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Resumen La presente investigación tuvo como objetivo principal identificar los factores considerados claves en la competitividad de un destino turístico, llevada a cabo en el municipio de San Carlos, Antioquia, Colombia. Mediante un análisis factorial exploratorio y confirmatorio, los resultados muestran que esta región será más competitiva en materia de turismo, si desarrolla los recursos inherentes, los recursos creados, y los factores de apoyo, y si promueve una mejor gestión del destino. Estos resultados tienen implicaciones importantes para el diseño de la política pública turística, tanto en la región como en otras afines. Abstract The purpose of this research is to identify the key factors explaining the competitiveness of a tourist destination, namely San Carlos in Antioquia, Colombia. The main results of the exploratory and confirmatory factor analysis show that this Colombian region will fully materialize its tourism competitive potential if it develops more integrated support action plans, supports the effective exploitation of inherent resources, and promotes a better management of the destination. These results have important implications for the design of public tourism policy, both in the region and in other territories.

This publication calls for a broad reflection on the current problems of education in Colombia and in the world by stressing the importance of developing critical thinking as a crosscutting competence to achieve major development goals set out in the international agenda. This necessarily implies transformations that must be promoted from the educational field so that they can permeate individuals, institutions, social practices, and society in general. One concern this book addresses is related to the deterioration of the minimum conditions for a healthy coexistence due to the conflict experienced in the different contexts in Colombia, ranging from the family to the school and social contexts. This shows a structural problem that leads to the need to re-think education from disruptive premises and paradigms that can provide a significant orientation to pedagogical practice. We consider that this is possible within the framework of a philosophical education where man can be understood as an end in himself and not as a means to achieve interests outside the needs and potentialities of his own nature. Esta obra invita a una amplia reflexión sobre la problemática actual de la educación en Colombia y en el mundo, insistiendo en la importancia del desarrollo del pensamiento crítico como una competencia transversal para el logro de los grandes objetivos de desarrollo consignados en la agenda internacional, lo cual supone, necesariamente, transformaciones que deben ser impulsadas desde el ámbito educativo para que puedan permear al individuo, las instituciones, las prácticas sociales y la sociedad en general. Una de las preocupaciones que se aborda en el libro tiene que ver con el deterioro de las condiciones mínimas para una sana convivencia debido a la conflictividad que se experimenta en los diferentes contextos en Colombia, que van de lo familiar, a lo escolar y social. Lo que expresa un problema estructural que remite a la necesidad de repensar la educación desde premisas y paradigmas disruptivos, que logren aportar una orientación significativa a la práctica pedagógica. Lo cual consideramos es posible en el marco de una educación filosófica, en la que se encauce el hombre como un fin en sí mismo y no como un medio para el logro de intereses por fuera de las necesidades y potencialidades que reviste su propia naturaleza. Esta obra convida a uma ampla reflexão sobre os problemas atuais da educação na Colômbia e no mundo, insistindo na importância do desenvolvimento do pensamento crítico como competência transversal para a realização dos grandes objetivos de desenvolvimento estabelecidos na agenda internacional, o que implica necessariamente em transformações que devem ser promovidas a partir da esfera educacional para que possam permear o indivíduo, as instituições, as práticas sociais e a sociedade em geral. Uma das preocupações abordadas no livro tem a ver com a deterioração das condições mínimas para uma convivência saudável devido ao conflito que se vive em diferentes contextos na Colômbia, desde a família, até os contextos escolar e social. Isto expressa um problema estrutural que se refere à necessidade de repensar a educação a partir de premissas e paradigmas perturbadores que podem fornecer uma orientação significativa para a prática pedagógica. Acreditamos que isto é possível no âmbito de uma educação filosófica, na qual o homem é canalizado como um fim em si mesmo e não como um meio para alcançar interesses fora das necessidades e potencialidades de sua própria natureza.

Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: >= 0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903), European Research Council (ERC) European Commission 20132018 340918, Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensive sobre la actividad fisica Cohorte PREDIMED-Plus grant, Recercaixa Grant 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017 European Cooperation in Science and Technology (COST) European Commission CA16112, Balearic Islands Health Research Institute (IDISBA), European Commission CIBEROBN CB06/03 CB12/03 European Commission European Commission Joint Research Centre EAT2BENICE_H2020_SFS2016, Fundacio La Marato TV3 201630.10, Fernando Tarongi Bauza Grant, 'Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund' PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017, the Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI14/00853 PI14/01374 PI14/00972 PI14/00728 PI14/01471 PI16/00473 PI16/00662 PI16/01873 PI16/01094 PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI19/01226, "Spanish government, ISCIII, through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund" PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158

Graficas UML Las actividades deportivas han tomado importancia en las personas, por el modelo de mejoramiento en cuestiones de salud. Estos mejoramientos hacen que tomemos nuevos hábitos los cuales queremos llegar a tener un registro de cada actividad que realicemos. Por eso la nueva tendencia en tecnología es brindar al usuario un alcance más accesible en cuanto a la movilidad y en el alcance de la información registrada mediante aplicaciones deportivas. De acuerdo con el contexto tecnológico, se focaliza mediante el uso de aplicaciones deportivas el registro de actividades como lo puede ser el ciclismo, patinaje o trote. Por esa razón es importante contar con el monitoreo o seguimiento constante de las actividades y sus registros, construyendo un historial de actividades y alcances que brindan a sus clientes resultados que se pueden visualizar inmediatamente. ImfitApp, pretende que, por medio de una aplicación móvil, se pueda tener este completo surtido de actividades que harán al deportista mejorar es sus hábitos generando el uso adecuado de estas actividades mencionadas, obteniendo un registro estadístico y conservando un historial. Sports activities have become important in people, due to the improvement model in health issues. These improvements make us take new habits which we want to have a record of each activity we do. That is why the new trend in technology is to provide the user with a more accessible scope in terms of mobility and in the scope of the information registered through sports applications. According to the technological context, the registration of activities such as cycling, skating or jogging is focused through the use of sports applications. For this reason, it is important to have constant monitoring or follow-up of activities and their records, building a history of activities and scopes that provide your clients with results that they can see directly. ImfitApp, claims that, through a mobile application, you can have this complete assortment of activities that can be athletes improve their habits by generating the proper use of these activities, obtaining a statistical record and preserving a history.

We describe a non-invasive technique to isolate genomic DNA from connective tissue present in the antlers of deer of the genus Hippocamelus. This method is simpler and more effective than conventional more-destructive procedures which damage the collection material. This method is applicable to all cervids that annually regenerate their antlers.

