Author: "Mallon, Patrick W." / Publication Year Range: Last 10 years - Searchworks@Jio Institute Digital Library Search Results

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255 results on '"Mallon, Patrick W."'

1. SARS-CoV-2 Seropositivity in Urban Population of Wild Fallow Deer, Dublin, Ireland, 2020-2022

Author: Purves, Kevin, Brown, Hannah, Haverty, Ruth, Ryan, Andrew, Griffin, Laura L., McCormack, Janet, O'Reilly, Sophie, Mallon, Patrick W., Gautier, Virginie, Cassidy, Joseph P., Fabre, Aurelie, Carr, Michael J., Gonzalez, Gabriel, Ciuti, Simone, and Fletcher, Nicola F.
Subjects: Wildlife diseases -- Statistics -- Risk factors, White-tailed deer -- Statistics -- Health aspects, Urban fauna -- Statistics -- Health aspects
Abstract: SARS-CoV-2, a member of the family Coronaviridae, is a positive-sense, single-stranded RNA (ssRNA) virus that has an [approximately equal to] 30-kb genome (1). During the COVID-19 pandemic, SARS-CoV-2 has caused [...]
Published: 2024
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2. Challenges in assessing the immunization status of adults in Germany—lessons from a population-based VACCELERATE survey on polio vaccination

Author: Nacov, Julia A., Stemler, Jannik, Salmanton-García, Jon, Cremer, Louise M., Zeitlinger, Markus, Mallon, Patrick W. G., Pana, Zoi Dorothea, Schmitt, Heinz-Josef, and Cornely, Oliver A.
Published: 2024
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3. Impact of vaccination and variants of concern on long COVID clinical phenotypes

Author: Kenny, Grace, McCann, Kathleen, O’Brien, Conor, O’Broin, Cathal, Tinago, Willard, Yousif, Obada, O’Gorman, Tessa, Cotter, Aoife G., Lambert, John S., Feeney, Eoin R., de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Savinelli, Stefano, and Mallon, Patrick W. G.
Published: 2023
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4. Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time

Author: Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., and Mallon, Patrick W. G.
Published: 2023
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5. Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity

Author: MacCann, Rachel, Ghosh, Tarini Shankar, Garcia Leon, Alejandro Abner, Li, Junhui, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Tinago, Willard, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G., de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Landay, Alan, O'Toole, Paul W., and Mallon, Patrick W.
Published: 2024
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6. Predicting the next pandemic: VACCELERATE ranking of the WorldHealth Organization's Blueprint forAction toPreventEpidemics

Author: Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin-Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia-Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz-Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, and Cornely, Oliver A.
Published: 2024
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7. Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination

Author: Kelly, Neil E. Wrigley, De Barra, Conor, Shaamile, Ferrah, Holland, Aisling, Shaw, Liam, Mallon, Patrick W. G., O’Connell, Jean, Hogan, Andrew E., and O’Shea, Donal
Published: 2023
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8. Prediction of low pulse oxygen saturation in COVID-19 using remote monitoring post hospital discharge

Author: Doheny, Emer P., Flood, Matthew, Ryan, Silke, McCarthy, Cormac, O'Carroll, Orla, O'Seaghdha, Conall, Mallon, Patrick W., Feeney, Eoin R., Keatings, Vera M., Wilson, Moya, Kennedy, Niall, Gannon, Avril, Edwards, Colin, and Lowery, Madeleine M.
Published: 2023
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9. Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Author: Fogarty, Helen, Ward, Soracha E., Townsend, Liam, Karampini, Ellie, Elliott, Stephanie, Conlon, Niall, Dunne, Jean, Kiersey, Rachel, Naughton, Aifric, Gardiner, Mary, Byrne, Mary, Bergin, Colm, O'Sullivan, Jamie M., Martin-Loeches, Ignacio, Nadarajan, Parthiban, Bannan, Ciaran, Mallon, Patrick W., Curley, Gerard F., Preston, Roger J.S., Rehill, Aisling M., Baker, Ross I., Cheallaigh, Cliona Ni, O'Donnell, James S., O’Connell, Niamh, Ryan, Kevin, Kenny, Dermot, and Fazavana, Judicael
Published: 2022
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10. Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

Author: McElvaney, Oisin F., Asakura, Takanori, Meinig, Suzanne L., Torres-Castillo, Jose L., Hagan, Robert S., Gabillard-Lefort, Claudie, Murphy, Mark P., Thorne, Leigh B., Borczuk, Alain, Reeves, Emer P., Zumwalt, Ross E., Mikami, Yu, Carroll, Tomas P., Okuda, Kenichi, Hogan, Grace, McElvaney, Oliver J., Clarke, Jennifer, McEvoy, Natalie L., Mallon, Patrick W., McCarthy, Cormac, Curley, Ger, Wolfgang, Matthew C., Boucher, Richard C., and McElvaney, Noel G.
Published: 2022
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11. Navigating the Landscape of B Cell Mediated Immunity and Antibody Monitoring in SARS-CoV-2 Vaccine Efficacy: Tools, Strategies and Clinical Trial Insights.

