatric Patients With Left Ventricular Noncompaction

Author

Hirono, Keiichi, primary, Hata, Yukiko, additional, Miyao, Nariaki, additional, Okabe, Mako, additional, Takarada, Shinya, additional, Nakaoka, Hideyuki, additional, Ibuki, Keijiro, additional, Ozawa, Sayaka, additional, Origasa, Hideki, additional, Nishida, Naoki, additional, Ichida, Fukiko, additional, Takeda, Atsuhito, additional, Shimabukuro, Atsuya, additional, Akita, Chisato, additional, Fukumi, Daichi, additional, Nishihara, Eiki, additional, Tsuda, Etsuko, additional, Sakaguchi, Heima, additional, Ishida, Hidekazu, additional, Tomita, Hideshi, additional, Kise, Hiroaki, additional, Nagamine, Hiroki, additional, Uchiyama, Hiroki, additional, Katayama, Hiromi, additional, Ooki, Hiroo, additional, Nishikawa, Hiroshi, additional, Ono, Hiroshi, additional, Horigome, Hisanori Sakazaki, Hitoshi, additional, Muneuchi, Jun, additional, Yoshimoto, Jun, additional, Soumura, Junpei, additional, Kamada, Masahiro, additional, Yasuda, Kazushi, additional, Ikeda, Kazuyuki, additional, Yasuda, Keiji, additional, Kurosaki, Kenichi, additional, Mine, Kenji, additional, Ueno, Kentaro, additional, Takigiku, Kiyohiro, additional, Ogawa, Kiyoshi, additional, Inaguma, Kotaro, additional, Oyama, Kotaro, additional, Urayama, Kotaro, additional, Takahashi, Kunihiko, additional, Ohta, Kunio, additional, Nakazawa, Makoto, additional, Nakayashiro, Mami, additional, Ayusawa, Mamoro, additional, Toyono, Manatomo, additional, Nii, Masaki, additional, Miura, Masaru, additional, Fujino, Mitsuhiro, additional, Kuwabara, Naoshi, additional, Momoi, Nobuo, additional, Tsujii, Nobuyuki, additional, Motoki, Noriko, additional, Matsuo, Osamu, additional, Baba, Reizo, additional, Inuzuka, Ryo, additional, Kido, Sachiko, additional, Iwashima, Satoru, additional, Yasukochi, Satoshi, additional, Okada, Seigo, additional, Sato, Seiichi, additional, Mitsuru, Seki, additional, Kogaki, Shigetoyo, additional, Hoshino, Shinsuke, additional, Tsukano, Shinya, additional, Fujita, Shuhei, additional, Kimura, Sumito, additional, Urata, Susumu, additional, Kato, Taichi, additional, Toda, Takako, additional, Uchiyama, Takamichi, additional, Shindo, Takahiro, additional, Higaki, Takashi, additional, Kobayashi, Tomio, additional, Ozaki, Tomoyasu, additional, Tanaka, Yasuhiko, additional, Katsube, Yasuhiro, additional, Hamabuchi, Yasunobu, additional, Kajiyama, Yo, additional, Yoshida, Yoko, additional, Murakami, Yosuke, additional, Abe, Yuriko, additional, Hiraumi, Yoshimi, additional, Fukuda, Yutaka, additional, and Odanaka, Yutaka, additional

Published
2020
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16. Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants

Author

Go, Hayato, primary, Maeda, Hajime, additional, Miyazaki, Kyohei, additional, Maeda, Ryo, additional, Kume, Yohei, additional, Namba, Fumihiko, additional, Momoi, Nobuo, additional, Hashimoto, Koichi, additional, Otsuru, Satoru, additional, Kawasaki, Yukihiko, additional, Hosoya, Mitsuaki, additional, and Dennery, Phyllis A, additional

Published
2020
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19. Perinatal Factors Affecting Coagulation Parameters at Birth in Preterm and Term Neonates: A Retrospective Cohort Study

