73 results on '"Messaoudi H"'
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2. Pose des chambres implantables par la veine céphalique. À propos de 109 cas
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Bessrour, H., primary, Bakhti, A., additional, Messaoudi, H., additional, Raghmoun, W., additional, Lajmi, M., additional, Dardouri, S., additional, Kalai, S., additional, and Hachicha, S., additional
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- 2024
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3. Breast Cancer and Pregnancy about a Case and Review of the Literature, Experience of the Obstetric Gynecology Department of the Military Training Hospital Mohamed V of Rabat
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Balde, MA, primary, Dembele, C., additional, Messaoudi, H., additional, Mangoub, F. El, additional, Bouhou, A. Ait, additional, Guelzim, K., additional, Hassani, MR, additional, Babahabib, A., additional, and Kouach, J., additional
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- 2023
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4. Evaluation of the role of endothelin in aortic stenosis
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Levesque, T., primary, Perzo, N., additional, Berg, E., additional, Dovonou, E., additional, Messaoudi, H., additional, Herbet, A., additional, Colleville, B., additional, Eltchaninoff, H., additional, Boquet, D., additional, Richard, V., additional, Bellien, J., additional, and Durand, E., additional
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- 2023
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5. Study of Ni–M/MgO and Ni–M–Mg/Al (M=Fe or Cu) catalysts in the CH4–CO2 and CH4–H2O reforming
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Djaidja, A., Messaoudi, H., Kaddeche, D., and Barama, A.
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- 2015
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6. L’atteinte cardiaque au cours de la maladie de Takayashu : à propos d’un cas…
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Ghaoui, N.E., primary, Messaoudi, H., additional, Ibrir-Khati, M., additional, Si-Ahmed, D., additional, and Bouali, F., additional
- Published
- 2022
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7. Calcification of aortic valvular interstitial cells induced by endothelin receptor blockers
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Levesque, T., primary, Perzo, N., additional, Berg, E., additional, Messaoudi, H., additional, Herbet, A., additional, Colleville, B., additional, Dumesnil, A., additional, Doguet, F., additional, Eltchaninoff, H., additional, Boquet, D., additional, Richard, V., additional, and Bellien, J., additional
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- 2021
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8. SAR Reduction in the Human Head Model using Metamaterials
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Messaoudi, H., primary and Aguili, T., additional
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- 2019
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9. Modelling of Graphene Nanoribbons Antenna Based on MoM‐GEC Method to Enhance Nanocommunications in Terahertz Range
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Aidi, M., primary, Hajji, M., additional, Messaoudi, H., additional, and Aguili, T., additional
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- 2019
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10. Tribological Properties of Multi-Layer a-C:H:W/a-C:H PVD-Coatings Micro-Structured by Picosecond Laser Ablation
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Hasselbruch, Henning, primary, Lu, Y., additional, Messaoudi, H., additional, Mehner, Andreas, additional, and Vollertsen, Frank, additional
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- 2019
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11. Comparaison entre la cardioplégie chaude et la cardioplégie froide basée sur la cinétique des cytokines
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Taamallah, K., Braham, W., Ghodbane, W., Ben Azeiz, M., Messaoudi, H., Ferjani, M., and Chenik, S.
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Cardioplegia ,Cytokines ,Cardiac surgery - Abstract
JCTCV:21(4), Introduction: Cytokines play an important role in the inflammatory response associated with cardiopulmonary bypass (CPB) and may contribute to postoperative complications. The aim of our work was to compare the efficacy of myocardial protection of two blood temperatures (warm and cold) on myocardial protection and to study the different inflammatory responses following CPB. Methods: Our prospective, randomized study involving 30 patients (2 groups: cold cardioplegia [ccp] group [n = 15 patients] and warm cardioplegia [wcp] group [n = 15 patients]) undergoing complete revascularization with coronary artery bypass grafting between March 2012 and February 2013. All clinical and biological data (troponin Ic, interleukins [IL-1, IL-6, IL-8, IL-10], and TNF-α) were collected before and after surgery in order to compare the blood concentrations and the kinetics of five cytokines (TNF-α, IL-1, IL-6, IL-8, and IL-10) in these two groups of patients. Results: There were no differences between the 2 groups in terms of age, sex ratio, clinical data, echocardiographic and angiographic findings, number of grafts, and duration of CPB and aortic cross-clamping. The quality of myocardial protection was identical in both groups, and this quality of protection remained identical in the subgroups (i.e., diabetic, left ventricular dysfunction, tri-troncular coronary lesions, and patients with stenosis of the main left coronary). Conclusion: The type of cardioplegia did not seem to influence the postoperative levels and kinetics of interleukins and TNF-α between the two groups. Thus, our data suggest that the use of warm blood cardioplegia or cold crystalloid cardioplegia is followed by the same inflammatory response to CPB.
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- 2017
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12. Improvement of the corrosion behavior of aluminum alloy 6061-T6 with yttrium and lanthanum conversion coatings
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Bekhiti, D., primary, Creus, J., additional, Mesrati, N., additional, Abdi, A., additional, and Messaoudi, H., additional
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- 2018
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13. Real-time simulation of a new design of a smart and fast electric vehicle charger
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Messaoudi Hanen, Bourogaoui Manef, and Abdelghani Afef Bennani-Ben
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electric vehicles ,fast battery charging ,smart can communication ,pfc-based vienna rectifier ,real-time simulation ,rt-lab platform ,Technology ,Science - Abstract
Due to the growing global adoption of electric vehicles (EVs), there is a pressing demand for the development of charging infrastructure that offers enhanced performance while reducing the charging time of EVs. Combining innovative fast and smart charging technologies can result in cost-efficient charging solutions, optimized energy exploitation, and reduced charging time for EVs. This paper proposes a new design of a smart and fast charger for EV batteries. The charger is made of a PFC-based Vienna Rectifier (VR) and an isolated Dual Active Bridge (DAB) converter. The proposed charger enables intelligent data flow between the battery and the charger thanks to the Controller Area Network (CAN) communication employed by the CHAdeMO charging protocol. To validate the effectiveness and feasibility of the proposed charger, the results of real-time simulations performed on RT-LAB platform, from OPAL-RT are presented and discussed.
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- 2024
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14. Relativistic laser nano-plasmonics for effective fast particle production
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Andreev, A, primary, Platonov, K, additional, Braenzel, J, additional, Lübcke, A, additional, Das, S, additional, Messaoudi, H, additional, Grunwald, R, additional, Gray, C, additional, McGlynn, E, additional, and Schnürer, M, additional
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- 2015
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15. Femtosecond-laser induced nanostructuring for surface enhanced Raman spectroscopy.
- Author
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Messaoudi, H., Das, S. K., Lange, J., Heinrich, F., Schrader, S., Frohme, M., and Grunwald, R.
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- 2014
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16. Removal behavior and output quality for laser chemical machining of tool steels
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Messaoudi Hamza, Mikulewitsch Merlin, Brand Daniel, von Freyberg Axel, and Fischer Andreas
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Micro machining ,laser chemical machining ,passivation ,quality ,roughness ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Technology (General) ,T1-995 ,Manufactures ,TS1-2301 - Abstract
Laser chemical machining represents a promising technology for manufacturing metallic micro parts. It is usually based on the selective thermal activation of electrochemical material dissolution of self-passivating metals in an electrolyte environment. Prior to widespread industrial acceptance, its machining quality needs to be classified within the subtractive machining processes and the range of machinable materials needs to be expanded. For this purpose, line and square cavities with dimensions ≤300 μm are machined into high speed steel HS10-4-3-10 in a H3PO4-environment and compared to those of the self-passivating cobalt-chrome alloy Stellite 21. As a result, the laser-induced removal velocities in HS10-4-3-10 amount to 50 μm/s. These are two orders of magnitudes higher than the background etching (2 nm/s at room temperature) and three times higher than those obtained in Stellite 21 (12 μm/s). However, the microscopic and spectroscopic analyses of both materials reveal a high shape accuracy with edge radii from 10 to 20 μm, a surface roughness down to 0.8 μm and a negligible microstructural impact. Despite lower removal rates and higher surface roughness, laser chemical machining provides higher dimensional accuracy in comparison with micro milling and shows its suitability for micro machining of structures
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- 2019
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17. Impact of geometrical parameters of micro-textured DLC on tribological properties under dry sliding friction
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Shimizu Tetsuhide, Kan Hironori, Messaoudi Hamza, Vollertsen Frank, and Yang Ming
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Surface texturing ,DLC ,dry sliding friction ,picosecond pulsed laser processing ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Technology (General) ,T1-995 ,Manufactures ,TS1-2301 - Abstract
To achieve a stable and high wear resistive functional surface under dry sliding friction, the present study proposes micro-textured diamond-like carbon coatings fabricated by ionized physical vapor deposition (I-PVD) using metallic masks. To clarify the suitable geometrical design under dry sliding friction, geometrical quantities of textured array patterns are varied by using metallic masks with different circular hole array patterns fabricated by picosecond pulsed laser processing. The effect of texturing on friction and wear properties is evaluated by ball-on-disk type friction tests for the condition of a constant DLC-coverage per unit area. Thereby, textured DLC pattern with diameters of 50 μm, 100 μm, and 150 μm are applied. Within the first 10 000 laps stable and lower coefficient of friction is obtained with the smallest diameters of 50 μm. However, at further rotation of more than 40 000 laps, the wear of the smaller diameters becomes more pronounced due to the increase of stress concentration at the edge of the structure. Based on these findings, geometrical design of micro-textured DLC coating is discussed with regard to the suppression of three-body plowing and the prevention of stress concentration.
