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Your search keyword '"Miranda, Aline S."' showing total 29 results
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29 results on '"Miranda, Aline S."'

1. Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

Author

Lackie, Rachel E., de Miranda, Aline S., Lim, Mei Peng, Novikov, Vladislav, Madrer, Nimrod, Karunatilleke, Nadun C., Rutledge, Benjamin S., Tullo, Stephanie, Brickenden, Anne, Maitland, Matthew E. R., Greenberg, David, Gallino, Daniel, Luo, Wen, Attaran, Anoosha, Shlaifer, Irina, Del Cid Pellitero, Esther, Schild-Poulter, Caroline, Durcan, Thomas M., Fon, Edward A., Duennwald, Martin, Beraldo, Flavio H., Chakravarty, M. Mallar, Bussey, Timothy J., Saksida, Lisa M., Soreq, Hermona, Choy, Wing-Yiu, Prado, Vania F., and Prado, Marco A. M.

Published
2022
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3. Neuromuscular defects after infection with a beta coronavirus in mice

Author

Rossi, Leonardo, Santos, KiviaB.S., Mota, Bárbara I., Pimenta, Jordane, Oliveira, Bruna, Machado, Caroline A., Fernandes, Heliana B., Barbosa, Leticia A., Rodrigues, Hermann A., Marques, Gabriel, Gomes-Martins, Gabriel A., Chaimowicz, Gabriel F., Queiroz-Junior, Celso Martins, Chaves, Ian, Tapia, Juan C., Teixeira, Mauro M., Costa, Vivian V., Miranda, Aline S., and Guatimosim, Cristina

Published
2023
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5. Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.

Author

Tullo, Stephanie, Miranda, Aline S., del Cid‐Pellitero, Esther, Lim, Mei Peng, Gallino, Daniel, Attaran, Anoosha, Patel, Raihaan, Novikov, Vladislav, Park, Megan, Beraldo, Flavio H., Luo, Wen, Shlaifer, Irina, Durcan, Thomas M., Bussey, Timothy J., Saksida, Lisa M., Fon, Edward A., Prado, Vania F., Prado, Marco A. M., and Chakravarty, M. Mallar

Subjects
*PARKINSON'S disease, *MAGNETIC resonance imaging, *CELLULAR pathology, *LABORATORY mice, *ANIMAL disease models
Abstract

Significant evidence suggests that misfolded alpha‐synuclein (aSyn), a major component of Lewy bodies, propagates in a prion‐like manner contributing to disease progression in Parkinson's disease (PD) and other synucleinopathies. In fact, timed inoculation of M83 hemizygous mice with recombinant human aSyn preformed fibrils (PFF) has shown symptomatic deficits after substantial spreading of pathogenic alpha‐synuclein, as detected by markers for the phosphorylation of S129 of aSyn. However, whether accumulated toxicity impact human‐relevant cognitive and structural neuroanatomical measures is not fully understood. Here we performed a single unilateral striatal PFF injection in M83 hemizygous mice, and using two assays with translational potential, ex vivo magnetic resonance imaging (MRI) and touchscreen testing, we examined the combined neuroanatomical and behavioral impact of aSyn propagation. In PFF‐injected mice, we observed widespread atrophy in bilateral regions that project to or receive input from the injection site using MRI. We also identified early deficits in reversal learning prior to the emergence of motor symptoms. Our findings highlight a network of regions with related cellular correlates of pathology that follow the progression of aSyn spreading, and that affect brain areas relevant for reversal learning. Our experiments suggest that M83 hemizygous mice injected with human PFF provides a model to understand how misfolded aSyn affects human‐relevant pre‐clinical measures and suggest that these pre‐clinical biomarkers could be used to detect early toxicity of aSyn and provide better translational measures between mice and human disease. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

Author

Tullo, Stephanie, primary, Miranda, Aline S, additional, del Cid-Pellitero, Esther, additional, Lim, Mei Peng, additional, Gallino, Daniel, additional, Attaran, Anoosha, additional, Patel, Raihaan, additional, Novikov, Vladislav, additional, Park, Megan, additional, Beraldo, Flavio H., additional, Luo, Wen, additional, Shlaifer, Irina, additional, Durcan, Thomas M., additional, Bussey, Timothy J., additional, Saksida, Lisa M., additional, Fon, Edward A., additional, Prado, Vania F., additional, Prado, Marco A.M., additional, and Chakravarty, M. Mallar, additional

Published
2022
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12. A three-compartment apparatus alters the brain concentration of cytokines and neurotrophic factors in cocaine-induced CPP in mice

Author

Rosa, Magda L.P., primary, Machado, Caroline A., additional, Asth, Laila, additional, Toscano, Eliana C.B., additional, da Silva Oliveira, Bruna, additional, Marzano, Lucas A.S., additional, Ferreira, Rodrigo N., additional, Teixeira, Antônio L., additional, Moreira, Fabrício A., additional, and Miranda, Aline S., additional