Author

Go, Hayato, additional, Ohto, Hitoshi, additional, Nollet, Kenneth E., additional, Kashiwabara, Nozomi, additional, Ogasawara, Kei, additional, Chishiki, Mina, additional, Miyazaki, Kyohei, additional, Sato, Kenichi, additional, Sato, Maki, additional, Kawasaki, Yukihiko, additional, Momoi, Nobuo, additional, and Hosoya, Mitsuaki, additional

Published
2019
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21. Clinical and Echocardiographic Impact of Tafazzin Variants on Dilated Cardiomyopathy Phenotype in Left Ventricular Non-Compaction Patients in Early Infancy

Author

Hirono, Keiichi, primary, Hata, Yukiko, additional, Nakazawa, Makoto, additional, Momoi, Nobuo, additional, Tsuji, Tohru, additional, Matsuoka, Taro, additional, Ayusawa, Mamoru, additional, Abe, Yuriko, additional, Hayashi, Tamaki, additional, Tsujii, Nobuyuki, additional, Abe, Tadaaki, additional, Sakaguchi, Heima, additional, Wang, Ce, additional, Takasaki, Asami, additional, Takarada, Shinya, additional, Okabe, Mako, additional, Miyao, Nariaki, additional, Nakaoka, Hideyuki, additional, Ibuki, Keijiro, additional, Saito, Kazuyoshi, additional, Ozawa, Sayaka, additional, Nishida, Naoki, additional, Bowles, Neil E., additional, and Ichida, Fukiko, additional

Published
2018
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24. Volumetric Analysis of Gallbladder in Extremely Premature Infants

Author

Imamura, Takashi, primary, Sato, Maki, additional, Go, Hayato, additional, Ogasawara, Kei, additional, Kanai, Yuji, additional, Chishiki, Mina, additional, Maeda, Hajime, additional, Haneda, Kentarou, additional, Kashiwabara, Nozomi, additional, Goto, Aya, additional, Momoi, Nobuo, additional, and Hosoya, Mitsuaki, additional

Published
2017
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27. Pulmonary Artery Banding for Congenitally Corrected Transposition of the Great Arteries With Hydrops Fetalis: A Case Report

Author

Takeda, Yuka, Momoi, Nobuo, Hayashi, Mariko, Endo, Kisei, Aoyagi, Yoshimichi, Kawashima, Ryoko, Wakamatsu, Hiroki, and Kurosawa, Hiroyuki

Abstract

At 32 weeks of gestation, a male fetus with congenitally corrected transposition of the great arteries developed hydrops fetalis caused by a combination of mitral valve regurgitation and tricuspid valve regurgitation (TR). We performed a pulmonary artery banding (PAB) at 108 days old for gradually progressing TR, after confirming that a balloon dilatation test in the main pulmonary artery reduced TR. As the patient grew, the PAB became tighter and systolic blood pressure in the morphological left ventricle increased. At present, the patient is waiting for a double switch operation.

Published
2020
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34. A Novel MYH7Gene Mutation in a Fetus With Left Ventricular Noncompaction

Author

Nomura, Yasuhisa, Momoi, Nobuo, Hirono, Keiichi, Hata, Yukiko, Takasaki, Asami, Nishida, Naoki, and Ichida, Fukiko

Abstract

Left ventricular noncompaction (LVNC) is a recently defined cardiomyopathy characterized by a pattern of prominent trabecular meshwork and deep intertrabecular recesses. LVNC is rarely described in fetal life, and a small number of cases have been reported. We report the first fetal case, to our knowledge, of LVNC associated with a novel mutation in the MYH7gene (c.1625A>C; p.Lys542Thr). This patient showed cardiomegaly on prenatal ultrasonographic examinations, with features indicating noncompaction of the myocardium apparent in the second trimester. This case highlights the importance of prenatal ultrasonography for the diagnosis of LVNC and suggests that abnormal myocardial development underlies the pathogenesis of LVNC.

Published
2015
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35. Determination of Genotype and Phenotypes in Pediatric Patients With Biventricular Noncompaction.