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- 2019
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18. Geometrical design of micro-textured DLC coatings toward lubricant-free metal forming
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Shimizu Tetsuhide, Kan Hironori, Messaoudi Hamza, Vollertsen Frank, and Yang Ming
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Surface modification ,Tribology ,Wear ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
To achieve a stable and high wear resistive functional surface under dry sliding friction, the present study proposes micro-textured diamond like carbon coatings fabricated by ionized physical vapour deposition (I-PVD) using metallic masks. To clarify the optimized geometrical dimensions under dry sliding friction, geometrical conditions of textured array patterns are varied by using metallic masks with different circular hole array patterns fabricated by picosecond pulsed laser processing. The effect of texturing on friction and wear properties is evaluated by ball-on-disk type friction tests for the condition of a constant DLC-coverage per unit area. Thereby, textured DLC pattern with diameters of 50 μm, 100 μm and 150 μm are applied. Within the first 10,000 laps stable and lower coefficient of friction is obtained with the smallest diameters of 50 μm. However, at further rotation of more than 40,000 laps, the wear of the smaller diameters becomes more pronounced due to the increase of stress concentration at the edge of the structure. Based on these findings, geometrical design of micro-textured DLC coating is discussed with regard to the suppression of three-body ploughing and the prevention of stress concentration.
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- 2018
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19. Chances and Limitations in the Application of Laser Chemical Machining for the Manufacture of Micro Forming Dies
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Messaoudi Hamza, Böhmermann Florian, Mikulewitsch Merlin, von Freyberg Axel, Fischer Andreas, Riemer Oltmann, and Vollertsen Frank
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Micro machining ,Machine tool ,Quality ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Laser chemical machining, a non-conventional processing method based on thermally activated electrochemical material dissolution, represents a promising technology for manufacturing metallic dies for micro forming applications. Prior to widespread industrial acceptance the machining quality of laser chemical machining should be characterized. For this purpose, laser chemical machining is compared with micro milling regarding both the dimensional accuracy and the surface quality. Therefore, square micro cavities exhibiting side walls between 100 μm and 400 μm in length and 60 μm in depth are machined with both manufacturing processes into the cobalt-chrome alloy Stellite 21. The geometrical features are investigated using laser-scanning confocal microscopy and scanning electron microscopy. On the one hand, laser chemical machining is more suitable for manufacturing cavities with dimensions < 200 μm due to higher shape accuracy with stable mean edge radii of (11.2 ± 1.3) μm as a result of roughing and finishing steps. On the other hand, the finish quality of micro milling with mean surface roughness Sa of 0.2 μm could not be achieved with laser chemical machining due to in-process induced waviness. Finally, the metallographic analysis of the surface-near layers reveals that both manufacturing processes ensure gentle machining without any noticeable micro structural impact.
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- 2018
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20. CO2 Reforming of Methane over LaNiO3 Perovskite Supported Catalysts: Influence of Silica Support.
- Author
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Sellam, D., Ikkour, K., Dekkar, S., Messaoudi, H., Belaid, T., and Roger, A.C.
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CATALYST supports , *PEROVSKITE , *SILICA , *SYNTHESIS gas , *METHANE , *KAOLIN - Abstract
The study presents the dry reforming of methane using natural Kaolin silica as catalyst support. The silica-supported LaNiO3 perovskite catalysts (20LaNiO3SiO2and 40LaNiO3/SiO2 and bulk LaNiO3 catalyst were synthesized by auto-combustion method. The resulting catalysts were characterized by X-ray diffraction (XRD), N2 adsorption - desorption isotherm measurement, scanning electron microscopy (SEM) and temperature-programmed reduction (TPR). After reduction at 700 °C, they were used as catalysts for the reaction of dry reforming of methane into synthesis gas at atmospheric pressure at 800 °C. The reduced 40LaNiO3/SiO2 exhibited high catalytic activity. This result was attributed to the small Ni metallic particles obtained from the reduced perovskite highly dispersed on the support and the good reducibility. The increase of reduction temperature at 800 °C resulted in a further enhancement of the catalytic performance of 40LaNiO3/SiO2 catalyst. Copyright © 2019 BCREC Group. All rights reserved. [ABSTRACT FROM AUTHOR]
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- 2019
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21. Lobular carcinoma metastasis to endometrial polyps: Insights from a case report and literature analysis.
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Benlghazi A, Messaoudi H, Benali S, Tazi I, Elhassani MM, and Kouach J
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Introduction and Importance: Endometrial polyps are rare sites of metastatic breast carcinoma. Such cases have mainly been reported in tamoxifen-related polyps., Case Presentation: We describe the case of a 56-year-old woman with invasive lobular carcinoma who was experiencing vaginal bleeding. She underwent hysteroscopy with biopsy. Microscopic examination revealed an endometrial polyp with foci of adenocarcinoma. The morphological features of the tumor matched those of the original breast carcinoma., Clinical Discussion: Neoplasms originating from extra-genital sites frequently spread to the female genital organs. However, these metastases are mainly concentrated in the ovaries and vagina, while those affecting the uterus are rare. Among non-genital malignant tumors, mammary carcinoma - particularly the lobular type - is the most common to affect the uterus, followed by digestive and pulmonary tumors. Metastases within an endometrial polyp are particularly unusual., Conclusions: It is crucial to consider metastatic tumors when assessing vaginal bleeding in patients with breast carcinoma. Because of the possibility of endometrial polyps being affected by metastasis, pathologists must examine them rigorously and thoroughly., Competing Interests: Conflict of interest statement Saad Benali Hamza Messaoudi, Abdelhamid Benlghazi were responsible for the patient's diagnosis and clinical management. Abdelhamid Benlghazi and Saad Benali wrote the manuscript. Moulay Mehdi Elhassani and Kouach Jaouad contributed to the analysis, supervision, writing, reviewing, and editing of the manuscript for intellectual content. All authors have read and approved the final manuscript., (Copyright © 2024. Published by Elsevier Ltd.)
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- 2024
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22. Concurrent rectosigmoid cancer and Krukenberg tumor in a pregnant patient: A rare clinicopathological presentation - Case report.
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Benali S, Benlghazi A, Messaoudi H, El Agouri H, Belouad M, and Kouach J
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Introduction and Importance: The occurrence of ovarian tumors during pregnancy is relatively low, with an incidence of approximately 0.05 %. Both primary ovarian cancer and metastatic malignancies are uncommon in pregnant women, and there is often a delay in diagnosing these conditions., Case Presentation: We report the case of rectal cancer with ovarian metastasis discovered in a 36-year-old multiparous pregnant woman who presented at 21 weeks gestation with constipation and increased abdominal volume over the past three weeks. These symptoms were associated with loss of appetite and general fatigue. Further investigations revealed a 12 × 9 cm mass on the left side of the uterus and a 5.2 × 4 × 3.6 cm mass in the recto-sigmoid region. Initially, the patient underwent left adnexectomy, peritoneal cytology, biopsies of the peritoneum, epiploic region, and right ovary. Subsequently, the pregnancy was continued until 34 weeks' amenorrhea, when the fetus was extracted, and a complete surgical procedure was performed, including total hysterectomy, right adnexectomy, resection of the recto-sigmoid tumor with appendectomy and infra-gastric omentectomy. After surgery, the patient received adjuvant chemotherapy., Clinical Discussion: It is important to consider the possibility of malignancy during pregnancy when atypical clinical presentations occur. Gastrointestinal cancer is the most common cause of Krukenberg's tumor in pregnant women. Early diagnosis of cancer at an operable stage is essential to improve prognosis., Conclusions: This clinical case highlights the rarity of Krukenberg's tumor during pregnancy and the challenges encountered in diagnosing and treating this disease., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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23. Flow cytometry-based diagnostic approach for inborn errors of immunity: experience from Algeria.
