1. Differences between the real and the desired worlds in the results of clinical trials
- Author
-
El Dib, Regina [UNESP], Dib, Regina El, Jorge, Eliane Chaves [UNESP], Kamegasawa, Amélia [UNESP], Daher, Solange Ramires [UNESP], Spagnuolo, Regina Stella [UNESP], da Silva, Marise Pereira [UNESP], Braga, Gabriel Pereira [UNESP], Volpato, Enilze [UNESP], Módolo, Norma Sueli Pinheiro [UNESP], Betini, Marluci [UNESP], Do Valle, Adriana [UNESP], Corrêa, Ione [UNESP], Bazan, Rodrigo [UNESP], Almeida, Ricardo Augusto M. B. [UNESP], Weber, Silke Anna Theresa [UNESP], Molina, Silvana [UNESP], Yoo, Hugo [UNESP], Boas, Paulo Villas [UNESP], Corrente, José Eduardo [UNESP], Mathew, Joseph, Kapoor, Anil, Carvalho, Raíssa Pierri [UNESP], Vital, Roberto Bezerra [UNESP], Braz, Leandro Gobbo [UNESP], Do Nascimento Junior, Paulo [UNESP], Universidade Estadual Paulista (Unesp), McMaster University, McMaster Institute of Urology, and Pediatric Pulmonology, PGIMER
- Subjects
Research design ,medicine.medical_specialty ,Efficacy ,Systematic survey ,Psychological intervention ,MEDLINE ,Effectiveness ,law.invention ,Randomized controlled trial ,law ,medicine ,Humans ,Clinical Trials ,Randomized Controlled Trials as Topic ,Clinical Trials as Topic ,lcsh:R5-920 ,Evidence-Based Medicine ,business.industry ,Research ,General Medicine ,Evidence-based medicine ,Clinical Science ,Clinical trial ,Clinical Practice ,Treatment Outcome ,Bibliometrics ,Research Design ,Physical therapy ,Clinical Medicine ,business ,lcsh:Medicine (General) - Abstract
Made available in DSpace on 2018-12-11T17:25:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-01-01. Added 1 bitstream(s) on 2019-10-09T18:32:09Z : No. of bitstreams: 1 S1807-59322015000900618.pdf: 243111 bytes, checksum: 6fbbe57cd02f4260c36d6a9a23cd10c0 (MD5) OBJECTIVE: We refer to the effectiveness (known as pragmatic or real world) and efficacy (known as explanatory or desired or ideal world) of interventions. However, these terms seem to be randomly chosen by investigators who design clinical trials and do not always reflect the true purpose of the study. A pragmaticexplanatory continuum indicator summary tool was thus developed with the aim of identifying the characteristics of clinical trials that distinguish between effectiveness and efficacy issues. We verified whether clinical trials used the criteria proposed by the indicator summary tool, and we categorized these clinical trials according to a new classification. METHOD: A systematic survey of randomized clinical trials was performed. We added a score ranging from 0 (more efficacious) to 10 (more effective) to each domain of the indicator summary tool and proposed the following classifications: high efficacy (
- Published
- 2015