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Background and Objectives: Chronic pain (CP), affecting approximately 20 % of adults globally, imposes a profound burden on individuals and healthcare systems. This condition, characterized by persistent pain, muscle stiffness, and emotional distress, often results in a complex interplay of physical and psychological factors that exacerbate symptoms and hinder recovery. Biofeedback (BFB), a non-invasive intervention, offers a promising rehabilitation strategy by enabling individuals to monitor and self-regulate physiological responses, such as muscle tension, heart rate, and skin temperature. Through this process, BFB disrupts the vicious cycle of pain and stress, fostering relaxation, reducing muscle strain, and alleviating emotional distress. This systematic review aimed to examine the mechanisms underlying BFB's therapeutic effects in CP rehabilitation, specifically its ability to enhance self-regulation and promote relaxation to improve pain control. Furthermore, it aimed to evaluate the impact of BFB on key outcomes, including pain severity, functional capabilities, and quality of life, with the goal of guiding its integration into contemporary rehabilitation practices., Materials and Methods: Following PRISMA guidelines, a systematic search was conducted in PubMed, Web of Science, and Embase (2014-2024) to identify studies on BFB for CP. Inclusion criteria included original research involving BFB as a primary or secondary intervention for CP, with outcomes related to pain management and rehabilitation. This review is registered on Open OSF (X5HPB)., Results: BFB has shown consistent efficacy as a complementary therapy in CP management, offering significant reductions in pain intensity and enhancements in quality of life across diverse CP conditions. Mechanistically, BFB facilitates improved self-regulation by training patients to modulate physiological responses, such as muscle tension and heart rate variability, leading to better pain control and stress reduction., Conclusions: BFB shows significant promise as a supplementary treatment for different CP disorders. The evidence that was examined shows that it is effective in improving how pain is perceived, increasing functional results, and boosting overall quality of life among a variety of patient groups., Competing Interests: The authors declare the following financial interests/personal relationships: Maria Grazia Maggio reports financial support was provided by 10.13039/501100003196Ministry of Health, Italy., (© 2025 The Authors.)

Introduction: Apraxia is a neurological disorder that is common after a stroke and impairs the planning and execution of movements. In the rehabilitation field, virtual reality (VR) presents new opportunities and offers advantages to both rehabilitation teams and individuals with neurological conditions. Indeed, VR can stimulate and improve cognitive reserve and abilities, including executive function, and enhance the patient's emotional status., Aim: The objective of this research is to determine the effectiveness of VR in improving praxis skills and behavioural functioning in individuals with severe stroke., Methods: A total of 20 stroke patients were enrolled from February 2022 to March 2023 and divided by the order of their recruitment into two groups: the experimental group (EG: n = 10) received training to improve their praxis skills using VR whereas the control one (CG: n = 10) received the same amount of standard training. All patients underwent an evaluation using a psychometric battery that consisted of the Hamilton Rating Scale for Depression (HRS-D), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), Spinnler and Tognoni test, and De Renzi and Faglioni test. Valuations were performed before rehabilitation (T0) and after its completion (T1)., Results: Both groups demonstrated significant improvements post-intervention. The EG showed a greater enhancement in their MMSE scores ( p = 0.002), and reductions in both ideomotor and constructive apraxia ( p = 0.002 for both), compared to the CG. The VR-based training also resulted in significant improvements in their depression symptoms (HRSD scores improved, p = 0.012 in EG vs. p = 0.021 in CG)., Conclusions: This pilot study suggests that VR could help reduce cognitive, constructive apraxia and ideomotor apraxia symptoms caused by stroke injury.