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Your search keyword '"Makiko Kawamoto"' showing total 8 results
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8 results on '"Makiko Kawamoto"'

1. Presence of periodontitis may synergistically contribute to cancer progression via Treg and IL-6

Author

Ryo Kajihara, Hironori Sakai, Yibing Han, Kei Amari, Makiko Kawamoto, Yusuke Hakoyama, Sachiho Nagashio, Shin-ichi Yamada, Hideki Sanjo, and Hiroshi Kurita

Subjects
Medicine, Science
Abstract

Abstract A close causal relationship has been suggested to exist between cancer and periodontitis. We hypothesized that the immune surveillance system is impaired in patients with periodontitis, which contributes to cancer development and growth. Therefore, the present study investigated the relationship between immune surveillance mechanisms and periodontitis in cancer patients. The presence or absence of periodontitis was assessed and the peripheral blood (PB) concentrations of IL-6, immunosuppressive cytokines (VEGF, TGF-β1, and CCL22) and proportion of T regulatory cells (Treg, CD3 + CD4 + CD25 + Foxp3 +) were measured. Subjects were classified into the following four groups: non-cancer patients without periodontitis (C − P −), non-cancer patients with periodontitis (C − P +), cancer patients without periodontitis (C + P −), and cancer patients with periodontitis (C + P +). The results of a multivariate analysis showed that the PB concentration of IL-6 was significantly higher in C + than in C- and higher in C + P + than in C + P −. The PB proportion of Treg was significantly higher in C + P + than in C + P −, C − P + , and C − P −. The results of this study suggested that the presence of periodontitis and cancer synergistically increased Treg in PB, which may be one of the underlying causes of immunosuppression and immune evasion in cancer. It was also suggested that the presence of periodontal disease and/or cancer also increases IL-6 in PB, which would be associated with cancer progression. These results suggest the possibility that the presence of periodontitis might synergistically contribute to cancer progression.

Published
2022
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2. Exploration of correlation of oral hygiene and condition with influenza infection.

Author

Makiko Kawamoto, Hirokazu Tanaka, Akinari Sakurai, Hiroki Otagiri, Imahito Karasawa, Shin-Ichi Yamada, and Hiroshi Kurita

Subjects
Medicine, Science
Abstract

Influenza viruses are known to be infected through epithelial cells of the upper respiratory tract. The oral cavity is in close anatomical proximity to the upper respiratory tract, and it is conceivable that the viruses could pass through the oral cavity and infect to the upper respiratory tract. Several researchers have suggested that colonization of certain pathogenic bacteria such as Staphylococcus aureus or Streptococcus pneumoniae might affect the risk of influenza viral disease, indicating that oral hygiene and/or condition might play an important role in respiratory viral infection. Therefore, the purpose of this study was to investigate whether an oral hygiene/condition might impact influenza infection. We conducted a retrospective observational study of Japanese citizens' regional cohort (N = 2,904) consisting of National Health Insurance beneficiaries who underwent annual health/dental examination with data entries in the Kokuho database (KDB). Trained dentists checked the oral hygiene/condition, and saliva specimens were examined using the LION dental saliva multi-test (SMT) kit. Influenza infection was identified from the diagnosis recorded in the KDB. The correlations between influenza infection and oral hygiene, dryness of the mouth, or various salivary test results were examined by a multivariate analysis adjusting for confounding factors such as gender, age, recent smoking, alcohol drinking, BMI, HbA1c, RBC for influenza infection. The logistic regression model showed that age significantly correlated with influenza infection. In addition, oral hygiene status had a nearly significant impact on influenza infection (p = 0.061), whereby, the subjects with poor oral hygiene had a higher risk of influenza infection than those with good oral hygiene (odds ratio: 1.63, 95% confidence interval: 0.89-2.95). Further, the prevalence of influenza infection was lower in the subjects with saliva weakly acidic and/or containing higher protein level. The results of this study suggested that the maintenance of oral health conditions might be one of the pivotal factors for preventing and reducing influenza infection.

Published
2021
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3. Immunohistochemical investigation of biomarkers for predicting adipose tissue invasion in oral squamous cell carcinoma

Author

Hiroki Otagiri, Yibing Han, Eiji Kondo, Makiko Kawamoto, Takeshi Uehara, Atsushi Takizawa, Hirokazu Tanaka, Hironori Sakai, Hiroshi Kurita, Takahiko Gibo, Shin-ichi Yamada, and Masao Hashidume

Subjects
Pathology, medicine.medical_specialty, Buccal fat pad, medicine.diagnostic_test, business.industry, Adipose tissue, Computed tomography, Fat pad, Pathology and Forensic Medicine, stomatognathic diseases, Otorhinolaryngology, medicine, Immunohistochemistry, Surgery, Basal cell, Oral Surgery, business, Preoperative imaging, Predictive biomarker
Abstract

The purpose of the present study was to identify histological biomarkers that could be used to predict adipose tissue invasion by oral squamous cell carcinoma (OSCC). The medical records and preoperative computed tomography scans of patients with primary OSCC with suspected buccal fat pad invasion were retrospectively reviewed, and an immunohistochemical study of candidate predictive biomarkers of adipose tissue invasion (α-SMA, E-cadherin, N-cadherin, FABP4, Col VI, and MMP-11) was carried out. Thirty OSCC patients whose tumors were suspected to be in contact with the buccal fat pad based on preoperative imaging were included in this study. Of these, infiltrative adipose tissue invasion was histopathologically confirmed in 6 patients (20.0 %). The significant higher immunoreactivity of candidate predictive biomarkers was detected in the tumor-buccal fat pad contact area compared to in the tumor surface area.(Pearson’s correlation coefficient test: α-SMA: 0.422, p