Author: O'Reilly, Sophie, Byrne, Joanne, Feeney, Eoin R., Mallon, Patrick W. G., and Gautier, Virginie
Subjects: IMMUNOLOGIC memory, VACCINE trials, IMMUNE response, VACCINE approval, HUMORAL immunity
Abstract: Correlates of Protection (CoP) are biomarkers above a defined threshold that can replace clinical outcomes as primary endpoints, predicting vaccine effectiveness to support the approval of new vaccines or follow up studies. In the context of COVID-19 vaccination, CoPs can help address challenges such as demonstrating vaccine effectiveness in special populations, against emerging SARS-CoV-2 variants or determining the durability of vaccine-elicited immunity. While anti-spike IgG titres and viral neutralising capacity have been characterised as CoPs for COVID-19 vaccination, the contribution of other components of the humoral immune response to immediate and long-term protective immunity is less well characterised. This review examines the evidence supporting the use of CoPs in COVID-19 clinical vaccine trials, and how they can be used to define a protective threshold of immunity. It also highlights alternative humoral immune biomarkers, including Fc effector function, mucosal immunity, and the generation of long-lived plasma and memory B cells and discuss how these can be applied to clinical studies and the tools available to study them. [ABSTRACT FROM AUTHOR]
Published: 2024
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12. Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus.

Author: McGettrick, Padraig, Tinago, Willard, O'Brien, Julie, Miles, Sarah, Lawler, Leo, Garcia-Leon, Alejandro, Mahon, Niall, Lambert, John, Sheehan, Gerard, Landay, Alan, Sabin, Caroline A, Cotter, Aoife G, Mallon, Patrick W G, and Study, for the HIV Understanding the Pathology of Comorbid Disease in HIV-Infected Individuals With Coronary Artery Disease (UPBEAT) Study Group and the All Ireland Infectious Diseases (AIID) Cohort
Subjects: HIV, PRINCIPAL components analysis, HIERARCHICAL clustering (Cluster analysis), INDIVIDUALIZED medicine, PHENOTYPES
Abstract: Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH. [ABSTRACT FROM AUTHOR]
Published: 2024
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13. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author: Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, and Forghieri, Fabio
Published: 2024

14. Obesity in HIV infection: host-pathogen interaction

Author: Savinelli, Stefano, Wrigley Kelly, Neil E., Feeney, Eoin R., OʼShea, Donal B., Hogan, Andrew E., Overton, Edgar T., Landay, Alan L., and Mallon, Patrick W.
Published: 2022
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15. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author: Salmanton-García, Jon, primary, Wipfler, Pauline, additional, Leckler, Janina, additional, Nauclér, Pontus, additional, Mallon, Patrick W., additional, Bruijning-Verhagen, Patricia C.J.L., additional, Schmitt, Heinz-Joseph, additional, Bethe, Ullrich, additional, Olesen, Ole F., additional, Stewart, Fiona A., additional, Albus, Kerstin, additional, Cornely, Oliver A., additional, Busch, Martin, additional, Seifert, Ulrike, additional, Widmer, Andreas, additional, Nagao, Miki, additional, Rello, Jordi, additional, Todorova, Tatina, additional, Cviljević, Sabina, additional, Heath, Christopher H., additional, Jančorienė, Ligita, additional, Fischer, Thea Koelsen, additional, Orth, Hans Martin, additional, Johansen, Isik Somuncu, additional, Doymaz, Mehmet, additional, Tragiannidis, Athanasios, additional, Löscher, Thomas, additional, Xu, Jin-Fu, additional, Husa, Petr, additional, Oteo, José Antonio, additional, Issack, Mohammad I., additional, Zeitlinger, Markus, additional, Le Grand, Roger, additional, Zdziarski, Przemysław, additional, Demirkan, Fatih, additional, Amador, Paloma Merino, additional, García-Lozano, Tomás, additional, Cao, Qing, additional, Vázquez, Lourdes, additional, Caeiro, Juan Pablo, additional, Hermans, Peter, additional, Nahrwar, Shahroch, additional, Avsar, Korkut, additional, Kumar, Deepak, additional, Fernández, Norma, additional, Mardani, Masoud, additional, Segal, Esther, additional, Pan, Angelo, additional, Gkentzi, Despoina, additional, Gioula, Georgia, additional, Cortés, Jorge Alberto, additional, Oliveira, Joaquim, additional, van Damme, Pierre, additional, Bin Mohd Zaili, Mohd Zaki, additional, Antinori, Spinello, additional, Zablockienė, Birutė, additional, Papazisis, Georgios, additional, Aneke, Chioma Inyang, additional, Valerio, Maricela, additional, McConkey, Samuel, additional, Aujayeb, Avinash, additional, Azzini, Anna Maria, additional, Roganović, Jelena, additional, Greve-Isdahl Mohn, Kristin, additional, Kremsner, Peter, additional, Gkrania-Klotsas, Effrossyni, additional, Corzo, Dora, additional, Khanna, Nina, additional, Smiatacz, Tomasz, additional, Scheithauer, Simone, additional, Merelli, Maria, additional, Klempa, Boris, additional, Vrḫovac, Radovan, additional, Ruggiero, Antonio, additional, Chaudhary, Pankaj, additional, Maquera-Afaray, Julio, additional, Ekkelenkamp, Miquel, additional, Jindra, Pavel, additional, Pantić, Nikola, additional, Guerra, Gemma Jiménez, additional, Weiss, Guenter, additional, Roohi, Behrad, additional, Argyropoulos, Christos D., additional, Silfverdal, Sven Aprne, additional, van Praet, Jens, additional, Bal, Zumrut Sahbudak, additional, Kanj, Souha, additional, Young, Barnaby, additional, Pana, Zoi Dorothea, additional, Roilides, Emmanuel, additional, Stearns, Stephen C., additional, Wauters, Joost, additional, Baño, Jesús Rodríguez, additional, Pletz, Mathias W., additional, Travar, Maja, additional, Kühn, Steven, additional, Riera, Fernando, additional, Cornely, Daniel, additional, Laura, Vlad Jeni, additional, Koehler, Philipp, additional, Eley, Brian, additional, Nair, Pravin K., additional, Ciesek, Sandra, additional, Olaru, Ioana Diana, additional, Marques, Laura, additional, Pontali, Emanuele, additional, Naunheim, Alexandra, additional, Lieb, Adrian, additional, Gerhard, Markus, additional, Farooqi, Joveria Qais, additional, Turtle, Lance, additional, Méndez, Gustavo Adolfo, additional, Cox, Rebecca Jane, additional, Goodman, Nigel, additional, Caceca, Billie, additional, Pemán, Javier, additional, Dawood, Halima, additional, Askling, Helena Hervius, additional, Fomsgaard, Anders, additional, Hernández, Alejandra Calderón, additional, Staehelin, Cornelia, additional, Liu, Chia-Ying, additional, Icardi, Giancarlo, additional, Castagnola, Elio, additional, Salzer, Helmut J.F., additional, Lundgren, Jens, additional, Javadli, Samir, additional, and Forghieri, Fabio, additional
Published: 2024
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16. The Challenges of Vaccine Trial Participation among Underserved and Hard-to-Reach Communities: An Internal Expert Consultation of the VACCELERATE Consortium