Published
2022
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13. List of Contributors

Author

Aigner, Bernhard, primary, Allison, W. Ted, additional, Andreatini, Roberto, additional, Antonelli, Marta, additional, Arndt, Saskia S., additional, Austin, Amazon, additional, Brand, Cristin, additional, Bukowska, Joanna, additional, Caprariello, Andrew C., additional, Carlisle, Rachel E., additional, Chaible, Lucas M., additional, Chen, Li, additional, Chen, Mengqi, additional, Chi, Thomas, additional, Choudhury, Mohammed E., additional, Clarke, Iain J., additional, Coleman, Kristine, additional, Colpo, Gabriela D., additional, Damm, Oliver S., additional, Davis, Catherine M., additional, Davis, Erica E., additional, de Lecea, Luis, additional, de Miranda, Aline S., additional, de Souza, Diogo B., additional, Dickhout, Jeffrey G., additional, Donaldson, Paul J., additional, Donnan, Geoffrey A., additional, Emoto, Yuko, additional, Feifel, David, additional, Finzi Corat, Marcus A., additional, Frasch, Martin G., additional, Fukumura, Ryutaro, additional, Fukusato, Toshio, additional, Fuller-Jackson, John-Paul, additional, Fyffe-Maricich, Sharyl, additional, Gawronska-Kozak, Barbara, additional, Getz, Godfrey S., additional, Gondo, Yoichi, additional, Henry, Belinda A., additional, Howells, David W., additional, Jamwal, Sumit, additional, Kasahara, Jiro, additional, Katsanis, Nicholas, additional, Kemp, Matthew W., additional, Kessler, Barbara, additional, Khan, Imran, additional, King, Aileen, additional, Kinoshita, Denise, additional, Klymiuk, Nikolai, additional, Koyama, Ryuta, additional, Kretzschmar, Doris, additional, Kumar, Puneet, additional, Kuncova, Jitka, additional, Kuro, Maki, additional, Kurome, Mayuko, additional, Lardelli, Michael, additional, Lawson, Heather A., additional, Lewejohann, Lars, additional, Lim, Julie C., additional, Lyons, David M., additional, Macleod, Malcolm R., additional, Makino, Shigeru, additional, Martinez-Lage, Marta, additional, Martis, Renita M., additional, Meijer, Ellen, additional, Metz, Gerlinde A.S., additional, Miller, Robert H., additional, Miura, Yuichiro, additional, Mohammed-Ali, Zahraa, additional, Musk, Gabrielle C., additional, Nademi, Samera, additional, Nalca, Aysegul, additional, Newman, Morgan, additional, Nie, Yu, additional, Nishikawa, Noriko, additional, Nomoto, Masahiro, additional, Nordquist, Rebecca E., additional, O’Collins, Victoria E., additional, Ogawa, Masatoshi, additional, Pereira-Sampaio, Marco A., additional, Praud, Jean-Paul, additional, Quevedo, João, additional, Reardon, Catherine A., additional, Regan, Christopher P., additional, Renner, Simone, additional, Ribeiro, Fabiola M., additional, Rocha, Natalia P., additional, Rodriguez-Perales, Sandra, additional, Ruiz, Sara I., additional, Saito, Masatoshi, additional, J.B. Sampaio, Francisco, additional, Schapiro, Steven J., additional, Schatzberg, Alan F., additional, Schulkin, Jay, additional, Shamchuk, Angela L., additional, Shannon, Richard P., additional, Shen, You-Tang, additional, Shilling, Paul D., additional, Stengl, Milan, additional, Stoller, Marshall L., additional, Stürzenbaum, Stephen R., additional, Sviglerova, Jitka, additional, Taguchi, Kazumi, additional, Takahashi, Yoshihisa, additional, Tanabe, Akie, additional, Tanaka, Junya, additional, Tannenbaum, Jerrold, additional, Teixeira, Antônio L., additional, Testani, Jeffrey M., additional, Tierney, Keith B., additional, Torres-Ruiz, Raul, additional, Tsubura, Airo, additional, Tsuji, Ryosuke, additional, Tzou, David T., additional, Usuda, Haruo, additional, Valvassori, Samira S., additional, van der Staay, Franz J., additional, Varela, Roger B., additional, Verdile, Giuseppe, additional, Vorontsova, Irene, additional, Wayhart, Jessica P., additional, Weed, James L., additional, Welsh, JoEllen, additional, Werler, Steffi, additional, Wistuba, Joachim, additional, Wolf, Eckhard, additional, Wünsch, Annegret, additional, Yamamoto, Toshiyuki, additional, Yokoyama, Hironori, additional, Yoshizawa, Katsuhiko, additional, Zaidan Dagli, Maria L., additional, Zhang, Jennifer Y., additional, Zhou, Yu, additional, and Zumbrun, Elizabeth E., additional

Published
2017
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15. Neuroprotective effect of CTK 01512‐2 recombinant toxin at the spinal cord in a model of Huntington's disease

