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2. Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Author

Souverein, Patrick C., Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G. M., Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J., Groenwold, Rolf H. H., Reynolds, Robert, Schlienger, Raymond G., Logie, John W., de Groot, Mark C. H., Klungel, Olaf H., van Staa, Tjeerd P., Egberts, Toine C. G., De Bruin, Marie L., and Gardarsdottir, Helga

Published
2016
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3. Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project

Author

Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C., De Bruin, Marie L., Slattery, Jim, De Groot, Mark C. H., Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G., Reynolds, Robert F., Klungel, Olaf H., and de Abajo, Francisco José

Published
2016
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4. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project

Author

Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C., Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, De Groot, Mark C. H., Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H., and de Abajo, Francisco J.

Published
2016
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5. A systematic scoping review on the consequences of stress-related hyperglycaemia

Author

Olariu, Elena, Pooley, Nicholas, Danel, Aurélie, Miret, Montserrat, Preiser, Jean-Charles, Olariu, Elena, Pooley, Nicholas, Danel, Aurélie, Miret, Montserrat, and Preiser, Jean-Charles

Abstract

Background Stress-related hyperglycaemia (SHG) is commonly seen in acutely ill patients and has been associated with poor outcomes in many studies performed in different acute care settings. We aimed to review the available evidence describing the associations between SHG and different outcomes in acutely ill patients admitted to an ICU. Study designs, populations, and outcome measures used in observational studies were analysed. Methods We conducted a systematic scoping review of observational studies following the Joanna Briggs methodology. Medline, Embase, and the Cochrane Library were searched for publications between January 2000 and December 2015 that reported on SHG and mortality, infection rate, length of stay, time on ventilation, blood transfusions, renal replacement therapy, or acquired weakness. Results The search yielded 3,063 articles, of which 43 articles were included (totalling 536,476 patients). Overall, the identified studies were heterogeneous in study conduct, SHG definition, blood glucose measurements and monitoring, treatment protocol, and outcome reporting. The most frequently reported outcomes were mortality (38 studies), ICU and hospital length of stay (23 and 18 studies, respectively), and duration of mechanical ventilation (13 studies). The majority of these studies (40 studies) compared the reported outcomes in patients who experienced SHG with those who did not. Fourteen studies (35.9%) identified an association between hyperglycaemia and increased mortality (odds ratios ranging from 1.13 to 2.76). Five studies identified hyperglycaemia as an independent risk factor for increased infection rates, and one identified it as an independent predictor of increased ICU length of stay. Discussion SHG was consistently associated with poor outcomes. However, the wide divergences in the literature mandate standardisation of measuring and monitoring SHG and the creation of a consensus on SHG definition. A better comparability between practices will, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

8. Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Author

Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, Gardarsdottir, Helga, Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, and Gardarsdottir, Helga

Abstract

PURPOSE: Results from observational studies on the same exposure-outcome association may be inconsistent because of variations in methodological factors, clinical factors or health care systems. We evaluated the consistency of results assessing the association between antidepressant use and the risk of hip/femur fractures in three European primary care databases using two different study designs.METHODS: Cohort and nested case control studies were conducted in three European primary care databases (Spanish BIFAP, Dutch Mondriaan and UK THIN) to assess the association between use of antidepressants and hip/femur fracture. A common protocol and statistical analysis plan was applied to harmonize study design and conduct between data sources.RESULTS: Current use of antidepressants was consistently associated with a 1.5 to 2.5-fold increased risk of hip/femur fractures in all data sources with both designs, with estimates for SSRIs generally higher than those for TCAs. In general, risk estimates in Mondriaan, the smallest data source, were higher compared to the other data sources. This difference may be partially explained by an interaction between SSRI and age in Mondriaan. Adjustment for GP-recorded lifestyle factors and matching on general practice had negligible impact on adjusted relative risk estimates.CONCLUSION: We found a consistent increased risk of hip/femur fracture with current use of antidepressants across different databases and different designs. Applying similar pharmacoepidemiological study methods resulted in similar risks for TCA use and some variation for SSRI use. Some of these differences may express real (or natural) variance in the exposure-outcome co-occurrences. Copyright © 2016 John Wiley & Sons, Ltd.

