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7. Sex differences in long-term survival following cardiac surgery in patients with underlying atrial fibrillation

Author

Kuźma, Łukasz, primary, Kowalewski, Mariusz, additional, Gostomczyk, Karol, additional, Litwinowicz, Radosław, additional, Kurasz, Anna, additional, Jasiński, Marek, additional, Widenka, Kazimierz, additional, Hirnle, Tomasz, additional, Deja, Marek, additional, Bartuś, Krzysztof, additional, Lorusso, Roberto, additional, Tobota, Zdzisław, additional, Maruszewski, Bohdan, additional, Suwalski, Piotr, additional, and KROK Investigators, On behalf of, additional

Published
2024
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9. Gender Differences in Survival after Coronary Artery Bypass Grafting—13-Year Results from KROK Registry.

Author

Hirnle, Grzegorz, Stankiewicz, Adrian, Mitrosz, Maciej, Aboul-Hassan, Sleiman Sebastian, Deja, Marek, Rogowski, Jan, Cichoń, Romuald, Anisimowicz, Lech, Bugajski, Paweł, Tobota, Zdzisław, Maruszewski, Bohdan, and Hrapkowicz, Tomasz

Subjects
CORONARY artery bypass, BODY mass index, TRANSPLANTATION of organs, tissues, etc., OPERATIVE surgery, DEATH rate
Abstract

The influence of gender on both early and long-term outcomes of coronary artery bypass grafting (CABG) is not clearly defined. Objectives: This study aimed to assess the impact of gender on early and long-term mortality after CABG using data from the KROK Registry. Methods: All 133,973 adult patients who underwent CABG in Poland between 1 January 2009 and 31 December 2019 were included in the Polish National Registry of Cardiac Surgical Procedures (KROK Registry). The study enrolled 90,541 patients: 68,401 men (75.55%) and 22,140 women (24.45%) who met the inclusion criteria. Then, 30-day mortality, 1-year mortality, and long-term mortality rates were compared. Results: Advanced age, higher Canadian Cardiovascular Society (CCS) and New York Heart Association (NYHA) grade, diabetes, hypercholesterolemia, arterial hypertension, body mass index BMI > 35 kg/m2, and renal failure, before the propensity matching, were more frequently observed in women. Women more frequently underwent urgent surgery, including single and double graft surgery, and off-pump CABG (OPCAB) (p < 0.001). In propensity-matched groups, early mortality (30 days) was significantly higher in women (3.4% versus 2.8%, p < 0.001). The annual mortality remained higher in this group (6.6% versus 6.0%, p = 0.025). However, long-term mortality differed significantly between the groups and was higher in the male group (33.0% men versus 28.8% women, p < 0.001). Conclusions: There are no apparent differences in long-term mortality between the two sexes in the entire population. In propensity-matched patients, early mortality was lower for men, but the long-term survival was found to be better in women. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Survival after surgical ablation for atrial fibrillation in mitral valve surgery: Analysis from the Polish National Registry of Cardiac Surgery Procedures (KROK)

Author

Anisimowicz, Lech, Biederman, Andrzej, Borkowski, Dariusz, Bugajski, Paweł, Cholewiński, Paweł, Cichoń, Romuald, Cisowski, Marek, Deja, Marek, Dziatkowiak, Antoni, Gburek, Tadeusz, Gryczko, Leszek, Haponiuk, Ireneusz, Hendzel, Piotr, Jabłonka, Stanisław, Jarmoszewicz, Krzysztof, Jasiński, Jarosław, Jaszewski, Ryszard, Jemielity, Marek, Kalawski, Ryszard, Kapelak, Bogusław, Kaperczak, Jacek, Karolczak, Maciej A., Krejca, Michał, Kustrzycki, Wojciech, Kuśmierczyk, Mariusz, Kwinecki, Paweł, Missima, Maurycy, Moll, Jacek J., Ogorzeja, Wojciech, Pająk, Jacek, Pawliszak, Wojciech, Pietrzyk, Edward, Religa, Grzegorz, Rogowski, Jan, Różański, Jacek, Sadowski, Jerzy, Sharma, Girish, Skalski, Janusz, Stanisławski, Ryszard, Stążka, Janusz, Stępiński, Piotr, Suwalski, Kazimierz, Tułecki, Łukasz, Wojtalik, Michał, Woś, Stanisław, Żelazny, Piotr, Suwalski, Piotr, Kowalewski, Mariusz, Jasiński, Marek, Staromłyński, Jakub, Zembala, Marian, Widenka, Kazimierz, Brykczyński, Mirosław, Skiba, Jacek, Zembala, Michał Oskar, Bartuś, Krzysztof, Hirnle, Tomasz, Dziembowska, Inga, Tobota, Zdzisław, and Maruszewski, Bohdan J.

Published
2019
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14. Single versus multiple arterial coronary artery bypass grafting in men and women: results from Polish National Registry of Cardiac Surgery Procedures.

