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21 results on '"Moen, Stine Marit"'

12. Digital oppfølging og støtte for personer med multippel sklerose. Erfaringer fra prosjektet MS-DOS

Author

Røhne, Mette, Halvorsrud, Ragnhild, Strisland, Frode, Moen, Stine Marit, and Celius, Elisabeth Gulowsen

Subjects
multipel sklerose, nevrologiske lidelser, MS-DOS, digital oppfølging
Abstract

MS-DOS er et forprosjekt som undersøker muligheter for at personer med multippel sklerose (MS) og relevante helseaktører kan ta i bruk digitale hjelpemidler for bedre oppfølging, behandling og mestring av sykdommen. Målet for MS-DOS er å samle informasjon om hvilke utfordringer personer med MS opplever på grunn av sin sykdom, og vurdere i hvilken grad digitale verktøy kan gjøre livet bedre for denne gruppen. Denne rapporten gir et overblikk over helsetilbudet til personer med MS. Deretter presenteres resultater fra en dybdestudie hvor vi følger tre personer med MS over en periode på seks uker. Metoden vi har brukt er observasjon og intervjuer, samt kartlegging av planlagte og reelle pasientforløp ved hjelp av Customer Journey Modelling Language. Rapporten presenterer til slutt muligheter for bruk av digitale støtteverktøy, og forslag til videre studier Oppdragsgiver: Helsedirektoratet ved Innomed

Published
2018

13. Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients

Author

Rhead, Brooke, primary, Brorson, Ina S., additional, Berge, Tone, additional, Adams, Cameron, additional, Quach, Hong, additional, Moen, Stine Marit, additional, Berg-Hansen, Pål, additional, Celius, Elisabeth Gulowsen, additional, Sangurdekar, Dipen P., additional, Bronson, Paola G., additional, Lea, Rodney A., additional, Burnard, Sean, additional, Maltby, Vicki E., additional, Scott, Rodney J., additional, Lechner-Scott, Jeannette, additional, Harbo, Hanne F., additional, Bos, Steffan D., additional, and Barcellos, Lisa F., additional

Published
2018
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15. NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk

Author

Antel, Jack, primary, Ban, Maria, additional, Baranzini, Sergio, additional, Barcellos, Lisa, additional, Barizzone, Nadia, additional, Beecham, Ashley, additional, Berge, Tone, additional, Bernardinelli, Luisa, additional, Booth, David, additional, Bos, Steffan, additional, Buck, Dorothea, additional, Butkiewicz, Mariusz, additional, Celius, Elisabeth G., additional, Comabella, Manuel, additional, Compston, Alastair, additional, Dedham, Katrina, additional, Cotsapas, Chris, additional, D’ Alfonso, Sandra, additional, De Jager, Phil, additional, Dubois, Benedicte, additional, Duquette, Pierre, additional, Fontaine, Bertrand, additional, Gasperi, Christiane, additional, Gil, Elia, additional, Goris, An, additional, Gourraud, Pierre Antoine, additional, Graetz, Christiane, additional, Gyllenberg, Alexandra, additional, Hadjigeorgiou, Georgios, additional, Hafler, David, additional, Hribko, Deanna, additional, Haines, Jonathan, additional, Harbo, Hanne, additional, Hauser, Stephen, additional, Warto, Shannon, additional, Hawkins, Clive, additional, Hemmer, Bernhard, additional, Henry, Roland, additional, Hintzen, Rogier, additional, Horakova, Dana, additional, Ivinson, Adrian, additional, Howard, Melissa, additional, Jelcic, Ilijas, additional, Kaskow, Belinda, additional, Kira, Jun-Ichi, additional, Kleinova, Pavlina, additional, Kockum, Ingrid, additional, Kucerova, Karolina, additional, Lill, Christina, additional, Luessi, Felix, additional, Malhotra, Sunny, additional, Martin, Roland, additional, Martinelli, Filippo, additional, Matsushita, Takuya, additional, McCabe, Cristin, additional, McCauley, Jacob, additional, Mescheriakkova, Julia, additional, Mitrovic, Mitja, additional, Moen, Stine-Marit, additional, Montalban, Xavier, additional, Muhlau, Mark, additional, Nakmura, Yuri, additional, Oksenberg, Jorge, additional, Olsson, Tomas, additional, Oturai, Annette, additional, Palotie, Aarno, additional, Patsopoulos, Nikolaos, additional, Pavlicova, Jana, additional, Pericak-Vance, Peggy, additional, Piehl, Fredrik, additional, Rebeix, Isabelle, additional, Rioux, John, additional, Saarela, Janna, additional, Sawcer, Stephen, additional, Sellebjerg, Finn, additional, Sondergaard, Helle Bach, additional, Sorensen, Per Soelberg, additional, Sospedra, Mireia, additional, Spurkland, Anne, additional, Stewart, Graeme, additional, Taylor, Bruce, additional, Uitterlinden, Andre, additional, Van Duijn, Cornelia, additional, and Zipp, Frauke, additional