Author: Poulimeneas, Dimitrios, primary, Koniordou, Markela, additional, Kousi, Dimitra, additional, Merakou, Christina, additional, Kopsidas, Ioannis, additional, Tsopela, Grammatiki Christina, additional, Argyropoulos, Christos D., additional, Themistocleous, Sophia C., additional, Shiamakkides, George, additional, Constantinou, Marinos, additional, Alexandrou, Alexandra, additional, Noula, Evgenia, additional, Nearchou, Andria, additional, Salmanton-García, Jon, additional, Stewart, Fiona A., additional, Heringer, Sarah, additional, Albus, Kerstin, additional, Álvarez-Barco, Elena, additional, Macken, Alan, additional, Di Marzo, Romina, additional, Luis, Catarina, additional, Valle-Simón, Paula, additional, Askling, Helena H., additional, Hellemans, Margot, additional, Spivak, Orly, additional, Davis, Ruth Joanna, additional, Azzini, Anna Maria, additional, Barta, Imre, additional, Součková, Lenka, additional, Jancoriene, Ligita, additional, Akova, Murat, additional, Mallon, Patrick W. G., additional, Olesen, Ole F., additional, Frias-Iniesta, Jesus, additional, van Damme, Pierre, additional, Tóth, Krisztina, additional, Cohen-Kandli, Miriam, additional, Cox, Rebecca Jane, additional, Husa, Petr, additional, Nauclér, Pontus, additional, Marques, Laura, additional, Ochando, Jordi, additional, Tacconelli, Evelina, additional, Zeitlinger, Markus, additional, Cornely, Oliver A., additional, Pana, Zoi Dorothea, additional, and Zaoutis, Theoklis E., additional
Published: 2023
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17. Tenofovir alafenamide plus emtricitabine versus abacavir plus lamivudine for treatment of virologically suppressed HIV-1-infected adults: a randomised, double-blind, active-controlled, non-inferiority phase 3 trial

Author: Winston, Alan, Post, Frank A, DeJesus, Edwin, Podzamczer, Daniel, Di Perri, Giovanni, Estrada, Vicente, Raffi, François, Ruane, Peter, Peyrani, Paula, Crofoot, Gordon, Mallon, Patrick W G, Castelli, Francesco, Yan, Mingjin, Cox, Stephanie, Das, Moupali, Cheng, Andrew, and Rhee, Martin S
Published: 2018
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18. Body composition and metabolic outcomes after 96 weeks of treatment with ritonavir-boosted lopinavir plus either nucleoside or nucleotide reverse transcriptase inhibitors or raltegravir in patients with HIV with virological failure of a standard first-line antiretroviral therapy regimen: a substudy of the randomised, open-label, non-inferiority SECOND-LINE study

Author: Boyd, Mark A, Amin, Janaki, Mallon, Patrick W G, Kumarasamy, Nagalingeswaran, Lombaard, Johan, Wood, Robin, Chetchotisakd, Ploenchan, Phanuphak, Praphan, Mohapi, Lerato, Azwa, Iskandar, Belloso, Waldo H, Molina, Jean-Michel, Hoy, Jennifer, Moore, Cecilia L, Emery, Sean, and Cooper, David A
Published: 2017
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19. Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection

Author: Freitas, Inês T., Tinago, Willard, Sawa, Hirofumi, McAndrews, Julie, Doak, Brenda, Prior-Fuller, Charlotte, Sheehan, Gerard, Lambert, John S., Muldoon, Eavan, Cotter, Aoife G., Hall, William W., Mallon, Patrick W. G., and Carr, Michael J.
Published: 2020
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20. Anticholinergic medications associated with falls and frailty in people with HIV.