Author

Aboul-Hassan, Sleiman Sebastian, Hirnle, Grzegorz, Perek, Bartlomiej, Jemielity, Marek, Hirnle, Tomasz, Brykczynski, Miroslaw, Deja, Marek, Rogowski, Jan, Cisowski, Marek, Krejca, Michal, Anisimowicz, Lech, Widenka, Kazimierz, Gerber, Witold, Pacholewicz, Jerzy, Bugajski, Pawel, Stepinski, Piotr, Maruszewski, Bohdan J., Cichon, Romuald, and Hrapkowicz, Tomasz

Abstract

Background: The objective of this multicenter study aimed to investigate the impact of sex on long-term survival among patients with multivessel coronary artery disease undergoing coronary artery bypass grafting (CABG) using multiple arterial grafting (MAG) or a single artery with saphenous vein grafts. Materials and methods: Data were obtained from the Polish National Registry of Cardiac Surgery Procedures database. This study included 81 136 patients who underwent CABG for multivessel disease between January 2012 and December 2020 (22.9 were women and 77.1% were men). MAG was performed in 8.3 and 11.7% of female and male patients, respectively. A 1:1 propensity score (PS)-matching was performed. Long-term mortality was compared between matched groups of men and women. Subgroup analyses of patients aged <70 and = 70 years, with an ejection fraction (EF) >40% and =40%, and with and without diabetes, obesity, peripheral artery disease (PAD), or chronic lung disease (CLD) were performed separately in women and men. Results: MAG was associated with lower long-term mortality than saphenous vein grafts in 1528 PS-matched female pairs [hazard ratio (HR): 0.74; 95% CI: 0.59-0.92; P =0.007) and 7283 PS-matched male pairs (HR: 0.80; 95% CI: 0.72-0.88; P<0.001). Subgroup analyses confirmed the results among female patients aged <70 years, with diabetes and EF > 40%, and without PAD or CLD, and of male patients aged <70 and =70 years; with EF >40%; with or without diabetes, obesity, or PAD; and without CLD. Conclusions: In patients undergoing CABG, MAG was associated with significantly improved survival in both sexes. The long-term benefits of MAG observed across subgroups of men and women support the consideration of a multiarterial revascularization strategy for a broader spectrum of patients. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Surgical ablation, left atrial appendage occlusion or both? Nationwide registry analysis of cardiac surgery patients with underlying atrial fibrillation.

Author

Pasierski, Michał, Batko, Jakub, Kuźma, Łukasz, Wańha, Wojciech, Jasiński, Marek, Widenka, Kazimierz, Deja, Marek, Bartuś, Krzysztof, Hirnle, Tomasz, Wojakowski, Wojciech, Lorusso, Roberto, Tobota, Zdzisław, Maruszewski, Bohdan J, Suwalski, Piotr, Kowalewski, Mariusz, and Investigators, KROK

Subjects
CARDIAC surgery, ATRIAL fibrillation, AORTIC valve surgery, CARDIAC patients, PROPORTIONAL hazards models
Abstract

Open in new tab Download slide OBJECTIVES The aim of this study was to evaluate in-hospital outcomes and long-term survival of patients undergoing cardiac surgery with preoperative atrial fibrillation (AF). We compared different strategies, including no-AF treatment, left atrial appendage occlusion (LAAO) alone, concomitant surgical ablation (SA) alone or both. METHODS A retrospective analysis using the KROK registry included all patients with preoperative diagnosis of AF who underwent cardiac surgery in Poland between between January 2012 and December 2022. Risk adjustment was performed using regression analysis with inverse probability weighting of propensity scores. We assessed 6-year survival with Cox proportional hazards models. Sensitivity analysis was performed based on index cardiac procedure. RESULTS Initially, 42 510 patients with preoperative AF were identified, and, after exclusion, 33 949 included in the final analysis. A total of 1107 (3.26%) received both SA and LAAO, 1484 (4.37%) received LAAO alone, 3921 (11.55%) SA alone and the remaining 27 437 (80.82%) had no AF-directed treatment. As compared to no treatment, all strategies were associated with survival benefit over 6-year follow-up. A gradient of treatment was observed with the highest benefit associated with SA + LAAO followed by SA alone and LAAO alone (log-rank P  < 0.001). Mortality benefits were reflected when stratified by surgery type with the exception of aortic valve surgery where LAAO alone fare worse than no treatment. CONCLUSIONS Among patients with preoperative AF undergoing cardiac surgery, surgical management of AF, particularly SA + LAAO, was associated with lower 6-year mortality. These findings support the benefits of incorporating SA and LAAO in the management of AF during cardiac surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Tricuspid intervention for less-than-severe regurgitation simultaneously with minimally invasive mitral valve surgery in patients with atrial fibrillation

Author

Kowalewski, Mariusz, primary, Dąbrowski, Emil Julian, additional, Kuźma, Łukasz, additional, Jasiński, Marek, additional, Pasierski, Michał, additional, Widenka, Kazimierz, additional, Hirnle, Tomasz, additional, Deja, Marek, additional, Bartuś, Krzysztof, additional, Lorusso, Roberto, additional, Tobota, Zdzisław, additional, Maruszewski, Bohdan, additional, Suwalski, Piotr, additional, and Investigators, KROK, additional

Published
2023
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18. The impact of sex on in-hospital and long-term mortality rates in patients undergoing surgical aortic valve replacement: The SAVR and SEX study

Author

Pawlik, Artur, primary, Litwinowicz, Radosław, additional, Kowalewski, Mariusz, additional, Suwalski, Piotr, additional, Deja, Marek, additional, Widenka, Kazimierz, additional, Tobota, Zdzisław, additional, Maruszewski, Bohdan, additional, Rzeszutko, Łukasz, additional, Januszek, Rafał, additional, Plens, Krzysztof, additional, Legutko, Jacek, additional, Bartuś, Stanisław, additional, Kapelak, Bogusław, additional, and Bartuś, Krzysztof, additional