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Tahiat A, Belbouab R, Yagoubi A, Hakem S, Fernini F, Keddari M, Belhadj H, Touri S, Aggoune S, Stoddard J, Niemela J, Zerifi F, Melzi S, Aboura R, Saad-Djaballah A, Ferhani Y, Ketfi A, Messaoudi H, Bencharif Madani T, Benhacine Z, Dehimi A, Okka K, Amroune F, Fellahi M, Bendahmane C, Khoulani R, Oukil A, Soufane A, Bourelaf I, Boubidi C, Boukhenfouf N, Amine Ifri M, Khelafi N, Boudiaf H, Khelifi Touhami T, Meçabih F, Boucelma M, Zelaci A, Gacem O, Ladj MS, Mekki A, Bensaadi N, Benhalima M, Zeroual Z, Bioud B, Benameur M, Bouhdjila R, Bouzerar Z, Ibsaine O, Maouche H, Kedji L, Smati L, Boukari R, Lambert C, Rosenzweig SD, Notarangelo LD, and Djenouhat K
- Subjects
- Humans, Male, Female, Algeria, Child, Child, Preschool, Infant, Adolescent, Adult, Retrospective Studies, Immunophenotyping, Young Adult, Infant, Newborn, Immunologic Deficiency Syndromes diagnosis, Immunologic Deficiency Syndromes immunology, Immunologic Deficiency Syndromes genetics, Flow Cytometry methods
- Abstract
Purpose: In this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic approaches adapted to different clinical scenarios., Methods: Between May 2017 and February 2024, pediatric and adult patients presenting with clinical features suggestive of immunodeficiency were subjected to FCM evaluation, including lymphocyte subset analysis, detection of specific surface or intracellular proteins, and functional analysis of immune cells., Results: Over a nearly seven-year period, our laboratory diagnosed a total of 670 patients (372 (55.5%) males and 298 (44.5%) females), distributed into 70 different IEIs belonging to 9 different categories of the International Union of Immunological Societies classification. FCM was used to diagnose and categorize IEI in 514 patients (76.7%). It provided direct diagnostic insights for IEIs such as severe combined immunodeficiency, Omenn syndrome, MHC class II deficiency, familial hemophagocytic lymphohistiocytosis, and CD55 deficiency. For certain IEIs, including hyper-IgE syndrome, STAT1-gain of function, autoimmune lymphoproliferative syndrome, and activated PI3K delta syndrome, FCM offered suggestive evidence, necessitating subsequent genetic testing for confirmation. Protein expression and functional assays played a crucial role in establishing definitive diagnoses for various disorders. To setup such diagnostic assays at high and reproducible quality, high level of expertise is required; in house reference values need to be determined and the parallel testing of healthy controls is highly recommended., Conclusion: Flow cytometry has emerged as a highly valuable and cost-effective tool for diagnosing and studying most IEIs, particularly in low-income countries where access to genetic testing can be limited. FCM analysis could provide direct diagnostic insights for most common IEIs, offer clues to the underlying genetic defects, and/or aid in narrowing the list of putative genes to be analyzed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Tahiat, Belbouab, Yagoubi, Hakem, Fernini, Keddari, Belhadj, Touri, Aggoune, Stoddard, Niemela, Zerifi, Melzi, Aboura, Saad-Djaballah, Ferhani, Ketfi, Messaoudi, Bencharif Madani, Benhacine, Dehimi, Okka, Amroune, Fellahi, Bendahmane, Khoulani, Oukil, Soufane, Bourelaf, Boubidi, Boukhenfouf, Amine Ifri, Khelafi, Boudiaf, Khelifi Touhami, Meçabih, Boucelma, Zelaci, Gacem, Ladj, Mekki, Bensaadi, Benhalima, Zeroual, Bioud, Benameur, Bouhdjila, Bouzerar, Ibsaine, Maouche, Kedji, Smati, Boukari, Lambert, Rosenzweig, Notarangelo and Djenouhat.)
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- 2024
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24. Warm-up music and low-dose caffeine enhance the activity profile and psychophysiological responses during simulated combat in female taekwondo athletes.
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Delleli S, Ouergui I, Messaoudi H, Bridge C, Ardigò LP, and Chtourou H
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- Humans, Female, Young Adult, Double-Blind Method, Warm-Up Exercise, Adult, Athletic Performance physiology, Athletic Performance psychology, Arousal drug effects, Arousal physiology, Caffeine pharmacology, Caffeine administration & dosage, Music psychology, Athletes psychology, Martial Arts physiology, Cross-Over Studies, Heart Rate drug effects
- Abstract
To assess the effects of warm-up music and low dose (3 mg·kg
-1 ) of caffeine (CAF) on female taekwondo athlete's activity profile and psychophysiological responses during simulated combat. In a double-blinded, randomized, crossover study, 16 female athletes participated in simulated combats under one control and 5 experimental conditions [i.e., CAF alone (CAF), placebo alone (PL), CAF with music (CAF + M), PL with music (PL + M), and no supplement with music (M)]. After warming-up, athletes rated their felt arousal (FAS). Mean (HRmean ) and peak (HRpeak ) heart rate values were determined for each combat. After fighting, athletes rated their perceived exertion (RPE), feeling scale (FS), FAS, and physical enjoyment (PACES). Time-motion and technical-tactical variables were analyzed. CAF + M induced shorter skip and pause time, while attack time increased compared to other conditions (p < 0.05). Moreover, CAF + M increased single attacks, combined attacks, counter-attacks (p < 0.001), and defensive actions (p < 0.05) than other conditions. HRmean and HRpeak were lower under CAF + M than other conditions (p < 0.05). Additionally, higher FAS post-combat, FS, and PACES were observed under CAF + M, while RPE was lower (except CAF condition) compared to the other conditions (p < 0.05.Using CAF with warm-up music may increase combat cadence and improve the psychological state in female athletes more effectively than either strategy alone., (© 2024. The Author(s).)- Published
- 2024
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25. A challenging diagnosis and treatment of embryonal rhabdomyosarcoma in the cervix of an adult woman: A surgical case report.
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Messaoudi H, Benlghazi A, Elktaibi A, Belouad M, Moulay Mehdi E, and Kouach J
- Abstract
Introduction and Importance: Embryonal Rhabdomyosarcoma is a rare form of sarcoma mainly seen in children and adolescents. In the specific case of the cervix, embryonal Rhabdomyosarcoma is an extremely rare mesenchymal tumor, accounting for <1 % of all cervical cancers. This highly malignant tumor mainly affects adolescents and young adults., Case Presentation: We describe the case of a 29-year-old woman with embryonal rhabdomyosarcoma of the cervix, which manifested as an exophytic cervical mass. Histopathological and immunohistochemical findings confirmed the presence of embryonal rhabdomyosarcoma of the cervix. This patient was successfully treated with a combination of neoadjuvant chemoradiotherapy, total abdominal hysterectomy with bilateral ovary transposition, and adjuvant chemoradiotherapy., Clinical Discussion: Embryonal Rhabdomyosarcoma of the cervix may manifest by vaginal bleeding, a cervical mass and pelvic symptoms. The diagnosis is confirmed by histopathology and immunohistochemistry. With multimodal treatment including surgery, chemotherapy and radiotherapy, outcomes improve for patients., Conclusions: Uterine cervix embryonal RMS is an uncommon cancer in adult patients. While rare, it should be considered as a potential diagnosis in patients presenting with vaginal bleeding and a significant cervical polyp. Histopathology, complemented by relevant immunohistochemistry, is crucial for accurately detecting the tumor and guiding appropriate management strategies., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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26. Myasthenia gravis and pregnancy: Lessons learned from a complex a case report.
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Benlghazi A, Messaoudi H, Belouad M, Bouhtouri Y, Benali S, Rachid AB, El Mangoub F, Elhassani MM, and Kouach J
- Abstract
Myasthenia gravis primarily affects young adults, with a higher incidence in women, particularly between the ages of 20 and 30. When a young woman with myasthenia gravis contemplates pregnancy, healthcare providers must consider the potential implications. The interplay between hormonal factors and changes in the immune system establishes a complex relationship between myasthenia gravis and pregnancy. On one hand, pregnancy can alter the course of the disease, while on the other hand, the disease can impact the progression of the pregnancy and the well-being of the fetus. In this case report, we present the case of a 28-year-old woman suffering from myasthenia gravis who had undergone a thymectomy 5 years ago and was being treated with an acetylcholinesterase inhibitor. After a planned conception, the patient presented a relapse of her disease during the third trimester of pregnancy, with the onset of severe hydramnios. This observation highlights a specific case of decompensation of myasthenia gravis during pregnancy, associated with the presence of severe hydramnios. Subsequently, we delve into the existing literature to examine the reciprocal influence between myasthenia gravis and pregnancy, as well as the effects of anti-myasthenic treatments on pregnancy outcomes., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)
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- 2024
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27. Idiopathic granulomatous mastitis: A challenging case report and comprehensive review of the literature.