Author: Doctor, Jessica, Winston, Alan, Vera, Jaime H., Post, Frank A., Boffito, Marta, Mallon, Patrick W. G., Anderson, Jane, Prechtl, Christina, Williams, Ian, Johnson, Margaret, Bagkeris, Emmanouil, Sachikonye, Memory, and Sabin, Caroline A.
Subjects: HIV-positive persons, RESEARCH, PARASYMPATHOMIMETIC agents, FRAIL elderly, CONFIDENCE intervals, RISK assessment, PATIENTS' attitudes, ACCIDENTAL falls, QUESTIONNAIRES, DESCRIPTIVE statistics, DRUG monitoring, RESEARCH funding, STATISTICAL correlation, LOGISTIC regression analysis, ODDS ratio, MIDDLE age, OLD age
Abstract: Background: Anticholinergic medications (ACMs) are associated with poorer age‐related outcomes, including falls and frailty. We investigate associations between ACM use and recurrent falls and frailty among older (aged ≥50 years) people with HIV in the POPPY study. Methods: Anticholinergic potential of co‐medications at study entry was coded using the anticholinergic burden score, anticholinergic risk score, and Scottish Intercollegiate Guidelines Network score; drugs scoring ≥1 on any scale were defined as ACM. Associations with recurrent falls (two or more falls in the previous 28 days) and frailty (modified Fried's) were assessed using logistic regression adjusting for (1) possible demographic/lifestyle confounders and (2) clinical factors and depressive symptoms (Patient Health Questionnaire‐9). Results: ACM use was reported by 193 (28%) of 699 participants, with 64 (9%) receiving two or more ACM; commonly prescribed ACMs were codeine (12%), citalopram (12%), loperamide (9%), and amitriptyline (7%). Falls were reported in 63/673 (9%), and 126/609 (21%) met the frailty criteria. Both recurrent falls and frailty were more common in ACM users than in non‐users (recurrent falls: 17% in users vs. 6% in non‐users, p < 0.001; frailty: 32% vs. 17%, respectively, p < 0.001). Use of two or more ACMs was associated with increased odds of falls after adjustment for demographic/lifestyle factors (odds ratio [OR] 4.53; 95% confidence interval [CI] 2.06–9.98) and for clinical factors (OR 3.58; 95% CI 1.37–9.38). Similar albeit weaker associations were seen with frailty (OR 2.26; 95% CI 1.09–4.70 and OR 2.12; 95% CI 0.89–5.0, respectively). Conclusions: ACM are commonly prescribed for people living with HIV, and evidence exists for an association with recurrent falls and frailty. Clinicians should be alert to this and reduce ACM exposure where possible. [ABSTRACT FROM AUTHOR]
Published: 2023
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21. Associations Between Widespread Pain and Sleep Quality in People With HIV

Author: Sabin, Caroline A., Harding, Richard, Doyle, Nicki, Redline, Susan, de Francesco, Davide, Mallon, Patrick W. G., Post, Frank A., Boffito, Marta, Sachikonye, Memory, Geressu, Adam, Winston, Alan, and Kunisaki, Ken M.
Published: 2020
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22. Investigating the effect of antiretroviral switch to tenofovir alafenamide on lipid profiles in people living with HIV

Author: Lacey, Aoife, Savinelli, Stefano, Barco, Elena Alvarez, Macken, Alan, Cotter, Aoife G., Sheehan, Gerard, Lambert, John S., Muldoon, Eavan, Feeney, Eoin, Mallon, Patrick W., and Tinago, Willard
Published: 2020
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23. Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity

Author: MacCann, Rachel, primary, Leon, Alejandro Abner Garcia, additional, Gonzalez, Gabriel, additional, Carr, Michael J., additional, Feeney, Eoin R., additional, Yousif, Obada, additional, Cotter, Aoife G., additional, de Barra, Eoghan, additional, Sadlier, Corinna, additional, Doran, Peter, additional, and Mallon, Patrick W., additional
Published: 2023
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24. Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets

Author: Kenny, Grace, primary, Townsend, Liam, additional, Savinelli, Stefano, additional, and Mallon, Patrick W. G., additional
Published: 2023
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25. Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening.

Author: O'Reilly, Sophie, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Gu, Lili, Angeliadis, Matthew, de Masson d'Autume, Valentin, Garcia Leon, Alejandro, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick W. G., and Gautier, Virginie
Subjects: VACCINE trials, IMMUNOGLOBULINS, MEDICAL screening, CLINICAL medicine, SARS-CoV-2 Omicron variant, CONVALESCENT plasma
Abstract: Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cytometry-based micro-neutralisation test to evaluate Neutralising Antibody (NAb) responses against live SARS-CoV-2 Wild Type and Variants of Concern (VOC) in convalescent/vaccinated populations. Flow Cytometry-Based Micro-Neutralisation Test (Micro-NT) was performed in 96-well plates using clinical isolates WT-B, WT-B.1.177.18 and/or VOCs Beta and Omicron. Plasma samples (All Ireland Infectious Diseases (AIID) Cohort) were serially diluted (8 points, half-log) from 1:20 and pre-incubated with SARS-CoV-2 (1h, 37°C). Virus-plasma mixture were added onto Vero E6 or Vero E6/TMPRSS2 cells for 18h. Percentage infected cells was analysed by automated flow cytometry following trypsinisation, fixation and SARS-CoV-2 Nucleoprotein intracellular staining. Half-maximal Neutralisation Titres (NT50) were determined using non-linear regression. Our assay was compared to Plaque Reduction Neutralisation Test (PRNT) and validated against the First WHO International Standard for anti-SARS-CoV-2 immunoglobulin. Both Micro-NT and PRNT achieved comparable NT50 values. Further validation showed adequate correlation with PRNT using a panel of secondary standards of clinical convalescent and vaccinated plasma samples. We found the assay to be reproducible through measuring both repeatability and intermediate precision. Screening 190 convalescent samples and 11 COVID-19 naive controls (AIID cohort) we demonstrated that Micro-NT has broad dynamic range differentiating NT50s <1/20 to >1/5000. We could also characterise immune-escape VOC Beta and Omicron BA.5, achieving fold-reductions in neutralising capacity similar to those published. Our flow cytometry-based Micro-NT is a robust and reliable assay to quantify NAb titres, and has been selected as an endpoint in clinical trials. [ABSTRACT FROM AUTHOR]
Published: 2023
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26. Changes in multimorbidity burden over a 3–5 year period among people with HIV