Additional file 1: Figure S1. K-mer distribution. Figure S2. Detailed sampling map of all sequenced individual. Figure S3. Treemix phylogeny and variance plot. Figure S4. Introgression segments into llama (fd). Figure S5. PSMC plot for all four SAC species. Figure S6. MSMC plots for (a) guanaco; (b) llama; (c) vicuña; (d) alpaca. Figure S7. Manhattan plot of selection signatures detected in the comparison between vicuña and alpaca (XP-EHH upper, FST bottom). Figure S8. Manhattan plot of selection signatures detected in the comparison between guanaco and llama (XP-EHH upper, FST bottom). Figure S9. Comparison between region-wide FST and SNP distribution among wild ancestors and domestic relatives for the OR5 and OR2 olfactory receptor family. Figure S10. Comparison between region-wide FST and SNP distribution among wild ancestors and domestic relatives for the HoxD gene clusters and OLA1 gene related to morphology development. Figure S11. SNP distribution among wild ancestors and domestic relatives with evidence of introgression from llama to alpaca on Chr10. Figure S12. SNP distribution among wild ancestors and domestic relatives with evidence of introgression from alpaca to llama: CORIN, FGF21, GNAS, TAGLN. Figure S13. cDNA sequence, expression histogram, Western Blot and protein expression histogram for the alpaca skin FGF5 expression analysis. Figure S14. The phylogeny of South American camelids with segments of high guanaco ancestry removed from alpaca genomes. Table S1. Statistics of the clean data for the de novo genomes. Table S2a-c. Assembly statistics for each species. Table S3. Genome coverage assessed by transcriptome unigenes. Table S4. The BUSCO results of the three new assembled SAC genomes. Table S5. K-mer analysis. Table S6. Aligned sequence data for de novo genomes. Table S6a. Aligned sequence between the de novo genomes and related species: pairwise whole-genome alignment was performed using LASTZ. Table S6b. Synteny analysis for aligned de novo genomes. Table S7a-c. the number of predicted genes for each species. Table S8. Sampling details. Table S9. Resequencing data summary. Table S10. ABBA-BABA statistics. Table S11. Introgressed segments from llama into alpaca using fd and LAI. Table S12. Introgressed segments from alpaca into llama using fd and LAI. Table S13. Introgressed segment and genes showing low and high LAI introgression on the inferred X-chromosome of alpaca. Table S14. Selection signatures detected in comparisons between vicuña and alpaca (XP-EHH). Table S15. Selection signatures detected in comparisons between vicuña and alpaca (FST). Table S16. Selection signatures detected in comparisons between vicuña and alpaca (overlap between methods). Table S17. Selection signatures detected in comparisons between guanaco and llama (XP-EHH). Table S18. Selection signatures detected in comparisons between guanaco and llama (FST). Table S19. Selection signatures detected in comparisons between guanaco and llama (overlap between methods). Table S20. Olfactory receptor gene numbers in South American camelids, compared to the cow. Table S21. PCR and qPCR primers. Table S22. Blood and skin tissue expression counts for de novo sequenced SACs and Chinese alpaca, respectively. Supplementary Note S1 - De novo Genome Sequencing a. Genome size estimation. b. De novo sequencing, assembly and annotation. Supplementary Note S2 - Introgression analysis. Supplementary Note S3- Sample collection, DNA extraction and permits.

Introducción: La frecuencia de consumo de alimentos y bebidas en los niños depende de diferentes patrones de comportamiento. Objetivos:Evaluar el efecto de la duración del sueño de los niños sobre la frecuencia de consumo de alimentos, y describir las frecuencias de consumo según su estado ponderal y el nivel de educación familiar. Método: Se estudiaron 2721 niños y niñas de 6 a 9 años del Estudio ALADINO 2015 en Andalucía. Se recogieron el número de horas de sueño y la frecuencia semanal de consumo de 24 grupos de alimentos. Se calculó el estado ponderal mediante el índice de masa corporal, con los estándares de crecimiento de la OMS, se recogió el nivel educativo de los padres y madres. Las frecuencias medias de consumo de alimentos se calcularon según la duración del sueño (mayor o menor que la media diaria). Se ajustaron modelos de regresión logística para evaluar las asociaciones independientes de las horas de sueño sobre las frecuencias de consumo de alimentos (variables resultado), ajustando por edad, sexo, nivel de educación de los padres, estado ponderal y disponibilidad de medios de ocio pasivo en la habitación. Resultados: Dormir suficiente número de horas se asocia con mayor probabilidad de consumir fruta (OR:1,23;IC95%:1,06-1,42) y verdura (OR:1,19;IC95%:1,01-1,40), y menor probabilidad de consumir refrescos azucarados (OR:0,80;IC95%:0,67-0,97), zumos con azúcar (OR:0,79;IC95%:0,64-0,99), snacks salados (OR:0,46;IC95%:0,33-0,65), chocolates o caramelos (OR:0,71;IC95%:0,55-0,92), y galletas y bollos (OR:0,70;IC95%:0,58-0,84). El consumo de frutas y verduras medio semanal es mayor en niños sin sobrepeso y en hijos de padres con mayor nivel educativo. Conclusiones: Una duración de sueño adecuada está asociada con mayor consumo de frutas y verduras, y menos alimentos con alta densidad de energía. Mejorar la higiene del sueño es fundamental para mejorar los hábitos alimentarios, y especialmente en niños con sobrepeso, y de menor nivel educativo Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Additional file 2. Review history.