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Benlghazi A, Messaoudi H, Belouad M, Ait Bouhou R, Elhassani MM, and Kouach J
- Abstract
Introduction and Importance: Idiopathic granulomatous mastitis is an uncommon, long-lasting inflammatory condition of the female breast. It is characterized by the development of a painful breast mass that gradually increases in size. This condition is benign and its cause is unknown. It primarily affects women of childbearing age who have a history of pregnancy and breastfeeding. The main feature of idiopathic granulomatous mastitis is the presence of chronic inflammation in the breast., Case Presentation: We report a 36-year-old woman with a history of pregnancy and breastfeeding presented with pain and swelling of the right breast. Physical examination revealed a mass with redness and retraction of the nipple. Imaging revealed localized density and hypoechoic areas with collection, suggesting granulomatous mastitis. A biopsy confirmed the diagnosis. The abscess was drained through a small incision performed under local anesthesia. Treatment with corticosteroids resulted in significant improvement, with complete resolution after one month., Clinical Discussion: A comprehensive evaluation of potential causes is necessary to confirm the diagnosis of idiopathic granulomatous mastitis. Histologically, it is distinguished by the predominant presence of neutrophils and the absence of caseous necrosis. Treatment remains controversial, with recent literature supporting the efficacy of conservative management with steroid and immunosuppressive therapy, leaving surgical excision for complicated and refractory cases., Conclusions: Idiopathic granulomatous mastitis is an uncommon breast condition where the exact causes and recommended treatment approaches are not well-defined. It is important to consider this condition in women who are in their reproductive years., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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28. Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell.
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Messaoudi H, Yaşa Atmaca G, Türkkol A, Bilgin MD, and Erdoğmuş A
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- Humans, Male, Photosensitizing Agents pharmacology, Photosensitizing Agents chemistry, Photosensitizing Agents chemical synthesis, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Drug Screening Assays, Antitumor, PC-3 Cells, Photochemotherapy, Photochemical Processes, Cell Line, Tumor, Molecular Structure, Indoles chemistry, Indoles pharmacology, Schiff Bases chemistry, Schiff Bases pharmacology, Singlet Oxygen metabolism, Prostatic Neoplasms drug therapy, Prostatic Neoplasms pathology, Prostatic Neoplasms metabolism, Organosilicon Compounds chemistry, Organosilicon Compounds pharmacology, Cell Survival drug effects
- Abstract
This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the synthesized Schiff-base diaxially substituted silicon phthalocyanines. In photochemical studies, the singlet oxygen quantum yields (Φ
∆ ) were determined as 0.43 for Si1a, 0.94 for Q-Si1a, 0.58 for S-Si1a, and 0.49 for B-Sia1. In sono-photochemical studies, the Φ∆ values were reached to 0.67 for Si1a, 1.06 for Q-Si1a, 0.65 for S-Si1a, and 0.67 for B-Sia1. In addition, this study demonstrates the therapeutic efficacy of phthalocyanines synthesized as sensitizers on the PC3 prostate cancer cell line through in vitro experiments. The application of these treatment modalities exhibited notable outcomes, leading to a substantial decrease in cell viability within the PC3 prostate cancer cell line. These findings highlight the potential of utilizing these synthesized phthalocyanines as promising therapeutic agents for prostate cancer treatment., (© 2024. The Author(s).)- Published
- 2024
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29. Acute effects of plyometric-based conditioning activity and warm-up music stimuli on physical performance and affective state in male taekwondo athletes.
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Messaoudi H, Ouergui I, Delleli S, Ballmann CG, Ardigò LP, and Chtourou H
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Introduction: This study assesses the acute effects of combining a plyometric-based conditioning activity (CA) with different musical stimuli during warm-up on taekwondo (TKD) performance and related psychological aspects., Methods: In a randomized cross-over study design, 16 male TKD athletes (age: 19.94 ± 1.12 years) performed the TKD-specific agility test (TSAT), frequency speed of kick test (FSKT-10s) and its multiple version (FSKT-mult) under 7 experimental and one control condition. For the experimental conditions, participants experienced varying combinations of music selection process [self-selected (SSM) vs. pre-selected (PSM)], and music tempo [fast (F) vs. slow (S)], within preferred (PG) and non-preferred (NPG) music genre; all in the presence of a plyometric based-CA. Athletes were instructed to rate their perceived exertion (RPE) after each test and their felt arousal (FAS), feeling scale (FS), and motivation after testing completion., Results: Findings showed that combining a plyometric-based CA with SSMPG at both fast and slow tempo improved TSAT, FSK-10s, FSKT-mult, FAS, motivation, and RPE post-TSAT greater than the other conditions (all p < 0.05). Additionally, FSSMPG combined with CA improved FS, and RPE after both FSKT-10s and FSKT-mult better than the other conditions (all p < 0.05)., Conclusion: In conclusion, listening to fast self-selected music from a preferred genre in combination with a plyometric-based CA during warm-up setups an individualized warm-up strategy and serves to improve the subsequent specific performances and the related psychological aspects in TKD athletes., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Messaoudi, Ouergui, Delleli, Ballmann, Ardigò and Chtourou.)
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- 2024
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30. The effects of pre-task music on exercise performance and associated psycho-physiological responses: a systematic review with multilevel meta-analysis of controlled studies.
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Delleli S, Ouergui I, Ballmann CG, Messaoudi H, Trabelsi K, Ardigò LP, and Chtourou H
- Abstract
This systematic review summarized the studies that examined the pre-task music effects on performance aspects and quantitatively analyzed their outcomes. A systematic search for controlled studies investigating the acute effects of pre-task music on physical performance, cognitive aspects and associated psycho-physiological responses was performed through Scopus, PubMed, Web of Science and Cochrane Library databases up to 17 May 2023, with thirty studies fulfilled the inclusion criteria. Data was analyzed using the robust multilevel meta-analysis model of standardized mean difference "SMD" with 95% confidence intervals (95%CI) and prediction intervals (PI) were reported. Pre-task music induced improvements of completion time (SMD = -0.24; 95% CI = -0.46 to -0.01; PI = -0.82 to 0.35; p = 0.04), relative mean power (RMP) (SMD = 0.38; 95% CI = 0.16 to 0.60; PI = -0.36 to 1.12; p = 0.003) and fatigue (SMD = -0.20; 95% CI = -0.32 to -0.09; PI = -0.36 to -0.05; p = 0.01), moderate effects on relative peak power (RPP) (SMD = 0.53; 95% CI = 0.21 to 0.85; PI = -0.42 to 1.48; p = 0.005), and high effect on feeling scale (FS) (SMD = 2.42; 95% CI = 0.52 to 4.31; PI = -11.43 to 16.26; p = 0.03). Greater benefits were recorded in jumping performance in males than females ( p = 0.01), and for active than trained subjects for completion time ( p = 0.02), RPP ( p = 0.02) and RMP ( p = 0.03). Larger benefits were obtained for FS post-warming up than after testing ( p = 0.04). Self-selected music induced greater effects than pseudo- and pre-selected for performance decrement index ( p = 0.05) and FS ( p = 0.02). It could be concluded that pre-task music improved psychological responses and fatigue-related symptoms associated with exercise performance enhancement., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2023 Delleli, Ouergui, Ballmann, Messaoudi, Trabelsi, Ardigò and Chtourou.)
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- 2023
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31. Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2.
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Dhayni K, Chabry Y, Hénaut L, Avondo C, Boudot C, Ouled-Haddou H, Bigot-Corbel E, Touati G, Caus T, Messaoudi H, Bellien J, Tribouilloy C, Messika-Zeitoun D, Zibara K, Kamel S, and Bennis Y
- Abstract
Aims: Inflammatory cytokines play a critical role in the progression of calcific aortic valve disease (CAVD), for which there is currently no pharmacological treatment. The aim of this study was to test the hypothesis that interleukin-8 (IL-8), known to be involved in arterial calcification, also promotes aortic valve calcification (AVC) and to evaluate whether pharmacologically blocking the IL-8 receptor, CXC motif chemokine receptor 2 (CXCR2), could be effective in preventing AVC progression., Methods and Results: A cohort of 195 patients (median age 73, 74% men) diagnosed with aortic valve stenosis (severe in 16.9% of cases) were prospectively followed by CT for a median time of 2.6 years. A Cox proportional hazards regression analysis indicated that baseline IL-8 serum concentrations were associated with rapid progression of AVC, defined as an annualized change in the calcification score by CT ≥ 110 AU/year, after adjustment for age, gender, bicuspid anatomy, and baseline disease severity. In vitro, exposure of primary human aortic valvular interstitial cells (hVICs) to 15 pg/mL IL-8 induced a two-fold increase in inorganic phosphate (Pi)-induced calcification. IL-8 promoted NFκB pathway activation, MMP-12 expression, and elastin degradation in hVICs exposed to Pi. These effects were prevented by SCH527123, an antagonist of CXCR2. The expression of CXCR2 was confirmed in hVICs and samples of aortic valves isolated from patients with CAVD, in which the receptor was mainly found in calcified areas, along with MMP-12 and a degraded form of elastin. Finally, in a rat model of chronic kidney disease-associated CAVD, SCH527123 treatment (1 mg/kg/day given orally for 11 weeks) limited the decrease in aortic cusp separation, the increase in maximal velocity of the transaortic jet, and the increase in aortic mean pressure gradient measured by echocardiography, effects that were associated with a reduction in hydroxyapatite deposition and MMP-12 expression in the aortic valves., Conclusion: Overall, these results highlight, for the first time, a significant role for IL-8 in the progression of CAVD by promoting calcification via a CXCR2- and MMP-12-dependent mechanism that leads to elastin degradation, and identify CXCR2 as a promising therapeutic target for the treatment of CAVD., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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32. Bilateral serous retinal detachment in pre-eclampsia a rare but favorable complication: case report.