Published
2016

9. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project

Author

Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Sub Pharmacoepidemiology, Pharmacoepidemiology and Clinical Pharmacology, Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C, Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, De Groot, Mark C H, Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H, de Abajo, Francisco J, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Sub Pharmacoepidemiology, Pharmacoepidemiology and Clinical Pharmacology, Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C, Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, De Groot, Mark C H, Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H, and de Abajo, Francisco J

Published
2016

10. Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Author

Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, Gardarsdottir, Helga, Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Sub Clinical Pharmacy, Pharmacoepi, Pharmacoepidemiology and Clinical Pharmacology, Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, and Gardarsdottir, Helga

Published
2016

11. Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project

Author

Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology, Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C, De Bruin, Marie L, Slattery, Jim, De Groot, Mark C H, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G, Reynolds, Robert F, Klungel, Olaf H, de Abajo, Francisco José, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Clinical Pharmacy, Pharmacoepi, Sub Pharmacoepidemiology, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology, Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C, De Bruin, Marie L, Slattery, Jim, De Groot, Mark C H, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G, Reynolds, Robert F, Klungel, Olaf H, and de Abajo, Francisco José

Published
2016

12. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): A methodological approach to assess consistencies across databases from the PROTECT-EU project

Author

Circulatory Health, Apotheek Onderzoek 1, CDL Upod, Other research (not in main researchprogram), Global Health, JC onderzoeksprogramma Methodologie, Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C., Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, de Groot, Mark C H, Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H., de Abajo, Francisco J., Circulatory Health, Apotheek Onderzoek 1, CDL Upod, Other research (not in main researchprogram), Global Health, JC onderzoeksprogramma Methodologie, Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C., Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, de Groot, Mark C H, Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H., and de Abajo, Francisco J.

Published
2016

13. Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: A cross-national descriptive study from the PROTECT-EU Project

Author

Circulatory Health, Apotheek Onderzoek 1, CDL Upod, Other research (not in main researchprogram), Global Health, JC onderzoeksprogramma Methodology, Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C., De Bruin, Marie L., Slattery, Jim, de Groot, Mark C H, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G., Reynolds, Robert F., Klungel, Olaf H., de Abajo, Francisco José, Circulatory Health, Apotheek Onderzoek 1, CDL Upod, Other research (not in main researchprogram), Global Health, JC onderzoeksprogramma Methodology, Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C., De Bruin, Marie L., Slattery, Jim, de Groot, Mark C H, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G., Reynolds, Robert F., Klungel, Olaf H., and de Abajo, Francisco José

Published
2016

14. Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Author

Epi Methoden Team 2, Circulatory Health, CDL Upod, Global Health, JC onderzoeksprogramma Methodology, Apotheek, Apotheek Onderzoek 1, Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, Gardarsdottir, Helga, Epi Methoden Team 2, Circulatory Health, CDL Upod, Global Health, JC onderzoeksprogramma Methodology, Apotheek, Apotheek Onderzoek 1, Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L, and Gardarsdottir, Helga

Published
2016

15. Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross‐national descriptive study from the PROTECT‐EU Project

Author

Huerta, Consuelo, primary, Abbing‐Karahagopian, Victoria, additional, Requena, Gema, additional, Oliva, Belén, additional, Alvarez, Yolanda, additional, Gardarsdottir, Helga, additional, Miret, Montserrat, additional, Schneider, Cornelia, additional, Gil, Miguel, additional, Souverein, Patrick C., additional, De Bruin, Marie L., additional, Slattery, Jim, additional, De Groot, Mark C. H., additional, Hesse, Ulrik, additional, Rottenkolber, Marietta, additional, Schmiedl, Sven, additional, Montero, Dolores, additional, Bate, Andrew, additional, Ruigomez, Ana, additional, García‐Rodríguez, Luis Alberto, additional, Johansson, Saga, additional, de Vries, Frank, additional, Schlienger, Raymond G., additional, Reynolds, Robert F., additional, Klungel, Olaf H., additional, and de Abajo, Francisco José, additional

Published
2015
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16. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project

Author

Requena, Gema, primary, Huerta, Consuelo, additional, Gardarsdottir, Helga, additional, Logie, John, additional, González-González, Rocío, additional, Abbing-Karahagopian, Victoria, additional, Miret, Montserrat, additional, Schneider, Cornelia, additional, Souverein, Patrick C., additional, Webb, Dave, additional, Afonso, Ana, additional, Boudiaf, Nada, additional, Martin, Elisa, additional, Oliva, Belén, additional, Alvarez, Arturo, additional, De Groot, Mark C. H., additional, Bate, Andrew, additional, Johansson, Saga, additional, Schlienger, Raymond, additional, Reynolds, Robert, additional, Klungel, Olaf H., additional, and de Abajo, Francisco J., additional

Published
2015
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