Author

Joviano‐Santos, Julliane V., primary, Valadão, Priscila A. C., additional, Magalhães‐Gomes, Matheus P. S., additional, Fernandes, Lorena F., additional, Diniz, Danuza M., additional, Machado, Thatiane C. G., additional, Soares, Kivia B., additional, Ladeira, Marina S., additional, Massensini, Andre R., additional, Gomez, Marcus V., additional, Miranda, Aline S., additional, Tápia, Juan C., additional, and Guatimosim, Cristina, additional

Published
2022
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16. Metabotropic Glutamate Receptor 5 Knockout Rescues Obesity Phenotype in a Mice Model of Huntington´s Disease

Author

Santos, Rebeca P. M., primary, Ribeiro, Roberta, additional, Vieira, Talita H. F., additional, Aires, Rosaria D., additional, Souza, Jessica M., additional, Silva, Bruna S., additional, Lima, Anna Luiza D., additional, Oliveira, Antônio Carlos P., additional, Reis, Helton J., additional, Miranda, Aline S., additional, Vieira, Erica M. L., additional, Ribeiro, Fabiola M., additional, and Vieira, Luciene B., additional

Published
2021
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18. Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

Author

Oliveira, Tadeu P. D., primary, Gonçalves, Bruno D. C., additional, Oliveira, Bruna S., additional, de Oliveira, Antonio Carlos P., additional, Reis, Helton J., additional, Ferreira, Claudia N., additional, Aguiar, Daniele C., additional, de Miranda, Aline S., additional, Ribeiro, Fabiola M., additional, Vieira, Erica M. L., additional, Palotás, András, additional, and Vieira, Luciene B., additional

Published
2021
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24. Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

Author

Vilela, Luciano R., primary, Lima, Isabel V., additional, Kunsch, Érica B., additional, Pinto, Hyorrana Priscila P., additional, de Miranda, Aline S., additional, Vieira, Érica Leandro M., additional, de Oliveira, Antônio Carlos P., additional, Moraes, Marcio Flávio D., additional, Teixeira, Antônio L., additional, and Moreira, Fabricio A., additional

Published
2017
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27. Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria

Author

Val, Cynthia H, primary, Brant, Fátima, additional, Miranda, Aline S, additional, Rodrigues, Flávia G, additional, Oliveira, Bruno C L, additional, Santos, Elândia A, additional, Assis, Diego R R, additional, Esper, Lísia, additional, Silva, Bruno C, additional, Rachid, Milene A, additional, Tanowitz, Herbert B, additional, Teixeira, Antônio L, additional, Teixeira, Mauro M, additional, Régis, Wiliam C B, additional, and Machado, Fabiana S, additional

Published
2015
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28. Neurotrophic Factors in Parkinson's Disease: What Have we Learned from Pre-Clinical and Clinical Studies?

Author

Ferreira, Rodrigo N., Miranda, Aline S. de, Rocha, Natalia P., Silva, Ana C. Simoes e, Teixeira, Antonio L., and Camargos, Elizabeth R. da Silva

Abstract

Background: Parkinson´s Disease (PD) is a chronic, progressive condition, being the second most common neurodegenerative disorder worldwide. The classical features include: bradykinesia, resting tremor, rigidity and festination. These neurological alterations are probably due to the death of dopaminergic neurons in the Substantia Nigra pars compacta and consequent reduction of dopamine input into the striatum. The decrease of dopamine levels may also be involved in the emergence of non-motor symptoms, including cognitive impairment, anxiety and depression symptoms. Neurotrophic Factors (NF) are proteins that modulate neuronal function, development, and survival. It has been reported that NF might exert a protective role in PD. Objective: We aim to discuss the emerging evidence from pre-clinical and clinical studies regarding the role of NF in PD as well as their potential as promising therapeutic strategies. Methods: We carried out an extensive literature search in PubMed central. Results: Pre-clinical studies using NF to treat PD are divergent probably due to several methodological differences, thus precluding any conclusion. Clinical studies findings obtained with the administration of NF in patients with PD were even more disappointed. On the other hand, pre-clinical and clinical studies generally support that physical activity is a low-cost, non-pharmacologic strategy with good results to treat PD. Conclusion: The use of NF as a treatment for PD is still a promise not incorporated in clinical practice. Methods to deliver NFs, doses and compounds administered, side effects, population characteristics and duration of disease may probably contribute to the unsuccessful results.

Published
2018
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29. Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.

Author

Belisário AR, Vieira ÉLM, de Almeida JA, Mendes FG, Miranda AS, Rezende PV, Viana MB, and Simões E Silva AC

Subjects
Age Factors, Albuminuria diagnosis, Anemia, Sickle Cell diagnosis, Angiotensin-Converting Enzyme 2, Biomarkers, Child, Disease Susceptibility, Humans, Renin-Angiotensin System, Albuminuria etiology, Albuminuria urine, Anemia, Sickle Cell complications, Peptidyl-Dipeptidase A urine
Published
2019
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