Published
2023
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19. Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Author

Jacobs, Jeffrey P, primary, Krasemann, Thomas, additional, Herbst, Claudia, additional, Tobota, Zdzislaw, additional, Maruszewski, Bohdan, additional, Fragata, Jose, additional, Ebels, Tjark, additional, Vida, Vladimiro L, additional, Mattila, Ilkka, additional, Kansy, Andrzej, additional, Asfour, Boulos, additional, Hörer, Jürgen, additional, Lotto, Attilio A, additional, Çiçek, M Sertaç, additional, Liuba, Petru, additional, Dittrich, Sven, additional, Chessa, Massimo, additional, Bökenkamp, Regina, additional, Sharland, Gurleen, additional, Hanséus, Katarina, additional, Blom, Nico A, additional, and Sarris, George E, additional

Published
2023
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20. Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Author

Jacobs, Jeffrey P., primary, Krasemann, Thomas, additional, Herbst, Claudia, additional, Tobota, Zdzislaw, additional, Maruszewski, Bohdan, additional, Fragata, Jose, additional, Ebels, Tjark, additional, Vida, Vladimiro L., additional, Mattila, Ilkka, additional, Kansy, Andrzej, additional, Asfour, Boulos, additional, Hörer, Jürgen, additional, Lotto, Attilio A., additional, Sertaç Çiçek, M., additional, Liuba, Petru, additional, Dittrich, Sven, additional, Chessa, Massimo, additional, Bökenkamp, Regina, additional, Sharland, Gurleen, additional, Hanséus, Katarina, additional, Blom, Nico A., additional, and Sarris, George E., additional

Published
2023
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21. Prognostic Impact of Preoperative Atrial Fibrillation in Patients Undergoing Heart Surgery in Cardiogenic Shock

Author

Kowalewski, Mariusz, primary, Raffa, Giuseppe M., additional, Pasierski, Michał, additional, Kołodziejczak, Michalina, additional, Litwinowicz, Radosław, additional, Wańha, Wojciech, additional, Wojakowski, Wojciech, additional, Rogowski, Jan, additional, Jasiński, Marek, additional, Widenka, Kazimierz, additional, Hirnle, Tomasz, additional, Deja, Marek, additional, Bartus, Krzysztof, additional, Lorusso, Roberto, additional, Tobota, Zdzisław, additional, Maruszewski, Bohdan, additional, and Suwalski, Piotr, additional

Published
2023
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24. TGA + IVS + LVOTO: patterns of practice and outcomes

Author

Esmaeil, Husain, primary, Jacobs, Jeffrey P., additional, Tchervenkov, Christo I., additional, Kansy, Andrzej, additional, Maruszewski, Bohdan, additional, Tobota, Zdzislaw, additional, St. Louis, James D., additional, Kirklin, James K., additional, Overman, David M., additional, Vida, Vladimiro, additional, Herbst, Claudia, additional, Ashfaq, Awais, additional, Al-Halees, Zohair, additional, and Sarris, George E., additional

Published
2023
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25. Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database:The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Author

Jacobs, Jeffrey P., Krasemann, Thomas, Herbst, Claudia, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Ebels, Tjark, Vida, Vladimiro L., Mattila, Ilkka, Kansy, Andrzej, Asfour, Boulos, Hörer, Jürgen, Lotto, Attilio A., Çiçek, M. Sertaç, Liuba, Petru, Dittrich, Sven, Chessa, Massimo, Bökenkamp, Regina, Sharland, Gurleen, Hanséus, Katarina, Blom, Nico A., Sarris, George E., Jacobs, Jeffrey P., Krasemann, Thomas, Herbst, Claudia, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Ebels, Tjark, Vida, Vladimiro L., Mattila, Ilkka, Kansy, Andrzej, Asfour, Boulos, Hörer, Jürgen, Lotto, Attilio A., Çiçek, M. Sertaç, Liuba, Petru, Dittrich, Sven, Chessa, Massimo, Bökenkamp, Regina, Sharland, Gurleen, Hanséus, Katarina, Blom, Nico A., and Sarris, George E.

Abstract

The European Congenital Heart Surgeons Association (ECHSA) Congenital Database (CD) is the second largest clinical pediatric and congenital cardiac surgical database in the world and the largest in Europe, where various smaller national or regional databases exist. Despite the dramatic increase in interventional cardiology procedures over recent years, only scattered national or regional databases of such procedures exist in Europe. Most importantly, no congenital cardiac database exists in the world that seamlessly combines both surgical and interventional cardiology data on an international level; therefore, the outcomes of surgical and interventional procedures performed on the same or similar patients cannot easily be tracked, assessed, and analyzed. In order to fill this important gap in our capability to gather and analyze information on our common patients, ECHSA and The Association for European Paediatric and Congenital Cardiology (AEPC) have embarked on a collaborative effort to expand the ECHSA-CD with a new module designed to capture data about interventional cardiology procedures. The purpose of this manuscript is to describe the concept, the structure, and the function of the new AEPC Interventional Cardiology Part of the ECHSA-CD, as well as the potentially valuable synergies provided by the shared interventional and surgical analyses of outcomes of patients. The new AEPC Interventional Cardiology Part of the ECHSA-CD will allow centers to have access to robust surgical and transcatheter outcome data from their own center, as well as robust national and international aggregate outcome data for benchmarking. Each contributing center or department will have access to their own data, as well as aggregate data from the AEPC Interventional Cardiology Part of the ECHSA-CD. The new AEPC Interventional Cardiology Part of the ECHSA-CD will allow cardiology centers to have access to aggregate cardiology data, just as surgical centers already have access to ag