Author

Hirono K, Hata Y, Imamura T, Tsuboi K, Takarada S, Okabe M, Nakaoka H, Ibuki K, Ozawa S, Ichimata S, Nishida N, Iwasaki H, Urata S, Okada S, Hiratsuji T, Sakaguchi H, Takigiku K, Nakazawa M, Nishihara E, Harada M, Matsuo O, Yasuda K, Yoshida Y, Namiki H, Yasuda K, Ifuku T, Urayama K, Oka H, Ogino K, Kato A, Kan N, Seki S, Seki M, Odanaka Y, Iwashima S, Yoshida S, Miyata T, Miyamoto T, Watanabe K, Kuwabara N, Inuzuka R, Takahashi Y, Sakazaki H, Muneuchi J, Kogaki S, Numano F, Kido S, Nii M, Hoshino S, Ishida H, Maeda J, Hayabuchi Y, Otsubo Y, Ikeda K, Tsukano S, Watanabe M, Momoi N, Fujii T, Fujioka T, Fujino M, Uchiyama H, Baba S, Horigome H, Honda T, Suzuki K, and Ichida F

Subjects
Humans, Male, Female, Infant, Child, Preschool, Child, Infant, Newborn, Heart Defects, Congenital genetics, Heart Defects, Congenital mortality, Heart Defects, Congenital diagnosis, Japan epidemiology, Genotype, Genetic Predisposition to Disease, Isolated Noncompaction of the Ventricular Myocardium genetics, Isolated Noncompaction of the Ventricular Myocardium physiopathology, Isolated Noncompaction of the Ventricular Myocardium diagnosis, Isolated Noncompaction of the Ventricular Myocardium mortality, Cardiomyopathies genetics, Cardiomyopathies physiopathology, Retrospective Studies, Phenotype
Abstract

Background: Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy characterized by prominent trabeculations. Detailed characteristics of biventricular noncompaction (BiVNC) remain unknown. This study aimed to elucidate the clinical characteristics and genetic landscape of BiVNC., Methods and Results: We recruited children with left ventricular noncompaction from Japanese multi-institutional centers from 2013 to 2021. Left ventricular noncompaction was classified as BiVNC, congenital heart disease, arrhythmia, dilated cardiomyopathy, or normal function. In these patients, cardiomyopathy-associated genes were screened. A total of 234 patients (127 male; mean age, 4 months [range, 0-6.6 years]) were enrolled in this study, of whom 25 had BiVNC; 55, normal function; 84, dilated cardiomyopathy; 38, congenital heart disease; and 32, arrhythmia. BiVNC was diagnosed during the perinatal period in 10 patients, in whom the prevalence was higher than that in other patients. A total of 14 patients in the group with BiVNC had congenital heart disease, but not necessarily right heart lesions. Left ventricular dyskinesis was frequently observed in the lateral wall (24%) and apex (28%). Eleven pathogenic variants were found in 11 patients with BiVNC (44.0%). The group with BiVNC had a higher ratio of mitochondrial and developmental gene variants than the other groups. Among all groups, the group with BiVNC had the worst survival rate ( P =0.0009)., Conclusions: Pediatric patients with BiVNC had a high rate of ventricular dyskinesis and poor outcome. A comprehensive and careful screening for disease-causing genes and phenotype may help identify specific patients with left ventricular noncompaction and mortality-related cardiac phenotypes.

Published
2024
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36. Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants.

Author

Go H, Maeda H, Miyazaki K, Maeda R, Kume Y, Namba F, Momoi N, Hashimoto K, Otsuru S, Kawasaki Y, Hosoya M, and Dennery PA