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Benlghazi A, Bouhtouri Y, Belouad M, Brarou H, Messaoudi H, Benali S, El Hassani MM, and Kouach J
- Abstract
Pre-eclampsia is a serious pregnancy-related condition that can cause damage to multiple organs, including the eyes. While pre-eclampsia is commonly associated with the narrowing of the retinal arteries, more severe complications such as cortical blindness, optic neuropathy, and serous retinal detachment (SRD) can occur in rare cases. This case report describes a 26-year-old primiparous woman who presented with headaches, bilateral visual fog, and tinnitus and was diagnosed with pre-eclampsia based on elevated blood pressure and proteinuria. Despite receiving antihypertensive treatment, the patient's visual symptoms worsened, prompting an emergency cesarean section. An ophthalmological examination revealed bilateral macular SRD. SRD in pre-eclampsia is a rare complication that can occur even in the immediate post-partum period, with a favorable prognosis. It should be noted that any pre-eclamptic patient presenting with visual symptoms in the third trimester or post-partum should be considered for serous retinal detachment., Competing Interests: None declared., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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33. Effects of caffeine consumption combined with listening to music during warm-up on taekwondo physical performance, perceived exertion and psychological aspects.
- Author
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Delleli S, Ouergui I, Messaoudi H, Ballmann CG, Ardigò LP, and Chtourou H
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- Adolescent, Humans, Male, Young Adult, Caffeine pharmacology, Cross-Over Studies, Double-Blind Method, Physical Exertion, Athletic Performance physiology, Music
- Abstract
The effects of caffeine (CAF) and music have been well documented when used separately, but their combined effects are not yet studied. Thus, the present study assessed the acute effects of combining a low dose of CAF with listening to music during warm-up on taekwondo physical performance, perceived exertion (RPE), and psychological responses during taekwondo-specific tasks in male elite athletes. In a double-blinded, randomized, placebo-controlled crossover study design, male taekwondo athletes (n = 16; age: 18.25 ± 0.75 years) performed the taekwondo-specific agility test (TSAT), 10 s frequency speed of kick test (FSKT-10s) and the multiple version of FSKT (FSKT-mult) under the following conditions: 1) CAF without music (CAF+NoM), 2) placebo (PL) without music (PL+NoM), 3) CAF with music (CAF+M), 4) PL with music (PL+M), 5) no supplement with music (NoS+M) and no supplement without music (control). RPE, feeling scale (FS), felt arousal scale (FAS) and physical enjoyment (PACES) were determined after each test. Findings showed the CAF+M condition induced better performances than other conditions for TSAT, FSKT-10s, FSKT-mult, RPE, FAS and FS and PACES post FSKT-10s (all p<0.05). Moreover, CAF+M resulted in better responses than other conditions for PACES post TSAT (p<0.05) with the exception of CAF+NoM. Likewise, CAF+M condition induced better physical enjoyment than PL+NoM, NoS+M and PL+M conditions post FSKT-mult (p<0.05). Combining low dose of CAF with music during warm-up was an effective strategy that induced greater effects than their isolated use during taekwondo specific tasks., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Delleli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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34. Abortifacient power of potassium permanganate rebirth of an archaic myth: Case report.
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Benlghazi A, Belouad M, Messaoudi H, Benali S, El Hassani MM, and Kouach J
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Introduction and Importance: Potassium permanganate has been historically used as an abortifacient, but it is now considered an outdated practice. Despite the lack of scientific evidence supporting its effectiveness as an abortifacient, some communities still hold misguided beliefs about its abortifacient properties., Case Presentation: We report a case of a 38-year-old multiparous North African woman. Who experienced excessive vaginal bleeding after using potassium permanganate as an abortifacient. The examination revealed carbonized ulcerated lesions on the vaginal walls and cervix. Once the patient was stabilized, the medical team performed sutures on the vaginal lesions and inserted an intravaginal tampon to arrest the bleeding. The patient was discharged after 72 h., Clinical Discussion: In the last century, potassium permanganate was utilized as a method of abortion, but this practice has gradually fallen out of use. Regrettably, due to misinformation and a lack of comprehensive documentation, certain underdeveloped regions persist in employing this unsafe approach. The aim of this report is to inform obstetricians about the harmful effects of potassium permanganate, and the injuries it can cause. Given the scarcity and age of published reports on the subject, this document highlights the crucial importance of proper management to prevent these practices and ensure the safety of the women concerned., Conclusions: The use of potassium permanganate in abortion presents serious risks, and despite its outdated nature, false beliefs about its abortifacient properties persist. Raising awareness among healthcare professionals and the general public is crucial in preventing the harmful effects of these erroneous beliefs., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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35. Spontaneous successful term delivery in a unicornuate uterus: A case report and literature review.
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Benlghazi A, Belouad M, Messaoudi H, Benali S, El Hassani MM, and Kouach J
- Abstract
Introduction and Importance: Malformations of the uterus are generally rare and are due to defective fusion of Mullerian duct. These include the unicorn uterus, with or without a rudimentary horn. Pregnancy in a unicornuate uterus is a rare event and carries with it maternal-fetal risks., Case Presentation: In this report, we present an exceptional case of a pregnancy reaching full term in a unicornuate uterus without an accessory horn, which was serendipitously discovered during an emergency cesarean section. Intraoperatively, the uterus exhibited a distinct cylindrical shape with a flattened left wall, with the absence of both the left fallopian tube and left ovary. No additional abnormalities within the abdominopelvic cavity were noted. Notably, the postoperative recovery was uneventful for both the mother and newborn, without any notable complications., Clinical Discussion: The presence of a unicornuate uterus is associated with adverse obstetric outcomes, including recurrent miscarriage, premature delivery, fetal malposition, intrauterine growth retardation, and uterine rupture. In addition, around 40 % of women with this malformation may experience infertility. Although the efficacy of preconception or early interventions, such as rudimentary uterine horn resection and prophylactic cervical cerclage has not been fully established in improving obstetric outcomes, their usefulness is suggested by current medical practice., Conclusion: Women with a unicornuate uterus are known to be at increased risk of obstetrical complications, such as spontaneous abortion, premature delivery, post-partum hemorrhage, abnormal fetal presentation and cesarean delivery. It is important to consider women with this anomaly as being at high obstetrical risk., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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36. Giant ovarian serous cyst and postmenopausal adnexal torsion: An unusual case report and literature review.
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Benlghazi A, Belouad M, Messaoudi H, Benali S, Elhassani MM, and Kouach J
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Introduction and Importance: Adnexal torsion is an uncommon but urgent surgical situation more frequently observed during the reproductive years and rarely in postmenopausal women., Case Presentation: This case report describes a postmenopausal woman with a large left ovarian cyst measuring 18 × 20 × 22 cm who experienced adnexal torsion, which is a rare occurrence in this age group. To avoid the potential requirement for additional surgical procedures in case of cyst recurrence in the remaining ovary or the development of uterine diseases a total abdominal hysterectomy and bilateral salpingo-oophorectomy with cystectomy were performed. Histopathological analysis of the cyst confirmed that it was a benign serous cystadenoma of the ovary., Clinical Discussion: Adnexal torsion can happen at any age but is less likely to occur after menopause. Moreover, giant ovarian cysts (>10 cm) are uncommon, making adnexal torsion on these cysts a rare event. While laparotomy remains the gold standard surgical intervention, laparoscopy is beginning to play a role in management of giant cyst., Conclusions: This report documenting a rare case of adnexal torsion in a postmenopausal woman following a serous giant cystadenoma emphasizes that this surgical emergency can occur at any age. In addition, the report highlights that the presence of an ovarian mass or cyst increases the risk of adnexal torsion, regardless of age., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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37. Acute effects of caffeine supplementation on taekwondo performance: the influence of competition level and sex.