Published
2023

27. sj-docx-1-pch-10.1177_21501351231168829 - Supplemental material for Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Author

Jacobs, Jeffrey P, Krasemann, Thomas, Herbst, Claudia, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Ebels, Tjark, Vida, Vladimiro L, Mattila, Ilkka, Kansy, Andrzej, Asfour, Boulos, Hörer, Jürgen, Lotto, Attilio A, Çiçek, M Sertaç, Liuba, Petru, Dittrich, Sven, Chessa, Massimo, Bökenkamp, Regina, Sharland, Gurleen, Hanséus, Katarina, Blom, Nico A, and Sarris, George E

Subjects
Cardiology, Paediatrics, Surgery
Abstract

Supplemental material, sj-docx-1-pch-10.1177_21501351231168829 for Combining Congenital Heart Surgical and Interventional Cardiology Outcome Data in a Single Database: The Development of a Patient-Centered Collaboration of the European Congenital Heart Surgeons Association (ECHSA) and the Association for European Paediatric and Congenital Cardiology (AEPC) by Jeffrey P Jacobs, Thomas Krasemann, Claudia Herbst, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata, Tjark Ebels, Vladimiro L Vida, Ilkka Mattila, Andrzej Kansy, Boulos Asfour, Jürgen Hörer, Attilio A Lotto, M Sertaç Çiçek, Petru Liuba, Sven Dittrich, Massimo Chessa, Regina Bökenkamp, Gurleen Sharland, Katarina Hanséus, Nico A Blom and George E Sarris in World Journal for Pediatric and Congenital Heart Surgery

Published
2023
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28. Pulmonary Artery Banding for Functional Regeneration of End-Stage Dilated Cardiomyopathy in Young Children: World Network Report

Author

Schranz, Dietmar, Akintuerk, Hakan, Bailey, Leonard, Miera, Oliver, Danne, Friederike, Kavarana, Minoo N., Felmly, Mac, Panzer, Joseph, Bove, Thierry, De Wolf, Daniël, Recla, Sabine, Adachi, Iki, Dreyer, Jeffrery W., Chacon, Martin A., Tanidir, Cansaran, Guzeltas, Alper, Haydin, Sertac, Pretre, Rene, Di Bernado, Stefano, Gewillig, Marc, Cools, Bjorn, Gordon, Brent, Cheng, Dexter, Saucedo, Norma Balderrábano, Orellana, Julio Erdmenger, Cerdán, Alejandro Bolio, Ewert, Peter, Balling, Gunter, Padalino, Massimo, Stellin, Giovanni, Castaldi, Biagio, Koubský, Karel, Gebauer, Roman, Janousek, Jan, Maruszewski, Bohdan, Kansy, Andrzej, and Kozlowski, Michal

Published
2018
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30. Benchmarking in Congenital Heart Surgery Using Machine Learning-Derived Optimal Classification Trees

Author

Massachusetts Institute of Technology. Operations Research Center, Sloan School of Management, Bertsimas, Dimitris, Zhuo, Daisy, Levine, Jordan, Dunn, Jack, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Sarris, George E, Massachusetts Institute of Technology. Operations Research Center, Sloan School of Management, Bertsimas, Dimitris, Zhuo, Daisy, Levine, Jordan, Dunn, Jack, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, and Sarris, George E

Abstract

Background: We have previously shown that the machine learning methodology of optimal classification trees (OCTs) can accurately predict risk after congenital heart surgery (CHS). We have now applied this methodology to define benchmarking standards after CHS, permitting case-adjusted hospital-specific performance evaluation. Methods: The European Congenital Heart Surgeons Association Congenital Database data subset (31 792 patients) who had undergone any of the 10 “benchmark procedure group” primary procedures were analyzed. OCT models were built predicting hospital mortality (HM), and prolonged postoperative mechanical ventilatory support time (MVST) or length of hospital stay (LOS), thereby establishing case-adjusted benchmarking standards reflecting the overall performance of all participating hospitals, designated as the “virtual hospital.” These models were then used to predict individual hospitals’ expected outcomes (both aggregate and, importantly, for risk-matched patient cohorts) for their own specific cases and case-mix, based on OCT analysis of aggregate data from the “virtual hospital.” Results: The raw average rates were HM = 4.4%, MVST = 15.3%, and LOS = 15.5%. Of 64 participating centers, in comparison with each hospital's specific case-adjusted benchmark, 17.0% statistically (under 90% confidence intervals) overperformed and 26.4% underperformed with respect to the predicted outcomes for their own specific cases and case-mix. For MVST and LOS, overperformers were 34.0% and 26.4%, and underperformers were 28.3% and 43.4%, respectively. OCT analyses reveal hospital-specific patient cohorts of either overperformance or underperformance. Conclusions: OCT benchmarking analysis can assess hospital-specific case-adjusted performance after CHS, both overall and patient cohort-specific, serving as a tool for hospital self-assessment and quality improvement.