Author: Sukumaran, Luxsena, primary, De Francesco, Davide, additional, Winston, Alan, additional, Mallon, Patrick W. G., additional, Doyle, Nicki, additional, Anderson, Jane, additional, Boffito, Marta, additional, Williams, Ian, additional, Post, Frank A., additional, Vera, Jaime, additional, Sachikonye, Memory, additional, Johnson, Margaret A., additional, and Sabin, Caroline A., additional
Published: 2023
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27. A novel antiviral formulation containing caprylic acid inhibits SARS-CoV-2 infection of a human bronchial epithelial cell model

Author: Purves, Kevin, primary, Haverty, Ruth, additional, O'Neill, Tiina, additional, Folan, David, additional, O'Reilly, Sophie, additional, Baird, Alan W., additional, Scholz, Dimitri, additional, Mallon, Patrick W., additional, Gautier, Virginie, additional, Folan, Michael, additional, and Fletcher, Nicola F., additional
Published: 2023
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28. Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19

Author: Karampini, Ellie, primary, Fogarty, Helen, additional, Elliott, Stephanie, additional, Morrin, Hannah, additional, Bergin, Colm, additional, O’Sullivan, Jamie M., additional, Byrne, Mary, additional, Martin-Loeches, Ignacio, additional, Mallon, Patrick W., additional, Curley, Gerard F., additional, Glavey, Siobhan, additional, Baker, Ross I., additional, Lavin, M., additional, Preston, Roger J.S., additional, Cheallaigh, Cliona Ni, additional, Ward, Soracha E., additional, and O’Donnell, James S., additional
Published: 2023
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29. Bone mineral density and inflammatory and bone biomarkers after darunavir–ritonavir combined with either raltegravir or tenofovir–emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial

Author: Bernardino, Jose I, Mocroft, Amanda, Mallon, Patrick W, Wallet, Cedrick, Gerstoft, Jan, Russell, Charlotte, Reiss, Peter, Katlama, Christine, De Wit, Stephane, Richert, Laura, Babiker, Abdel, Buño, Antonio, Castagna, Antonella, Girard, Pierre-Marie, Chene, Genevieve, Raffi, Francois, and Arribas, Jose R
Published: 2015
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30. 77. Demonstration of stable clusters of symptoms in long COVID

Author: Kenny, Grace, primary, McCann, Kathleen, additional, O'Brien, Conor, additional, Savinelli, Stefano, additional, O'Broin, Cathal, additional, Tinago, Willard, additional, Yousif, Obada, additional, Lambert, John S, additional, Feeney, Eoin, additional, de Barra, Eoghan, additional, Sadlier, Corinna, additional, Landay, Alan, additional, Doran, Peter, additional, and Mallon, Patrick W G, additional
Published: 2022
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31. Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination

Author: Kelly, Neil E. Wrigley, primary, De Barra, Conor, additional, Shaamile, Ferrah, additional, Holland, Aisling, additional, Shaw, Liam, additional, Mallon, Patrick W. G., additional, O’Connell, Jean, additional, Hogan, Andrew E., additional, and O’Shea, Donal, additional
Published: 2022
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32. A novel antiviral formulation inhibits SARS-CoV-2 infection of human bronchial epithelium

Author: Purves, Kevin, primary, Haverty, Ruth, additional, O’Neill, Tiina, additional, Folan, David, additional, O’Reilly, Sophie, additional, Baird, Alan W., additional, Scholz, Dimitri, additional, Mallon, Patrick W, additional, Gautier, Virginie, additional, Folan, Michael, additional, and Fletcher, Nicola F, additional
Published: 2022
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33. Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study

Author: Bakewell, Nicholas, primary, Sabin, Caroline A, additional, Negi, Riya, additional, Garcia-Leon, Alejandro, additional, Winston, Alan, additional, Sachikonye, Memory, additional, Doyle, Nicki, additional, Redline, Susan, additional, Mallon, Patrick W G, additional, and Kunisaki, Ken M, additional
Published: 2022
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34. Individuals with obesity who survive SARS‐CoV ‐2 infection have preserved antigen‐specific T cell frequencies

Author: Wrigley Kelly, Neil E., primary, Kenny, Grace, additional, Cassidy, Féaron C., additional, Garcia‐Leon, Alejandro A., additional, De Barra, Conor, additional, Mallon, Patrick W. G., additional, Hogan, Andrew E., additional, and O'Shea, Donal, additional
Published: 2022
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35. List of Contributors

Author: Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional
Published: 2017
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36. Issues in the Aging HIV-Positive Patient

Author: Mallon, Patrick W., primary and Powderly, William G., additional
Published: 2017
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37. COVID19- clinical presentation and therapeutic considerations

Author: Kenny, Grace and Mallon, Patrick W.
Subjects: 0301 basic medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), media_common.quotation_subject, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biophysics, Severe disease, Immunothearpies, Abnormal host response, Therapeutics, Antiviral Agents, Biochemistry, Article, Mini review, 03 medical and health sciences, Presentation, Clinical trials, 0302 clinical medicine, Pandemic, Humans, Medicine, Intensive care medicine, Pandemics, Molecular Biology, media_common, SARS-CoV-2, business.industry, COVID-19, Cell Biology, COVID-19 Drug Treatment, Clinical trial, 030104 developmental biology, 030220 oncology & carcinogenesis, business
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection.
Published: 2021
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38. Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021

