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Your search keyword '"Menghini, V."' showing total 6 results
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6 results on '"Menghini, V."'

1. Stereotactic body radiotherapy of bone metastases in oligometastatic disease: Prognostic factors of oncologic outcomes

Author

Ursino, S, Montrone, S, Cantarella, M, Menghini, V, Matteucci, F, Mazzotti, V, Fiorica, F, Fedele, D, Erba, P, Morganti, R, Fabrini, M, Caramella, D, Ursino S., Montrone S., Cantarella M., Menghini V., Matteucci F., Mazzotti V., Fiorica F., Fedele D., Erba P., Morganti R., Fabrini M. G., Caramella D., Ursino, S, Montrone, S, Cantarella, M, Menghini, V, Matteucci, F, Mazzotti, V, Fiorica, F, Fedele, D, Erba, P, Morganti, R, Fabrini, M, Caramella, D, Ursino S., Montrone S., Cantarella M., Menghini V., Matteucci F., Mazzotti V., Fiorica F., Fedele D., Erba P., Morganti R., Fabrini M. G., and Caramella D.

Abstract

Background: To evaluate the safety of stereotactic body radiotherapy (SBRT) of bone metastases in oligometastatic disease and to investigate prognostic factors of local control (LC), progression/disease-free survival (PDFS), and overall survival (OS). Methods: Eligibility criteria were number of metastates ≤5, controlled primary tumor without evidence of progression under systemic therapy, exclusion of surgery, and no previous radiotherapy of the lesion of interest. Oligometastatic status was classified into only bone (BOD) and outside bone disease (OBOD), whereas SBRT was delivered to bone lesions using 2 different schedules: 24 Gy/1 fraction or 27 Gy/3 fractions. A positron emission tomography study of the lesion of interest was performed at baseline and at 3 months after SBRT to evaluate metabolic response according to European Organization for Research and Treatment of Cancer (EORTC) criteria. A Cox regression model was used for univariate and multivariate analysis. Results: Between January 2010 and December 2013, 40 patients were enrolled. Only 1 patient experienced severe late toxicity (radiation-related fracture). Local control was longer among responders' than nonresponders' lesions (94.2% and 91.2% versus 63% and 35% at 1 and 2 years, respectively) (p = 0.004; hazard ratio = 9.958). The multivariate analysis of PDFS showed a significant correlation with planning target volume (PTV) size (p = 0.003) and oligometastatic status (p = 0.002). The multivariate analysis of OS confirmed a statistically significant value of the oligometastatic status (p = 0.002) and a significant trend for PTV size (p = 0.065). Conclusions: Stereotactic body radiotherapy is safe with a low incidence of severe toxicity. Positron emission tomography response was a strong prognostic factor of LC whereas BOD status and small PTV size could identify a subset of oligometastatic patients at better prognosis.

Published
2016

5. Stereotactic body radiotherapy of bone metastases in oligometastatic disease: prognostic factors of oncologic outcomes

Author

S. Montrone, Francesco Fiorica, Fabrizio Matteucci, David Fedele, Valentina Mazzotti, Riccardo Morganti, Stefano Ursino, Maria Grazia Fabrini, Paola Anna Erba, Valentina Menghini, Davide Caramella, M. Cantarella, Ursino, S, Montrone, S, Cantarella, M, Menghini, V, Matteucci, F, Mazzotti, V, Fiorica, F, Fedele, D, Erba, P, Morganti, R, Fabrini, M, and Caramella, D

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Positron emission tomography, Stereotactic body radiotherapy, medicine.medical_treatment, Standardized uptake value, Bone Neoplasms, Radiosurgery, Risk Assessment, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, medicine, Humans, Oligometastatic disease, Survival analysis, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Dose fractionation, Retrospective cohort study, General Medicine, Middle Aged, Prognosis, Survival Analysis, Surgery, Bone metastase, Treatment Outcome, Oncology, Italy, 030220 oncology & carcinogenesis, Predictive value of tests, Positron-Emission Tomography, Standard uptake value, Female, Radiology, Dose Fractionation, Radiation, business, 030217 neurology & neurosurgery
Abstract

