7 results on '"Martine Mauget-Faysse"'
Search Results
2. A Randomized Controlled Trial of OPT-302, a VEGF-C/D Inhibitor for Neovascular Age-Related Macular Degeneration
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Timothy L. Jackson, Jason Slakter, Marc Buyse, Kun Wang, Pravin U. Dugel, Charles C. Wykoff, David S. Boyer, Michael Gerometta, Megan E. Baldwin, Clare F. Price, Bohdan Kousal, Jan Studnicka, Michal Veith, Catherine Creuzot-Garcher, Flore De Bats, David Gaucher, Martine Mauget-Faysse, Eric Souied, Ramin Tadayoni, Andrea Facsko, Agnes Kerénvi, Andras Papp, Alexis Tsorbatzoglou, Gabor Vogt, Yoreh Barak, Itay Chowers, Michaella Goldstein, Joel Hanhart, Haya Morori-Katz, Irit Rosenblatt, Alexander Rubowitz, Oren Tomkins Netzer, Francesco Bandello, Antonio Ciardella, Federico Ricci, Giovanni Staurenghi, Gianni Virgili, Kristine Baumane, Guna Laganovska, Signe Ozolina, Ilze Strautmane, Bartlomiej Kaluzny, Jerzy Mackiewicz, Marta Misiuk-Hoilo, Ewa Mrukwa-Kominek, Piotr Oleksy, Krystyna Raczynska, Tomasz Zarnowski, Alfredo Adan, Javier Araiz, Anna Boixadera, Alvaro Fernández-Vega, Alfredo Garcia Layana, Francisco Gomez-Ulla, Javier Montero, Jose Maria Ruiz Moreno, David Gilmour, Timothy Jackson, Sidath Liyanage, Luke Membrey, Geeta Menon, Niro Narendran, Sobha Sivaprasad, Daniel Alfaro, Andrew Antoszyk, Carl Baker, Ivan Batille, Brian Berger, David Boyer, William Bridges, Harold Brooks, David Brown, Margaret Chang, Daniel Chao, Sanford Chen, Courtney Crawford, Pravin Dugel, Alexander Eaton, David Eichenbaum, Jordana Fein, Leonard Feiner, Christina Flaxel, Frank Garber, Alan Gordon, Sunil Gupta, Curtis Haegedorn, George Hampton, Thomas Hanscom, Vrinda Hershberger, Peter Kaiser, Randy Katz, Arshad Khanani, Erik Kruger, Denis Marcus, Matthew Ohr, Sunil Patel, Joel Pearlman, Richard Pesavento, Dante Pieramici, John Pitcher, Jay Prensky, John Randolf, Carl Regillo, Steven Rose, Michael Samuel, Todd Schneiderman, Sumit Shah, Michael Singer, Nathan Steinle, Glenn Stoller, Alan Thach, John Thompson, Michael Varenhorst, Alan Wagner, Joseph Walker, John Wells, Jonathan Williams, Robert Wong, and Charles Wykoff
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Ophthalmology - Published
- 2023
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3. Prospective longitudinal study on prognostic factors of visual recovery and structural change after a first episode of optic neuritis
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Romain Deschamps, Natalia Shor, Catherine Vignal, Jessica Guillaume, Marine Boudot de la Motte, Flore Salviat, Augustin Lecler, Romain Marignier, Rabih Hage, Sarah Coulette, Samuel Bidot, Antoine Gueguen, Martine Mauget‐Faysse, Caroline Bensa, Vivien Vasseur, Olivier Gout, and Cedric Lamirel
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Multiple Sclerosis ,Optic Neuritis ,Neurology ,Vision Disorders ,Humans ,Longitudinal Studies ,Prospective Studies ,Neurology (clinical) ,Prognosis ,Tomography, Optical Coherence - Abstract
This study was undertaken to determine the role of optical coherence tomography (OCT) in predicting the final visual and structural outcome, and to evaluate the correlation between functional eye outcome and retinal changes, in patients with a first episode of optic neuritis (ON).In this prospective study, consecutive adult patients with acute ON underwent ophthalmological evaluation at baseline and at 1 and 12 months, including OCT measurements of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell and inner plexiform layer, and inner nuclear layer thicknesses; high- and low-contrast visual acuity; visual field assessment; and baseline brain magnetic resonance imaging. Univariate and multivariate linear regressions were used to assess predictive factors of outcome. Correlations between 12-month visual function and retinal structure were estimated by Spearman coefficients. Two groups of patients were analyzed, with or without multiple sclerosis (MS).Among 116 patients, 79 (68.1%) had MS, and 37 (31.9%) had ON not related to MS (including 19 idiopathic [i.e., isolated] ON, and 13 and five with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies, respectively). We found no independent predictive factor of visual and retinal outcome. Analysis of the relationship between the visual field test (mean deviation) and pRNFL thickness demonstrated a threshold of 75.4 μm and 66.4 μm, below which the mean deviation was worse, for patients with MS (p = 0.007) and without MS (p lt; 0.001), respectively.We found that inner retinal layer measurements during the first month are not predictive of final outcome. The critical threshold of axonal integrity, below which visual function is damaged, is different between patients with and without MS.