Author: Ryom, Lene, De Miguel, Rosa, Cotter, Aoife Grace, Podlekareva, Daria, Beguelin, Charles, Waalewijn, Hylke, Arribas, Josè R., Mallon, Patrick W. G., Marzolini, Catia, Kirk, Ole, Bamford, Alasdair, Rauch, Andri, Molina, Jean Michel, Kowalska, Justyna Dominika, Guaraldi, Giovanni, Winston, Alan, Boesecke, Christoph, Cinque, Paola, Welch, Steven, Collins, Simon, Behrens, Georg M.N., Ryom, Lene, De Miguel, Rosa, Cotter, Aoife Grace, Podlekareva, Daria, Beguelin, Charles, Waalewijn, Hylke, Arribas, Josè R., Mallon, Patrick W. G., Marzolini, Catia, Kirk, Ole, Bamford, Alasdair, Rauch, Andri, Molina, Jean Michel, Kowalska, Justyna Dominika, Guaraldi, Giovanni, Winston, Alan, Boesecke, Christoph, Cinque, Paola, Welch, Steven, Collins, Simon, and Behrens, Georg M.N.
Abstract: Background: The European AIDS Clinical Society (EACS) Guidelines were revised in 2021 for the 17th time with updates on all aspects of HIV care. Key points of the Guidelines update: Version 11.0 of the Guidelines recommend six first-line treatment options for antiretroviral treatment (ART)-naïve adults: tenofovir-based backbone plus an unboosted integrase inhibitor or plus doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. Recommendations on preferred and alternative first-line combinations from birth to adolescence were included in the new paediatric section made with Penta. Long-acting cabotegravir plus rilpivirine was included as a switch option and, along with fostemsavir, was added to all drug–drug interaction (DDI) tables. Four new DDI tables for anti-tuberculosis drugs, anxiolytics, hormone replacement therapy and COVID-19 therapies were introduced, as well as guidance on screening and management of anxiety disorders, transgender health, sexual health for women and menopause. The sections on frailty, obesity and cancer were expanded, and recommendations for the management of people with diabetes and cardiovascular disease risk were revised extensively. Treatment of recently acquired hepatitis C is recommended with ongoing risk behaviour to reduce transmission. Bulevirtide was included as a treatment option for the hepatitis Delta virus. Drug-resistant tuberculosis guidance was adjusted in accordance with the 2020 World Health Organization recommendations. Finally, there is new guidance on COVID-19 management with a focus on continuance of HIV care. Conclusions: In 2021, the EACS Guidelines were updated extensively and broadened to include new sections. The recommendations are available as a free app, in interactive web format and as an online pdf.
Published: 2022

39. Lipid Changes After Switch From TDF to TAF in the OPERA Cohort: LDL Cholesterol and Triglycerides

Author: Mallon, Patrick W G, primary, Brunet, Laurence, additional, Fusco, Jennifer S, additional, Prajapati, Girish, additional, Beyer, Andrew, additional, Fusco, Gregory P, additional, and Wohlfeiler, Michael B, additional
Published: 2021
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40. Persistent endotheliopathy in the pathogenesis of long COVID syndrome

Author: Fogarty, Helen, Townsend, Liam, Morrin, Hannah, Ahmad, Azaz, Comerford, Claire, Karampini, Ellie, Englert, Hanna, Byrne, Mary, Bergin, Colm, O’Sullivan, Jamie M., Martin‐Loeches, Ignacio, Nadarajan, Parthiban, Bannan, Ciaran, Mallon, Patrick W., Curley, Gerard F., Preston, Roger J.S., Rehill, Aisling M., McGonagle, Dennis, Ni Cheallaigh, Cliona, Baker, Ross I., Renné, Thomas, Ward, Soracha E., O’Donnell, James S., O’Connell, Niamh, Ryan, Kevin, Kenny, Dermot, and Fazavana, Judicael
Published: 2021
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41. ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19

Author: Ward, Soracha E., Fogarty, Helen, Karampini, Ellie, Lavin, Michelle, Schneppenheim, Sonja, Dittmer, Rita, Morrin, Hannah, Glavey, Siobhan, Ni Cheallaigh, Cliona, Bergin, Colm, Martin‐Loeches, Ignacio, Mallon, Patrick W., Curley, Gerard F., Baker, Ross I., Budde, Ulrich, O’Sullivan, Jamie M., O’Donnell, James S., O’Connell, Niamh, Byrne, Mary, Townsend, Liam, McEvoy, Natalie L., Clarke, Jennifer, Boylan, Maria, Alalqam, Razi, Worrall, Amy P., Kelly, Claire, de Barra, Eoghan, Preston, Roger, and Kenny, Dermot
Published: 2021
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42. Risk factors and impact of patterns of co-occurring comorbidities in people living with HIV