Background To evaluate the safety of stereotactic body radiotherapy (SBRT) of bone metastases in oligometastatic disease and to investigate prognostic factors of local control (LC), progression/disease-free survival (PDFS), and overall survival (OS). Methods Eligibility criteria were number of metastates ≤5, controlled primary tumor without evidence of progression under systemic therapy, exclusion of surgery, and no previous radiotherapy of the lesion of interest. Oligometastatic status was classified into only bone (BOD) and outside bone disease (OBOD), whereas SBRT was delivered to bone lesions using 2 different schedules: 24 Gy/1 fraction or 27 Gy/3 fractions. A positron emission tomography study of the lesion of interest was performed at baseline and at 3 months after SBRT to evaluate metabolic response according to European Organization for Research and Treatment of Cancer (EORTC) criteria. A Cox regression model was used for univariate and multivariate analysis. Results Between January 2010 and December 2013, 40 patients were enrolled. Only 1 patient experienced severe late toxicity (radiation-related fracture). Local control was longer among responders’ than nonresponders’ lesions (94.2% and 91.2% versus 63% and 35% at 1 and 2 years, respectively) (p = 0.004; hazard ratio = 9.958). The multivariate analysis of PDFS showed a significant correlation with planning target volume (PTV) size (p = 0.003) and oligometastatic status (p = 0.002). The multivariate analysis of OS confirmed a statistically significant value of the oligometastatic status (p = 0.002) and a significant trend for PTV size (p = 0.065). Conclusions Stereotactic body radiotherapy is safe with a low incidence of severe toxicity. Positron emission tomography response was a strong prognostic factor of LC whereas BOD status and small PTV size could identify a subset of oligometastatic patients at better prognosis.

Published
2016

6. Stereotactic body radiotherapy of bone metastases in oligometastatic disease: prognostic factors of oncologic outcomes.

Author

Ursino S, Montrone S, Cantarella M, Menghini V, Matteucci F, Mazzotti V, Fiorica F, Fedele D, Erba P, Morganti R, Fabrini MG, and Caramella D

Subjects
Adult, Aged, Bone Neoplasms mortality, Disease-Free Survival, Dose Fractionation, Radiation, Female, Humans, Italy, Male, Middle Aged, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Survival Analysis, Treatment Outcome, Bone Neoplasms secondary, Bone Neoplasms surgery, Radiosurgery adverse effects, Radiosurgery methods
Abstract

Background: To evaluate the safety of stereotactic body radiotherapy (SBRT) of bone metastases in oligometastatic disease and to investigate prognostic factors of local control (LC), progression/disease-free survival (PDFS), and overall survival (OS)., Methods: Eligibility criteria were number of metastates ≤5, controlled primary tumor without evidence of progression under systemic therapy, exclusion of surgery, and no previous radiotherapy of the lesion of interest. Oligometastatic status was classified into only bone (BOD) and outside bone disease (OBOD), whereas SBRT was delivered to bone lesions using 2 different schedules: 24 Gy/1 fraction or 27 Gy/3 fractions. A positron emission tomography study of the lesion of interest was performed at baseline and at 3 months after SBRT to evaluate metabolic response according to European Organization for Research and Treatment of Cancer (EORTC) criteria. A Cox regression model was used for univariate and multivariate analysis., Results: Between January 2010 and December 2013, 40 patients were enrolled. Only 1 patient experienced severe late toxicity (radiation-related fracture). Local control was longer among responders' than nonresponders' lesions (94.2% and 91.2% versus 63% and 35% at 1 and 2 years, respectively) (p = 0.004; hazard ratio = 9.958). The multivariate analysis of PDFS showed a significant correlation with planning target volume (PTV) size (p = 0.003) and oligometastatic status (p = 0.002). The multivariate analysis of OS confirmed a statistically significant value of the oligometastatic status (p = 0.002) and a significant trend for PTV size (p = 0.065)., Conclusions: Stereotactic body radiotherapy is safe with a low incidence of severe toxicity. Positron emission tomography response was a strong prognostic factor of LC whereas BOD status and small PTV size could identify a subset of oligometastatic patients at better prognosis.

Published
2016
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