Published
2022
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6. Relationship between dry mouth and hypertension

Author

Hirokazu Tanaka, Atsushi Takizawa, Takahiko Gibo, Ryo Kajihara, Hironori Sakai, Shin-ichi Yamada, Hiroshi Kurita, Junichi Yajima, Tomoki Kaneko, Sachiho Nagashio, Eiji Kondo, Takeshi Uehara, and Makiko Kawamoto

Subjects
medicine.medical_specialty, business.industry, Submandibular Gland, 030206 dentistry, Arteriosclerosis, Degeneration (medical), medicine.disease, Dry mouth, Gastroenterology, Xerostomia, 03 medical and health sciences, Stenosis, 0302 clinical medicine, stomatognathic system, 030220 oncology & carcinogenesis, Internal medicine, Epidemiology, Hypertension, Medicine, Humans, In patient, Fatty infiltration, medicine.symptom, business, General Dentistry
Abstract

Salivary dysfunction, such as reduced salivary flow and an altered salivary composition, is caused by several diseases, medical conditions, and medications. The purpose of the present study was to clarify the relationship between hypertension and morphological changes in the submandibular glands. An epidemiological study was conducted to elucidate the relationship between hypertension and dry mouth. The effects of hypertension on morphological changes and the intima thickness of arteries in the submandibular glands were histopathologically investigated. Among 1933 subjects in the epidemiological study, 155 (8.0%) had dry mouth. A multivariate analysis revealed that dry mouth correlated with age (p

Published
2020

7. Immunohistochemical Investigation of Predictive Biomarkers for Mandibular Bone Invasion in Oral Squamous Cell Carcinoma

Author

Hiroshi Kurita, Makiko Kawamoto, Takeshi Uehara, Takahiko Gibo, and Shin-ichi Yamada

Subjects
0301 basic medicine, Male, Cancer Research, Pathology, medicine.medical_specialty, Computed tomography, Bone Neoplasms, Pathology and Forensic Medicine, Bone contact, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, Medicine, Humans, Basal cell, Neoplasm Invasiveness, Predictive biomarker, Aged, Retrospective Studies, Aged, 80 and over, Predictive marker, medicine.diagnostic_test, business.industry, Mandible, General Medicine, Middle Aged, Prognosis, Mandibular resection, Immunohistochemistry, Survival Rate, stomatognathic diseases, Mandibular Neoplasms, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, business, Follow-Up Studies
Abstract

The accurate preoperative determination of the extent of mandibular resection remains a challenge for the surgeons. The purpose of the present study was to immunohistochemically investigate predictive markers for histological bone invasion of oral squamous cell carcinoma (OSCC). The medical records of primary OSCC patients with mandibular bone contact in preoperative computed tomography scans between January 2003 and December 2017 were retrospectively reviewed and an immunohistochemical investigation was performed. Forty-five OSCC patients with mandibular bone contact radiographically were included in this study. Histopathologically, infiltrative bone invasion was observed in 19 patients (42.2%) and compressive bone invasion in 15 (33.3%). A correlation was noted between the histological pattern of bone invasion and mode of invasion (chi-squared test, p

Published
2020

8. Relationship Between the Quantity of Oral Candida and Systemic Condition/Diseases of the Host: Oral Candida Increases with Advancing Age and Anemia

Author

Akinari Sakurai, Hiroshi Kurita, Makiko Kawamoto, Kiyonori Hayashi, Fumihiro Nishimaki, and Shin-ichi Yamada

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Anemia, Veterinary (miscellaneous), Health Status, 030106 microbiology, Colony Count, Microbial, Physiology, Decreased red blood cell count, Applied Microbiology and Biotechnology, Microbiology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Red Blood Cell Count, medicine, Humans, Mannan, Aged, Candida, Aged, 80 and over, Univariate analysis, Mouth, Host (biology), business.industry, Age Factors, Middle Aged, medicine.disease, stomatognathic diseases, Cross-Sectional Studies, Close relationship, Female, business, Agronomy and Crop Science
Abstract

The impact of host systemic conditions/diseases on the prosperity of oral Candida colonies remains unclear. The aim of the present study was to investigate whether a relationship exists between the quantity of oral Candida and the systemic condition/diseases of the host. The cross-sectional relationship between Candida mannan concentrations and health check-up results was analyzed in consideration of local conditions that influence the prevalence of oral Candida. Candida mannan concentrations correlated with age, the number of untreated decayed teeth, number of prosthetic teeth, salivary pH, HbA1c, and the red blood cell count in a univariate analysis. In a multivariate analysis, Candida mannan concentrations correlated with age, the number of untreated decayed teeth, number of prosthetic teeth, salivary pH, and the red blood cell count. Candida mannan concentrations were higher in subjects older than 80 years, with a higher number of either untreated or prosthetic teeth, with a lower salivary pH, and with a decreased red blood cell count. Mannan concentrations were slightly higher in subjects with elevated HbA1c. The present results suggest a close relationship between the quantity of oral Candida and the systemic condition/diseases of the host. Oral Candida may increase in immunocompromised hosts.

Published
2018

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