Author: de Francesco, Davide, Underwood, Jonathan, Bagkeris, Emmanouil, Anderson, Jane, Williams, Ian, Vera Rojas, Jaime H, Post, Frank A, Boffito, Marta, Johnson, Margaret, Mallon, Patrick W G, Winston, Alan, Sabin, Caroline A, and Pharmacokinetic and Clinical Observations in PeoPle Over fiftY
Subjects: Adult, Male, 0301 basic medicine, Adolescent, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Comorbidity, medicine.disease_cause, Communicable Diseases, Severity of Illness Index, RC0109, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Metabolic Diseases, Co occurring, Risk Factors, Poppy, Environmental health, Humans, Immunology and Allergy, Medicine, 030212 general & internal medicine, business.industry, Mental Disorders, Middle Aged, medicine.disease, Treatment Outcome, 030104 developmental biology, Infectious Diseases, Cardiovascular Diseases, Female, business
Abstract: Aims: \ud To assess associations of comorbidity patterns observed in people living with HIV (PLWH) with risk factors and health outcomes.\ud \ud Methods: \ud Common patters of comorbidities in PLWH participating in the Pharmacokinetic and Clinical Observations in People Over Fifty study were determined using principal component analysis and a severity score for each pattern was derived. Associations between each pattern's severity score and risk factors were assessed using median regression. The independent associations of patterns’ severity scores with self-reported physical and mental health (SF-36 summary scores) were assessed using linear regression, with functional impairment (Lawton IADL < 8) and hospitalization in last year using logistic regression and with number of general practitioner visits using Poisson regression.\ud \ud Results: \ud A total of 1073 PLWH were analysed: 85.2% male, median (interquartile range) age 52 (47–59) years, 98% on therapy. Duration of HIV was associated with higher severity in 4/6 of patterns: cardiovascular diseases, mental health problems, metabolic disorders and chest/other infections (all P ≤ 0.001). Prior AIDS was associated with higher severity scores for the same patterns and for the pattern of cancers (P < 0.001). The pattern of cardiovascular diseases was associated with poorer physical health (P = 0.02), higher risk of functional impairment (P = 0.02) and hospitalization (P < 0.001) and with higher number of general practitioner visits (P < 0.001). Severity of mental health (all P < 0.001) and of chest/other infections patterns negatively affected all the five health outcomes.\ud \ud Conclusion: \ud Common patterns of comorbidities seen in PLWH appear to have different risk factors and to differently affect health outcomes. These findings may assist the development of targeted intervention to prevent, treat and manage the increasingly prevalent multimorbidity in PLWH.
Published: 2019
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43. Dynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses

Author: Mallon, Patrick W G, Tinago, Willard, Leon, Alejandro Garcia, McCann, Kathleen, Kenny, Grace, McGettrick, Padraig, Green, Sandra, Inzitari, Rosanna, Cottere, Aoife G, Feeney, Eoin R, Savinelli, Stefano, Doran, Peter, Gavin, P, Eustace, J, Horgan, M, Sadlier, C, Lambert, J, McGinty, T, Low, J, Whelan, B, McNicholas, B, Yousif, O, Courtney, G, DeBarra, E, Kelly, C, and Bracken, T
Subjects: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunoglobulin G, Serology, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Major Article, Medicine, Clinical significance, 030212 general & internal medicine, Prospective cohort study, Antibody, Polymerase chain reaction, 030304 developmental biology, 0303 health sciences, biology, SARS-CoV-2, business.industry, COVID-19, 3. Good health, AcademicSubjects/MED00290, Infectious Diseases, Oncology, Immunoglobulin M, Immunology, biology.protein, business
Abstract: Background Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood. Methods Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)–confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We calculated sensitivity, specificity, and relationship with disease severity and mapped the kinetics of antibody responses over time using generalized additive models. Results We analyzed 1001 samples from 752 subjects, 327 with confirmed SARS-CoV-2 (29.7% with severe disease) spanning a period of 90 days from symptom onset. Sensitivity was lower (44.1%–47.1%) early (80% after 10 days. IgM positivity increased earlier than IgG-targeted assays, but positivity peaked between days 32 and 38 post–onset of symptoms and declined thereafter, a dynamic that was confirmed when antibody levels were analyzed, with a more rapid decline observed with IgM. Early ( Conclusions This study suggests that postinfectious antibody responses in those with confirmed COVID-19 begin to decline relatively early postinfection and suggests a potential role for higher IgM levels early in infection in the prediction of subsequent disease severity.
Published: 2021
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44. Inflammatory pathways amongst people living with HIV in Malawi differ according to socioeconomic status

Author: Kelly, Christine, primary, Tinago, Willard, additional, Alber, Dagmar, additional, Hunter, Patricia, additional, Luckhurst, Natasha, additional, Connolly, Jake, additional, Arrigoni, Francesca, additional, Garcia Abner, Alejandro, additional, Kamn’gona, Raphael, additional, Sheha, Irene, additional, Chammudzi, Mishek, additional, Jambo, Kondwani, additional, Mallewa, Jane, additional, Rapala, Alicja, additional, Mallon, Patrick W. G., additional, Mwandumba, Henry, additional, Klein, Nigel, additional, and Khoo, Saye, additional
Published: 2021
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45. Tocilizumab for the treatment of non‐critical COVID‐19 pneumonia: an overview of the rationale and clinical evidence to date

Author: Kenny, Grace, primary and Mallon, Patrick W. G., additional
Published: 2021
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46. Reply

Author: Savinelli, Stefano, McCarthy, Cormac, and Mallon, Patrick W.
Subjects: Pulmonary and Respiratory Medicine, TheoryofComputation_COMPUTATIONBYABSTRACTDEVICES, ComputingMilieux_THECOMPUTINGPROFESSION, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Correspondence, ComputingMilieux_MISCELLANEOUS
Abstract: See related reply
Published: 2020

47. Sleep health and cognitive function among people with and without HIV: the use of different machine learning approaches