Published
2022

31. Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach

Author

Massachusetts Institute of Technology. Operations Research Center, Sloan School of Management, Bertsimas, Dimitris, Zhuo, Daisy, Dunn, Jack, Levine, Jordan, Zuccarelli, Eugenio, Smyrnakis, Nikos, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Sarris, George E, Massachusetts Institute of Technology. Operations Research Center, Sloan School of Management, Bertsimas, Dimitris, Zhuo, Daisy, Dunn, Jack, Levine, Jordan, Zuccarelli, Eugenio, Smyrnakis, Nikos, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, and Sarris, George E

Abstract

Objective: Risk assessment tools typically used in congenital heart surgery (CHS) assume that various possible risk factors interact in a linear and additive fashion, an assumption that may not reflect reality. Using artificial intelligence techniques, we sought to develop nonlinear models for predicting outcomes in CHS. Methods: We built machine learning (ML) models to predict mortality, postoperative mechanical ventilatory support time (MVST), and hospital length of stay (LOS) for patients who underwent CHS, based on data of more than 235,000 patients and 295,000 operations provided by the European Congenital Heart Surgeons Association Congenital Database. We used optimal classification trees (OCTs) methodology for its interpretability and accuracy, and compared to logistic regression and state-of-the-art ML methods (Random Forests, Gradient Boosting), reporting their area under the curve (AUC or c-statistic) for both training and testing data sets. Results: Optimal classification trees achieve outstanding performance across all three models (mortality AUC = 0.86, prolonged MVST AUC = 0.85, prolonged LOS AUC = 0.82), while being intuitively interpretable. The most significant predictors of mortality are procedure, age, and weight, followed by days since previous admission and any general preoperative patient risk factors. Conclusions: The nonlinear ML-based models of OCTs are intuitively interpretable and provide superior predictive power. The associated risk calculator allows easy, accurate, and understandable estimation of individual patient risks, in the theoretical framework of the average performance of all centers represented in the database. This methodology has the potential to facilitate decision-making and resource optimizatio

Published
2022

32. Early and late outcomes after surgical repair of congenital supravalvular aortic stenosis: a European Congenital Heart Surgeons Association multicentric study†

Author

Padalino, Massimo A., Frigo, Anna Chiara, Comisso, Marina, Kostolny, Martin, Omeje, Ikenna, Schreiber, Christian, von Ohain, Jelena Pabst, Cleuziou, Julie, Barron, David J., Meyns, Bart, Hraska, Viktor, Maruszewski, Bohdan, Kozlowski, Michal, Vricella, Luca A., Hibino, Narutoshi, Collica, Sarah, Berggren, Hakan, Synnergren, Mats, Lazarov, Stojan, Kalfa, David, Bacha, Emile, Pizarro, Christian, Hazekamp, Mark, Sojak, Vlado, Jacobs, Jeffrey P., Nosal, Matej, Fragata, Jose, Cicek, Sertac, Sarris, George E., Zografos, Panayotis, Vida, Vladimiro L., and Stellin, Giovanni

Published
2017
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33. Burden of hospitalizations in newly diagnosed heart failure patients in Poland: real world population based study in years 2013–2019

Author

Leszek, Przemysław, primary, Waś, Daniel, additional, Bartolik, Kinga, additional, Witczak, Kladiusz, additional, Kleinork, Andrzej, additional, Maruszewski, Bohdan, additional, Brukało, Katarzyna, additional, Rolska‐Wójcik, Paulina, additional, Celińska‐Spodar, Małgorzata, additional, Hryniewiecki, Tomasz, additional, and Załęska‐Kocięcka, Marta, additional

Published
2022
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34. sj-docx-3-pch-10.1177_21501351221103794 - Supplemental material for Ten Years of Data Verification: The European Congenital Heart Surgeons Association Congenital Database Audits

Author

Herbst, Claudia, Tobota, Zdzislaw, Urganci, Erhan, Sarris, George, Jacobs, Jeffrey P., Kansy, Andrzej, and Maruszewski, Bohdan

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental material, sj-docx-3-pch-10.1177_21501351221103794 for Ten Years of Data Verification: The European Congenital Heart Surgeons Association Congenital Database Audits by Claudia Herbst, Zdzislaw Tobota, Erhan Urganci, George Sarris, Jeffrey P. Jacobs, Andrzej Kansy and Bohdan Maruszewski in World Journal for Pediatric and Congenital Heart Surgery

Published
2022
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35. sj-docx-1-pch-10.1177_21501351221103794 - Supplemental material for Ten Years of Data Verification: The European Congenital Heart Surgeons Association Congenital Database Audits

Author

Herbst, Claudia, Tobota, Zdzislaw, Urganci, Erhan, Sarris, George, Jacobs, Jeffrey P., Kansy, Andrzej, and Maruszewski, Bohdan

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental material, sj-docx-1-pch-10.1177_21501351221103794 for Ten Years of Data Verification: The European Congenital Heart Surgeons Association Congenital Database Audits by Claudia Herbst, Zdzislaw Tobota, Erhan Urganci, George Sarris, Jeffrey P. Jacobs, Andrzej Kansy and Bohdan Maruszewski in World Journal for Pediatric and Congenital Heart Surgery

Published
2022
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36. Outcomes of Transannular Repair of Tetralogy of Fallot With a Contegra®Monocuspid Patch