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Ouergui I, Delleli S, Bridge CA, Messaoudi H, Chtourou H, Ballmann CG, Ardigò LP, and Franchini E
- Subjects
- Humans, Female, Male, Cross-Over Studies, Athletes, Dietary Supplements, Caffeine pharmacology, Martial Arts
- Abstract
The purpose of this study was to assess the effects of acute caffeine supplementation on physical performance and perceived exertion during taekwondo-specific tasks in male and female athletes with varying expertise. In a double-blinded, randomized, placebo-controlled crossover study design, 52 young athletes from elite (n = 32; 16 males and 16 females) and sub-elite competitive level (n = 20; 10 males and 10 females) participated. Athletes performed taekwondo-specific tasks including the taekwondo-specific agility test (TSAT), 10 s frequency speed of kick test (FSKT-10 s) and multi-bout FSKT (FSKT-multi) under the following conditions: (1) Caffeine (CAF; 3 mg kg
-1 ), placebo (PLA), and no supplement control (CON). Session rating of perceived exertion (s-RPE) was determined after the tests. Findings show that regardless of condition, males performed better than females (p < 0.05) and elite athletes had superior performance compared to their sub-elite counterparts (p < 0.05). For the TSAT (p < 0.001), FSKT-10s (p < 0.001), and FSKT-multi (p < 0.001), CAF enhanced performance in elite female athletes compared to sub-elite females. Likewise, CAF ingestion resulted in superior performance in elite males compared to sub-elite males for FSKT-10s (p = 0.003) and FSKT-multi (p < 0.01). The ergogenic potential of CAF during taekwondo-specific tasks appears to be related to a competitive level, with greater benefits in elite than sub-elite athletes., (© 2023. Springer Nature Limited.)- Published
- 2023
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38. Primary clear cell adenocarcinoma of the vagina not associated with diethylstilbestrol metastasizing to the lung: a case report.
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Benlghazi A, Belouad M, Messaoudi H, Benali S, Aitbouhou R, Fatima EM, Elhassani MM, and Kouach J
- Abstract
Primary clear cell carcinoma of the vagina (PCCAV) is a rare form of vaginal cancer that typically affects young women with a history of prenatal exposure to DES. However, data on non-DES PCCAV cases are limited. This report describes a case of PCCAV in a 47-year-old patient who presented with post-coital bleeding and was diagnosed with clear cell adenocarcinoma via biopsy and MRI. The patient had no history of DES exposure and further testing showed no signs of metastasis, leading to surgery and chemotherapy. Four years later, the patient presented with dyspnea, and a chest CT scan revealed a lung nodule, later confirmed to be a metastasis of clear cell adenocarcinoma from the vaginal cancer. The patient passed away a month later due to complications from COVID-19., Competing Interests: No conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2023
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39. Listening to Preferred and Loud Music Enhances Taekwondo Physical Performances in Adolescent Athletes.
- Author
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Ouergui I, Jebabli E, Delleli S, Messaoudi H, Bridge CA, Chtourou H, Franchini E, Ballmann CG, and Ardigò LP
- Subjects
- Humans, Male, Adolescent, Female, Auditory Perception, Exercise, Athletes, Physical Functional Performance, Athletic Performance
- Abstract
In this study, we aimed to investigate the effects of warm-up music preference and loudness on physical performance, perceived exertion (RPE), and enjoyment in young taekwondo athletes. In a crossover counterbalanced design, 20 taekwondo athletes (10 male, 10 female) performed a battery of physical tasks specific to taekwondo under the following five conditions: (a) No music (NM), (b) Preferred music-Soft (60 dB; PMS), (c) Preferred music-Loud (80 dB; PML), (d) Non-preferred music-Soft (60 dB; NPMS), and (e) Non-preferred music-Loud (80 dB; NPML). On each lab visit, participants completed a taekwondo-specific agility test (TSAT), a10-second kick test (KSKT-10s) and a multiple frequency speed of kick tests (FSKT) within each music condition. Pre-exercise enjoyment was assessed using the Physical Activity Enjoyment Scale (PACES) after the warm-up, while we obtained RPE scores after each test. The PML condition resulted in significantly better agility test times on the TSAT compared to PMS ( p < .001), and NPML ( p < .001). Furthermore, PML led to a greater number of total kicks during the FSKT-10s test compared to the PMS ( p < .001), and NPML ( p < .001) conditions. The decrement index on the FSKT was lower in PML than in PMS and NPML conditions ( p < .001). For RPE, values were significantly lower with preferred than non-preferred music ( p < .001). These findings lend support to ergogenic benefits of listening to PML prior to taekwondo physical tasks, with important implications for enhancing taekwondo training and performance.
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- 2023
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40. Cross-dimensional transfer learning in medical image segmentation with deep learning.
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Messaoudi H, Belaid A, Ben Salem D, and Conze PH
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- Humans, Neural Networks, Computer, Image Processing, Computer-Assisted methods, Tomography, X-Ray Computed methods, Imaging, Three-Dimensional methods, Deep Learning
- Abstract
Over the last decade, convolutional neural networks have emerged and advanced the state-of-the-art in various image analysis and computer vision applications. The performance of 2D image classification networks is constantly improving and being trained on databases made of millions of natural images. Conversely, in the field of medical image analysis, the progress is also remarkable but has mainly slowed down due to the relative lack of annotated data and besides, the inherent constraints related to the acquisition process. These limitations are even more pronounced given the volumetry of medical imaging data. In this paper, we introduce an efficient way to transfer the efficiency of a 2D classification network trained on natural images to 2D, 3D uni- and multi-modal medical image segmentation applications. In this direction, we designed novel architectures based on two key principles: weight transfer by embedding a 2D pre-trained encoder into a higher dimensional U-Net, and dimensional transfer by expanding a 2D segmentation network into a higher dimension one. The proposed networks were tested on benchmarks comprising different modalities: MR, CT, and ultrasound images. Our 2D network ranked first on the CAMUS challenge dedicated to echo-cardiographic data segmentation and surpassed the state-of-the-art. Regarding 2D/3D MR and CT abdominal images from the CHAOS challenge, our approach largely outperformed the other 2D-based methods described in the challenge paper on Dice, RAVD, ASSD, and MSSD scores and ranked third on the online evaluation platform. Our 3D network applied to the BraTS 2022 competition also achieved promising results, reaching an average Dice score of 91.69% (91.22%) for the whole tumor, 83.23% (84.77%) for the tumor core and 81.75% (83.88%) for enhanced tumor using the approach based on weight (dimensional) transfer. Experimental and qualitative results illustrate the effectiveness of our methods for multi-dimensional medical image segmentation., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
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- 2023
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41. Effects of conditioning activity mode, rest interval and effort to pause ratio on post-activation performance enhancement in taekwondo: a randomized study.
- Author
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Ouergui I, Delleli S, Messaoudi H, Bridge CA, Chtourou H, Franchini E, and Ardigò LP
- Abstract
Introduction: The present study assessed the effects of conditioning activities, using different effort-to-pause ratios and rest intervals, on taekwondo physical performance. Methods: Twenty-one athletes (13 males and 8 females) (Mean ± SD; age = 20.4 ± 1.4 years) performed a control (CC) and twelve experimental conditions. Each condition contained a standard warm-up (i.e., CC: running at 9 km/h for 10 min) and conditioning activities comprising plyometrics P) or repeated high-intensity techniques (RT) using 1:6, 1:9 and self-selected rest (SSR) ratios, and two rest intervals (3 and 7 min). Athletes then performed a battery of fitness tests: countermovement jump (CMJ), taekwondo specific agility (TSAT), 10s and multiple frequency speed kick test (FSKT-10s and FSKT-mult, respectively). Results: All of the preloads provided higher performance outputs compared to the control trial (all p < 0.05). For CMJ, 1:6 ratio with 3 min induced lower values with RT compared to P ( p = 0.037) and 1:9 ratio using 3 min induced higher values with RT compared to P ( p = 0.027). Additionally, 1:6 ratio using 7 min induced higher values with RT compared to P ( p = 0.016). For FSKT-10, 3 min using 1:6 induced higher values with P compared to RT, while RT induced higher values with 7 min using 1:6 ratio compared to P (both p < 0.001). Moreover, 3 min using 1:9 ratio induced higher values with P compared to RT ( p = 0.034), while RT induced higher values with 1:9 ratio using 7 min compared to P ( p < 0.001). Finally, 3 min using SSR ratio induced higher values with RT compared to P ( p = 0.034). Conclusion: Plyometrics and RT activities improved performance with plyometrics requiring shorter rest interval to induce potentiation effects compared to RT, which required longer interval., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Ouergui, Delleli, Messaoudi, Bridge, Chtourou, Franchini and Ardigò.)
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- 2023
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42. Repeated High-Intensity Technique Training and Repeated Sprint Training Elicit Similar Adjustment in Physiological Responses But Divergent Perceptual Responses and Combat-Related Performances in Adolescent Taekwondo Matches.
