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Quito, the capital city of Ecuador hosting ∼2 million inhabitants, lies on the hanging wall of a ∼60-km-long reverse fault offsetting the Inter-Andean Valley in the northern Andes. Such an active fault poses a significant risk, enhanced by the high density of population and overall poor building construction quality. Here, we constrain the present-day strain accumulation associated with the Quito fault with new Global Positioning System (GPS) data and Persistent Scatterer Interferometric Synthetic Aperture Radar (PS-InSAR) analysis. Far field GPS data indicate 3–5 mm yr–1 of horizontal shortening accommodated across the fault system. In the central segment of the fault, both GPS and PS-InSAR results highlight a sharp velocity gradient, which attests for creep taking place along the shallowest portion of the fault. Smoother velocity gradients observed along the other segments indicate that the amount of shallow creep decreases north and south of the central segment. 2-D elastic models using GPS horizontal velocity indicate very shallow (<1 km) locking depth for the central segment, increasing to a few kilometres south and north of it. Including InSAR results in the inversion requires locking to vary both along dip and along strike. 3-D spatially variable locking models show that shallow creep occurs along the central 20-km-long segment. North and south of the central segment, the interseismic coupling is less resolved, and data still allows significant slip deficit to accumulate. Using the interseismic moment deficit buildup resulting from our inversions and the seismicity rate, we estimate recurrence time for magnitude 6.5 + earthquake to be between 200 and 1200 yr. Finally, PS-InSAR time-series identify a 2 cm transient deformation that occurred on a secondary thrust, east of the main Quito fault between 1995 and 1997. [ABSTRACT FROM AUTHOR]