Author

Wasiak, Aleksandra, Jaworski, Radoslaw, Pastuszko, Andrzej, Birbach, Mariusz, Kozlowski, Michal, Mirkowicz-Malek, Malgorzata, Friedman-Gruszczynska, Joanna, Maruszewski, Bohdan, and Kansy, Andrzej

Abstract

Background Surgical repair of tetralogy of Fallot (ToF) depends on the anatomical variations of the heart defect. A group of patients with a hypoplastic pulmonary valve annulus required a transannular patch. This study aimed to evaluate the early and late outcomes of ToF repair with a transannular Contegra® monocuspid patch in a single center.Methods A retrospective review of medical records was conducted. This study included 224 children with a median age of 13 months who underwent ToF repair with a Contegra® transannular patch in over 20 years of observation. The primary outcomes were hospital mortality and need for early reoperations. The secondary outcomes were late death and event-free survival.Results The hospital mortality in our group was 3.1%, whereas two patients required early reoperation. Three patients were excluded from the study because follow-up data were not available. In the remaining group of patients (212 patients), the median follow-up was 116 (range, 1-206) months. One patient died because of sudden cardiac arrest at home six months after surgery. Event-free survival was observed in 181 patients (85.4%), whereas the remaining 30 patients (14.1%) required graft replacement. The median time to reoperation was 99 (range, 4-183) months.Conclusions Although surgical treatment of ToF has been performed for more than 60 years worldwide, the optimal approach in children with a hypoplastic pulmonary valve annulus remains debatable. Among options, the Contegra® monocuspid patch can be effectively used in transannular repair of ToF with good long-term results.

Published
2023
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37. Repair or Replacement for Secondary Mitral Regurgitation: Results From Polish National Registry

Author

Deja, Marek A., primary, Malinowski, Marcin, additional, Widenka, Kazimierz, additional, Stożyński, Nikodem, additional, Bartuś, Krzysztof, additional, Kapelak, Bogusław, additional, Kuśmierczyk, Mariusz, additional, Hrapkowicz, Tomasz, additional, Suwalski, Piotr, additional, Jasiński, Marek, additional, Cisowski, Marek, additional, Tobota, Zdzisław, additional, Davis, Alan T., additional, and Maruszewski, Bohdan J., additional

Published
2022
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39. Perioperative Antibiotic Prophylaxis in Pediatric Cardiac Surgery—Simple Is Better.

Author

Burzyńska, Julia, Jaworski, Radoslaw, Maruszewski, Bohdan, Kansy, Andrzej, and Dzierżanowska-Fangrat, Katarzyna

Subjects
PEDIATRIC surgery, ANTIBIOTIC prophylaxis, CARDIAC surgery, SURGICAL site infections, ELECTIVE surgery
Abstract

Pediatric cardiac surgery requires perioperative antibiotic prophylaxis (PAP) to reduce the risk of surgical site infections. However, the complexity of these procedures and the metabolic immaturity of children impede the establishment of PAP regimens that are both efficacious and in line with antimicrobial stewardship (AMS). In this study, we compared two PAP regimens: cefazolin with gentamicin (in a retrospective group) and cefazolin only (prospectively) in children undergoing elective cardiac surgery. In the prospective group, additional elements of AMS were introduced, i.e., restricted access to cefazolin and more diligent use of empirical antibiotics proceeded by consultation with an AMS team. The rate of surgical site infections (SSI), the scope of PAP deviations, and the postoperative use of antibiotics other than PAP within 30 days after surgery were analyzed. There were no significant differences in the rate of SSIs between the groups (3.9% vs. 1.2% in the prospective and retrospective groups, respectively (p = 0.35)). However, in the prospective group, the PAP violation was significantly reduced compared with the retrospective group (full compliance with the PAP regimen was 45.5% vs. 4.8%, p < 0.001, respectively). In addition, a reduction of postoperative antibiotic use was observed in the prospective group (0.991 vs. 1.932 defined daily doses, respectively). [ABSTRACT FROM AUTHOR]

Published
2023
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40. A Machine Learning Approach

Author

Bertsimas, Dimitris, Zhuo, Daisy, Dunn, Jack, Levine, Jordan, Zuccarelli, Eugenio, Smyrnakis, Nikos, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, Sarris, George E., and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
congenital heart surgery, statistics-survival analysis, Surgery, statistics-risk analysis/modeling, Pediatrics, Perinatology, and Child Health, artificial intelligence, outcomes, Cardiology and Cardiovascular Medicine
Abstract

Funding Information: The authors wish to gratefully acknowledge the contributions of all ECDB participating surgeons and centers, as the contributions of the data concerning their patients who had surgery with CHD over the years have made this study possible. The author(s) received no financial support for the research, authorship, and/or publication of this article. Publisher Copyright: © The Author(s) 2021. Objective: Risk assessment tools typically used in congenital heart surgery (CHS) assume that various possible risk factors interact in a linear and additive fashion, an assumption that may not reflect reality. Using artificial intelligence techniques, we sought to develop nonlinear models for predicting outcomes in CHS. Methods: We built machine learning (ML) models to predict mortality, postoperative mechanical ventilatory support time (MVST), and hospital length of stay (LOS) for patients who underwent CHS, based on data of more than 235,000 patients and 295,000 operations provided by the European Congenital Heart Surgeons Association Congenital Database. We used optimal classification trees (OCTs) methodology for its interpretability and accuracy, and compared to logistic regression and state-of-the-art ML methods (Random Forests, Gradient Boosting), reporting their area under the curve (AUC or c-statistic) for both training and testing data sets. Results: Optimal classification trees achieve outstanding performance across all three models (mortality AUC = 0.86, prolonged MVST AUC = 0.85, prolonged LOS AUC = 0.82), while being intuitively interpretable. The most significant predictors of mortality are procedure, age, and weight, followed by days since previous admission and any general preoperative patient risk factors. Conclusions: The nonlinear ML-based models of OCTs are intuitively interpretable and provide superior predictive power. The associated risk calculator allows easy, accurate, and understandable estimation of individual patient risks, in the theoretical framework of the average performance of all centers represented in the database. This methodology has the potential to facilitate decision-making and resource optimization in CHS, enabling total quality management and precise benchmarking initiatives. publishersversion published