- Author
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Ouergui I, Delleli S, Messaoudi H, Bridge CA, Chtourou H, Franchini E, and Ardigò LP
- Subjects
- Adolescent, Female, Humans, Male, Athletes, Lactic Acid, Athletic Performance physiology, Martial Arts physiology, Running physiology
- Abstract
Purpose: This study investigated the effects of 4 weeks of repeated sprint training (RST) versus repeated high-intensity technique training (RTT) on the physiological responses (ie, blood lactate), mean and peak heart rate, rating of perceived exertion, technical-tactical performance, and time-motion variables during simulated taekwondo combats., Methods: Twenty-four taekwondo athletes (18 male and 6 female; age: 16 [1] y) were randomly and equally assigned to RST (10 × 35-m running sprints interspersed by 10-s rest) or RTT (10 × 6-s bandal-tchagui kicking executions interspersed by 10-s rest) groups in addition to their regular training. Both groups performed simulated combats before and after training., Results: Delta lactate and peak heart rate were attenuated following training (P < .001 and P = .03, respectively), with no differences identified between RTT and RST conditions. Rating of perceived exertion decreased after training only in the RTT (P = .002). Time fighting and preparatory activities increased following training (P < .001), with higher values observed following RTT than RST (P < .001). Nonpreparatory time decreased after training (P < .001), with more pronounced reductions observed following RTT when compared to RST (P < .001). The number of single attacks decreased only following RST (P < .001), whereas combined attacks increased only after RTT training (P < .001)., Conclusions: Similar adjustments in the physiological responses to combat were observed following 4 weeks of either RST or RTT, but RTT elicited more favorable perceptual responses and combat-related performance. This highlights the importance of specificity of training and its effective transfer to combat.
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- 2023
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43. The effects of tempo and loudness variations during warm-up with music on perceived exertion, physical enjoyment and specific performances in male and female taekwondo athletes.
- Author
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Ouergui I, Jebabli A, Messaoudi H, Delleli S, Chtourou H, Bouassida A, Bouhlel E, Franchini E, and Ardigò LP
- Subjects
- Adolescent, Female, Humans, Male, Athletes, Physical Exertion, Pleasure, Music, Warm-Up Exercise
- Abstract
The ergogenic effect of pre-selected warm-up music with the tempo and loudness variations on the performance of combat sports' athletes as well as the difference between sexes is not well established. The present study aimed to assess the effects of listening to music with different tempos and loudness during warm-up on perceived exertion, physical enjoyment and physical performances in young taekwondo athletes. In a randomized study design, 20 taekwondo athletes (10 males, mean ± SD: age: 17.5 ± 0.7 years, taekwondo experience: ≥ 6 year) performed the taekwondo specific agility test (TSAT) and the 10s and multiple frequency speed of kick test (FSKT-10s and FSKT-mult) after warming-up with or without music. The music was played at high (140 beats·min-1) or very high (200 beats·min-1) tempo combined with low (60 dB) or high (80 dB) loudness, resulting in four experimental and control conditions. The ratings of perceived exertion (RPE) and physical activity enjoyment scale (PACES) were assessed after each condition. After normality, homogeneity and sphericity checks, two-way (or multivariate) analysis of variance and Bonferrroni (or Friedman's and Wilcoxon's test) post-hoc test were operated when necessary. For TSAT, 140 beats·min-1+80 dB induced better performance compared with 200 beats·min-1+80 dB, 200 beats·min-1+60 dB, control and the 140 beats·min-1+60 dB conditions. For FSKT-10s, 140 beats·min-1+80 dB condition induced higher performance compared with 200 beats·min-1+60 dB, 200 beats·min-1+80 dB, 140 beats·min-1+60 dB and the control conditions. For FSKT-mult, 140 beats·min-1+80 dB induced higher number of techniques compared with 200 beats·min-1+60 dB, 140 beats·min-1+60 dB, control and the 200 beats·min-1+80 dB conditions. Moreover, 140 beats·min-1+80 dB induced lower decrement index (DI) compared with the other conditions and lower DI in 140 beats·min-1+60 dB compared with 200 beats·min-1+80 dB and control conditions. Moreover, 140 beats·min-1+80 dB resulted in greater PACES scores compared with 200 beats·min-1+80 dB and control conditions. Better performance was found for males compared with females in TSAT, FSKT-10s and FSKT-mult (i.e., techniques' number), as well as lower DI and higher RPE post-FSKT-10s. Pre-selected warm-up music played at 140 beats·min-1 and 80 dB is an efficient strategy to enhance physical activity enjoyment and specific performances in taekwondo., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Ouergui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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44. Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats.
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Leuillier M, Platel V, Tu L, Feugray G, Thuillet R, Groussard D, Messaoudi H, Ottaviani M, Chelgham M, Nicol L, Mulder P, Humbert M, Richard V, Morisseau C, Brunel V, Duflot T, Guignabert C, and Bellien J
- Subjects
- Rats, Humans, Animals, Epoxide Hydrolases therapeutic use, Lung, Heart, Cells, Cultured, Hypertension, Pulmonary
- Abstract
Inhibitors of soluble epoxide hydrolase (sEH), which catalyzes the hydrolysis of various natural epoxides to their corresponding diols, present an opportunity for developing oral drugs for a range of human cardiovascular and inflammatory diseases, including, among others, diabetes and neuropathic pain. However, some evidence suggests that their administration may precipitate the development of pulmonary hypertension (PH). We thus evaluated the impact of chronic oral administration of the sEH inhibitor TPPU (N-[1-(1-Oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea) on hemodynamics, pulmonary vascular reactivity, and remodeling, as well as on right ventricular (RV) dimension and function at baseline and in the Sugen (SU5416) + hypoxia (SuHx) rat model of severe PH. Treatment with TPPU started 5 weeks after SU5416 injection for 3 weeks. No differences regarding the increase in pulmonary vascular resistance, remodeling, and inflammation, nor the abolishment of phenylephrine-induced pulmonary artery constriction, were noted in SuHx rats. In addition, TPPU did not modify the development of RV dysfunction, hypertrophy, and fibrosis in SuHx rats. Similarly, none of these parameters were affected by TPPU in normoxic rats. Complementary in vitro data demonstrated that TPPU reduced the proliferation of cultured human pulmonary artery-smooth muscle cells (PA-SMCs). This study demonstrates that inhibition of sEH does not induce nor aggravate the development of PH and RV dysfunction in SuHx rats. In contrast, a potential beneficial effect against pulmonary artery remodeling in humans is suggested.
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- 2023
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45. Subtotal Nephrectomy Associated with a High-Phosphate Diet in Rats Mimics the Development of Calcified Aortic Valve Disease Associated with Chronic Renal Failure.
- Author
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Messaoudi H, Levesque T, Perzo N, Berg E, Feugray G, Dumesnil A, Brunel V, Guerrot D, Eltchaninoff H, Richard V, Kamel S, Durand E, Bennis Y, and Bellien J
- Abstract
Introduction. This study addressed the hypothesis that subtotal nephrectomy associated with a high-phosphorus diet (5/6Nx + P) in rats represents a suitable animal model to mimic the cardiovascular consequences of chronic kidney disease (CKD) including calcified aortic valve disease (CAVD). Indeed, the latter contributes to the high morbidity and mortality of CKD patients and sorely lacks preclinical models for pathophysiological and pharmacological studies. Methods. Renal and cardiovascular function and structure were compared between sham-operated and 5/6 Nx rats + P 10 to 12 weeks after surgery. Results. As expected, 11 weeks after surgery, 5/6Nx + P rats developed CKD as demonstrated by their increase in plasma creatinine and urea nitrogen and decrease in glomerular filtration rate, estimated by using fluorescein-isothiocyanate-labelled sinistrin, anemia, polyuria, and polydipsia compared to sham-operated animals on a normal-phosphorus diet. At the vascular level, 5/6Nx + P rats had an increase in the calcium content of the aorta; a decrease in mesenteric artery dilatation in response to a stepwise increase in flow, illustrating the vascular dysfunction; and an increase in blood pressure. Moreover, immunohistology showed a marked deposition of hydroxyapatite crystals in the aortic valve of 5/6Nx + P rats. Echocardiography demonstrated that this was associated with a decrease in aortic valve cusp separation and an increase in aortic valve mean pressure gradient and in peak aortic valve velocity. Left-ventricular diastolic and systolic dysfunction as well as fibrosis were also present in 5/6Nx + P rats. Conclusion. This study demonstrates that 5/6Nx + P recapitulates the cardiovascular consequences observed in humans with CKD. In particular, the initiation of CAVD was shown, highlighting the interest of this animal model to study the mechanisms involved in the development of aortic stenosis and test new therapeutic strategies at an early stage of the disease.
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- 2023
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46. Middle lobe suffering due to malposition and 180° tilt of the 2 remaining lobes after right upper lobectomy.