Subjects
Animals, Animals, Newborn, Antagomirs genetics, Antagomirs metabolism, Biomarkers metabolism, Chronic Disease, Disease Models, Animal, Extracellular Vesicles chemistry, Extracellular Vesicles metabolism, Female, Gene Expression Profiling, Gene Expression Regulation, Humans, Hyperoxia blood, Hyperoxia physiopathology, Infant, Newborn, Infant, Premature, Lung Diseases blood, Lung Diseases physiopathology, Male, Mice, Mice, Inbred C57BL, MicroRNAs agonists, MicroRNAs antagonists & inhibitors, MicroRNAs blood, MicroRNAs classification, Oligonucleotide Array Sequence Analysis, Oligoribonucleotides genetics, Oligoribonucleotides metabolism, Prognosis, Hyperoxia diagnosis, Hyperoxia genetics, Lung Diseases diagnosis, Lung Diseases genetics, MicroRNAs genetics
Abstract

Premature infants are often exposed to positive pressure ventilation and supplemental oxygen, which leads to the development of chronic lung disease (CLD). There are currently no standard serum biomarkers used for prediction or early detection of patients who go on to develop CLD. MicroRNAs (miRNAs) are a novel class of naturally occurring, short, noncoding substances that regulate gene expression at the posttranscriptional level and cause translational inhibition and/or mRNA degradation and present in body fluids packaged in extracellular vesicles (EVs), rendering them remarkably stable. Our aim was to evaluate miRNAs identified in serum EVs of premature infants as potential biomarkers for CLD. Serum EVs were extracted from premature infants at birth and on the 28th day of life (DOL). Using a human miRNA array, we identified 62 miRNAs that were universally expressed in CLD patients and non-CLD patients. Of the 62 miRNAs, 59 miRNAs and 44 miRNAs were differentially expressed on DOL0 and DOL28 in CLD and non-CLD patients, respectively. Of these miRNAs, serum EV miR-21 was upregulated in CLD patients on DOL28 compared with levels at birth and downregulated in non-CLD patients on DOL28 compared with levels at birth. In neonatal mice exposed to hyperoxia for 7days, as a model of CLD, five miRNAs (miR-34a, miR-21, miR-712, miR-682, and miR-221) were upregulated, and 7 miRNAs (miR-542-5p, miR-449a, miR-322, miR-190b, miR-153, miR-335-3p, miR-377) were downregulated. MiR-21 was detected as a common miRNA that changed in CLD patients and in the hyperoxia exposed mice. We conclude that EV miR-21 may be a biomarker of CLD.

Published
2020
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37. Myelomeningocele with Unilateral Right Renal Agenesis: A Case Report.

Author

Maeda H, Go H, Sakuma J, Imamura T, Sato M, Momoi N, and Hosoya M

Abstract

Congenital anomalies of the spine may occur with malformations of the central nervous, cardiovascular, gastrointestinal, respiratory, and genitourinary systems. This is a case of myelomeningocele with unilateral right renal agenesis in a newborn. The patient suffered complications of cerebrospinal fluid leak and meningitis, but was successfully treated and discharged on day 86. In this case, unilateral right renal agenesis represented a significant surgical risk because failure of the remaining kidney could result in renal failure. Because congenital anomalies of the spine may be associated with malformations of the genitourinary system, and additional surgeries were necessary in our case following birth, it is very important that the presence of genitourinary malformations be evaluated.

Published
2018
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38. Early Postnatal Seizures in a Neonate with Wolf-Hirschhorn Syndrome.

Author

Go H, Haneda K, Maeda H, Ogasawara K, Imamura T, Momoi N, and Hosoya M

Abstract

Background  Wolf-Hirschhorn syndrome (WHS), which is characterized by a typical facial appearance, growth retardation, mental retardation, seizures, and congenital cardiac defects, has an estimated incidence of 1 per 50,000 births. Case  We report a case of a low birth weight neonate with WHS and seizures, as well as persistent pulmonary hypertension in the early neonatal period. Apgar scores were 6 (1 minute) and 8 (5 minutes) with evident retraction. After admission to the neonatal intensive care unit, the patient had tonic-clonic seizures with epilepticus 30 minute after birth. Although the seizures were uncontrollable, continuous thiopental administration was effective for seizure mitigation. Conclusion  Neonatal seizures with WHS occur rarely. This is the first case report on seizures just after birth in a neonate with WHS.

Published
2016
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