Published
2016
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16. Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients.

Author

Rhead, Brooke, Brorson, Ina S., Berge, Tone, Adams, Cameron, Quach, Hong, Moen, Stine Marit, Berg-Hansen, Pål, Celius, Elisabeth Gulowsen, Sangurdekar, Dipen P., Bronson, Paola G., Lea, Rodney A., Burnard, Sean, Maltby, Vicki E., Scott, Rodney J., Lechner-Scott, Jeannette, Harbo, Hanne F., Bos, Steffan D., and Barcellos, Lisa F.

Subjects
CD4 antigen, DNA methylation, MULTIPLE sclerosis, T cell receptors, GENE expression, ENVIRONMENTAL exposure, ETIOLOGY of diseases
Abstract

DNA methylation is an epigenetic mark that is influenced by environmental factors and is associated with changes to gene expression and phenotypes. It may link environmental exposures to disease etiology or indicate important gene pathways involved in disease pathogenesis. We identified genomic regions that are differentially methylated in T cells of patients with relapsing remitting multiple sclerosis (MS) compared to healthy controls. DNA methylation was assessed at 450,000 genomic sites in CD4+ and CD8+ T cells purified from peripheral blood of 94 women with MS and 94 healthy women, and differentially methylated regions were identified using bumphunter. Differential DNA methylation was observed near four loci: MOG/ZFP57, HLA-DRB1, NINJ2/LOC100049716, and SLFN12. Increased methylation of the first exon of the SLFN12 gene was observed in both T cell subtypes and remained present after restricting analyses to samples from patients who had never been on treatment or had been off treatment for more than 2.5 years. Genes near the regions of differential methylation in T cells were assessed for differential expression in whole blood samples from a separate population of 1,329 women with MS and 97 healthy women. Gene expression of HLA-DRB1, NINJ2, and SLFN12 was observed to be decreased in whole blood in MS patients compared to controls. We conclude that T cells from MS patients display regions of differential DNA methylation compared to controls, and corresponding gene expression differences are observed in whole blood. Two of the genes that showed both methylation and expression differences, NINJ2 and SLFN12, have not previously been implicated in MS. SLFN12 is a particularly compelling target of further research, as this gene is known to be down-regulated during T cell activation and up-regulated by type I interferons (IFNs), which are used to treat MS. [ABSTRACT FROM AUTHOR]

Published
2018
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17. S.M. Moen og medarbeidere svarer

Author

Moen, Stine Marit, primary, Harbo, Hanne Flinstad, primary, Celius, Elisabeth Gulowsen, primary, Sowa, Piotr, primary, Nygaard, Gro Owren, primary, and Beyer, Mona K., primary

Published
2016
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21. [MRI in multiple sclerosis].

Author

Moen SM, Harbo HF, Sowa P, Celius EG, Nygaard GO, and Beyer MK

Subjects
Humans, Practice Guidelines as Topic, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging standards, Multiple Sclerosis diagnostic imaging
Published
2016
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