- Author
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Janet-Vendroux A, Al Zreibi C, Reverdito G, Arame A, Badia A, Masmoudi H, Messaoudi H, and Le Pimpec-Barthes F
- Abstract
Middle lobe (ML) suffering after right upper lobectomy (RUL) is rare but represents a major complication usually due to lobar torsion. We report 3 atypical consecutive cases of ML suffering due to malposition of the 2 remaining right lobes with a 180° tilt. All 3 female patients had surgery for non-small-cell carcinoma including RUL associated with radical hilar and mediastinal lymph node removal. Postoperative chest X-ray abnormalities appeared at days 1-3 respectively. The diagnosis of malposition of the 2 lobes was done on contrast-enhanced chest CT scan at days 7, 7 and 6, respectively. A reoperation for suspected ML torsion was required in all patients. Three repositionings of the 2 lobes and 1 middle lobectomy were performed. The postoperative courses were then uneventful, and the 3 patients were alive at a mean follow-up of 12 months. Before thoracic approach closure after RUL, systematic check of good positioning of the 2 reinflated remaining lobes is indispensable. It may prevent ML suffering secondary to 180° lobar tilt leading to whole pulmonary malposition., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.)
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- 2023
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47. Does Beetroot Supplementation Improve Performance in Combat Sports Athletes? A Systematic Review of Randomized Controlled Trials.
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Delleli S, Ouergui I, Messaoudi H, Trabelsi K, Glenn JM, Ammar A, and Chtourou H
- Subjects
- Female, Humans, Athletes, Dietary Supplements, Muscle, Skeletal, Randomized Controlled Trials as Topic, Athletic Performance physiology, Nitrates pharmacology
- Abstract
While studies on dietary nitrate (NO
3 - ) supplementation and its impact on combat sports performance are increasing, finite conclusions from currently available investigations remain unclear. Thus, the present systematic review examined the acute and chronic ergogenic effect(s) of dietary nitrate intake from beetroot on different aspects of combat sports performance. A systematic search for randomized placebo-controlled studies investigating the effects of beetroot supplementation on combat sports outcomes was performed through Scopus, PubMed/MEDLINE, Web of Science, Scielo, Sport Discus, and Cochrane Library databases up to 2 January 2023. The different terms related to beetroot and to combat sports were connected in the search strategies using the Boolean operators 'AND' and 'OR'. A total of nine studies with good methodological quality (based on the Cochrane risk of bias tool) fulfilled the inclusion criteria. Seven studies used an acute supplementation strategy, while the other two studies utilized chronic supplementation. Findings showed beetroot intake may be an effective tool to improve oxidative metabolism and muscle force production (i.e., isokinetic and isometric) in combat sports athletes. However, these effects may depend on the population, intake duration, muscle group activated, and exercise type. Future studies are required to (1) understand the effects on female athletes and (2) elucidate the impacts of dosing protocols and specific exercise modalities for enhancing combat sports performance.- Published
- 2023
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48. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury.
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Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut PA, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry JP, Renet S, Mulder P, Wan D, Tesson L, Heslan JM, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego JL, do Rego JC, Afonso C, Hammock B, Madec AM, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, and Bellien J
- Subjects
- Animals, Female, Male, Rats, CRISPR-Cas Systems, Heart Diseases genetics, Heart Diseases metabolism, Heart Diseases pathology, Insulin Resistance genetics, Lysophospholipids, Phosphoric Monoester Hydrolases genetics, Phosphoric Monoester Hydrolases metabolism, Reperfusion Injury genetics, Epoxide Hydrolases genetics, Epoxide Hydrolases metabolism, Heart Injuries genetics, Heart Injuries metabolism, Heart Injuries pathology, Obesity genetics, Obesity metabolism
- Abstract
Introduction: Although the physiological role of the C-terminal hydrolase domain of the soluble epoxide hydrolase (sEH-H) is well investigated, the function of its N-terminal phosphatase activity (sEH-P) remains unknown., Objectives: This study aimed to assess in vivo the physiological role of sEH-P., Methods: CRISPR/Cas9 was used to generate a novel knock-in (KI) rat line lacking the sEH-P activity., Results: The sEH-P KI rats has a decreased metabolism of lysophosphatidic acids to monoacyglycerols. KI rats grew almost normally but with less weight and fat mass gain while insulin sensitivity was increased compared to wild-type rats. This lean phenotype was more marked in males than in female KI rats and mainly due to decreased food consumption and enhanced energy expenditure. In fact, sEH-P KI rats had an increased lipolysis allowing to supply fatty acids as fuel to potentiate brown adipose thermogenesis under resting condition and upon cold exposure. The potentiation of thermogenesis was abolished when blocking PPARγ, a nuclear receptor activated by intracellular lysophosphatidic acids, but also when inhibiting simultaneously sEH-H, showing a functional interaction between the two domains. Furthermore, sEH-P KI rats fed a high-fat diet did not gain as much weight as the wild-type rats, did not have increased fat mass and did not develop insulin resistance or hepatic steatosis. In addition, sEH-P KI rats exhibited enhanced basal cardiac mitochondrial activity associated with an enhanced left ventricular contractility and were protected against cardiac ischemia-reperfusion injury., Conclusion: Our study reveals that sEH-P is a key player in energy and fat metabolism and contributes together with sEH-H to the regulation of cardiometabolic homeostasis. The development of pharmacological inhibitors of sEH-P appears of crucial importance to evaluate the interest of this promising therapeutic strategy in the management of obesity and cardiac ischemic complications., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Production and hosting by Elsevier B.V.)
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- 2023
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49. Spontaneous Resolution of a Pulmonary Cystic Amyloidosis Mass.
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Guediri N, Mejri I, Boubaker N, Mhamdi S, Daboussi S, Aichaouia C, Messaoudi H, Ayadi A, and Moatemri Z
- Abstract
Introduction: Amyloidosis is a rare illness characterized by the deposition in organs of amyloid, which can be detected by histological staining. Amyloidosis restricted to the lower respiratory tract is unusual., Results: We reported the case of a 68-year-old woman with no history of chronic diseasewho presented with dyspnoea on exertion, cough and fatigue. The physical examination was unremarkable. A CT scan showed a cystic mass with a thickened wall in the apical segment of the left lower lobe. A biopsy of the mass was performed, and histological and immunohistochemical study confirmed the diagnosis of AL amyloidosis. The patient's clinical and radiological symptoms spontaneously improved without treatment after 3 years., Conclusion: Amyloid-related cystic lung disease is a rare presentation of amyloidosis in the thorax. More case reports are required to determine if such masses can resolve without treatment and whether amyloid-associated cystic lung disease actually exists., Learning Points: Dyspnoea and cough are a rare atypical presentation that can reveal pulmonary amyloidosis.A cystic lung mass should raise suspicion for pulmonary amyloidosis.Clinical symptoms and radiological findings of a cystic mass spontaneously resolved without treatment after 3 years in this patient with pulmonary amyloidosis., Competing Interests: Conflicts of Interests: The authors declare there are no competing interests., (© EFIM 2022.)
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- 2022
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50. Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis.
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Delleli S, Ouergui I, Messaoudi H, Trabelsi K, Ammar A, Glenn JM, and Chtourou H
- Subjects
- Caffeine pharmacology, Dietary Supplements, Hand Strength physiology, Physical Exertion, Physical Functional Performance, Athletic Performance physiology, Performance-Enhancing Substances pharmacology
- Abstract
Although the effects of caffeine supplementation on combat sports performance have been extensively investigated, there is currently no consensus regarding its ergogenic benefits.This systematic review with meta-analysis aimed to summarize the studies investigating the effects of caffeine supplementation on different aspects of performance in combat sports and to quantitatively analyze the results of these studies to better understand the ergogenic effect of caffeine on combat sports outcomes. A systematic search for randomized placebo-controlled studies investigating the effects of caffeine supplementation on combat sports' performance was performed through Scopus, Pubmed, Web of Science and Cochrane Library databases up to 18 April 2022. Random-effects meta-analyses of standardized mean differences (Hedge's g) were performed to analyze the data. Twenty-six studies of good and excellent methodological quality (based on the Pedro scale) fulfilled the inclusion criteria. The meta-analysis results revealed caffeine has a small but evident effect size (ES) on handgrip strength (ES = 0.28; 95% CI: 0.04 to 0.52; p = 0.02), and total number of throws during the special judo fitness test (SJFT) (ES = 0.42; 95% CI: 0.06 to 0.78; p = 0.02). Regarding the physiological responses, caffeine increased blood lactate concentration ([La]) in anaerobic exercise (ES = 1.23; 95% CI: 0.29 to 2.18; p = 0.01) and simulated combat (ES = 0.91; 95% CI: 0.34 to 1.47; p = 0.002). For Heart Rate (HR), caffeine increased HR final (ES = 0.31; 95% CI: 0.11 to 0.52; p = 0.003), and HR 1min (ES = 0.20; 95% CI 0.004 to 0.40; p = 0.045). However, caffeine had no impact on the countermovement jump height, the SJFT index, the judogi strength-endurance test, the number and duration of offensive actions, HR at the end of the fight, and the rating of perceived exertion. Caffeine supplementation may be ergogenic for a range of combat sports aspects involving isometric strength, anaerobic power, reaction time, and anaerobic metabolism. However, supplementation effects might be ineffective under certain circumstances, indicating supplementation needs to take into account the performance metric in question prior to creating a dosing protocol.
- Published
- 2022
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