Published
2021

41. Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11)

Author

Jacobs, Jeffrey P., primary, Franklin, Rodney C. G., additional, Béland, Marie J., additional, Spicer, Diane E., additional, Colan, Steven D., additional, Walters, Henry L., additional, Bailliard, Frédérique, additional, Houyel, Lucile, additional, St. Louis, James D., additional, Lopez, Leo, additional, Aiello, Vera D., additional, Gaynor, J. William, additional, Krogmann, Otto N., additional, Kurosawa, Hiromi, additional, Maruszewski, Bohdan J., additional, Stellin, Giovanni, additional, Weinberg, Paul Morris, additional, Jacobs, Marshall Lewis, additional, Boris, Jeffrey R., additional, Cohen, Meryl S., additional, Everett, Allen D., additional, Giroud, Jorge M., additional, Guleserian, Kristine J., additional, Hughes, Marina L., additional, Juraszek, Amy L., additional, Seslar, Stephen P., additional, Shepard, Charles W., additional, Srivastava, Shubhika, additional, Cook, Andrew C., additional, Crucean, Adrian, additional, Hernandez, Lazaro E., additional, Loomba, Rohit S., additional, Rogers, Lindsay S., additional, Sanders, Stephen P., additional, Savla, Jill J., additional, Tierney, Elif Seda Selamet, additional, Tretter, Justin T., additional, Wang, Lianyi, additional, Elliott, Martin J., additional, Mavroudis, Constantine, additional, and Tchervenkov, Christo I., additional

Published
2021
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44. Current Status of Training and Certification for Congenital Heart Surgery Around the World: Proceedings of the Meetings of the Global Council on Education for Congenital Heart Surgery of the World Society for Pediatric and Congenital Heart Surgery

Author

Tchervenkov, Christo I., primary, Herbst, Claudia, additional, Jacobs, Jeffrey P., additional, Al-Halees, Zohair, additional, Edwin, Frank, additional, Dearani, Joseph A., additional, Finucane, Kirsten, additional, Sandoval, Nestor, additional, Sarris, George E., additional, Fragata, Jose, additional, Abdulgani, Hafil B., additional, Arboleda, Miguel, additional, Bacha, Emile A., additional, Barron, David J., additional, Becker, Pedro, additional, Boumzebra, Drissi, additional, Cervantes, Jorge, additional, Elgamal, Adel, additional, Helvind, Morten H., additional, Iyer, Krishna S., additional, Jatene, Marcelo B., additional, Jun, Tae-Gook, additional, Kirklin, James K., additional, Kreutzer, Christian, additional, Lee, Cheul, additional, Lotto, Attilio A., additional, Manuel, Valdano, additional, Maruszewski, Bohdan, additional, Najm, Hani, additional, Overman, David, additional, Rahmat, Budi, additional, Reddy, Darshan, additional, Sakamoto, Kisaburo, additional, Samankatiwat, Piya, additional, Sivalingam, Sivakumar, additional, St. Louis, James D., additional, Stellin, Giovanni, additional, Stephens, Elizabeth H., additional, Tretter, Justin T., additional, Truong, Nguyen Ly Thinh, additional, Tweddell, James S., additional, Vida, Vladimiro, additional, Vosloo, Susan, additional, Zhang, Hao, additional, Zheleva, Bistra, additional, and Jonas, Richard A., additional

Published
2021
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45. Pediatric Cardiac Surgical Patterns of Practice and Outcomes in Japan and Europe

Author

Hörer, Jürgen, primary, Hirata, Yasutaka, additional, Tachimori, Hisateru, additional, Ono, Masamichi, additional, Vida, Vladimiro, additional, Herbst, Claudia, additional, Kansy, Andrzej, additional, Jacobs, Jeffrey P., additional, Tobota, Zdzislaw, additional, Sakamoto, Kisaburo, additional, Ebels, Tjark, additional, and Maruszewski, Bohdan, additional

Published
2021
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46. Supplemental Material, sj-docx-1-pch-10.1177_2150135120988634 - Pediatric Cardiac Surgical Patterns of Practice and Outcomes in Japan and Europe

Author

Hörer, Jürgen, Hirata, Yasutaka, Hisateru Tachimori, Ono, Masamichi, Vida, Vladimiro, Herbst, Claudia, Kansy, Andrzej, Jacobs, Jeffrey P., Zdzislaw Tobota, Kisaburo Sakamoto, Ebels, Tjark, and Maruszewski, Bohdan

