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Your search keyword '"Mailland, F."' showing total 5 results
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5 results on '"Mailland, F."'

1. Precision Charge Control for Isolated Free-Falling Test Masses: LISA Pathfinder Results

Author

Armano, M., Audley, H., Baird, J., Binetruy, P., Born, M., Bortoluzzi, D., Castelli, E., Cavalleri, A., Cesarini, A., Cruise, A. M., Danzmann, K., Silva, M. de Deus, Diepholz, I., Dixon, G., Dolesi, R., Ferraioli, L., Ferroni, V., Fitzsimons, E. D., Freschi, M., Gesa, L., Giardini, D., Gibert, F., Giusteri, R., Grimani, C., Grzymisch, J., Harrison, I., Heinzel, G., Hewitson, M., Hollington, D., Hoyland, D., Hueller, M., Inchauspé, H., Jennrich, O., Jetzer, P., Karnesis, N., Kaune, B., Korsakova, N., Killow, C. J., Liu, L., Lloro, I., Lobo, J. A., López-Zaragoza, J. P., Maarschalkerweerd, R., Mailland, F., Mance, D., Martín, V., Martin-Polo, L., Martin-Porqueras, F., Martino, J., Mateos, I., McNamara, P. W., Mendes, J., Mendes, L., Meshskar, N., Nofrarias, M., Paczkowski, S., Perreur-Lloyd, M., Petiteau, A., Pfeil, M., Pivato, P., Plagnol, E., Ramos-Castro, J., Reiche, J., Robertson, D. I., Rivas, F., Russano, G., Santoruvo, G., Sarra, P., Shaul, D., Slutsky, J., Sopuerta, C. F., Sumner, T., Texier, D., Thorpe, J. I., Trenkel, C., Vetrugno, D., Vitale, S., Wanner, G., Ward, H., Waschke, S., Wass, P. J., Weber, W. J., Wissel, L., Wittchen, A., and Zweifel, P.

Subjects
Physics - Instrumentation and Detectors
Abstract

The LISA Pathfinder charge management device was responsible for neutralising the cosmic ray induced electric charge that inevitably accumulated on the free-falling test masses at the heart of the experiment. We present measurements made on ground and in-flight that quantify the performance of this contactless discharge system which was based on photo-emission under UV illumination. In addition, a two-part simulation is described that was developed alongside the hardware. Modelling of the absorbed UV light within the Pathfinder sensor was carried out with the GEANT4 software toolkit and a separate MATLAB charge transfer model calculated the net photocurrent between the test masses and surrounding housing in the presence of AC and DC electric fields. We confront the results of these models with observations and draw conclusions for the design of discharge systems for future experiments like LISA that will also employ free-falling test masses.

Published
2018
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5. Entry inhibition of HSV-1 and -2 protects mice from viral lethal challenge.

Author

Clementi N, Criscuolo E, Cappelletti F, Quaranta P, Pistello M, Diotti RA, Sautto GA, Tarr AW, Mailland F, Concas D, Burioni R, Clementi M, and Mancini N

Subjects
Animals, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal immunology, Antibodies, Viral immunology, Antibodies, Viral pharmacology, Chlorocebus aethiops, Cross Protection immunology, Disease Models, Animal, Eye pathology, Female, HEK293 Cells, Herpes Simplex transmission, Herpes Simplex virology, Herpesvirus 1, Human pathogenicity, Herpesvirus 2, Human pathogenicity, Humans, Kidney pathology, Mice, Mice, Inbred C57BL, Neutralization Tests, Vero Cells, Viral Envelope Proteins immunology, Viral Plaque Assay, Virus Replication drug effects, Antibodies, Monoclonal pharmacology, Herpes Simplex immunology, Herpes Simplex prevention & control, Herpesvirus 1, Human drug effects, Herpesvirus 1, Human immunology, Herpesvirus 2, Human drug effects, Herpesvirus 2, Human immunology, Virus Internalization drug effects
Abstract

The present study focused on inhibition of HSV-1 and -2 replication and pathogenesis in vitro and in vivo, through the selective targeting of the envelope glycoprotein D. Firstly, a human monoclonal antibody (Hu-mAb#33) was identified that could neutralise both HSV-1 and -2 at nM concentrations, including clinical isolates from patients affected by different clinical manifestations and featuring different susceptibility to acyclovir in vitro. Secondly, the potency of inhibition of both infection by cell-free viruses and cell-to-cell virus transmission was also assessed. Finally, mice receiving a single systemic injection of Hu-mAb#33 were protected from death and severe clinical manifestations following both ocular and vaginal HSV-1 and -2 lethal challenge. These results pave the way for further studies reassessing the importance of HSV entry as a novel target for therapeutic intervention and inhibition of cell-to-cell virus transmission., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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