Author: De Francesco, Davide, primary, Sabin, Caroline A, additional, Winston, Alan, additional, Rueschman, Michael N, additional, Doyle, Nicki D, additional, Anderson, Jane, additional, Vera, Jaime H, additional, Boffito, Marta, additional, Sachikonye, Memory, additional, Mallon, Patrick W G, additional, Haddow, Lewis, additional, Post, Frank A, additional, Redline, Susan, additional, and Kunisaki, Ken M, additional
Published: 2021
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48. Sustained VWF‐ADAMTS‐13axis imbalance and endotheliopathy in long COVIDsyndrome is related to immune dysfunction

Author: Fogarty, Helen, Ward, Soracha E., Townsend, Liam, Karampini, Ellie, Elliott, Stephanie, Conlon, Niall, Dunne, Jean, Kiersey, Rachel, Naughton, Aifric, Gardiner, Mary, Byrne, Mary, Bergin, Colm, O'Sullivan, Jamie M., Martin‐Loeches, Ignacio, Nadarajan, Parthiban, Bannan, Ciaran, Mallon, Patrick W., Curley, Gerard F., Preston, Roger J. S., Rehill, Aisling M., Baker, Ross I., Cheallaigh, Cliona Ni, O'Donnell, James S., O’Connell, Niamh, Ryan, Kevin, Kenny, Dermot, and Fazavana, Judicael
Abstract: Prolonged recovery is common after acute SARS‐CoV‐2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS‐13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute COVID‐19. We hypothesized that VWF/ADAMTS‐13 imbalance persists in convalescence together with endothelial cell (EC) activation and angiogenic disturbance. Additionally, we postulate that ongoing immune cell dysfunction may be linked to sustained EC and coagulation activation. Fifty patients were reviewed at a minimum of 6 weeks following acute COVID‐19. ADAMTS‐13, Weibel Palade Body (WPB) proteins, and angiogenesis‐related proteins were assessed and clinical evaluation and immunophenotyping performed. Comparisons were made with healthy controls (n= 20) and acute COVID‐19 patients (n= 36). ADAMTS‐13 levels were reduced (p= 0.009) and the VWF‐ADAMTS‐13 ratio was increased in convalescence (p= 0.0004). Levels of platelet factor 4 (PF4), a putative protector of VWF, were also elevated (p= 0.0001). A non‐significant increase in WPB proteins Angiopoietin‐2 (Ang‐2) and Osteoprotegerin (OPG) was observed in convalescent patients and WPB markers correlated with EC parameters. Enhanced expression of 21 angiogenesis‐related proteins was observed in convalescent COVID‐19. Finally, immunophenotyping revealed significantly elevated intermediate monocytes and activated CD4+ and CD8+ T cells in convalescence, which correlated with thrombin generation and endotheliopathy markers, respectively. Our data provide insights into sustained EC activation, dysregulated angiogenesis, and VWF/ADAMTS‐13 axis imbalance in convalescent COVID‐19. In keeping with the pivotal role of immunothrombosis in acute COVID‐19, our findings support the hypothesis that abnormal T cell and monocyte populations may be important in the context of persistent EC activation and hemostatic dysfunction during convalescence.
Published: 2022
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49. Identification of Distinct Long COVID Clinical Phenotypes Through Cluster Analysis of Self-Reported Symptoms.

Author: Kenny, Grace, McCann, Kathleen, O'Brien, Conor, Savinelli, Stefano, Tinago, Willard, Yousif, Obada, Lambert, John S, O'Broin, Cathal, Feeney, Eoin R, Barra, Eoghan De, Doran, Peter, Mallon, Patrick W G, and Group, All-Ireland Infectious Diseases (AIID) Cohort Study
Abstract: Background We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID. Methods This was an analysis within a multicenter, prospective cohort study of individuals with a confirmed diagnosis of COVID-19 and persistent symptoms >4 weeks from onset of acute symptoms. We performed a multiple correspondence analysis (MCA) on the most common self-reported symptoms and hierarchical clustering on the results of the MCA to identify symptom clusters. Results Two hundred thirty-three individuals were included in the analysis; the median age of the cohort was 43 (interquartile range [IQR], 36–54) years, 74% were women, and 77.3% reported a mild initial illness. MCA and hierarchical clustering revealed 3 clusters. Cluster 1 had predominantly pain symptoms with a higher proportion of joint pain, myalgia, and headache; cluster 2 had a preponderance of cardiovascular symptoms with prominent chest pain, shortness of breath, and palpitations; and cluster 3 had significantly fewer symptoms than the other clusters (2 [IQR, 2–3] symptoms per individual in cluster 3 vs 6 [IQR, 5–7] and 4 [IQR, 3–5] in clusters 1 and 2, respectively; P < .001). Clusters 1 and 2 had greater functional impairment, demonstrated by significantly longer work absence, higher dyspnea scores, and lower scores in SF-36 domains of general health, physical functioning, and role limitation due to physical functioning and social functioning. Conclusions Clusters of symptoms are evident in long COVID patients that are associated with functional impairments and may point to distinct underlying pathophysiologic mechanisms of disease. [ABSTRACT FROM AUTHOR]
Published: 2022
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50. Sleep Disorders in Human Immunodeficiency Virus: A Substudy of the Pharmacokinetics and Clinical Observations in People Over Fifty (POPPY) Study

Author: Kunisaki, Ken M, primary, De Francesco, Davide, additional, Sabin, Caroline A, additional, Winston, Alan, additional, Mallon, Patrick W G, additional, Anderson, Jane, additional, Bagkeris, Emmanouil, additional, Boffito, Marta, additional, Doyle, Nicki, additional, Haddow, Lewis, additional, Post, Frank A, additional, Sachikonye, Memory, additional, Vera, Jaime, additional, Khalil, Wajahat, additional, and Redline, Susan, additional
Published: 2020
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