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental Material, sj-docx-1-pch-10.1177_2150135120988634 for Pediatric Cardiac Surgical Patterns of Practice and Outcomes in Japan and Europe by Jürgen Hörer, Yasutaka Hirata, Hisateru Tachimori, Masamichi Ono, Vladimiro Vida, Claudia Herbst, Andrzej Kansy, Jeffrey P. Jacobs, Zdzislaw Tobota, Kisaburo Sakamoto, Tjark Ebels and Bohdan Maruszewski in World Journal for Pediatric and Congenital Heart Surgery

Published
2021
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47. sj-docx-1-pch-10.1177_21501351211051227 - Supplemental material for Benchmarking in Congenital Heart Surgery Using Machine Learning-Derived Optimal Classification Trees

Author

Bertsimas, Dimitris, Zhuo, Daisy, Levine, Jordan, Dunn, Jack, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, and Sarris, George E

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental material, sj-docx-1-pch-10.1177_21501351211051227 for Benchmarking in Congenital Heart Surgery Using Machine Learning-Derived Optimal Classification Trees by Dimitris Bertsimas, Daisy Zhuo, Jordan Levine, Jack Dunn, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata and George E Sarris in World Journal for Pediatric and Congenital Heart Surgery

Published
2021
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48. Supplemental Material, sj-docx-1-pch-10.1177_21501351211007106 - Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach

Author

Bertsimas, Dimitris, Zhuo, Daisy, Dunn, Jack, Levine, Jordan, Zuccarelli, Eugenio, Smyrnakis, Nikos, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, and Sarris, George E.

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental Material, sj-docx-1-pch-10.1177_21501351211007106 for Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach by Dimitris Bertsimas, Daisy Zhuo, Jack Dunn, Jordan Levine, Eugenio Zuccarelli, Nikos Smyrnakis, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata and George E. Sarris in World Journal for Pediatric and Congenital Heart Surgery

Published
2021
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49. Supplemental Material, sj-pdf-1-pch-10.1177_21501351211032919 - Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11)

Author

Jacobs, Jeffrey P., Franklin, Rodney C. G., Béland, Marie J., Spicer, Diane E., Colan, Steven D., Walters, Henry L., Bailliard, Frédérique, Houyel, Lucile, St. Louis, James D., Lopez, Leo, Aiello, Vera D., Gaynor, J. William, Krogmann, Otto N., Kurosawa, Hiromi, Maruszewski, Bohdan J., Stellin, Giovanni, Weinberg, Paul Morris, Jacobs, Marshall Lewis, Boris, Jeffrey R., Cohen, Meryl S., Everett, Allen D., Giroud, Jorge M., Guleserian, Kristine J., Hughes, Marina L., Juraszek, Amy L., Seslar, Stephen P., Shepard, Charles W., Srivastava, Shubhika, Cook, Andrew C., Crucean, Adrian, Hernandez, Lazaro E., Loomba, Rohit S., Rogers, Lindsay S., Sanders, Stephen P., Savla, Jill J., Tierney, Elif Seda Selamet, Tretter, Justin T., Wang, Lianyi, Elliott, Martin J., Mavroudis, Constantine, and Tchervenkov, Christo I.

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental Material, sj-pdf-1-pch-10.1177_21501351211032919 for Nomenclature for Pediatric and Congenital Cardiac Care: Unification of Clinical and Administrative Nomenclature – The 2021 International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Revision of the International Classification of Diseases (ICD-11) by Jeffrey P. Jacobs, Rodney C. G. Franklin, Marie J. Béland, Diane E. Spicer, Steven D. Colan, Henry L. Walters, Frédérique Bailliard, Lucile Houyel, James D. St. Louis, Leo Lopez, Vera D. Aiello, J. William Gaynor, Otto N. Krogmann, Hiromi Kurosawa, Bohdan J. Maruszewski, Giovanni Stellin, Paul Morris Weinberg, Marshall Lewis Jacobs, Jeffrey R. Boris, Meryl S. Cohen, Allen D. Everett, Jorge M. Giroud, Kristine J. Guleserian, Marina L. Hughes, Amy L. Juraszek, Stephen P. Seslar, Charles W. Shepard, Shubhika Srivastava, Andrew C. Cook, Adrian Crucean, Lazaro E. Hernandez, Rohit S. Loomba, Lindsay S. Rogers, Stephen P. Sanders, Jill J. Savla, Elif Seda Selamet Tierney, Justin T. Tretter, Lianyi Wang, Martin J. Elliott, Constantine Mavroudis and Christo I. Tchervenkov in World Journal for Pediatric and Congenital Heart Surgery

Published
2021
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50. Supplemental Material, sj-pptx-1-pch-10.1177_21501351211007106 - Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach

Author

Bertsimas, Dimitris, Zhuo, Daisy, Dunn, Jack, Levine, Jordan, Zuccarelli, Eugenio, Smyrnakis, Nikos, Tobota, Zdzislaw, Maruszewski, Bohdan, Fragata, Jose, and Sarris, George E.

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery, 111403 Paediatrics
Abstract

Supplemental Material, sj-pptx-1-pch-10.1177_21501351211007106 for Adverse Outcomes Prediction for Congenital Heart Surgery: A Machine Learning Approach by Dimitris Bertsimas, Daisy Zhuo, Jack Dunn, Jordan Levine, Eugenio Zuccarelli, Nikos Smyrnakis, Zdzislaw Tobota, Bohdan Maruszewski, Jose Fragata and George E. Sarris in World Journal for Pediatric and Congenital Heart Surgery

Published
2021
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