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- 2022
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4. Multimodal Imaging-Based Central Serous Chorioretinopathy Classification
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Jay Chhablani, Francine Behar Cohen, Pauline Aymard, Talal Beydoun, Elodie Bousquet, Alejandra Daruich-Matet, Alexandre Matet, Min Zhao, Chui Ming Gemmy Cheung, K. Bailey Freund, Richard Spaide, Alain Gaudric, Camiel J.F. Boon, E.H.C. van Dijk, Andrew Lotery, Marco Lupidi, Irmela Mantel, Thibaud Mathis, Martine Mauget-Faysse, Sarah Mrejen, Giuseppe Querques, Jorge Ruiz-Medrano, Jose-Maria Ruiz-Moreno, Shiri Shulman, Sumit Randhir Singh, Sobha Sivaprasad, Suzanne Yzer, Sandrine Zweifel, and ANS - Complex Trait Genetics
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Multimodal imaging ,medicine.medical_specialty ,Fundus Oculi ,business.industry ,MEDLINE ,Multimodal Imaging ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Ophthalmology ,Serous fluid ,Text mining ,Central Serous Chorioretinopathy ,Humans ,Medicine ,Medical physics ,Fluorescein Angiography ,business ,Tomography, Optical Coherence - Abstract
Item does not contain fulltext
- Published
- 2020
5. Spectralis High Magnification Module imaging in a case of Multiple Evanescent White Dot Syndrome
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Vivien Vasseur, Nicolas Arej, M.D., Anne-Sophie Alonso, Justine Lafolie, Manon Philibert, M.D., Catherine Vignal-Clermont, M.D., and Martine Mauget-Faÿsse, M.D.
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High magnification module ,Multiple evanescent white dot syndrome ,Photoreceptors ,Retina ,Imaging ,Ophthalmology ,RE1-994 - Abstract
Purpose: To report the use of Spectralis High Magnification Module (HMM) as part of multimodal imaging in Multiple Evanescent White Dot Syndrome (MEWDS). Observations: HMM imaging showed a blurry mosaic pattern corresponding to MEWDS-related photoreceptors’ lesions. These abnormalities remained detectable at later stages of the disease while other imaging modalities were negative. Conclusions and importance: HMM can be a useful technique to monitor the structure of the outer retina during the different stages of MEWDS.
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- 2020
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6. Assessment of Spontaneous Retinal Arterial Pulsations in Acute Central Retinal Vein Occlusions
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Nicolas Arej, Vivien Vasseur, Elyse Jabbour, Anthony Manassero, Céline Giraud, Sébastien Bruneau, Yannick Le Mer, and Martine Mauget-Faÿsse
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Ophthalmology ,RE1-994 - Abstract
Central retinal vein occlusion (CRVO) is a common retinal disease. Recent works mentioned spontaneous retinal arterial pulsations (SRAPs) as a feature of some CRVOs. This is a retrospective study on patients presenting with CRVO who were followed up for at least 6 months. The objective was to identify SRAP in the acute phase of the disease and determine their relationship with patients’ characteristics and visual prognosis. A 10-second infrared film centered on the optic disc was recorded within a month of the onset of symptoms, and SRAPs were detected in two-thirds of the cases. Patients with SRAP were significantly younger than those without SRAP. Mean central macular thickness was significantly higher in the absence of SRAP, which was translated into a more severe macular edema; however, this difference faded with time. BCVA tended to be higher in the presence of SRAP at the 6-month follow-up when adjusted to baseline. This study demonstrates that SRAPs are a frequent finding, easily detected by infrared fundus video recording, and associated with a younger age and lesser macular edema.
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- 2020
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7. Dietary, environmental, and genetic risk factors of Extensive Macular Atrophy with Pseudodrusen, a severe bilateral macular atrophy of middle-aged patients
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Aymeric Douillard, Marie-Christine Picot, Cécile Delcourt, Sabine Defoort-Dhellemmes, Nour Al-Dain Marzouka, Annie Lacroux, Xavier Zanlonghi, Isabelle Drumare, Elsa Jozefowicz, Béatrice Bocquet, Corinne Baudoin, Sarah Perez-Roustit, Sophie Arsène, Valérie Gissot, François Devin, Carl Arndt, Benjamin Wolff, Martine Mauget-Faÿsse, Maddalena Quaranta, Thibault Mura, Dominique Deplanque, Hassiba Oubraham, Salomon Yves Cohen, Pierre Gastaud, Olivia Zambrowski, Catherine Creuzot-Garcher, Saddek Mohand Saïd, José-Alain Sahel, Eric Souied, Solange Milazzo, Rocio Blanco Garavito, Vasiliki Kalatzis, Bernard Puech, Christian Hamel, Isabelle Audo, and Isabelle Meunier
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Medicine ,Science - Abstract
Abstract EMAP (Extensive Macular Atrophy with Pseudodrusen) is a maculopathy we recently described that shares pseudodrusen and geographic atrophy with Age-related Macular Disease (AMD). EMAP differs from AMD by an earlier age of onset (50-55 years) and a characteristic natural history comprising a night blindness followed by a severe visual loss. In a prospective case-control study, ten referral centers included 115 EMAP (70 women, 45 men) patients and 345 matched controls to appraise dietary, environmental, and genetic risk factors. The incidence of EMAP (mean 2.95/1.106) was lower in Provence-Côte d’Azur with a Mediterranean diet (1.9/1.106), and higher in regions with intensive farming or industrialized activities (5 to 20/1.106). EMAP patients reported toxic exposure during professional activities (OR 2.29). The frequencies of common AMD complement factor risk alleles were comparable in EMAP. By contrast, only one EMAP patient had a rare AMD variant. This study suggests that EMAP could be a neurodegenerative disorder caused by lifelong toxic exposure and that it is associated with a chronic inflammation and abnormal complement pathway regulation. This leads to diffuse subretinal deposits with rod dysfunction and cone apoptosis around the age of 50 with characteristic extensive macular atrophy and paving stones in the far peripheral retina.
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- 2018
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