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Introduction: Cardiac MRI (CMR) is the gold standard for right ventricular function (RVF) because echo assessment is limited. Potential echo parameters to assess RVF include RV fractional area change (FAC), RV free wall strain (FWS), and tricuspid annular plane systolic excursion (TAPSE) on apical 4-chamber (A4C) view. We compared a new Artificial Intelligence method that tracks the RV almost instantaneously in a single 4-chamber view (AI, LVivo RV®, DiA Imaging, Figure) to quantify RVF vs CMR. Methods: We compared AI RVF against CMR in 125 pts. Abnormal LVEF and RVEF were defined as 2 ) tests were calculated for each variable against CMR RVEF. Results: Of the 125 pts, 55 (44%) were female with median age 55 [Q1 44, Q3 67] years. Thirty pts (24%) had abnormal RVEF and 78 (62.4%) had abnormal LVEF by CMR. All pts with abnormal RVEF had abnormal LVEF. Compared to CMR, AI RV sensitivities and specificities for abnormal RVEF were: FAC 87% and 60%, FWS 80% and 61%, TAPSE 77% and 54%, any 2 criteria 83% and 61%, and all 3 criteria 63% and 69%. AI RV χ 2 values were: FAC 19.9 (p Conclusions: This is the first validation of a novel AI method (LVivo RV®) that can detect RV dysfunction using 3 standard RV measurements from a single A4C view with good sensitivity and specificity compared to volumetric CMR as the gold standard.

Infant colic (IC) is a common condition in young babies seen by primary care health professionals, especially health visitors. Nevertheless, the diagnostic criteria for IC are vague, which has resulted in a lack of clarity in published guidance on its causes and treatment. Credence has been given to alternative therapies, while health professionals are sceptical about the efficacy of over-the-counter treatments. Some 4004 parents of babies considered to have IC participated in this retrospective real world evidence study on the efficacy of a simeticone suspension in the treatment of IC. They were recruited via social media sources and were eligible for inclusion if their baby had received at least one dose of the simeticone suspension. Data were collected via an online questionnaire. The results showed that crying and discomfort-associated behaviour reduced and the babies' sleeping patterns improved following use of the suspension. More than two-thirds (69.7%) of respondents, who either used the suspension on its own or alongside another treatment, reported improvements in the signs of IC within one day. Almost all (93.2%) considered that its use was associated with either complete resolution of IC or had some effect on symptoms.

This retrospective open study evaluating the efficacy of Sudocrem Antiseptic Healing Cream (SAHC) in infantile nappy rash (NR) was based on real-world evidence collected using an online questionnaire that included Likert scales. Participants who had used SAHC in the past (n=2159) were recruited via social media and email. A total of 1818 respondents who had treated NR in the previous 6 months were asked to take part in the study. Over 50% of respondents saw an improvement in NR on the same day that treatment was started, and within 3 days 94.5% of respondents reported an improvement in NR. Of 1804 subjects who answered the question, 72.5% indicated that the NR had completely healed within 3 days of starting treatment and by the fifth day, 94.7% said that the NR had completely healed. A total of 71% of 1793 respondents said that an episode of NR had either no or minimal impact disrupting their normal lives, but 29% reported a noticeable impact, even though evidence suggests that mild to moderate nappy rash can be treated quickly. Based on this real-world retrospective study, the evidence suggests SAHC is rapidly effective, reduces signs and symptoms of inflammation, and heals NR.

We present a case of acute blunt traumatic bilateral renal artery thrombosis in the setting of multisystem trauma. Catheter-directed thrombolysis with tissue plasminogen activator afforded kidney salvage with return of glomerular filtration rate to normal values at the time of patient discharge. included a small left subdural hematoma, a left hemothorax and lung contusion. Bilateral renal infarctions with traumatic renal vascular thrombosis, and a right renal pelvis tear with minimal contrast extravasation was demonstrated. The remaining abdominal viscera were without acute injury. The right renal infarct was extensive compared to the left and involved the majority of the right kidney (Figure 1). A visceral angiogram confirmed bilateral renal infarctions, greater in the right kidney. The thrombus on the right renal artery was large and extending to several interlobar arteries (Figure 2). A catheter was placed in the right main renal artery for infusion of tissue plasminogen activator (TPA) at 2 mg/hr for four hours after an initial bolus of 8 mg for a total dose of 16 mg. The time from injury to the treatment with TPA was approximately 5 hours. The patient was also placed on systemic heparin drip due to the bilateral nature of the renal artery thrombosis. This decision was made following consultation with a neurosurgeon as the patient also had an acute subdural bleed. A collaborative decision was reached to proceed with

Masa remaja merupakan masa yang amat meresahkan (unsettling) di dalam kehidupan seseorang (masa transisi) karena banyak perubahan yang dialami baik secara fisik, maupun perubahan lain dari masa kanak-kanak ke masa dewasa. Masa remaja juga merupakan masa bertanya artinya mereka mulai mempertanyakan banyak hal yang sudah diajarkan kepada mereka dan seringkali remaja menolak sebagian atau bahkan seluruh nilai-nilai dan kepercayaan yang dipelajari sewaktu masa kanak-kanak. Dengan memahami perubahan pola pikir dalam diri remaja ke arah yang lebih rasional inilah maka akan berbahaya jika gereja hanya memberikan para remaja dengan aktivitas atau kegiatan gerejawi yang tidak berarti. Menurut penulis, kegiatan tahun remaja di HKBP Kedaton pada tahun 2014 terkesan monoton karena kegiatannya hanya mengikuti kegiatan-kegiatan tahun lalu seperti: Cerdas Cermat Alkitab (CCA), Cerdas Cermat Buku Ende (CCBE), tortor dan vocal grup. HKBP Kedaton belum bersungguh-sungguh dalam membuat sebuah kegiatan terutama di tahun 2014, Kegiatan tahun remaja HKBP dan ini merupakan kegiatan besar yang dirayakan oleh seluruh Gereja HKBP di dunia. Dalam tulisan ini, penulis menggunakan teori perkembangan iman James Fowler dan perkembangan remaja. Dalam tulisan ini pula, penulis menggunakan metode deskripsi-analisis dan jenis penelitian kualitatif. Dalam hal ini penulis menggunakan teknik wawancara dan focus grup discussion dengan responden yaitu pendeta ressort, pendeta remaja-pemuda, majelis di kategorial remaja, ketua remaja dan ketua panitia tahun remaja HKBP. Kegiatan yang telah dilaksanakan di HKBP Kedaton dalam rangka tahun remaja HKBP tidak mempertimbangkan tahapan perkembangan iman remaja ( sintetis-konvensional) dan tanpa mempertimbangkan aspek ego, fisik, moral, kognitif dari remaja sehingga tidak ada tujuan yang ingin dicapai dari kegiatan tersebut